22 results on '"Lowe D"'
Search Results
2. An Examination of Financial Sub-certification and Timing of Fraud Discovery on Employee Whistleblowing Reporting Intentions.
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Lowe, D., Pope, Kelly, and Samuels, Janet
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FRAUD ,CERTIFICATION laws ,FINANCIAL statement laws ,WHISTLEBLOWING ,EMPLOYEE psychology ,INTENTION ,DISCLOSURE ,UNITED States. Sarbanes-Oxley Act of 2002 - Abstract
The Sarbanes-Oxley Act of 2002 (SOX) requires company executives to certify financial statements and internal controls as a means of reducing fraud. Many companies have operationalized this by instituting a sub-certification process and requiring lower-level managers to sign certification statements. These lower-level organizational members are often the individuals who are aware of fraud and are in the best position to provide information on the fraudulent act. However, the sub-certification process may have the effect of reducing employees' intentions to report wrongdoing. We suggest that subordinates with knowledge of a superior who committed a fraudulent act and certified that there is no fraud will feel less personal responsibility to report the act, thus, decreasing reporting intentions. Additionally, we suggest that if the fraud is discovered subsequent to the reports being filed with the Securities and Exchange Commission (SEC), employees will perceive lower management responsiveness to investigate the fraud, which will reduce intentions to report. Using an experimental approach, we manipulate two between-participant variables: (1) the presence or absence of sub-certification by the transgressor and (2) the timing of fraud discovery, either before or after the reports have been filed with the SEC. We find that when sub-certification is present, perceived personal responsibility and intentions to report were diminished compared to when sub-certification is absent. Timing of the discovery of the fraudulent act did not influence perceived management responsiveness or reporting intentions. Supplemental analysis shows that personal responsibility partially mediates the relationship between sub-certification and reporting intentions. Our findings suggest that audit committees and senior executives may want to carefully consider the costs and benefits of the sub-certification process. [ABSTRACT FROM AUTHOR]
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- 2015
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3. The Effect of Evidence Strength and Internal Rewards on Intentions to Report Fraud in the Dodd-Frank Regulatory Environment.
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Brink, Alisa G., Jordan Lowe, D., and Victoravich, Lisa M.
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ACCOUNTING fraud ,MONETARY incentives ,WHISTLEBLOWING ,DODD-Frank Wall Street Reform & Consumer Protection Act ,UNITED States. Sarbanes-Oxley Act of 2002 - Abstract
There are many unanswered questions and concerns regarding the consequences of the fraud whistleblowing environment created by the Sarbanes-Oxley (SOX) and Dodd-Frank Acts. While SOX requires audit committees to implement anonymous internal reporting channels, the Dodd-Frank Act offers substantial monetary incentives that encourage reporting to the Securities and Exchange Commission (SEC). To mitigate concerns that employees might bypass internal channels, somecompanies are considering offering internal whistleblowing incentives. However, it is unclear how internal incentives will affect employee whistleblowing behavior. We experimentally examine the impact of an internal incentive on employees' intentions to report fraud. Across treatments, we find a greater likelihood of reporting internally than to the SEC. Evidence strength interacts with the presence of an internal incentive such that SEC reporting intentions are greatest when evidence is strong and an internal incentive is present. When evidence is weak, the presence of an internal incentive decreases SEC reporting intentions [ABSTRACT FROM AUTHOR]
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- 2013
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4. SV40 association with human malignancies and mechanisms of tumor immunity by large tumor antigen.
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Lowe, D. B., Shearer, M. H., Jumper, C. A., and Kennedy, R. C.
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SV40 (Virus) , *SIMIAN viruses , *POLIOMYELITIS vaccines , *IMMUNOTHERAPY , *MESOTHELIOMA , *CANCER - Abstract
SV40 was discovered as a contaminate of poliovirus vaccine lots distributed to millions of individuals in the United States between 1955 and 1963 while contaminated vaccine batches were later circulated worldwide. After SV40 was observed to cause in vitro animal and human cell transformations and in vivo tumor formations in animals, the search for a connection between the virus and human malignancies has continued to the present day. Different molecular methods have been used to detect SV40 gene products in a variety of human cancers, though SV40 causality in these tumor types has yet to be established. These data, however, are not without controversial issues related to inconclusive SV40 serological and epidemiological evidence alongside tools and methodologies that may contribute to false-positive results in human specimens. This review will also explore how vaccination against SV40 protein products may be used to help prevent and treat individuals with SV40-expressing cancers. [ABSTRACT FROM AUTHOR]
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- 2007
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5. A feasibility study of computer-assisted health-related quality of life data collection in patients with oral and oropharyngeal cancer.
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Millsopp, L., Frackleton, S., Lowe, D., and Rogers, S.N.
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CANCER patients ,QUALITY of life ,CANCER treatment - Abstract
Abstract: Touchscreen technology (TST) has been widely used in the field of medicine. The purpose of this study was to pilot a standard TST system to administer the University of Washington Quality of Life Questionnaire (UWQOL) in a routine head and neck oncology clinic. The UWQOLv4 was completed using TST and a semi-structured interview was used to evaluate patients’ experience of the data collection process. Forty-one of 44 consecutive cancer patients agreed to participate in the study. Although over three-quarters of patients reported never having used a computer, all but one found the UWQOLv4 ‘easy’ or ‘very easy’ to complete using the TST. They preferred the TST method to paper copy and the vast majority completed the TST in 10min or less. TST provides a very suitable mechanism for routine health-related quality of life data collection. The system is easy to programme and relatively inexpensive. [Copyright &y& Elsevier]
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- 2006
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6. The Mitigation of Hindsight Bias in Judges' Evaluation of Auditor Decisions.
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Anderson, John C., Jennings, Marianne M., Lowe, D. Jordan, and Reckers, Philip M. J.
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AUDITORS ,ACCOUNTING ,ACCOUNTING firms ,AUDITOR-client relationships ,LEGAL status of auditors - Abstract
The public accounting profession may be significantly disadvantaged if hindsight bias is manifest through the U.S. civil liability system. Auditors must make decisions without knowledge of an eventual outcome, but auditor liability is determined from a perspective that includes outcome knowledge. Ex post, litigants tend to blame auditors for failing to foresee and anticipate subsequent financial problems of their audit clients. This study was conducted to test the effectiveness of two methods of mitigating hindsight bias in a legal liability context. An experiment was conducted with 157 state general jurisdiction judges serving as subjects. Results indicate that these judges' evaluations of auditors' performance were subject to hindsight bias. More importantly, we found that under one of the mitigation methods, evaluative judgments were significantly more favorable than were judgments in the unmitigated negative outcome treatment, and essentially the same as evaluative judgments in the no outcome control condition. The primary contribution of this study is that it is the first to provide evidence that judges' hindsight bias can be mitigated in an audit legal liability context. Implications for audit legal liability and future research are also discussed. [ABSTRACT FROM AUTHOR]
- Published
- 1997
7. Initial renal replacement therapy (RRT) modality associates with 90-day postdischarge RRT dependence in critically ill AKI survivors.
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Koyner JL, Mackey RH, Echeverri J, Rosenthal NA, Carabuena LA, Bronson-Lowe D, Harenski K, and Neyra JA
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- Humans, Male, Female, Middle Aged, Aged, Intensive Care Units statistics & numerical data, Adult, Survivors, Continuous Renal Replacement Therapy methods, United States, Retrospective Studies, Acute Kidney Injury therapy, Acute Kidney Injury mortality, Critical Illness, Patient Discharge, Renal Replacement Therapy methods, Renal Replacement Therapy statistics & numerical data
- Abstract
Purpose: Real-world comparison of RRT modality on RRT dependence at 90 days postdischarge among ICU patients discharged alive after RRT for acute kidney injury (AKI)., Methods: Using claims-linked to US hospital discharge data (Premier PINC AI Healthcare Database [PHD]), we compared continuous renal replacement therapy (CRRT) vs. intermittent hemodialysis (IHD) for AKI in adult ICU patients discharged alive from January 1, 2018 to June 30, 2021. RRT dependence at 90 days postdischarge was defined as ≥2 RRT treatments in the last 8 days. Between-group differences were balanced using inverse probability treatment weighting (IPTW)., Results: Of 34,804 patients, 3804 patients (from 382 hospitals) had claims coverage for days 83-90 postdischarge. Compared to IHD-treated patients (n = 2740), CRRT-treated patients (n = 1064) were younger; had more admission to large teaching hospitals, surgery, sepsis, shock, mechanical ventilation, but lower prevalence of comorbidities (p < 0.05 for all). Compared to IHD-treated patients, CRRT-treated patients had lower RRT dependence at hospital discharge (26.5% vs. 29.8%, p = 0.04) and lower RRT dependence at 90 days postdischarge (4.9% vs. 7.4% p = 0.006) with weighted adjusted OR (95% CI): 0.68 (0.47-0.97), p = 0.03. Results persisted in sensitivity analyses including patients who died during days 1-90 postdischarge (n = 112) or excluding patients from hospitals with IHD patients only (n = 335), or when excluding patients who switched RRT modalities (n = 451)., Conclusions: Adjusted for potential confounders, the odds of RRT dependence at 90 days postdischarge among survivors of RRT for AKI was 30% lower for those treated first with CRRT vs. IHD, overall and in several sensitivity analyses., Summary: Critically ill patients in intensive care units (ICU) may develop acute kidney injury (AKI) that requires renal replacement therapy (RRT) to temporarily replace the injured kidney function of cleaning the blood. Two main types of RRT in the ICU are called continuous renal replacement therapy (CRRT), which is performed almost continuously, i.e., for >18 h per day, and intermittent hemodialysis (IHD), which is a more rapid RRT that is usually completed in a little bit over 6 h, several times per week. The slower CRRT may be gentler on the kidneys and is more likely to be used in the sickest patients, who may not be able to tolerate IHD. We conducted a data-analysis study to evaluate whether long-term effects on kidney function (assessed by ongoing need for RRT, i.e., RRT dependence) differ depending on use of CRRT vs. IHD. In a very large US linked hospital-discharge/claims database we found that among ICU patients discharge alive after RRT for AKI, fewer CRRT-treated patients had RRT dependence at hospital discharge (26.5% vs. 29.8%, p = 0.04) and at 90 days after discharge (4.9% vs. 7.4% p = 0.006). In adjusted models, RRT dependence at 90 days postdischarge was >30% lower for CRRT than IHD-treated patients. These results from a non-randomized study suggest that among survivors of RRT for AKI, CRRT may result in less RRT dependence 90 days after hospital discharge., Competing Interests: Declaration of Competing Interest JLK has received consultant fees from Baxter and Biomerieux and Research funding from Biomerieux and Fresenius Medical. JAN has received consultant fees from Baxter, Vifor Pharma, and Outset Medical. RHM, NAR, and LAC are full-time employees of Premier, Inc., which received payment from Baxter Healthcare to conduct the study and have no competing interests with respect to the study. JE, KH and DBL are full-time employees of Baxter International with ownership interests. The authors report no other conflicts of interest with this work., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
- Published
- 2024
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8. Change in Pediatric Adenotonsillectomy Postoperative Visit Patterns After Opioid Food and Drug Administration Warning.
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Cohen N, Schissler K, Jeter J, Stathas A, Lozano J, Dave S, and Lowe D
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- United States epidemiology, Child, Humans, Child, Preschool, Analgesics, Opioid adverse effects, Adenoidectomy adverse effects, Retrospective Studies, United States Food and Drug Administration, Pain drug therapy, Emergency Service, Hospital, Drug Prescriptions, Tonsillectomy adverse effects, Opioid-Related Disorders drug therapy
- Abstract
Study Objective: This study aimed to determine the association between opioid prescriptions given after tonsillectomy with adenoidectomy (T + A) and pain-related return visit rates in pediatric patients. Determine association between Food and Drug Administration (FDA) black box warning against opioid use in this population and pain-related return visit rates., Methods: This was a single-institution retrospective cohort study of pediatric patients who underwent T + A between April 2012 and December 2015 and had return visits to the emergency department or urgent care center. Data were obtained from the hospital electronic warehouse using International Classification of Diseases-9/10 procedure codes. Odds ratios (ORs) with 95% confidence intervals (CIs) for return visits were calculated. Multivariate logistic regression analysis was used to measure association between opioid prescriptions and return visit rates as well as FDA warning and return visit rates adjusting for confounders., Results: There were 4778 patients who underwent T + A, median age, 5 years. Of these, 752 (15.7%) had return visits. Pain-related return visits were higher in patients who received opioid prescriptions (adjusted OR, 1.31; 95% CI, 1.09-1.57). After FDA warning, opioids were prescribed at a lower rate (47.9%) compared with previous (98.6%) (OR, 0.01; 95% CI, 0.008-0.02). Pain-related return visits were lower after FDA warning (OR, 0.73; 95% CI, 0.61-0.87). Steroid prescription rate increased after FDA warning (OR, 415; 95% CI, 197-874)., Conclusions: Opioid prescriptions were associated with higher pain-related return visits after T + A, whereas issuance of FDA black box warning against codeine use was associated with lower pain-related return visits. Our data suggest that the black box warning potentially had unintended benefits in pain management and health care usage., Competing Interests: Disclosure: The authors declare no conflict of interest., (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
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- 2024
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9. Tecovirimat Resistance in Mpox Patients, United States, 2022-2023.
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Smith TG, Gigante CM, Wynn NT, Matheny A, Davidson W, Yang Y, Condori RE, O'Connell K, Kovar L, Williams TL, Yu YC, Petersen BW, Baird N, Lowe D, Li Y, Satheshkumar PS, and Hutson CL
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- Humans, United States epidemiology, Antiviral Agents pharmacology, Antiviral Agents therapeutic use, Benzamides therapeutic use, Biological Assay, Monkeypox virus, Mpox (monkeypox)
- Abstract
During the 2022 multinational outbreak of monkeypox virus (MPXV) infection, the antiviral drug tecovirimat (TPOXX; SIGA Technologies, Inc., https://www.siga.com) was deployed in the United States on a large scale for the first time. The MPXV F13L gene homologue encodes the target of tecovirimat, and single amino acid changes in F13 are known to cause resistance to tecovirimat. Genomic sequencing identified 11 mutations previously reported to cause resistance, along with 13 novel mutations. Resistant phenotype was determined using a viral cytopathic effect assay. We tested 124 isolates from 68 patients; 96 isolates from 46 patients were found to have a resistant phenotype. Most resistant isolates were associated with severely immunocompromised mpox patients on multiple courses of tecovirimat treatment, whereas most isolates identified by routine surveillance of patients not treated with tecovirimat remained sensitive. The frequency of resistant viruses remains relatively low (<1%) compared with the total number of patients treated with tecovirimat.
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- 2023
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10. Monkeypox Case Investigation - Cook County Jail, Chicago, Illinois, July-August 2022.
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Hagan LM, Beeson A, Hughes S, Hassan R, Tietje L, Meehan AA, Spencer H, Turner J, Richardson M, Howard J, Schultz A, Ali S, Butler MM, Arce Garza D, Morgan CN, Kling C, Baird N, Townsend MB, Carson WC, Lowe D, Wynn NT, Black SR, Kerins JL, Rafinski J, Defuniak A, Auguston P, Mosites E, Ghinai I, and Zawitz C
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- Chicago epidemiology, DNA, Humans, Illinois epidemiology, Jails, Male, United States, Mpox (monkeypox) diagnosis, Mpox (monkeypox) epidemiology
- Abstract
Knowledge about monkeypox transmission risk in congregate settings is limited. In July 2022, the Chicago Department of Public Health (CDPH) confirmed a case of monkeypox in a person detained in Cook County Jail (CCJ) in Chicago, Illinois. This case was the first identified in a correctional setting in the United States and reported to CDC during the 2022 multinational monkeypox outbreak. CDPH collaborated with CCJ, the Illinois Department of Public Health (IDPH), and CDC to evaluate transmission risk within the facility. Fifty-seven residents were classified as having intermediate-risk exposures to the patient with monkeypox during the 7-day interval between the patient's symptom onset and his isolation. (Intermediate-risk exposure was defined as potentially being within 6 ft of the patient with monkeypox for a total of ≥3 hours cumulatively, without wearing a surgical mask or respirator, or potentially having contact between their own intact skin or clothing and the skin lesions or body fluids from the patient or with materials that were in contact with the patient's skin lesions or body fluids.) No secondary cases were identified among a subset of 62% of these potentially exposed residents who received symptom monitoring, serologic testing, or both. Thirteen residents accepted postexposure prophylaxis (PEP), with higher acceptance among those who were offered counseling individually or in small groups than among those who were offered PEP together in a large group. Monkeypox virus (MPXV) DNA, but no viable virus, was detected on one surface in a dormitory where the patient had been housed with other residents before he was isolated. Although monkeypox transmission might be limited in similar congregate settings in the absence of higher-risk exposures, congregate facilities should maintain recommended infection control practices in response to monkeypox cases, including placing the person with monkeypox in medical isolation and promptly and thoroughly cleaning and disinfecting spaces where the person has spent time. In addition, officials should provide information to residents and staff members about monkeypox symptoms and transmission modes, facilitate confidential monkeypox risk and symptom disclosure and prompt medical evaluation for symptoms that are reported, and provide PEP counseling in a private setting., Competing Interests: All authors have completed and submitted the International Committee of Medical Journal Editors form for disclosure of potential conflicts of interest. No potential conflicts of interest were disclosed.
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- 2022
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11. Orthopoxvirus Testing Challenges for Persons in Populations at Low Risk or Without Known Epidemiologic Link to Monkeypox - United States, 2022.
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Minhaj FS, Petras JK, Brown JA, Mangla AT, Russo K, Willut C, Lee M, Beverley J, Harold R, Milroy L, Pope B, Gould E, Beeler C, Schneider J, Mostafa HH, Godfred-Cato S, Click ES, Borah BF, Galang RR, Cash-Goldwasser S, Wong JM, McCormick DW, Yu PA, Shelus V, Carpenter A, Schatzman S, Lowe D, Townsend MB, Davidson W, Wynn NT, Satheshkumar PS, O'Connor SM, O'Laughlin K, Rao AK, McCollum AM, Negrón ME, Hutson CL, and Salzer JS
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- Animals, Child, Female, Homosexuality, Male, Humans, Male, Monkeypox virus genetics, Travel, United States epidemiology, Communicable Diseases, Mpox (monkeypox) diagnosis, Mpox (monkeypox) epidemiology, Orthopoxvirus genetics, Sexual and Gender Minorities
- Abstract
Since May 2022, approximately 20,000 cases of monkeypox have been identified in the United States, part of a global outbreak occurring in approximately 90 countries and currently affecting primarily gay, bisexual, and other men who have sex with men (MSM) (1). Monkeypox virus (MPXV) spreads from person to person through close, prolonged contact; a small number of cases have occurred in populations who are not MSM (e.g., women and children), and testing is recommended for persons who meet the suspected case definition* (1). CDC previously developed five real-time polymerase chain reaction (PCR) assays for detection of orthopoxviruses from lesion specimens (2,3). CDC was granted 510(k) clearance for the nonvariola-orthopoxvirus (NVO)-specific PCR assay by the Food and Drug Administration. This assay was implemented within the Laboratory Response Network (LRN) in the early 2000s and became critical for early detection of MPXV and implementation of public health action in previous travel-associated cases as well as during the current outbreak (4-7). PCR assays (NVO and other Orthopoxvirus laboratory developed tests [LDT]) represent the primary tool for monkeypox diagnosis. These tests are highly sensitive, and cross-contamination from other MPXV specimens being processed, tested, or both alongside negative specimens can occasionally lead to false-positive results. This report describes three patients who had atypical rashes and no epidemiologic link to a monkeypox case or known risk factors; these persons received diagnoses of monkeypox based on late cycle threshold (Ct) values ≥34, which were false-positive test results. The initial diagnoses were followed by administration of antiviral treatment (i.e., tecovirimat) and JYNNEOS vaccine postexposure prophylaxis (PEP) to patients' close contacts. After receiving subsequent testing, none of the three patients was confirmed to have monkeypox. Knowledge gained from these and other cases resulted in changes to CDC guidance. When testing for monkeypox in specimens from patients without an epidemiologic link or risk factors or who do not meet clinical criteria (or where these are unknown), laboratory scientists should reextract and retest specimens with late Ct values (based on this report, Ct ≥34 is recommended) (8). CDC can be consulted for complex cases including those that appear atypical or questionable cases and can perform additional viral species- and clade-specific PCR testing and antiorthopoxvirus serologic testing., Competing Interests: All authors have completed and submitted the International Committee of Medical Journal Editors form for disclosure of potential conflicts of interest. Brian Pope reports travel support and provision of laboratory equipment from the Association for Public Health Laboratories and unpaid participation for service on the Awards and Nominations Committee for the Pan American Society for Clinical virology. Heba H. Mostafa reports grant support from the Maryland Department of Health, and research contract support from BioRad, DiaSorin, and Hologic. No other potential conflicts of interest were disclosed.
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- 2022
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12. Rapid Diagnostic Testing for Response to the Monkeypox Outbreak - Laboratory Response Network, United States, May 17-June 30, 2022.
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Aden TA, Blevins P, York SW, Rager S, Balachandran D, Hutson CL, Lowe D, Mangal CN, Wolford T, Matheny A, Davidson W, Wilkins K, Cook R, Roulo RM, White MK, Berman L, Murray J, Laurance J, Francis D, Green NM, Berumen RA 3rd, Gonzalez A, Evans S, Hudziec M, Noel D, Adjei M, Hovan G, Lee P, Tate L, Gose RB, Voermans R, Crew J, Adam PR, Haydel D, Lukula S, Matluk N, Shah S, Featherston J, Ware D, Pettit D, McCutchen E, Acheampong E, Buttery E, Gorzalski A, Perry M, Fowler R, Lee RB, Nickla R, Huard R, Moore A, Jones K, Johnson R, Swaney E, Jaramillo J, Reinoso Webb C, Guin B, Yost J, Atkinson A, Griffin-Thomas L, Chenette J, Gant J, Sterkel A, Ghuman HK, Lute J, Smole SC, Arora V, Demontigny CK, Bielby M, Geeter E, Newman KAM, Glazier M, Lutkemeier W, Nelson M, Martinez R, Chaitram J, Honein MA, and Villanueva JM
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- Humans, Laboratories, Orthopoxvirus, United States epidemiology, Variola virus, Diagnostic Techniques and Procedures, Disease Outbreaks prevention & control, Mpox (monkeypox) diagnosis, Mpox (monkeypox) epidemiology
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As part of public health preparedness for infectious disease threats, CDC collaborates with other U.S. public health officials to ensure that the Laboratory Response Network (LRN) has diagnostic tools to detect Orthopoxviruses, the genus that includes Variola virus, the causative agent of smallpox. LRN is a network of state and local public health, federal, U.S. Department of Defense (DOD), veterinary, food, and environmental testing laboratories. CDC developed, and the Food and Drug Administration (FDA) granted 510(k) clearance* for the Non-variola Orthopoxvirus Real-time PCR Primer and Probe Set (non-variola Orthopoxvirus [NVO] assay), a polymerase chain reaction (PCR) diagnostic test to detect NVO. On May 17, 2022, CDC was contacted by the Massachusetts Department of Public Health (DPH) regarding a suspected case of monkeypox, a disease caused by the Orthopoxvirus Monkeypox virus. Specimens were collected and tested by the Massachusetts DPH public health laboratory with LRN testing capability using the NVO assay. Nationwide, 68 LRN laboratories had capacity to test approximately 8,000 NVO tests per week during June. During May 17-June 30, LRN laboratories tested 2,009 specimens from suspected monkeypox cases. Among those, 730 (36.3%) specimens from 395 patients were positive for NVO. NVO-positive specimens from 159 persons were confirmed by CDC to be monkeypox; final characterization is pending for 236. Prompt identification of persons with infection allowed rapid response to the outbreak, including isolation and treatment of patients, administration of vaccines, and other public health action. To further facilitate access to testing and increase convenience for providers and patients by using existing provider-laboratory relationships, CDC and LRN are supporting five large commercial laboratories with a national footprint (Aegis Science, LabCorp, Mayo Clinic Laboratories, Quest Diagnostics, and Sonic Healthcare) to establish NVO testing capacity of 10,000 specimens per week per laboratory. On July 6, 2022, the first commercial laboratory began accepting specimens for NVO testing based on clinician orders., Competing Interests: All authors have completed and submitted the International Committee of Medical Journal Editors form for disclosure of potential conflicts of interest Remedios B. Gose reports membership on the APHL LRN Operational Work Group. Danielle Haydel reports support from APHL to attend the APHL Conference. Robert B. Lee reports receipt of general revenue funds from the state of Ohio. Robert Nickla reports providing contracted subject matter expert review and development of online lab training courses for MediaLab, receipt of past travel awards through APHL to attend meetings, unpaid volunteer membership on the APHL Public Health Preparedness and Response Committee, and chair of the APHL Sentinel Laboratory Partnerships and Outreach Subcommittee. Nicole M. Green reports support for attending the Southern California American Society for Microbiology meeting, leadership or fiduciary roles in the Southern California American Society for Microbiology, the California Association of Public Health Laboratory Directors, and APHL. Erin Swaney reports support from the Texas Department of State Health Services to travel to the 2020 Texas LRN Conference. Jessica Chenette reports support from the Vermont Department of Health Laboratory for purchase of reagents, supplies, equipment, and salary. Jessica Gant reports institutional support from APHL. Cynthia Reinoso Webb reports payment for a 2019 lecture from the Southwestern Association of Clinical Microbiology and a diverse portfolio in growth mutual funds and individual holdings in Apple, Amazon, Disney, and Ford corporations. No other potential conflicts of interest were disclosed.
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- 2022
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13. Asthma Disparities During the COVID-19 Pandemic: A Survey of Patients and Physicians.
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Baptist AP, Lowe D, Sarsour N, Jaffee H, Eftekhari S, Carpenter LM, and Bansal P
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- Adult, Black or African American statistics & numerical data, Asthma physiopathology, Betacoronavirus, COVID-19, Coronavirus Infections ethnology, Female, Health Knowledge, Attitudes, Practice ethnology, Hispanic or Latino statistics & numerical data, Humans, Male, Medically Uninsured ethnology, Pandemics, Physicians, Primary Care, Pneumonia, Viral ethnology, Pulmonologists, SARS-CoV-2, Severity of Illness Index, Social Class, Surveys and Questionnaires, United States epidemiology, White People statistics & numerical data, Anti-Asthmatic Agents therapeutic use, Asthma drug therapy, Coronavirus Infections epidemiology, Health Status Disparities, Healthcare Disparities ethnology, Pneumonia, Viral epidemiology, Racism, Unemployment statistics & numerical data
- Abstract
Background: The coronavirus disease 2019 (COVID-19) pandemic has demonstrated significantly worse outcomes for minority (black and Hispanic) individuals. Understanding the reasons for COVID-19-related disparities among patients with asthma has important public health implications., Objective: To determine factors contributing to health disparities in those with asthma during the COVID-19 pandemic., Methods: An anonymous survey was sent through social media to adult patients with asthma, and a separate survey was sent to physicians who provide asthma care. The patient survey addressed demographic information including socioeconomic status, asthma control, and attitudes/health behaviors during COVID-19., Results: A total of 1171 patients (10.1% minority individuals) and 225 physicians completed the survey. Minority patients were more likely to have been affected by COVID-19 (eg, became unemployed, lived in a community with high COVID-19 cases). They had worse asthma control (increased emergency visits for asthma, lower Asthma Control Test score), were more likely to live in urban areas, and had a lower household income. Initial differences in attitudes and health behaviors disappeared after controlling for baseline demographic features. Institutional racism was demonstrated by findings that minority individuals were less likely to have a primary care physician, had more trouble affording asthma medications due to COVID-19, and were more likely to have lost health insurance because of COVID-19, and that 25% of physicians found it more challenging to care for black individuals with asthma during COVID-19., Conclusions: Differences in socioeconomic status and the effects of institutional racism, but not health behaviors, sources of information, or attitudes, are playing a role in disparities seen for patients with asthma during COVID-19., (Copyright © 2020 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.)
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- 2020
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14. Role of Endoscopic Resection Versus Surgical Resection in Management of Malignant Colon Polyps: a National Cancer Database Analysis.
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Lowe D, Saleem S, Arif MO, Sinha S, and Brooks G
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- Aged, Colonic Neoplasms epidemiology, Colonic Neoplasms mortality, Colonic Neoplasms pathology, Colonic Neoplasms surgery, Colonic Polyps epidemiology, Colonic Polyps mortality, Colonic Polyps pathology, Databases, Factual statistics & numerical data, Female, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Retrospective Studies, United States epidemiology, Colectomy methods, Colectomy mortality, Colectomy statistics & numerical data, Colonic Polyps surgery, Colonoscopy mortality, Colonoscopy statistics & numerical data
- Abstract
Background: Endoscopic resection (polypectomy) or surgery, are the main approaches in management of malignant colon polyps. There are very few large population-based studies comparing outcomes between the two., Methods: Using the National Cancer Database, we identified patients ≥ 18 years with the first diagnosis of T1N0M0 malignant polyp from 2004 to 2015. Patients with a positive resection margin were excluded. Outcomes were compared between those who had surgery versus those who had polypectomy. Overall survival was compared using Kaplan-Meier curves. Multivariate Cox proportional hazards analysis was performed to generate hazard ratios, adjusted for patient, demographic, and tumor factors., Results: A total of 31,062 patients met the inclusion criteria, out of which 2593 (8.3%) underwent polypectomy alone and 28,469 (91.7%) had surgery. Overall survival was significantly better in the surgical group compared with the polypectomy group. One-year and 5-year survival for surgery were 95.8% and 86.1% respectively compared with 94.2% and 80.6% for polypectomy (p < .0001). Hazard ratio for surgery after adjusting for various clinical-, demographic-, and tumor-level factors was 0.53 (p < .0001)., Conclusion: Our study is the largest population-based analysis of patients with T1N0M0 malignant colon polyps. Overall survival was higher in patients who underwent surgery compared with polypectomy. This remained consistent even after adjusting for multiple patient and tumor factors between the two groups.
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- 2020
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15. Initial Public Health Laboratory Response After Hurricane Maria - Puerto Rico, 2017.
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Concepción-Acevedo J, Patel A, Luna-Pinto C, Peña RG, Cuevas Ruiz RI, Arbolay HR, Toro M, Deseda C, De Jesus VR, Ribot E, Gonzalez JQ, Rao G, De Leon Salazar A, Ansbro M, White BB, Hardy MC, Georgi JC, Stinnett R, Mercante AM, Lowe D, Martin H, Starks A, Metchock B, Johnston S, Dalton T, Joglar O, Stafford C, Youngblood M, Klein K, Lindstrom S, Berman L, Galloway R, Schafer IJ, Walke H, Stoddard R, Connelly R, McCaffery E, Rowlinson MC, Soroka S, Tranquillo DT, Gaynor A, Mangal C, Wroblewski K, Muehlenbachs A, Salerno RM, Lozier M, Sunshine B, Shapiro C, Rose D, Funk R, Pillai SK, and O'Neill E
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- Centers for Disease Control and Prevention, U.S., Communicable Diseases diagnosis, Communicable Diseases epidemiology, Diagnostic Tests, Routine, Humans, Population Surveillance, Puerto Rico epidemiology, United States, Cyclonic Storms, Disasters, Laboratories organization & administration, Public Health Practice
- Abstract
Hurricane Maria made landfall in Puerto Rico on September 20, 2017, causing major damage to infrastructure and severely limiting access to potable water, electric power, transportation, and communications. Public services that were affected included operations of the Puerto Rico Department of Health (PRDOH), which provides critical laboratory testing and surveillance for diseases and other health hazards. PRDOH requested assistance from CDC for the restoration of laboratory infrastructure, surveillance capacity, and diagnostic testing for selected priority diseases, including influenza, rabies, leptospirosis, salmonellosis, and tuberculosis. PRDOH, CDC, and the Association of Public Health Laboratories (APHL) collaborated to conduct rapid needs assessments and, with assistance from the CDC Foundation, implement a temporary transport system for shipping samples from Puerto Rico to the continental United States for surveillance and diagnostic and confirmatory testing. This report describes the initial laboratory emergency response and engagement efforts among federal, state, and nongovernmental partners to reestablish public health laboratory services severely affected by Hurricane Maria. The implementation of a sample transport system allowed Puerto Rico to reinitiate priority infectious disease surveillance and laboratory testing for patient and public health interventions, while awaiting the rebuilding and reinstatement of PRDOH laboratory services., Competing Interests: No conflicts of interest were reported.
- Published
- 2018
- Full Text
- View/download PDF
16. Self-reported information needs of anesthesia residency applicants and analysis of applicant-related web sites resources at 131 United States training programs.
- Author
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Chu LF, Young CA, Zamora AK, Lowe D, Hoang DB, Pearl RG, and Macario A
- Subjects
- Attitude of Health Personnel, Attitude to Computers, Career Choice, Health Knowledge, Attitudes, Practice, Humans, Multimedia, Perception, Program Evaluation, Self Report, Surveys and Questionnaires, United States, Access to Information, Anesthesiology education, Education, Medical, Graduate, Internet, Internship and Residency, Job Application
- Abstract
Background: Despite the use of web-based information resources by both anesthesia departments and applicants, little research has been done to assess these resources and determine whether they are meeting applicant needs. Evidence is needed to guide anesthesia informatics research in developing high-quality anesthesia residency program Web sites (ARPWs)., Methods: We used an anonymous web-based program (SurveyMonkey, Portland, OR) to distribute a survey investigating the information needs and perceived usefulness of ARPWs to all 572 Stanford anesthesia residency program applicants. A quantitative scoring system was then created to assess the quality of ARPWs in meeting the information needs of these applicants. Two researchers independently analyzed all 131 ARPWs in the United States to determine whether the ARPWs met the needs of applicants based on the scoring system. Finally, a qualitative assessment of the overall user experience of ARPWs was developed to account for the subjective elements of the Web site's presentation., Results: Ninety-eight percent of respondents reported having used ARPWs during the application process. Fifty-six percent reported first visiting the Stanford ARPW when deciding whether to apply to Stanford's anesthesia residency program. Multimedia and Web 2.0 technologies were "very" or "most" useful in "learning intangible aspects of a program, like how happy people are" (42% multimedia and Web 2.0 versus 14% text and photos). ARPWs, on average, contained only 46% of the content items identified as important by applicants. The average (SD) quality scores among all ARPWs was 2.06 (0.59) of 4.0 maximum points. The mean overall qualitative score for all 131 ARPWs was 4.97 (1.92) of 10 points. Only 2% of applicants indicated that the majority (75%-100%) of Web sites they visited provided a complete experience., Conclusion: Anesthesia residency applicants rely heavily on ARPWs to research programs, prepare for interviews, and formulate a rank list. Anesthesia departments can improve their ARPWs by including information such as total hours worked and work hours by rotation (missing in 96% and 97% of ARPWs) and providing a valid web address on the Fellowship and Residency Electronic Interactive Database Access System (FREIDA) (missing in 28% of ARPWs).
- Published
- 2011
- Full Text
- View/download PDF
17. The Stamp-in-Safety programme, an intervention to promote better supervision of children on childcare centre playgrounds: an evaluation in an urban setting.
- Author
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Chelvakumar G, Sheehan K, Hill AL, Lowe D, Mandich N, and Schwebel DC
- Subjects
- Accident Prevention, Accidental Falls statistics & numerical data, Behavior Control, Child Day Care Centers, Child, Preschool, Equipment Design, Female, Humans, Male, Social Environment, United States epidemiology, Accidental Falls prevention & control, Play and Playthings injuries
- Abstract
Using a non-equivalent control group design, this report evaluated a previously studied behavioural intervention, the Stamp-in-Safety programme, which is designed to reduce the injury risk for young children on playgrounds at childcare centres by increasing the quality of adult supervision and rewarding children for safe play. In an urban, commercial childcare centre, 71 children aged 3-5 years and 15 teachers participated. Primary outcome measures were teacher verbalisations (warnings, explanations, redirects), teacher location (core, outskirt, or fringe of playground), child risk-taking behaviours (using equipment appropriately) and the number of injuries on the playground. Analyses revealed that the intervention had a modest positive effect in promoting safer teacher and child playground behaviours. This study reaffirms previous results that the Stamp-in-Safety programme is an effective method to decrease the risk of playground injuries at childcare centres.
- Published
- 2010
- Full Text
- View/download PDF
18. Development of a medical supply set for corpsmen in the field.
- Author
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Emens-Hesslink KE, Galarneau MR, Lowe DJ, Smith TJ, and Konoske PJ
- Subjects
- Humans, Models, Theoretical, Task Performance and Analysis, United States, Emergency Treatment instrumentation, Equipment and Supplies, Military Medicine, Triage
- Abstract
Fleet Marine Force corpsmen are the first medical responders to treat casualties in the field. They carry an outdated bag of supplies called the surgical instrument and supply set. The purpose of this investigation is to develop an updated supply set for field corpsmen by linking each supply item to specific medical tasks conducted in the field, which then creates an audit trail. The review of medical supplies generated an updated list of supplies to be carried by corpsmen in a new medical module and a list of items that corpsmen can pull from the battalion aid station authorized medical allowance lists as needed. Items without a clinical requirement were not included. This improved set of supplies for corpsmen will greatly enhance treatment capability in the field. As technology and needs change, replacements, additions, and deletions of the items can easily be made.
- Published
- 2000
19. Trauma system development: the critical need for regional needs assessments.
- Author
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Lowe DK
- Subjects
- Humans, Program Development, United States, Needs Assessment, Regional Medical Programs organization & administration, Trauma Centers organization & administration
- Published
- 1999
- Full Text
- View/download PDF
20. Asian American health care attitudes.
- Author
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Perttula W, Lowe D, and Quon NS
- Subjects
- Age Factors, Asian statistics & numerical data, Cultural Characteristics, Data Collection, Health Facilities, Humans, Language, Patient Acceptance of Health Care, Physician-Patient Relations, Quality of Health Care, United States, Asian psychology, Attitude to Health, Marketing of Health Services methods, Patient Satisfaction statistics & numerical data
- Abstract
This paper describes the results of a survey of health care attitudes of a sample of respondents primarily of Asian American background. The importance of bilingualism, Asian background, age, and other attributes of a physician are discussed with relation to subgroups in the sample. The relative importance of the influence of doctors, family, and friends on the choice of physician and health care facility are also presented. The findings may help with the development of effective market segmentation and improved health care service to the Asian American community.
- Published
- 1999
- Full Text
- View/download PDF
21. Outcome measures, quality and health care reform.
- Author
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Lowe DK
- Subjects
- United States, Health Care Reform, Outcome Assessment, Health Care, Quality Assurance, Health Care
- Published
- 1993
22. Pesticides: nomenclature, specification, analysis, use, and residues in foods.
- Author
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Lowe DA and Stiles AR
- Subjects
- Food Analysis, Government Agencies, International Agencies, Maximum Allowable Concentration, Methods, Pesticides analysis, United States, World Health Organization, Food standards, Pesticide Residues analysis, Pesticides standards, Terminology as Topic
- Published
- 1973
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