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Abstract: In 2001, the National Nuclear Security Administration (NNSA) of the U.S. Department of Energy (DOE) in conjunction with the national security laboratories (i.e., Los Alamos National Laboratory, Lawrence Livermore National Laboratory, and Sandia National Laboratories) initiated development of a process designated quantification of margins and uncertainties (QMU) for the use of risk assessment methodologies in the certification of the reliability and safety of the nation''s nuclear weapons stockpile. A previous presentation, “Quantification of Margins and Uncertainties: Conceptual and Computational Basis,” describes the basic ideas that underlie QMU and illustrates these ideas with two notional examples. The basic ideas and challenges that underlie NNSA''s mandate for QMU are present, and have been successfully addressed, in a number of past analyses for complex systems. To provide perspective on the implementation of a requirement for QMU in the analysis of a complex system, three past analyses are presented as examples: (i) the probabilistic risk assessment carried out for the Surry Nuclear Power Station as part of the U.S. Nuclear Regulatory Commission''s (NRC''s) reassessment of the risk from commercial nuclear power in the United States (i.e., the NUREG-1150 study), (ii) the performance assessment for the Waste Isolation Pilot Plant carried out by the DOE in support of a successful compliance certification application to the U.S. Environmental Agency, and (iii) the performance assessment for the proposed high-level radioactive waste repository at Yucca Mountain, Nevada, carried out by the DOE in support of a license application to the NRC. Each of the preceding analyses involved a detailed treatment of uncertainty and produced results used to establish compliance with specific numerical requirements on the performance of the system under study. As a result, these studies illustrate the determination of both margins and the uncertainty in margins in real analyses. [Copyright &y& Elsevier]

Abstract: In 2001, the National Nuclear Security Administration of the U.S. Department of Energy in conjunction with the national security laboratories (i.e., Los Alamos National Laboratory, Lawrence Livermore National Laboratory and Sandia National Laboratories) initiated development of a process designated Quantification of Margins and Uncertainties (QMU) for the use of risk assessment methodologies in the certification of the reliability and safety of the nation''s nuclear weapons stockpile. A previous presentation, “Quantification of Margins and Uncertainties: Conceptual and Computational Basis,” describes the basic ideas that underlie QMU and illustrates these ideas with two notional examples that employ probability for the representation of aleatory and epistemic uncertainty. The current presentation introduces and illustrates the use of interval analysis, possibility theory and evidence theory as alternatives to the use of probability theory for the representation of epistemic uncertainty in QMU-type analyses. The following topics are considered: the mathematical structure of alternative representations of uncertainty, alternative representations of epistemic uncertainty in QMU analyses involving only epistemic uncertainty, and alternative representations of epistemic uncertainty in QMU analyses involving a separation of aleatory and epistemic uncertainty. Analyses involving interval analysis, possibility theory and evidence theory are illustrated with the same two notional examples used in the presentation indicated above to illustrate the use of probability to represent aleatory and epistemic uncertainty in QMU analyses. [Copyright &y& Elsevier]

The Minerals Management Service (MMS) International Activities and Marine Minerals Division is charged with management of Federal Outer Continental Shelf (OCS) sand and gravel resources that would be used for beach nourishment to repair storm damage and protect against sea-level rise. To reduce environmental damage associated with long-term and large-scale use of these resources, a project was funded by MMS to design a comprehensive physical and biological monitoring program for sand-mining activities. An initial task of this project was performance of a literature review to determine where information gaps existed regarding the effects of sand mining and which physical processes and biological resources should be the focus of monitoring. Based upon the literature review and a conference with other investigators, the monitoring program was designed to include the following elements: benthic communities and their trophic relationships to fishes, marine mammals and wildlife (operational monitoring), sediment sampling and analysis, wave monitoring and modeling, bathymetric and substrate surveys, and shoreline monitoring and modeling. Protocols were developed for these elements to ensure consistency of methods among studies. The two primary physical impacts of concern are changes to the sea bed resulting in changes to the erosion and sedimentation processes along the shore and changes to the sea bed that would have a direct and significant impact on the biological environment. The most important biological impacts from dredging to be monitored in this program are changes in benthic secondary production and trophic transfer to fishes. [ABSTRACT FROM AUTHOR]

Describes a substantial collection of lithic artifacts from test units excavated at the Watson Brake site in northeast Louisiana. Description of the artifacts in terms of production technology and use; Evidence for an expedient core technology; Biface manufacture and use; Blade production directed toward microdrill manufacture.

Examines the impact of psychosocial program, Pyramid House membership on the criminal justice system involvement of mentally ill in Harris County, Texas. Components of an effective mental health system; Significance of Pyramid House to Community Mental Health Center psychiatry unit; Benefits of voluntary psychosocial programs.

Abstract. Hindu temple construction has become common in suburban areas of the United States, following a steady wave of immigration from India. Immigrants hope to pass along traditional beliefs and cultural practices to a generation rapidly approaching adulthood. Small but committed groups have raised millions of dollars to build over 200 temples in the 1980s and 1990s. Temple builders face the usual land use concerns of any rezoning request, such as providing parking or shielding neighbors from externalities such as light and noise. Some proposals have met resistance from the established community based on misunderstandings and fears about Hindu practices and beliefs. Such resistance has slowed but not stopped the diffusion of Hindu temples across the United States. [ABSTRACT FROM AUTHOR]

Analyzes a collection of stone tools from a Chickasaw site in northeast Mississippi to determine the trade and political relations of the Chickasaw Indians with the Europeans. Discussion of the distribution of similar artifacts in time and space; Consideration of the differential impact of trade on the technology of the Indians of the Southwest.

Presents a study from a ethnographical approach on reducing the risks of HIV infections through the use of intravenous drugs. How study was conducted; Information on ethnopharmocology; Relation of experiences while using drug by some users; What ethnopharmacology is used for; Role played by culture in drug use and HIV.

Presents data from an ethnographic investigation of intravenous drug users' social network structures in Houston, Texas. Number of interpersonal linkages and frequency interactions; Heterogeneity and composition of interpersonal linkages; Strength of emotional linkages.

The article reports on the use of Electronic Common Technical Document (eCTD) for drug approval application required by the Food and Drug Administration in the U.S. The eCTD specification limits the file formats an applicant can use within an electronic submission. Applying the eCTD specifications to the XML standards also provides for reusability of the applicant's submission documents for different regional markets.

Simple Summary: Transporting weaned piglets from the farrowing house to a nursery or grow/finish site is a common but stressful procedure in United States swine production. Piglets removed from the sow at weaning undergo feed and water withdrawal during transportation, and this stress is further compounded by an abrupt change from a liquid to solid diet upon arrival at their destination. As a result, newly weaned and transported piglets exhibit reduced body weight and signs of dehydration post-transport. Unfortunately, in utero stressors can modify the offspring's physiological, immune, and behavioral responses during postnatal life and may pre-dispose animals to a greater stress response when exposed to novel postnatal procedures, such as weaning and transport. Therefore, the study objective was to evaluate the effects of in utero heat stress on the behavior and physiology of piglets following weaning and transport. We hypothesized that in utero heat-stressed piglets would exhibit a greater behavioral and physiological stress response following weaning and transportation. Additionally, in utero heat-stressed piglets were expected to show physiological signs of metabolic stress immediately following weaning and transport. It was determined that there was some evidence for altered physiological and behavioral responses among in utero heat stressed piglets compared to in utero thermoneutral piglets following weaning and transport. The study objective was to determine whether in utero heat stress (IUHS) affects piglet physiology and behavior following common production practices. A total of 12 gilts were confirmed pregnant and allocated to either heat stress (HS; n = 6) or thermoneutral (TN; n = 6) conditions on day 30–60 of gestation. At weaning (22.5 ± 2.3 days of age), 1 boar and 1 barrow of median weight were selected from each litter and transported for approximately 7 h. Piglets were then blocked into pens (n = 2/pen) by in utero treatment (IUHS (n = 12) or in utero thermoneutral (IUTN, n = 12)) and sexual status (boar (n = 6/in utero treatment) or barrow (n = 6/in utero treatment)). Plasma cortisol, non-esterified fatty acids (NEFA), insulin and glucose were evaluated 1 day prior to transport (pre-transport) and immediately after transport (post-transport). Behavioral data were collected on day 1–7 for 60 min at four different time points each day. In utero heat stressed piglets exhibited reduced cortisol concentrations compared to IUTN piglets immediately post-transport (p = 0.04). Glucose concentrations were not affected by in utero treatment. Insulin concentrations were reduced in IUTN piglets post-transport compared to pre-transport (p = 0.002), but no differences were detected for IUHS pigs. Non-esterified fatty acids tended to be reduced overall for IUHS vs. IUTN pigs (p = 0.08). Overall, IUHS piglets performed more drinking behaviors (p = 0.02) and tended to perform more aggressive behaviors (p = 0.07) than IUTN piglets in the 7 days post-transport. In summary, there was some evidence for altered physiological and behavioral responses among IUHS piglets compared to IUTN piglets following weaning and transport. [ABSTRACT FROM AUTHOR]