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1. Synthesis of new potent agonistic analogs of growth hormone-releasing hormone (GHRH) and evaluation of their endocrine and cardiac activities.

Author

Cai, Renzhi, Schally, Andrew V., Cui, Tengjiao, Szalontay, Luca, Halmos, Gabor, Sha, Wei, Kovacs, Magdolna, Jaszberenyi, Miklos, He, Jinlin, Rick, Ferenc G., Popovics, Petra, Kanashiro-Takeuchi, Rosemeire, Hare, Joshua M., Block, Norman L., and Zarandi, Marta

Subjects
*CHEMICAL synthesis, *AGONISTIC behavior in animals, *GROWTH hormone releasing factor, *ENDOCRINE system, *MEDICAL centers, *AMERICAN veterans
Abstract

Highlights: [•] Analogs of GHRH modified at the N- and/or C-terminus were designed and synthesized. [•] Endocrine activities and binding affinities were determined. [•] Two analogs highly activated myocardial repair after induced myocardial infarction. [•] The relationship between GH-releasing potency and structure is discussed. [•] Substitutions with N-Me-Tyr1, Arg30-NHCH3, or Apa30-NH2 increased GHRH activities. [Copyright &y& Elsevier]

Published
2014
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