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In March 2020, WHO declared SARS-CoV-2 a global pandemic and lockdowns were enforced in most of the United States. Self-protective measures and travel restrictions were implemented, and schools/universities initiated online learning. Consequently, the global incidence and hospitalization rates of seasonal respiratory infections decreased significantly up to early 2021. Despite the decrease in hospitalization rates due to respiratory illnesses other than Covid-19, hospitals and healthcare providers faced huge stressors regarding workload dueto the pandemic. Furthermore, higher vaccination rates across the United States decreased non pharmaceutical interventions (NPI) implementation increasing the risk of major seasonal viral outbreaks. This editorial discusses the increased Rhinovirus/Enterovirus infections in the United States, challenges faced by healthcare providers and provides recommendations to address the issue., (© The Author(s) 2023. Published by Oxford University Press on behalf of Postgraduate Medical Journal.)

Objective: The aim: Is to build a forecast of the COVID-19 disease course, considering the vaccination of the population from particular countries., Patients and Methods: Materials and methods: Based on the analysis of statistical data, the article deals with the topical issue of the impact made by vaccination on the prevention of the COVID-19 pandemic. The time series, showing the dynamics of changes in the number of infected in Chile, Latvia, Japan, Israel, Australia, Finland, India, United States of America, New Zealand, Czech Republic, Venezuela, Poland, Ukraine, Brazil, Georgia for the period 07.08. 2020-09.09.2021, are analyzed. Trend-cyclic models of time series are obtained using fast Fourier transform. The predicted values of the COVID-19 incidence rate for different countries in the period from September 10, 2021 to February 2, 2022 were calculated using the constructed models., Results: Results and conclusions: The results of the study show that vaccination of the population is one of the most effective methods to prevent the COVID-19 pandemic. The proposed method of modeling the dynamics of the incidence rate based on statistical data can be used to build further predictions of the incidence rate dynamics. The study of behavioral aspects of trust in vaccination is proposed to be conducted within the theory regarding the self-organization of complex systems.

Objective: The aim: To analyze and calculate CVR in patients with T2DM and concomitant obesity., Patients and Methods: Materials and methods: The selection of patients was carried out based on the Uzhhorod District Clinical Hospital, in the period from November 2016 to January 2020. All patients were divided into 3 groups: 1 (n=93) with T2DM and concomitant obesity, 2 (n=87) with T2DM, 3 (n=39) with obesity. The treatment period lasted 1 year and included dosed exercise for at least 30 minutes per day and dietary recommendations. Patients in groups 1 and 2 received metformin 850 mg twice daily in combination with dapagliflozin 10 mg once daily. CVR was determined at the time of enrollment and after 1 year of treatment using: American College of Cardiology / American Heart Association Guideline on the Assessment of Cardiovascular Risk (2013) (ASCVD Risk) and Framingham Risk Score (FRS)., Results: Results: The data obtained as a result of the study revealed the highest CVR in patients of group 1, in contrast to group 2 and 3 (p<0.05). After 1 year of complex treatment, CVR indicators were statistically significantly reduced in all experimental groups (p<0.05)., Conclusion: Conclusions: Determining CVR parameters and exposure to them within 10 years can remove unwanted cardiovascular complications.