1. Immunophenotype of acute lymphoblastic leukemia in minorities‐ analysis from the SEER database.
- Author
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Quiroz, Elisa, Venkateswaran, Aparajit Ram, Nelson, Rebecca, Aldoss, Ibrahim, Pullarkat, Vinod, Rego, Eduardo, Marcucci, Guido, and Douer, Dan
- Subjects
LYMPHOBLASTIC leukemia ,LATIN Americans ,ACUTE leukemia ,ETHNIC groups ,B cells - Abstract
Acute Lymphocytic Leukemia (ALL) is a malignancy that originates from immature lymphoid cells and is clinically established with flow cytometry through disease‐specific markers. Variation between ethnic groups is an epidemiological aspect of ALL. Higher incidence rates have been observed in Latin American patients and ALL in Latinos carries a dismal prognosis. The cell of origin in ALL is derived from immature cells of either the B or T lineage. Most reported data among Latinos either exclusively looks at B cell precursor ALL or do not distinguish between subtypes. We used the National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) database to delineate the differences in incidence rates of B‐ALL and T‐ALL across ethnic groups in the United States. Data from SEER‐18 was used to compare incidence rates of T‐ALL and B‐ALL. Due to the utilization of cytogenetics and subsequent changes in ICD coding over the years examined the most recent data reported from 2002 to 2017. We compared rates in Non‐Hispanic Whites (NHWs), Latinos, Blacks and Asian‐Pacific Islanders (API). Age‐adjusted incidence rates per 100,000 person‐years were calculated. The incidence rate of B‐ALL in the Latino population was consistently higher than other race/ethnicities throughout the years, ranging from 1.0 per 100,000 in 2002 to 2.5 per 100,000 in 2017. Blacks had the lowest age adjusted incidence rate (AAIR) of B‐ALL overall, with rates approximately one third of those found in Latinos and the highest AAIR of T‐ALL with an AAIR of 0.5 per 100,000. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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