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Summary: Background: The prevalence of childhood obesity in the U.S. has increased, likely due to decreased physical activity, increased sedentary behaviour and unhealthy diets. Little is known about the relationships between these factors and weight gain in those under the age of three. Objectives: This study aimed to understand the longitudinal associations of weight gain over 6‐month intervals with child and parent characteristics as children develop from 6 to 36 months. Methods: Mother and infant data were collected at 6‐month intervals from 6 to 36 months. Weight (kg) was the primary outcome variable, and potential explanatory variables included child and parent characteristics, physical activity, motor development, diet and sleep. Structural equation modelling was used to assess associations between explanatory variables and 6‐month weight gain. Results: Weight increased ~1 kg per 6‐month interval (p < 0.001) from 6 to 36 months. Childcare outside of the home at 12 months was associated with 0.272 kg (p = 0.002) greater weight gain at 18 months, while children's physical activity was associated with 0.228 kg (per 2 SD, p = 0.051) less weight gain during the same time period. Mother's TV and screen media use (0.102 kg per hour/day, p = 0.046) and child's intake of high‐energy beverages at 18 months (0.387 kg, p = 0.037) were both associated with greater weight gain at 24 months. Conclusion: Childcare, physical activity, screen media use and high‐energy beverage consumption might affect weight gain at different time points in early childhood. These insights can inform efforts to prevent excessive weight gain and childhood obesity effectively. [ABSTRACT FROM AUTHOR]

The article focuses on how emerging interest and research contributed to developmental or neuroprotective care in neonatal intensive care units (NICUs). Topics include theoretically based and empirically supported approaches, early conceptualization of the impact of sensory environments on babies, and a change in perspective to babies receiving too much sensory output.

The objective of this study was to obtain an understanding of audiologists' knowledge of Spanish speech perception materials for the paediatric hearing loss population. An electronic survey, the Knowledge of Spanish Audiology & Speech Tools (KSAST) was distributed via Qualtrics to audiologists who worked with Spanish-speaking children. One hundred and fifty-three audiologists practicing in the United States completed the electronic survey over a period of six months. Audiologists lacked knowledge of current Spanish measures and there was no consensus on what providers were administering for the paediatric population. The largest gaps in knowledge existed for the infancy through early childhood age groups. Notably, even when Spanish measures exist, audiologists reported feeling uncomfortable using them in clinic due to a variety of reasons (e.g., did not know how to access measure, did not know how to administer). This study highlights the lack of consensus in managing Spanish-speaking patients with hearing loss. There is a lack of validated age-appropriate measures to accurately assess speech perception for Spanish-speaking children. Future research should focus on improving training on management of Spanish-speaking patients, as well as development of speech measures and best practice guidelines for this population. [ABSTRACT FROM AUTHOR]

In the United States, most mothers work during pregnancy. Yet, until the passage of the Pregnant Workers Fairness Act in 2022, pregnant employees did not have a right to reasonable accommodations to work under safe conditions. This law is expected to increase employment among pregnant women, making it critical to understand the effects of work during pregnancy on health and the potential benefits of the law. Because the prenatal period has long‐lasting consequences for health, employment during pregnancy can affect children's health and development in childhood and beyond. In this article, we review theory and empirical evidence on the effects of work during pregnancy on maternal and infant health. We propose a conceptual framework that outlines the pathways through which work during pregnancy affects health, discuss policies that are expected to affect work during pregnancy and health and conclude with priorities for future research. [ABSTRACT FROM AUTHOR]

The article discusses the evolution of neonatal care practices in the United States, focusing on the transition from early incubator-based care to developmental or neuroprotective approaches. Topics include the initial emphasis on survival and infection control for premature infants, the shift toward developmental care informed by brain research, and historical practices in the care of "incubator babies" as documented in early 20th-century nursing literature.

Learning to descend stairs requires motor and cognitive capacities on the part of infants and opportunities for practice and assurance of safety offered by caregivers. The American Academy of Pediatrics prescribes the age strategy to teach toddlers to safely descend stairs but without much consideration for individual differences in infants' skills or caregivers' techniques. The purpose of this study was to observe the natural ways in which caregivers teach infants to descend stairs at home and the extent to which infants abide. Of particular interest was to examine the dynamic nature of caregivers' teaching and infants' learning over the session with attention to individual differences. Dyads (N = 59) were videorecorded on Zoom for 10 min interacting on stairs at home in the United States, Brazil, Canada, Italy, and Spain. Infants (n = 30 girls, 29 boys; 13-month-olds ± 1 week) were novice walkers (M = 2.04 months walking experience). Caregivers used a variety of teaching strategies and focused on "backing" and "scooting." Infants were more likely to heed caregivers' guidance when caregivers provided hands-on support and verbal encouragement suggesting infants were engaged and responsive to caregivers' overtures. Infants' walking experience predicted change in descent strategy over the session. Although infants did not show evidence of learning over the session, consistent caregiver instruction suggested caregivers were persistent, if not effective, teachers. Teaching and learning motor skills in a potentially risky task creates a unique opportunity for interaction, allowing infants and caregivers to learn from one another. Public Significance Statement: This work contributes to the general body of knowledge regarding infant motor development and problem solving in specific contexts. This study is one of the first to explore the nature of caregiver-infant interaction on stairs and identifies caregiver teaching strategies and infant motor characteristics that are associated with safe infant stair descent. By doing so, we hope to encourage further investigation of infant behavior in this context, upon which recommendations to caregivers for safe infant descent may be based. [ABSTRACT FROM AUTHOR]

Background: Most studies of the effects of prenatal alcohol exposure (PAE) on cognitive function have assumed that the dose-response curve is linear. However, data from a few animal and human studies suggest that there may be an inflection point in the dose-response curve above which PAE effects are markedly stronger and that there may be differences associated with pattern of exposure, assessed in terms of alcohol dose per drinking occasion and drinking frequency. Methods: We performed second-order confirmatory factor analysis on data obtained at school age, adolescence, and early adulthood from 2227 participants in six US longitudinal cohorts to derive a composite measure of cognitive function. Regression models were constructed to examine effects of PAE on cognitive function, adjusted for propensity scores. Analyses based on a single predictor (absolute alcohol (AA)/day) were compared with analyses based on two predictors (dose/occasion and drinking frequency), using (1) linear models and (2) nonparametric general additive models (GAM) that allow for both linear and nonlinear effects. Results: The single-predictor GAM model showed virtually no nonlinearity in the effect of AA/day on cognitive function. However, the two-predictor GAM model revealed differential effects of maternal drinking pattern. Among offspring of infrequent drinkers, PAE effects on cognitive function were markedly stronger in those whose mothers drank more than ~3 drinks/occasion, and the effect of dose/occasion was strongest among the very frequent drinkers. Frequency of drinking did not appear to alter the PAE effect on cognitive function among participants born to mothers who limited their drinking to ~1 drink/occasion or less. Conclusions: These findings suggest that linear models based on total AA/day are appropriate for assessing whether PAE affects a given cognitive outcome. However, examination of alcohol dose/occasion and drinking frequency is needed to fully characterize the impact of different levels of alcohol intake on cognitive impairment. [ABSTRACT FROM AUTHOR]

Infants with neuromotor disorders demonstrate delays in sitting skills (decreased capacity) and are less likely to maintain independent sitting during play than their peers with typical development (decreased performance). This study aimed to quantify developmental trajectories of sitting capacity and sitting performance in infants with typical development and infants with significant motor delay and to assess whether the relationship between capacity and performance differs between the groups. Typically developing infants (n = 35) and infants with significant motor delay (n = 31) were assessed longitudinally over a year following early sitting readiness. The Gross Motor Function Measure (GMFM) Sitting Dimension was used to assess sitting capacity, and a 5-min free play observation was used to assess sitting performance. Both capacity and performance increased at a faster rate initially, with more deceleration across time, in infants with typical development compared to infants with motor delay. At lower GMFM scores, changes in GMFM sitting were associated with larger changes in independent sitting for infants with typical development, and the association between GMFM sitting and independent sitting varied more across GMFM scores for typically developing infants. Intervention and assessment for infants with motor delay should target both sitting capacity and sitting performance. [ABSTRACT FROM AUTHOR]

Objective: Lambdoid craniosynostosis affects approximately 1 in 33 000 live births per year, and surgical correction is often sought in order to achieve normocephaly and allow for adequate brain growth. However, the effects of lambdoid synostosis and its treatment on cognitive development are unknown. Design: Systematic review and meta-analysis. Patients, Participants: A systematic review of Ovid Medline, Embase, Web of Science, Scopus, Cochrane Central Register of Controlled Trials, and Clinicaltrials.gov was conducted in January 2022. Included studies assessed cognitive development of patients with nonsyndromic unilateral lambdoid craniosynostosis. Main Outcome Measures: Results of developmental tests were compared to normative data or controls to generate Hedges' g for meta-analysis. Results: Nine studies met the inclusion criteria. Meta-analysis of 3 studies describing general cognition showed that cases scored significantly lower than their peers, but within 1 standard deviation (g = 0.37, 95% CI [−0.64, −0.10], P =.01). Meta-analysis of verbal and psychomotor development showed no significant differences in children with lambdoid synostosis. Studies were of fair quality and had moderate-to-high heterogeneity. Conclusions: Patients with lambdoid craniosynostosis may score slightly below average on tests of general cognition in comparison to normal controls, but results in other domains are variable. Analyses were limited by small sample sizes. Multidisciplinary care and involvement of a child psychologist may be helpful in identifying areas of concern and providing adequate scholastic support. Further research recruiting larger cohorts will be necessary to confirm these findings and extend them to other developmental domains such as attention and executive function. [ABSTRACT FROM AUTHOR]

Purpose: This study is a preliminary quantification and characterization of the development of marginal and canonical syllable patterns in 10 infants at risk for cerebral palsy (CP). Method: We calculated marginal and canonical babbling ratios from parent– infant laboratory recordings of 10 infants at two time points, approximately 13 and 16 months of age. The frequency and diversity of labial, coronal, and velar types of marginal and canonical syllables were also examined. Differences across three outcome groups were compared: infants later diagnosed with CP (n = 3, CP group), risk of CP due to ongoing gross motor delays (n = 4, risk group), and current typically developing status with resolved gross motor delays (n = 3, TDx group). Performance on the Mullen Scales was included for perspective on cognitive development. Results: Higher marginal syllable ratios were observed in the CP and risk groups than the TDx group. An increasing canonical syllable ratio across the two ages was consistently observed in the TDx group. The TDx group produced a greater frequency and diversity of canonical syllable types than the risk and CP groups, and of marginal syllable types than the CP group. Conclusions: This study offers preliminary support for the possibility that speech motor impairment in infants with CP have the potential to be observed and quantified early in vocal development prior to the expected onset of first words. Prolonged rates of marginal syllable forms may be suggestive of speech motor impairment; however, additional longitudinal outcome data over a longer time course and a larger sample of infants are needed to provide further support for this possibility. [ABSTRACT FROM AUTHOR]

Aim Bayley Scales of Infant and Toddler Development (Bayley-III) determines scaled scores and converts these into composite scores. It was shown that applying the German and the U.S. manual leads to different results. This study aims to systematically analyze the differences between the U.S. and German Bayley-III version and to develop conversion equations. Methods This simulation study generated a dataset of pairs of U.S. and German Bayley-III composite scores (cognitive: n = 4,416, language: n = 240,000, motor: n = 314,000) by converting the same number of achievable tasks for 48 age groups. Bland–Altman plot and regression analyses were performed to develop conversion equations for all age groups. Results German and US Bayley-III scores demonstrate distinct slope and interception for cognitive, language, and motor composite scores. Lower developmental performance leads to higher composite scores with U.S. norms compared with German norms (up to 15 points). These differences varied between age groups. With newly developed conversion equations, the results can be converted (R 2 > 0.98). Interpretation This study confirms systematic differences between U.S. and German Bayley test results due to different reference cohorts. Our data consider the full age range and add conversion equations. These findings need to be acknowledged when comparing Bayley Scores internationally. [ABSTRACT FROM AUTHOR]

Dance is a universal human behavior and a crucial component of human musicality. When and how does the motivation and tendency to move to music develop? How does this behavior change as a process of maturation and learning? We characterize infants' earliest dance behavior, leveraging parents' extensive at-home observations of their children. Parents of infants aged 0–24 months (N = 278, 82.7% White, 84.5% in the United States, 46.0% of household incomes ≥$100,000) were surveyed regarding their child's current and earliest dance behavior (movement by the child, during music, that the parent considered dance), motor development, and their own infant-directed dance. We found that dance begins early: 90% of infants produced recognizable dance by 12.8 months, and the age of onset was not solely a function of motor development. Infants who produced dance did so often, on average almost every day. We also found that dance shows qualitative developmental change over the first 2 years, rather than remaining stable. With motor development, age, and more time dancing, infants used a greater variety of movements in dance, and began to incorporate learned, imitated gestures (80% of infants by 17.9 months). 99.8% of parents reported dancing for or with their infants, raising questions about the role of infant-directed dance. These findings provide evidence that the motivation and tendency to move to music appears extremely early and that both learning and maturation lead to qualitative change in dance behavior during the first 2 years, informing broad questions about the origins of human musicality. Public Significance Statement: Music and dance impact human well-being, social behavior, and health. We find that the motivation and tendency to move to music appears extremely early in life, and shows developmental change over the first 2 years. Movement to music appears to be a fundamental part of infants' behavioral repertoire, with implications for early cognitive, emotional, social, and motor development. [ABSTRACT FROM AUTHOR]

Background: Down syndrome (DS) generally predisposes children to a pattern of relative developmental strengths and challenges, but within‐syndrome heterogeneity is also commonly observed across many dimensions. The present research examines whether heterogeneity in developmental presentation can be detected during infancy in DS and whether factors associated with differing profiles can be identified. Methods: Infants with DS (n = 75; age range: 3.9–17.6 months) were administered the Bayley Scales of Infant Development III (Bayley‐III). A primary caregiver provided information regarding developmental history and family demographics. Latent profile analysis was conducted to identify whether early profiles were present across the five Bayley‐III domains. Results: Three developmental profiles were observable within the sample: a 'Mild Delay' Profile, an 'Moderate Delay' Profile and a 'Pronounced Delay' Profile. In addition, chronological age, having received heart surgery and having received occupational therapy were associated with probability of profile membership. Conclusions: Findings from this study contribute to the growing knowledgebase regarding heterogenous presentations associated with DS and can inform early intervention planning. [ABSTRACT FROM AUTHOR]

The authors address growing attention on neuroprotection in the neonatal intensive care unit (NICU) and encourages neonatal caregivers and scientists to explore more opportunities to make the most of the potential of the developing brain during intensive caregiving. Topics discussed include origin of the term 'neuroprotection', neurologic cost of many neonatal therapies used in the NICU, and neuroprotective strategies in the NICU.

Infants with genital development considered atypical for assigned female sex may undergo feminizing genitoplasty (clitoroplasty and/or vaginoplasty) in early life. We sought to identify factors associated with parent/caregiver decisions regarding genitoplasty for their children with genital virilization. Longitudinal, observational study Twelve pediatric centers in the United States with multidisciplinary differences/disorders of sex development clinics, 2015-2020 Children under 2 years old with genital appearance atypical for female sex of rearing and their parents/caregivers Data on the child's diagnosis and anatomic characteristics before surgery were extracted from the medical record. Parents/caregivers completed questionnaires on psychosocial distress, experience of uncertainty, cosmetic appearance of their child's genitalia, and demographic characteristics. Urologists rated cosmetic appearance. For 58 patients from the study cohort with genital virilization being raised as girls or gender-neutral, we compared these data across 3 groups based on the child's subsequent surgical intervention: (i) no surgery (n = 5), (ii) vaginoplasty without clitoroplasty (V-only) (n = 15), and (iii) vaginoplasty and clitoroplasty (V+C) (n = 38). Fathers' and urologists' ratings of genital appearance were more favorable in the no-surgery group than in the V-only and V+C groups. Clitorophallic length was greater in the V+C group compared with the V-only group, with substantial overlap between groups. Mothers' depressive and anxious symptoms were lower in the no-surgery group compared with the V-only and V+C groups. Surgical decisions were associated with fathers' and urologists' ratings of genital appearance, the child's anatomic characteristics, and mothers' depressive and anxious symptoms. Further research on surgical decision-making is needed to inform counseling practices. [ABSTRACT FROM AUTHOR]

To evaluate the relationship between infant age of egg introduction and malnutrition‐related growth outcomes in the United States, we analysed secondary data of 1716 mother–child dyads in the Infant Feeding Practices Study II and its Year 6 Follow‐Up Study. Malnutrition‐related growth outcomes included body mass index z‐score (BMIZ), obesity (weight‐for‐height z‐score [WHZ] ≥3 or BMIZ ≥ 2), WHZ, wasting (WHZ < −2), height‐for‐age z‐score (HAZ), and stunting (HAZ < –2). Infant age at egg introduction was analysed as a continuous variable. We used generalised estimating equations to estimate the mean difference in continuous outcomes and relative risk [RR]) for binary outcomes, adjusting for related maternal and child confounders. We also explored interactions with child sex, maternal race/ethnicity, maternal educational level, ever breastfeeding, and formula feeding. In the total sample, a later infant age at egg introduction was associated with a lower mean difference in HAZ (confounder‐adjusted mean difference = −0.08, 95% confidence interval [CI]: −0.12 to −0.03 per month) and a higher risk of stunting (confounder‐adjusted RR = 1.17, 95% CI: 1.03–1.33 per month) at 6 years. The associations between infant age at egg introduction and 12‐month growth outcomes differed by child sex. Among females but not among males, later introduction of eggs was associated with a lower mean WHZ (−0.06 [−0.12 to 0.00] per month) at 12 months. Later egg introduction during infancy was associated with a lower mean HAZ and a higher risk of stunting in 6‐year‐old children. Besides this, it was associated with a lower WHZ among females at 12 months. Key messages: This secondary data analysis evaluated the relationship between infant age at egg introduction and malnutrition‐related growth outcomes among young US children within the Infant Feeding Practices Study II and its Year 6 Follow‐up Study.In the total sample, a later infant age at egg introduction was associated with a lower mean 6‐year height‐for‐age z‐score and a higher risk of stunting at 6 years.The associations between infant age at egg introduction and 12‐month growth outcomes differed by child sex. Later introduction of eggs was associated with a lower mean weight‐for‐height z‐score among females. However, this association was not observed among males. [ABSTRACT FROM AUTHOR]

The age at attaining infancy developmental milestones has been associated with later neurodevelopmental outcomes, but evidence from large and diverse samples is lacking. We investigated this by analyzing data of 5360 singleton children aged 9–10 from 17 states in the US enrolled in the Adolescent Brain Cognitive Development (ABCD) study during 2016–2020. Delays in four milestones (first roll over, unaided sitting, unaided walking, and speaking first words) were defined using the 90th percentile of age at attainment reported by children's biological mothers. Childhood neurocognitive function was measured by research assistants using the NIH toolbox, and children reported their behavioral problems using the Brief Problem Monitor. Linear mixed-effects models were employed to investigate the association between delays in single or multiple milestones and childhood neurobehavioral outcomes. Delays in first roll over, unaided sitting, or walking were associated with poorer childhood neurocognitive function, while delay in speaking first words was associated with both poorer neurocognitive function and behavioral problems. Children who had delays in both motor and language milestones had the worst neurocognitive function and behavioral outcomes. Our results suggest that delays in motor and language milestone attainment during infancy are predictive of childhood neurobehavioral outcomes. [ABSTRACT FROM AUTHOR]

How infants are held or contained throughout the day shape infants' experiences, particularly around movement and exploration. In Tajikistan, caregivers use 'gahvora' cradles, which severely restrict the body and limbs. The present study explored the variability and use of containment devices in U.S. and Tajik infants. Using time diaries, we compared 12‐month‐olds in the U.S. and Tajikistan on the types of containments used and the time spent in them throughout the day. During the day, Tajik infants accumulated more time in gahvoras than infants in the U.S. spent in cribs, primarily used for sleep, suggesting gahvoras served other functions. Given the availability of other devices, U.S. infants' time was distributed in short yet frequent bouts across devices. Accumulated time in these containments matched accumulated time Tajik infants spent in gahvoras. Tajik infants accumulated more unrestricted time on the ground, which was distributed in prolonged bouts, than U.S. infants. Findings highlight differences in infants' everyday experiences during the developmental period when motor skills emerge. By embracing commonalities and exploring differences between cultures, this study offers insights into differences in infants' everyday experiences and opportunities for movement. [ABSTRACT FROM AUTHOR]

Background: Excessive intake of ultra-processed foods, formulated from substances extracted from foods or derived from food constituents, may be a modifiable behavioral risk factor for adverse maternal and infant health outcomes. Prior work has predominately examined health correlates of maternal ultra-processed food intake in populations with substantially lower ultra-processed food intake compared to the US population. This longitudinal study investigated relations of ultra-processed food intake with maternal weight change and cardiometabolic health and infant growth in a US cohort. Methods: Mothers in the Pregnancy Eating Attributes Study were enrolled at ≤12 weeks gestation and completed multiple 24-Hour Dietary Recalls within six visit windows through one-year postpartum (458 mothers enrolled, 321 retained at one-year postpartum). The NOVA (not an acronym) system categorized food and underlying ingredient codes based on processing level. Maternal anthropometrics were measured throughout pregnancy and postpartum, and infant anthropometrics were measured at birth and ages 2 months, 6 months, and 1 year. Maternal cardiometabolic markers were analyzed from blood samples obtained during the second and third trimesters. Results: Holding covariates and total energy intake constant, a 1-SD greater percent energy intake from ultra-processed foods during pregnancy was associated with 31% higher odds of excessive gestational weight gain (p =.045, 95% CI [1.01, 1.70]), 0.68±0.29 mg/L higher c-reactive protein during pregnancy (p =.021, 95% CI [0.10, 1.26]), 6.7±3.4% greater gestational weight gain retained (p =.049, 95% CI [0.03, 13.30]), and 1.09±0.36 kg greater postpartum weight retention (p =.003, 95% CI [0.38, 1.80]). No other significant associations emerged. Conclusions: Ultra-processed food intake during pregnancy may be a modifiable behavioral risk factor for adverse maternal weight outcomes and inflammation. Randomized controlled trials are needed to test whether targeting ultra-processed food intake during pregnancy may support optimal maternal health. Trial registration: Clinicaltrials.gov. Registration ID – NCT02217462. Date of registration – August 13, 2014. [ABSTRACT FROM AUTHOR]

In May 2021, a reauthorization of the Child Abuse Prevention and Treatment Act (CAPTA) was introduced in the U.S. Senate. This reauthorization substantially amends provisions concerning infants affected by prenatal substance exposure (PSE) and decidedly shifts the policy from a child safety‐ to a public health‐focused approach to achieve the larger goals of healthy and safe child development and caregiver recovery from substance use disorder. Despite its honourable aspirations, no research has tested whether CAPTA "works." To advance scholarship on this policy, we summarize the service needs for this population and clarify how the CAPTA reauthorization aims to address these needs. We then apply a health utilization theory to understanding the mechanisms of effect on maternal‐child outcomes. Based on this theoretical analysis, we discuss directions for future research. [ABSTRACT FROM AUTHOR]

Objective The first years of life are particularly important because vital developments occur in all development domains including motor, cognition, communication, and social-emotional. Early detection of developmental delays is essential in planning for early intervention. This study aims to standardize the score of bayley scales of infants and toddlers development-third edition (Bayley-III) for Iranian samples aged 1-42 months. Materials & Methods Participants included 1700 children divided into 17 age groups of 100 children. The normative information was based on a national sample representative of Iran's population for infants aged 1-42 months based on the 2011 national population and housing census. For each age group, the total raw scores of each Bayley-III subscale (cognition, receptive communication, expressive communication, fine motor, and gross motor) were converted to scaled scores with a Mean±SD of 10±3. The composite scores (cognition, language and motor domains) were obtained by summing up the scaled scores. The composite scores were scaled to a metric with Mean±SD of 100±15 ranged 40-160. Growth scores (ranged 200-800, with a Mean±SD 500±100), percentile ranks (ranged from 1-99, with 50 as the mean and median), and developmental age equivalent were also determined. Confidence intervals for all five subscales were also determined. To compare the development level of the US children (norm samples) and Iranian children, their mean raw scores in five subscales were compared for finding the difference in scores. Results The Bayley-III was performed on 1744 children aged 0-42 months, including 908 (52.1%) girls and 836 (47.9%) boys. In comparing the development level of Iranian and US children, it was found that the mean scores were significantly different in 28 age groups (P<0.05). In seven age groups, the US children's scores were higher (age groups <6 months), and in 21 age groups, the scores of Iranian children were higher (age groups >6 months). Conclusion For early detection and intervention of children with developmental delays, a test with a normalized score should be used in Iran. Using the US norm-based scores in Iranian children leads to inaccuracy in the early detection of children with developmental delays. [ABSTRACT FROM AUTHOR]

National Surveys of Children's Health (NSCH, 2016–2018) data were analyzed to determine if conjoint monitoring and screening showed stronger associations with children under 5 identified with ASD compared to monitoring alone, screening alone or no monitoring or screening; and investigate relationships between monitoring and screening across racial/ethnic subgroups. 86 of 332 children with ASD received their diagnosis in a timeframe suggesting potential monitoring and screening for identification purposes. Analyses showed that conjoint monitoring and screening and monitoring alone, but not screening alone, was associated with early identified ASD cases across race groups. Caution is warranted as interpreting NSCH monitoring and screening items solely for identification purposes is inaccurate in many cases. More research on monitoring with screening is needed. [ABSTRACT FROM AUTHOR]

Many social scientists are working to course correct the historical mistakes, abuses, and exclusionary practices of the field. To diversify who participates in developmental science, both as participants and as researchers, we argue that more attention must be paid to how we teach the science of developmental science (i.e., research methods). We propose that undergraduate research methods courses offer an opportunity to intervene on the academic pipeline and invite students of color into research through course curriculum. In this essay, we discuss guiding principles instructors should consider to transform their curriculum in the research training of undergraduate developmental scientists. [ABSTRACT FROM AUTHOR]

PURPOSE OF THE STUDY: The purpose of this study was to examine the association between breastfeeding duration and the subsequent development of childhood asthma. STUDY POPULATION: The study included maternal-child dyads drawn from 3 prospective pregnancy cohorts and child follow-up at 4 to 6 years of age. These cohorts included dyads from multiple US sites enrolled in the ECHO-PATHWAYS consortium cohorts: (1) Conditions Affecting Neurocogni-tive Development and Learning in Early Childhood study, (2) The Infant Development and Environment Study, and (3) the Global Alliance to Prevent Prematurity and Stillbirth. METHODS: Any and exclusive breastfeeding duration was determined using a questionnaire at approximately 4 to 6 years of age. The International Study of Asthma and Allergies in Childhood questionnaire and others were used to assess child wheeze and asthma outcomes. Child wheeze and asthma outcomes were categorized as (1) current wheeze, (2) ever asthma, (3) current asthma, and (4) strict current asthma. Covariates included maternal demographics and selected effect modifiers (maternal asthma, mode of delivery, child sex). Multivariable logistic regression was used to assess the association between breastfeeding duration (any and exclusive breastfeeding) and child wheeze and asthma outcomes, adjusted for covari-ates and effect modifiers. RESULTS: The analysis included 2021 dyads. In unadjusted and multivariable analyses, breastfeeding duration was not associated with child wheeze and asthma outcomes. Longer duration of exclusive breastfeeding was associated with decreased odds of current asthma. When assessing for effect modification by maternal history of asthma, protective associations for any breastfeeding duration were found among mothers without asthma (adjusted odds ratio 0.58 [95% confidence interval, 0.37-0.92] for >6 months versus 0-2 months), but not among mothers with asthma. There was no statistically significant indication of effect modification by infant sex or mode of delivery. CONCLUSIONS: This study found evidence for protective associations between longer duration of exclusive breastfeeding ($2 months) and child asthma outcomes. Duration of any breastfeeding was not strongly associated with development of wheeze or asthma, apart from ever asthma. [ABSTRACT FROM AUTHOR]

OBJECTIVES: To examine the effects of the First 1000 Days intervention on the prevalence of infant overweight and maternal postpartum weight retention and care. METHODS: Using a quasi-experimental design, we evaluated the effects of the First 1000 Days program among 995 term, low-income infants and their mothers receiving care in 2 intervention community health centers and 650 dyads in 2 comparison health centers. The program includes staff training, growth tracking, health and behavioral screening, patient navigation, text messaging, educational materials, and health coaching. Comparison centers implemented usual care. Infant outcomes were assessed at 6 and 12 months, including weight-for-length z score and overweight (weight for length ≥97.7th percentile). We also examined maternal weight retention and receipt of care 6 weeks' post partum. RESULTS: The mean birth weight was 3.34 kg (SD 0.45); 57% of infants were Hispanic; 66% were publicly insured. At 6 months, infants had lower weight-for-length z scores (β: -.27; 95% confidence interval [CI]: -.39 to -.15) and lower odds of overweight (adjusted odds ratio [OR]: 0.46; 95% CI: 0.28 to 0.76) than infants in comparison sites; differences persisted at 12 months (z score β: -.18; 95% CI: -.30 to -.07; adjusted OR for overweight: 0.60; 95% CI: 0.39 to 0.92). Mothers in the intervention sites had modestly lower, but nonsignificant, weight retention at 6 weeks' post partum (β: -.51 kg; 95% CI: -1.15 to .13) and had higher odds (adjusted OR: 1.50; 95% CI: 1.16 to 1.94) of completing their postpartum visit compared with mothers in the comparison sites. CONCLUSIONS: An early-life systems-change intervention combined with coaching was associated with improved infant weight status and maternal postpartum care. [ABSTRACT FROM AUTHOR]

The United States is the only high‐income country that does not have a national policy mandating paid leave to working women who give birth. Increased rates of maternal employment post‐birth call for greater understanding of the effects of family leave on infant development. This study examined the links between paid leave and toddler language, cognitive, and socioemotional outcomes (24–36 months; N = 328). Results indicate that paid leave was associated with better language outcomes, regardless of socioeconomic status. Additionally, paid leave was correlated with fewer infant behavior problems for mothers with lower levels of educational attainment. Expanding access to policies that support families in need, like paid family leave, may aid in reducing socioeconomic disparities in infant development. [ABSTRACT FROM AUTHOR]

To determine if the United States reference values of the Bayley Scales of Infant and Toddler Development, version III motor scale are suitable for Surinamese infants, we assessed 151 healthy infants at 3, 12, 24 and 36 months of age. The mean fine motor, gross motor, and composite scores of the total group did not significantly differ from the US norms, although some significant but not clinically relevant differences were found (lower fine motor scores at 12 months, lower gross motor and total composite scores at 24 months, and higher scores for gross motor and composite scores at 3 months). • Per age group five out of twelve scores differed significantly. • Found differences were small, ≤ 1 SD and considered as not clinically relevant. • Fewer Surinamese infants were classified as delayed, which clinically is relevant. • The US reference values can be used at 3, 12, 24 and 36 months in Suriname. • The US values might underestimate, and at 3 months overestimate motor performance. [ABSTRACT FROM AUTHOR]

The purpose of this article is to provide evidence of the technical adequacy of the Assessment, Evaluation, and Programming System–Third Edition (AEPS-3). The AEPS has long been identified as one of the most psychometrically sound early childhood curriculum-based assessments. In this article, results of three studies of technical adequacy are reviewed. First, a utility study was conducted to examine the degree to which teachers and providers found the AEPS-3 useful for its intended purposes (i.e., goal development and programming). Second, we examined the interrater reliability of the AEPS-3 by having teachers and providers view videotapes and score AEPS-3 items. Finally, a concurrent validity study was conducted, whereby a group of children were assessed using a norm-referenced assessment and the AEPS-3. Results of all three studies show provide early evidence that the AEPS-3 is psychometrically sound. [ABSTRACT FROM AUTHOR]

The influence of socioeconomic variability on language and cognitive development is present from toddlerhood to adolescence and calls for investigating its earliest manifestation. Response to joint attention (RJA) abilities constitute a foundational developmental milestone that are associated with future language, cognitive, and social skills. How aspects of the family home environment shape RJA skills is relatively unknown. We investigated associations between family socioeconomic status (SES) —both parent education and family percentage of the federal poverty level (FPL)— parent depressive and anxiety symptoms and infant RJA performance in a cross‐sectional sample of 173 infants aged 8–18 months and their parents from a variety of socioeconomic backgrounds. Results suggest that, correcting for age and receptive language, infants in families with greater economic resources respond to relatively less redundant, more sophisticated cues for joint attention. Although parent depressive and anxiety symptoms are negatively correlated with SES, parent depressive and anxiety symptoms were not associated with infant RJA. These findings provide evidence of SES‐related differences in social cognitive development as early as infancy, calling on policymakers to address the inequities in the current socioeconomic landscape of the United States. [ABSTRACT FROM AUTHOR]

Incorporating systematic evidence with clinical expertise is a key element in the quest to improve quality of care and patient outcomes. The evidence supporting skin‐to‐skin contact in the first hour after birth is robust and includes significantly improved outcomes for both mother and infant. This paper compares available iterative data about newborn behaviour in the first hour after birth to further describe the observable behaviour pattern and to provide clinical insight for further research. Although the evidence for positive outcomes through skin‐to‐skin contact are robust, there is a dearth of research specifically focused on clinical practice. The methodology considers the four available data sets that used Widström's 9 stages, which consists of studies from Japan, Sweden, Italy and the United States, examining the parameters of each stage across settings from around the world. This research provides an expanded understanding of the timing of the newborn's progression through Widström's 9 observable stages. We found that newborns in all four data sets began with a birth cry and continued through the remaining stages of relaxation, awakening, activity, rest, crawling, familiarization, suckling and sleeping during the first hours after birth and consolidated the data into a Sign of the Stages chart to assist in further research. The evidence supports making a safe space and time for this important newborn behaviour. Clinical practices should encourage and protect this sensitive period. [ABSTRACT FROM AUTHOR]

Children's diets in their first 1000 days influence dietary preferences, eating habits, and long-term health. Yet the diets of most infants and toddlers in the United States do not conform to recommendations for optimal child nutrition. This narrative review examines whether marketing for infant formula and other commercial baby/toddler foods plays a role. The World Health Organization's International Code of Marketing Breast-milk Substitutes strongly encourages countries and manufacturers to prohibit marketing practices that discourage initiation of, and continued, breastfeeding. However, in the United States, widespread infant formula marketing negatively impacts breastfeeding. Research has also identified questionable marketing of toddler milks (formula/milk-based drinks for children aged 12–36 mo). The United States has relied exclusively on industry self-regulation, but US federal agencies and state and local governments could regulate problematic marketing of infant formula and toddler milks. Health providers and public health organizations should also provide guidance. However, further research is needed to better understand how marketing influences what and how caregivers feed their young children and inform potential interventions and regulatory solutions. [ABSTRACT FROM AUTHOR]

OBJECTIVES: To assess the relation between exposure to maternal depression before age 5 and 5 domains of developmental vulnerability at school entry, overall, and by age at exposure. METHODS: This cohort study included all children born in Manitoba, Canada, who completed the Early Development Instrument between 2005 and 2016 (N = 52 103). Maternal depression was defined by using physician visits, hospitalizations, and pharmaceutical data; developmental vulnerability was assessed by using the Early Development Instrument. Relative risk of developmental vulnerability was assessed by using log-binomial regression models adjusted for characteristics at birth. RESULTS: Children exposed to maternal depression before age 5 had a 17% higher risk of having at least 1 developmental vulnerability at school entry than did children not exposed to maternal depression before age 5. Exposure to maternal depression was most strongly associated with difficulties in social competence (adjusted relative risk [aRR] = 1.28; 95% confidence interval [CI]: 1.20-1.38), physical health and well-being (aRR = 1.28; 95% CI: 1.20-1.36), and emotional maturity (aRR = 1.27; 95% CI: 1.18-1.37). For most developmental domains, exposure to maternal depression before age 1 and between ages 4 and 5 had the strongest association with developmental vulnerability. CONCLUSIONS: Our finding that children exposed to maternal depression are at higher risk for developmental vulnerability at school entry is consistent with previous findings. We extended this literature by documenting that the adverse effects of exposure to maternal depression are specific to particular developmental domains and that these effects vary depending on the age at which the child is exposed to maternal depression. [ABSTRACT FROM AUTHOR]

Background: Identifying children with developmental delays and disabilities more effectively will require the participation of others such as preschool teachers who often have extended contact with the child in their first few years. We wished to determine how preschool teachers' reports of concerns compared with norming data from the Parents Evaluation of Developmental Status (PEDS). Methods: A total of 1,357 English responses from teachers of nine preschool centres were analyzed and matched with expected rates of concerns from the U.S. norming sample. Results: The preschool teachers' reporting of rates of concerns fell within the range of scores reported in norming studies from parent reports in the United States. Teachers were most concerned about children's language and behaviours. Conclusions: The preschool teacher reports of concerns are similar to expected parents PEDS ratings in the United States. Preschool teachers can screen children's development. There may be a role for the PEDS to be used as a developmental screener by preschool teachers for monitoring of developmental status. Further studies on the PEDS are recommended in the Singapore context. [ABSTRACT FROM AUTHOR]

The article discusses the history of human infancy, its development and mortality, including the framework for its biopolitical formation in the U.S. Topics discussed include the history of medical discourse surrounding newborn life, its inception as a biopolitical subject with the establishment of neonatal care at hospitals and diagnostic technology to determine dates of conception, and the political dimension of material feminism and its connection to the materiality of infant life.

Aim: The emotional connection between mothers and infants born preterm has been associated with positive behaviour. The aim of this study was to examine the longitudinal association between emotional connection at six months of age and behavioural problems at three years.Methods: This study was carried out by the University of North Texas, USA and comprised 49 mothers and infants from a longitudinal investigation of family interaction and infant development conducted in 1994-1997. Face-to-face interaction and toy-based play were videotaped and coded at six months of age using the Welch Emotional Connection Screen (WECS), a brief screening tool for relational health. When the children were three years of age, the mothers reported on child behavioural problems.Results: The children from dyads that were rated as emotionally connected at six months of age had fewer externalising and internalising behavioural problems at the age of three. No links were found between emotional connection during toy-based play at six months and later child behavioural problems.Conclusion: We showed that when the WECS was used at six months of age it was a promising and valid relational screening tool for infants at risk of adverse behavioural outcomes at the age of three. [ABSTRACT FROM AUTHOR]

Background: Many pregnant women in the United States have suboptimal vitamin D, but the impact on infant development is unclear. Moreover, no pregnancy-specific vitamin D recommendations have been widely accepted.Aims: Given the ubiquitous expression of vitamin D receptors in the brain, we investigated the association between early prenatal plasma 25-hydroxyvitamin D (25(OH)D) concentrations and children's social and emotional development in the Newborn Epigenetic Study, a prospective study of pregnancies from 2009 to 2011 in Durham, North Carolina.Methods: We measured 25(OH)D concentrations in first or second trimester plasma samples and categorized 25(OH)D concentrations into quartiles. Covariates were derived from maternal questionnaires. Mothers completed the Infant Toddler Social-Emotional Development Assessment when children were 12-24 months of age. We used multivariable linear regression to evaluate associations between 25(OH)D and specific behavior scores, adjusted for season of blood draw, maternal age, education, parity, smoking, marital status, prepregnancy BMI, and infant gender. We investigated effect-measure modification by race/ethnicity.Results: Of the 218 mother-infant pairs with complete data, Black mothers had much lower 25(OH)D concentrations as compared to White and Hispanic mothers. After adjustment, lower prenatal 25(OH)D was associated with slightly higher (less favorable) Internalizing scores among White children, but lower (more favorable) Internalizing scores among Black and Hispanic children. Lower prenatal 25(OH)D also appears to be associated with higher (less favorable) dysregulation scores, though only among White and Hispanic children.Conclusions: Though imprecise, preliminary results warrant further investigation regarding a role for prenatal vitamin D on children's early social and emotional development. [ABSTRACT FROM AUTHOR]

Background Air-displacement plethysmography (ADP) is a good candidate for monitoring body composition in newborns and young infants, but reference centile curves are lacking that allow for assessment at birth and across the first 6 mo of life. Objective Using pooled data from 4 studies, we aimed to produce new charts for assessment according to gestational age at birth (30 + 1 to 41 + 6 wk) and postnatal age at measurement (1–27 wk). Methods The sample comprised 222 preterm infants born in the United States who were measured at birth; 1029 term infants born in Ireland who were measured at birth; and 149 term infants born in the United States and 57 term infants born in Italy who were measured at birth, 1 and 2 wk, and 1, 2, 3, 4, 5, and 6 mo of age. Infants whose birth weights were <3rd or >97th centile of the INTERGROWTH-21st standard were excluded, thereby ensuring that the charts depict body composition of infants whose birth weights did not indicate suboptimal fetal growth. Sex-specific centiles for fat mass (kg), fat-free mass (kg), and percentage body fat were estimated using the lambda-mu-sigma (LMS) method. Results For each sex and measure (e.g. fat mass), the new charts comprised 2 panels. The first showed centiles according to gestational age, allowing term infants to be assessed at birth and preterm infants to be monitored until they reached term. The second showed centiles according to postnatal age, allowing all infants to be monitored to age 27 wk. The LMS values underlying the charts were presented, enabling researchers and clinicians to convert measurements to centiles and z scores. Conclusions The new charts provide a single tool for the assessment of body composition, according to ADP, in infants across the first 6 mo of life and will help enhance early-life nutritional management. [ABSTRACT FROM AUTHOR]

Alcohol exposure during pregnancy results in impaired growth, stillbirth, and fetal alcohol spectrum disorder. Fetal alcohol deficits are lifelong issues with no current treatment or established diagnostic or therapeutic tools to prevent and/or ameliorate some of these adverse outcomes. Despite the recommendation to abstain, almost half of the women consume alcohol in pregnancy in the United States. This review focuses on the trends in prenatal alcohol exposure, implications for maternal and fetal health, and evidence suggesting that preconception and the prenatal period provide a window of opportunity to intervene, mitigate, and ideally curtail the lifetime effects of fetal alcohol spectrum disorder. [ABSTRACT FROM AUTHOR]

The article offers information on 13th Congress of the International Society for the Study of Fatty Acids and Lipids from May 27–31, 2018 at Las Vegas, Nevada U.S. focused on role of arachidonic and docosahexaenoic acids in infant development.

Extrauterine growth restriction (EUGR) affects a significant number of very low birth weight (VLBW) infants and has the potential to impact neurodevelopmental outcome as well as other aspects of long-term health. More aggressive nutritional approaches have reduced the incidence of postnatal growth failure but many questions remain about the expected rate of growth for very preterm infants, the best ways to measure growth velocity, and the optimal approaches to supporting growth. This article examines some of the outstanding issues regarding postnatal growth failure and summarizes current practice recommendations. [ABSTRACT FROM AUTHOR]

The article discusses the study "Maternal Depression in Early Childhood and Developmental Vulnerability at School Entry" by E. Wall-Wieler, L. L. Roos, and I. H. Gotlib, that was published within the issue. Topics covered include developmental vulnerability of children exposed to maternal depression, prenatal depression, and socio-emotional development in early childhood.

Choline has been recognized as an essential nutrient by the Food and Nutrition Board of the National Academies of Medicine since 1998. Its metabolites have structural, metabolic, and regulatory roles within the body. Humans can endogenously produce small amounts of choline via the hepatic phosphatidylethanolamine N -methyltransferase pathway. However, the nutrient must be consumed exogenously to prevent signs of deficiency. The Adequate Intake (AI) for choline was calculated at a time when dietary intakes across the population were unknown for the nutrient. Unlike the traditional National Academy of Medicine approach of calculating an AI based on observed or experimentally determined approximations or estimates of intake by a group (or groups) of healthy individuals, calculation of the AI for choline was informed in part by a depletion-repletion study in adult men who, upon becoming deficient, developed signs of liver damage. The AI for other gender and life-stage groups was calculated based on standard reference weights, except for infants 0 to 6 months, whose AI reflects the observed mean intake from consuming human breast milk. Recent analyses indicate that large portions of the population (ie, approximately 90% of Americans), including most pregnant and lactating women, are well below the AI for choline. Moreover, the food patterns recommended by the 2015–2020 Dietary Guidelines for Americans are currently insufficient to meet the AI for choline in most age-sex groups. An individual's requirement for choline is dependent on common genetic variants in genes required for choline, folate, and 1-carbon metabolism, potentially increasing more than one-third of the population's susceptibly to organ dysfunction. The American Medical Association and American Academy of Pediatrics have both recently reaffirmed the importance of choline during pregnancy and lactation. New and emerging evidence suggests that maternal choline intake during pregnancy, and possibly lactation, has lasting beneficial neurocognitive effects on the offspring. Because choline is found predominantly in animal-derived foods, vegetarians and vegans may have a greater risk for inadequacy. With the 2020–2025 Dietary Guidelines for Americans recommending expansion of dietary information for pregnant women, and the inclusion of recommendations for infants and toddlers 0 to 2 years, better communication of the role that choline plays, particularly in the area of neurocognitive development, is critical. This narrative review summarizes the peer-reviewed literature and discussions from the 2018 Choline Science Summit, held in Washington, DC, in February 2018. [ABSTRACT FROM AUTHOR]

This article discusses why and how states are integrating DC:0--5TM: Diagnostic Classification of Mental Health and Developmental Disorders of Infancy and Early Childhood (DC:0--5) into state policy and systems; provides state examples to highlight some of the strategies that states have used to allow, promote, or require the use of DC:0--5; and provides recommendations for further improvements in state infant and early childhood mental health policy and practice. The article provides a point-in-time overview of how DC:0--5 is being integrated into state systems and policies and is a sample of the innovative work going on across the United States. The article is adapted from a paper of the same name published in 2018 by the ZERO TO THREE Policy Center. [ABSTRACT FROM AUTHOR]

Immigrant women face unique barriers to prenatal care access and patient-provider communication. Yet, few prior studies have examined U.S.-born/immigrant differences in the content of care. The purpose of this study was to investigate the roles of immigrant status, English proficiency and race/ethnicity on the receipt of self-reported prenatal counseling using nationally representative data. We used data from the Early Childhood Longitudinal Study-Birth Cohort (N ≈ 8100). We investigated differences in self-reported prenatal counseling by immigrant status, English proficiency, and race/ethnicity using logistic regression. Counseling topics included diet, smoking, drinking, medication use, breastfeeding, baby development and early labor. In additional analyses, we separately examined these relationships among Hispanic, Mexican and Non-Hispanic (NH) Asian women. Neither immigrant status nor self-reported English proficiency was associated with prenatal counseling. However, we found that being interviewed in a language other than English language by ECLS-B surveyors was positively associated with counseling on smoking (OR, 2.599; 95% CI, 1.229-5.495) and fetal development (OR, 2.408; 95% CI, 1.052-5.507) among Asian women. Race/ethnicity was positively associated with counseling, particularly among NH black and Hispanic women. There is little evidence of systematic overall differences in self-reported prenatal counseling between U.S.-born and immigrant mothers. Future research should investigate disparities in pregnancy-related knowledge among racial/ethnic subgroups. [ABSTRACT FROM AUTHOR]

BACKGROUND: Longitudinal growth curves, based on repeated measurements from the same group of infants, exist for preterm infant weight and length but not for BMI. Our existing BMI (weight divided by length squared) curves are based on cross-sectional birth data obtained from a different group of infants at each gestational age (GA). METHODS: We calculated BMI over time for 68 693 preterm infants between 24 and 36 weeks GA. Stratifying infants by sex, GA at birth, and quintiles based on birth BMI, we created longitudinal median curves using R and validated the resulting curves for empirical fit, proper classification, and normality of z scores. RESULTS: We created 2 sets of BMI growth charts. The first set displays fitted median curves for all 5 percentile groups in each GA group by sex. The second set displays fitted median curves with their corresponding third and 97th percentiles by percentile group, GA, and sex. In the validation analysis, percentage of daily observations below the median curve approximated the expected 50th percentile after the initial 3 days. Unlike the cross- sectional curves, the longitudinal curves reveal the pattern of change corresponding to nadir; postnadir, these curves remained consistently below the cross-sectional curves and varied by GA and sex as expected. The percentage of observations falling below the 50th percentile for cross-sectional curves (revealing optimal growth) was generally much higher than for longitudinal curves (revealing actual growth). CONCLUSIONS: These new longitudinal curves provide clinicians data on how premature infants' body proportionality changes over time. [ABSTRACT FROM AUTHOR]

Although a growing body of research has explored the early development of social evaluation, no research has directly compared social evaluations of infants between different cultures. In addition, there has been little understanding regarding socialization's effects on this ability. The goal of this study was to expand on earlier findings on social evaluation in infants by investigating a broader sample from two cultures, and to explore the influence of maternal socialization on infants’ social evaluation. Using the violation of expectations and the preferential reaching paradigm, four groups aged 6‐, 9‐, 12‐, and 15–18 months and their mothers from Japan and the United States (159 dyads) were compared in terms of spontaneous social evaluations. Japanese and European American infants showed similar performance in dishabituation to the inconsistent behavior and in their reaching preference for prosocial over antisocial agents, indicating that the emergence of spontaneous social evaluation is not culture‐specific. Furthermore, our study provides a novel finding regarding the relationship between mothers’ socially evaluative speech and infants’ preference for prosocial over antisocial agents. These results suggest that the development of sociomoral understanding results from complicated interactions among evolutionary, cognitive, and social factors. [ABSTRACT FROM AUTHOR]