1. [Hypertension, chronic kidney disease and genetics in patients with African ancestry].
- Author
-
Halimi JM
- Subjects
- Apolipoprotein A-I blood, Apolipoproteins genetics, Biomarkers blood, Humans, Hypertension blood, Hypertension epidemiology, Incidence, Mutation genetics, Polymorphism, Genetic genetics, Prevalence, Renal Insufficiency, Chronic blood, Renal Insufficiency, Chronic epidemiology, Risk Factors, Trypanosomiasis, African genetics, United States epidemiology, White People genetics, White People statistics & numerical data, Black or African American genetics, Black or African American statistics & numerical data, Apolipoprotein A-I genetics, Hypertension ethnology, Hypertension genetics, Renal Insufficiency, Chronic ethnology, Renal Insufficiency, Chronic genetics
- Abstract
The incidence and prevalence of hypertension is markedly elevated in Afro-American populations vs Caucasians. The development of end-stage renal disease is also more frequent in Afro-American subjects, independently of blood pressure control. As compared to Caucasians, Afro-American subjects have a higher risk of end-stage renal disease when they are infected with HIV or have lupus. For decades, these data remained mysterious. Within the last 3 years, results from studies in the field of genetics and infectious diseases have transformed our view on this problem. The aim of this paper is to explain how these results have changed our understanding of hypertension and its consequences in Afro-American subjects., (Copyright © 2014 Elsevier Masson SAS. All rights reserved.)
- Published
- 2014
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