1. Respiratory-related hospitalizations following prophylaxis in the Canadian registry for palivizumab (2005-2012) compared to other international registries.
- Author
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Paes B, Mitchell I, Li A, Harimoto T, and Lanctôt KL
- Subjects
- Canada epidemiology, Child, Preschool, Europe epidemiology, Humans, Infant, Infant, Newborn, Infant, Premature, Infant, Premature, Diseases epidemiology, Infant, Premature, Diseases virology, Palivizumab, Patient Compliance, Randomized Controlled Trials as Topic, Respiratory Syncytial Virus Infections epidemiology, Respiratory Syncytial Virus Infections virology, Respiratory Syncytial Viruses isolation & purification, Retrospective Studies, Treatment Outcome, United States epidemiology, Antibodies, Monoclonal, Humanized therapeutic use, Antiviral Agents therapeutic use, Hospitalization statistics & numerical data, Infant, Premature, Diseases prevention & control, Registries, Respiratory Syncytial Virus Infections prevention & control
- Abstract
Respiratory syncytial virus (RSV) infection occurs commonly in infants aged ≤2 years, and severe infection results in hospitalization with accompanying morbidity and mortality. Palivizumab has been available for prophylaxis for the past 15 years. Prospective data on patients who received palivizumab from 2005 to 2012 has been assembled in the Canadian registry (CARESS) to document utilization, compliance, and health outcomes in both hospital and community settings. Long-term data is necessary to evaluate the impact of palivizumab on the incidence of RSV infections, minimize healthcare resources, and identify which infant subpopulations are receiving prophylaxis. A database search was also conducted for similar information from published registries, and hospitalization rates were compared to results from randomized clinical trials (RCTs).Overall hospitalization rates (percent; range) for respiratory-related illnesses and RSV-specific infection in infants who meet standard indications for prophylaxis were 6.6 (3.3-7.7) and 1.55 (0.3-2.06), respectively, in CARESS, which closely aligns with registry data from 4 other countries, despite the former comprising the largest cohort of complex patients internationally. Overall RSV-related hospitalization rates were lower across registries compared to equivalent patients in RCTs. Registry data provides valuable information regarding real-world experience with palivizumab, while facilitating the genesis of new research themes.
- Published
- 2013
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