1. The contemporary trend in worsening prognosis of pancreatic acinar cell carcinoma: A population-based study.
- Author
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Duorui N, Shi B, Zhang T, Chen C, Fang C, Yue Z, Wu P, Wu Z, Huang X, and Li M
- Subjects
- Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Carcinoma, Acinar Cell epidemiology, Carcinoma, Acinar Cell mortality, Child, Child, Preschool, Female, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Pancreatic Neoplasms epidemiology, Pancreatic Neoplasms mortality, Prognosis, Proportional Hazards Models, SEER Program, Sex Factors, Survival Analysis, United States epidemiology, Young Adult, Pancreatic Neoplasms, Carcinoma, Acinar Cell diagnosis, Pancreatic Neoplasms diagnosis
- Abstract
Background: Primary acinar cell carcinoma (ACC) is a rare exocrine tumor of the pancreas with unclear clinical characteristics. Our goal was to determine the incidence and update the clinical characteristics and outcomes of ACC., Methods: Through the Surveillance, Epidemiology, and End Results (SEER) database, we identified 252 patients with the latest diagnosis of ACC (2004-2016). The age-adjusted incidence (AAI) was calculated using the SEER*Stat Software version 8.3.6. The Kaplan-Meier method was used to draw survival curves and differences among them were compared by the log-rank test. Cox proportional hazards models were used to evaluate factors that had independent predictive effects on the overall survival., Results: The AAI of pancreatic ACC was on the rise with the mean age at diagnosis of 63.79±14.79 years. Most patients (15.9%) had poorer differentiated tumors. The patients presented with distant stage were 54.4% compared with 53.1% between 1988 and 2003. The 1-, 2-, and 5-years survival rates for pancreatic ACC patients were 53.5%, 34.6%,17.5%, respectively (compared with 78.5%, 67.0%, and 42.8%, between 1988 and 2003). The multivariate COX analysis showed that the patient's age, surgery, chemotherapy, and summary stage, but not marital status were independent prognosis factors for ACC., Conclusions: Pancreatic ACC is a highly malignant tumor with an increasing incidence in recent years. The rate of distant metastasis is increasing and the survival rate is worse than in the past, suggesting that it may require more aggressive treatment and follow-up. Surgery, radiotherapy, and chemotherapy are all effective treatments, but prospective studies are still needed to verify them., Competing Interests: The authors have declared that no competing interests exist.
- Published
- 2020
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