8 results on '"Marmor, Michael F."'
Search Results
2. Research Note/ Issues in Wilson Scholarship: References to Early "Strokes" in the Papers of Woodrow Wilson.
- Author
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George, Juliette L., Marmor, Michael F., and George, Alexander L.
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HEALTH of Presidents of the United States ,CEREBROVASCULAR disease diagnosis - Abstract
Focuses on several references by physician Edwin A. Weinstein regarding alleged strokes suffered by former U.S. President Woodrow Wilson which were published in the book "Papers of Woodrow Wilson." Medical analysis of Robert T. Monroe, an internist and gerontologist, on the medical interpretation of Weinstein on Wilson's alleged strokes in May 1896 and May 1906; Number of references to Wilson's alleged strokes which were contained in the book; Opinion of several physicians that Weinstein's diagnoses are not consistent with a stroke; Criticism on the lack of objectivity in Weinstein's diagnoses.
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- 1984
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3. Pericentral Hydroxychloroquine Retinopathy in Korean Patients.
- Author
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Lee, Dong Hoon, Melles, Ronald B., Joe, Soo Geun, Lee, Joo Yong, Kim, June-Gone, Lee, Chang-Keun, Yoo, Bin, Koo, Bon San, Kim, Jee Taek, Marmor, Michael F., and Yoon, Young Hee
- Subjects
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RETINAL diseases , *CHLOROQUINE , *KOREANS , *OPTICAL coherence tomography , *DISEASE progression , *DISEASES - Abstract
Purpose A pericentral pattern of hydroxychloroquine (HCQ) retinopathy recently has been recognized in the United States in patients of Asian heritage. We report on an investigation of this pericentral retinopathy within a Korean population. Design Retrospective, observational study. Participants Patients taking HCQ who were referred to ophthalmology for screening of HCQ retinopathy. Methods The medical records of patients were reviewed, including spectral domain optical coherence tomography, fundus autofluorescence, and visual fields. Main Outcome Measures Frequency of pericentral pattern of HCQ retinopathy and features of progression. Results Among 218 patients referred, 9 (4.1%) were diagnosed with toxicity. Of these, 8 had a predominantly pericentral pattern of retinal change, whereas only 1 had the classic parafoveal distribution of retinal damage. Progression of retinopathy was documented in 3 patients followed more than 12 months while taking HCQ. No progression was seen in 2 patients without retinal pigment epithelial (RPE) damage who were followed for at least 12 months after discontinuation of HCQ. Conclusions We found that a pericentral pattern of HCQ retinopathy was predominant among Korean patients, rather than the traditional (bull's eye) parafoveal pattern of damage. Retinopathy progressed while on the drug, but the progression stopped in patients with toxicity detected before RPE damage. These observations suggest the need for new approaches when screening for HCQ toxicity in Asian patients. [ABSTRACT FROM AUTHOR]
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- 2015
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4. The 2016 American Academy of Ophthalmology Recommendations for Hydroxychloroquine Dosing Give Accurate Advice for All Patients.
- Author
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Marmor MF
- Subjects
- Humans, Hydroxychloroquine, Obesity, United States, Antirheumatic Agents, Ophthalmology, Retinal Diseases
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- 2019
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5. Recommendations on Screening for Chloroquine and Hydroxychloroquine Retinopathy (2016 Revision).
- Author
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Marmor MF, Kellner U, Lai TY, Melles RB, and Mieler WF
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- Academies and Institutes, Adult, Antirheumatic Agents administration & dosage, Asian People ethnology, Chloroquine administration & dosage, Electroretinography drug effects, Female, Fluorescein Angiography, Humans, Hydroxychloroquine administration & dosage, Maximum Allowable Concentration, Middle Aged, Ophthalmology organization & administration, Retinal Diseases chemically induced, Retinal Diseases ethnology, Risk Factors, Tomography, Optical Coherence, United States, Vision Disorders chemically induced, Vision Disorders ethnology, Visual Acuity drug effects, Visual Acuity physiology, Visual Field Tests, Visual Fields drug effects, Visual Fields physiology, Antirheumatic Agents toxicity, Chloroquine toxicity, Hydroxychloroquine toxicity, Retinal Diseases diagnosis, Vision Disorders diagnosis
- Abstract
Background: The American Academy of Ophthalmology recommendations on screening for chloroquine (CQ) and hydroxychloroquine (HCQ) retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools., Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. DOSE: We recommend a maximum daily HCQ use of ≤5.0 mg/kg real weight, which correlates better with risk than ideal weight. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using ≤2.3 mg/kg real weight., Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. At recommended doses, the risk of toxicity up to 5 years is under 1% and up to 10 years is under 2%, but it rises to almost 20% after 20 years. However, even after 20 years, a patient without toxicity has only a 4% risk of converting in the subsequent year., Major Risk Factors: High dose and long duration of use are the most significant risks. Other major factors are concomitant renal disease, or use of tamoxifen., Screening Schedule: A baseline fundus examination should be performed to rule out preexisting maculopathy. Begin annual screening after 5 years for patients on acceptable doses and without major risk factors., Screening Tests: The primary screening tests are automated visual fields plus spectral-domain optical coherence tomography (SD OCT). These should look beyond the central macula in Asian patients. The multifocal electroretinogram (mfERG) can provide objective corroboration for visual fields, and fundus autofluorescence (FAF) can show damage topographically. Modern screening should detect retinopathy before it is visible in the fundus., Toxicity: Retinopathy is not reversible, and there is no present therapy. Recognition at an early stage (before any RPE loss) is important to prevent central visual loss. However, questionable test results should be repeated or validated with additional procedures to avoid unnecessary cessation of valuable medication., Counseling: Patients (and prescribing physicians) should be informed about risk of toxicity, proper dose levels, and the importance of regular annual screening., (Copyright © 2016 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.)
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- 2016
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6. Fluorescein angiography: insight and serendipity a half century ago.
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Marmor MF and Ravin JG
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- Eye Diseases history, History, 20th Century, History, 21st Century, Humans, United States, Fluorescein Angiography history, Ophthalmology history
- Abstract
It has been 50 years since fluorescein angiography was developed as a clinical procedure by 2 medical students at Indiana University. The story of its discovery and the recognition of its value to ophthalmology involve a combination of insight and serendipity. Fluorescein had been in use clinically for more than half a century, but it took a pulmonary medicine laboratory to provide the stimulus for the development of flash and barrier filters that would make vascular photography practical. The first article was rejected by the ophthalmology literature, but several clinics heard about it and soon documented the enormous diagnostic value of the procedure.
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- 2011
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7. Revised recommendations on screening for chloroquine and hydroxychloroquine retinopathy.
- Author
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Marmor MF, Kellner U, Lai TY, Lyons JS, and Mieler WF
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- Academies and Institutes, Age Factors, Antirheumatic Agents administration & dosage, Chloroquine administration & dosage, Chloroquine adverse effects, Electroretinography, Fluorescein Angiography, Humans, Hydroxychloroquine administration & dosage, Ophthalmology standards, Risk Assessment, Tomography, Optical Coherence, United States, Antirheumatic Agents adverse effects, Diagnostic Techniques, Ophthalmological standards, Hydroxychloroquine adverse effects, Retina drug effects, Retinal Diseases chemically induced, Retinal Diseases diagnosis
- Abstract
Background: The American Academy of Ophthalmology recommendations for screening of chloroquine (CQ) and hydroxychloroquine (HCQ) retinopathy were published in 2002, but improved screening tools and new knowledge about the prevalence of toxicity have appeared in the ensuing years. No treatment exists as yet for this disorder, so it is imperative that patients and their physicians be aware of the best practices for minimizing toxic damage., Risk of Toxicity: New data have shown that the risk of toxicity increases sharply toward 1% after 5 to 7 years of use, or a cumulative dose of 1000 g, of HCQ. The risk increases further with continued use of the drug., Dosage: The prior recommendation emphasized dosing by weight. However, most patients are routinely given 400 mg of HCQ daily (or 250 mg CQ). This dose is now considered acceptable, except for individuals of short stature, for whom the dose should be determined on the basis of ideal body weight to avoid overdosage., Screening Schedule: A baseline examination is advised for patients starting these drugs to serve as a reference point and to rule out maculopathy, which might be a contraindication to their use. Annual screening should begin after 5 years (or sooner if there are unusual risk factors)., Screening Tests: Newer objective tests, such as multifocal electroretinogram (mfERG), spectral domain optical coherence tomography (SD-OCT), and fundus autofluorescence (FAF), can be more sensitive than visual fields. It is now recommended that along with 10-2 automated fields, at least one of these procedures be used for routine screening where available. When fields are performed independently, even the most subtle 10-2 field changes should be taken seriously and are an indication for evaluation by objective testing. Because mfERG testing is an objective test that evaluates function, it may be used in place of visual fields. Amsler grid testing is no longer recommended. Fundus examinations are advised for documentation, but visible bull's-eye maculopathy is a late change, and the goal of screening is to recognize toxicity at an earlier stage., Counseling: Patients should be aware of the risk of toxicity and the rationale for screening (to detect early changes and minimize visual loss, not necessarily to prevent it). The drugs should be stopped if possible when toxicity is recognized or strongly suspected, but this is a decision to be made in conjunction with patients and their medical physicians., (Copyright © 2011 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.)
- Published
- 2011
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8. Recommendations on screening for chloroquine and hydroxychloroquine retinopathy: a report by the American Academy of Ophthalmology.
- Author
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Marmor MF, Carr RE, Easterbrook M, Farjo AA, and Mieler WF
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- Academies and Institutes, Chloroquine adverse effects, Humans, Ophthalmology, Practice Guidelines as Topic, United States, Antirheumatic Agents adverse effects, Diagnostic Techniques, Ophthalmological standards, Hydroxychloroquine adverse effects, Retina drug effects, Retinal Diseases chemically induced, Retinal Diseases diagnosis
- Published
- 2002
- Full Text
- View/download PDF
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