Purpose: To investigate whether nonagenarians relative to octogenarians are at increased risk of ocular complications from cataract surgery in the US Veterans Health Administration (VHA)., Design: A retrospective cohort study., Participants: A total of 554 nonagenarians and 11 407 octogenarians who received cataract surgery in the VHA., Methods: Nonagenarians and octogenarians who received 1 cataract surgery without a second surgery within 90 days between October 1, 2005, and September 30, 2007, were identified using the National Patient Care Database (NPCD). Data collected include demographics, preoperative systemic and ocular comorbidities, intraoperative complications, and 90-day postoperative complications. The adjusted odds ratio (OR) of complications in nonagenarians using octogenarians as a reference group was calculated using logistic regression modeling., Main Outcome Measures: Intraoperative and postoperative ocular complications within 90 days of cataract surgery in nonagenarians versus octogenarians., Results: The most common systemic comorbidity for both age groups was diabetes mellitus (DM), and the most common ocular comorbidity for both age groups was age-related macular degeneration (AMD). Octogenarians had a higher prevalence of most systemic comorbidities, and nonagenarians had a higher prevalence of most ocular comorbidities. The most common intraoperative and postoperative complications for both age groups were vitreous loss or posterior capsular tear and posterior capsular opacification. The risk of having any intraoperative or postoperative complication was 13.5% for octogenarians and 13.4% for nonagenarians (P = 0.9001). The OR of having any intraoperative or postoperative complication in nonagenarians with octogenarians as a reference group was 0.94 (95% confidence interval, 0.73-1.22)., Conclusions: Nonagenarians relative to octogenarians are not at increased risk of ocular complications from cataract surgery in the VHA. Further studies are needed to evaluate other outcome parameters, such as visual function and quality of life, in nonagenarians undergoing cataract surgery., (Copyright © 2011 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.)