1. Early SARS-CoV-2 Reinfections Involving the Same or Different Genomic Lineages, Spain.
- Author
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Rodríguez-Grande C, Estévez A, Palomino-Cabrera R, Molero-Salinas A, Peñas-Utrilla D, Herranz M, Sanz-Pérez A, Alcalá L, Veintimilla C, Catalán P, Martínez-Laperche C, Alonso R, Muñoz P, Pérez-Lago L, and García de Viedma D
- Subjects
- United States, Humans, SARS-CoV-2 genetics, Spain epidemiology, Genomics, Risk Factors, Reinfection, COVID-19
- Abstract
Centers for Disease Control and Prevention guidelines consider SARS-CoV-2 reinfection when sequential COVID-19 episodes occur >90 days apart. However, genomic diversity acquired over recent COVID-19 waves could mean previous infection provides insufficient cross-protection. We used genomic analysis to assess the percentage of early reinfections in a sample of 26 patients with 2 COVID-19 episodes separated by 20-45 days. Among sampled patients, 11 (42%) had reinfections involving different SARS-CoV-2 variants or subvariants. Another 4 cases were probable reinfections; 3 involved different strains from the same lineage or sublineage. Host genomic analysis confirmed the 2 sequential specimens belonged to the same patient. Among all reinfections, 36.4% involved non-Omicron, then Omicron lineages. Early reinfections showed no specific clinical patterns; 45% were among unvaccinated or incompletely vaccinated persons, 27% were among persons <18 years of age, and 64% of patients had no risk factors. Time between sequential positive SARS-CoV-2 PCRs to consider reinfection should be re-evaluated.
- Published
- 2023
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