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This study is among the first few efforts to examine both individual and contextual correlates of major forms of cardiovascular diseases (CVDs) in a comprehensive manner. With data from the Behavioral Risk Factor Surveillance System, the 2010 Census, and a variety of other sources, we applied both geospatial and multilevel statistical analyses to investigate patterns of CVDs in conterminous U.S. counties, and identified underlying dynamics through a wide array of potential contributing factors. Our spatial analysis revealed hot spots primarily in the Southeastern United States, where CVDs prevalence rates exceeded those of other regions. We found that both individual and contextual factors were associated with CVDs, and some associations were disease-specific among heart attack, angina, and stroke. Beyond individual level socio-demographic characteristics and lifestyle choices, county level education attainment, geographic clustering of racial and ethnic minorities, fine particulates in the air and park area size and availability were among the most important correlates. Results from this project provided valuable insights into the complex processes behind CVDs in a spatially vast and heterogeneous study area by incorporating environmental in addition to traditional demographic, behavioral and socioeconomic status factors across multiple spatial scales through combined geospatial and traditional statistical methods. Some notable policy implications from this study to combat CVDs at the macro level included promoting spatially more equitable distributions of parks with respect to population, improving aggregate educational attainment, and creating more racially diverse communities. [ABSTRACT FROM AUTHOR]

In this article, we propose a shift in race research from a one-dimensional hierarchical approach to a multidimensional system of racial stratification. Building upon Claire Kim's (1999) racial triangulation theory, we examine how the American public rates Asians relative to blacks and whites along two dimensions of racial stratification: racial valorization and civic acceptance/ostracism. Using selected years from the General Social Survey, our analyses provide support for the multidimensional racial triangulation perspective as opposed to a singular hierarchical approach, although findings do not match all predictions by the racial triangulation thesis. Our results also suggest that on average whites are more likely than blacks to have more favorable views of the relative positions of Asians, particularly for family commitment, nonviolence and wealth, but blacks are more likely to assume racially egalitarian views than do whites. [ABSTRACT FROM PUBLISHER]

Despite mounting evidence for a strong and persistent association between socioeconomic status (SES) and health, this relationship is largely unknown among Asian immigrants, a fast growing minority group in the US population. Previous research has typically focused on objective SES (primarily education and income) and ignored self-perceived SES. Using data from the National Latino and Asian American Study (NLAAS) ( N = 1,570), we examined the impact of subjective as well as objective SES upon multiple self-reported health outcomes among Asian immigrants. Results indicated that conventional SES indicators by and large were non-significantly related to self-rated physical health, physical discomfort, self-rated mental health, and psychological distress. In contrast, subjective SES relative to people in the United States and people in the community showed strong associations with health outcomes above and beyond conventional SES markers. This study suggested a promising avenue to incorporate subjective SES in health disparities research, especially among immigrants. [ABSTRACT FROM AUTHOR]

This study examines the relationships between social status, perceived discrimination, and physical and emotional health using a nationally representative sample of 6,377 older adults from the 2006 and 2008 waves of the Health and Retirement Study. About 63% of older adults reported at least one type of everyday discrimination and 31% reported at least one major discriminatory event during lifetime. Blacks, those separated, divorced, or widowed, and those with lower household assets have higher levels of perceived discrimination than Whites, the married or partnered, and those with more assets. Perceived discrimination is negatively associated with changes in health over 2 years, and everyday discrimination has stronger effects than major discriminatory events, especially on emotional health. The effects of perceived everyday discrimination on changes in depressive symptoms and self-rated health are independent of general stress. Efforts to reduce discrimination, including perceptions of discrimination, can be beneficial for health in old age. [ABSTRACT FROM PUBLISHER]

Abstract: The relationship between human agency and health is an important yet under-researched topic. This study uses a life course perspective to examine how human agency (measured by voluntariness, migratory reasons, and planning) and timing (measured by age at immigration) affect mental health outcomes among Asian immigrants in the United States. Data from the National Latino and Asian American Study showed that Asian immigrants (n =1491) with multiple strong reasons to migrate were less likely to suffer from mental health problems (i.e., psychological distress and psychiatric disorders in the past 12 months) than those without clear goals. Moreover, Asian immigrants with adequate migratory planning had lower levels of distress and lower rates of 12-month psychiatric disorders than those with poorly planned migration. Compared with migrants of the youngest age category (six or younger), those who migrated during preteen and adolescent years without clear goals had higher levels of psychological distress, and those who migrated during adulthood (25 years or older) were less likely to suffer from recent depressive disorders (with the exception of those migrating for life-improving goals). Furthermore, we found that well-planned migration lowered acculturative stress, and multiple strong reasons for migration buffered the negative effect of acculturative stress upon mental health. Findings from this study advance research on immigrant health from the life course perspective by highlighting the effects of exercising human agency during the pre-migration stage upon post-migration mental health. [Copyright &y& Elsevier]

Objective. This article examines the black-white gap in confidence in education in the United States and how the gap has changed over time. Method. The study uses ordinal logit regression on General Social Surveys (1974–2002). Results. Whites have less confidence in education, partly because whites tend to have higher levels of education, income, and conservatism, and are more likely to be affiliated with the Republican Party and evangelical denominations. The black-white gap is largest at lower levels of education, and disappears among college graduates. The gap shrinks during Republican control of the presidency in the United States, and widens during Democratic control. Conclusion. The black-white gap in confidence is not due solely to individual factors, but also to the larger political context and to the groups' different relationships to the institution of education. [ABSTRACT FROM AUTHOR]

This paper explores the utility of machine learning methods for understanding bullying, a significant social-psychological issue in the United States, through social media data. Machine learning methods were applied to all public mentions of bullying on Twitter between September 1, 2011 and August 31, 2013 to extract the posts that referred to discrete bullying episodes ( N = 9,764,583) to address five key questions. Most posts were authored by victims and reporters and referred to general forms of bullying. Posts frequently reflected self-disclosure about personal involvement in bullying. The number of posts that originated from a state was positively associated with the state population size; the timing of the posts reveal that more posts were made on weekdays than on Saturdays and more posts were made during the evening compared to daytime hours. Potential benefits of merging social science and computer science methods to enhance the study of bullying are discussed. [ABSTRACT FROM AUTHOR]

Clinical studies of lymphoid malignancies (LMs) have suggested that the descriptive patterns of LMs differ in East Asia compared to Western populations. However, there are very limited available data on population-based, subtype-specific incidence rates of LMs in the East Asian population, particularly in Chinese. Using data from the Hong Kong (HK) Cancer Registry and United States (U.S.) SEER Program, we calculated and compared age-adjusted incidence rates of LM subtypes in HK to those in Whites and Asians living in the U.S. Overall and sex-specific rates were calculated for the period 2001-2010. The incidence of most subtypes was low in the HK population, with rates <1 case per 100,000 for all subtypes except for diffuse large B-cell lymphoma (3.26/100,000) and plasma cell neoplasms (1.99/100,000). Age-adjusted incidence rates of all evaluated B-cell subtypes were significantly higher in U.S. Whites compared to HK, with standardized rate ratios (SRRs) ranging from 1.6 (Burkitt lymphoma) to 9.1 (chronic lymphocytic leukemia/small lymphocytic lymphoma). Rates in U.S. Asians were generally intermediate to those in U.S. Whites and HK. Conversely, rates of extranodal NK/T-cell lymphoma were significantly lower in both U.S. Whites (SRR=0.2) and U.S. Asians (SRR=0.5) compared to HK. Our data provide new insight into the subtype-specific patterns of LMs in the Chinese population, and suggest the need for etiological studies of LMs in the East Asian population to elucidate the factors responsible for these differences in the geographic incidence patterns. [ABSTRACT FROM AUTHOR]

Abstract: The impact of marine isoprene emissions on summertime surface concentrations of isoprene, secondary organic aerosols (SOA), and ozone (O3) in the coastal areas of the continental United States is studied using the U.S. Environmental Protection Agency regional-scale Community Multiscale Air Quality (CMAQ) modeling system. Marine isoprene emission rates are based on the following five parameters: laboratory measurements of isoprene production from phytoplankton under a range of light conditions, remotely-sensed chlorophyll-a concentration ([Chl–a]), incoming solar radiation, surface wind speed, and sea-water optical properties. Model simulations show that marine isoprene emissions are sensitive to meteorology and ocean ecosystem productivity, with the highest rates simulated over the Gulf of Mexico. Simulated offshore surface layer marine isoprene concentration is less than 10 ppt and significantly dwarfed by terrestrial emissions over the continental United States. With the isoprene reactions included in this study, the average contribution of marine isoprene to SOA and O3 concentrations is predicted to be small, up to 0.004 μg m−3 for SOA and 0.2 ppb for O3 in coastal urban areas. The light-sensitivity of isoprene production from phytoplankton results in a midday maximum for marine isoprene emissions and a corresponding daytime increase in isoprene and O3 concentrations in coastal locations. The potential impact of the daily variability in [Chl-a] on O3 and SOA concentrations is simulated in a sensitivity study with [Chl-a] increased and decreased by a factor of five. Our results indicate that marine emissions of isoprene cause minor changes to coastal SOA and O3 concentrations. Comparison of model simulations with few available measurements shows that the model underestimates marine boundary layer isoprene concentration. This underestimation is likely due to the limitations in current treatment of marine isoprene emission and a coarse spatial resolution used in the model simulations. [Copyright &y& Elsevier]

Background: Proton pump inhibitors (PPIs) are commonly prescribed for treating upper gastrointestinal hemorrhage, eradicating Helicobacter pylori, and stress ulcer prophylaxis, among other digestive system diseases. Recent case reports provided limited evidence of a correlation between PPIs and drug reactions with eosinophilia and systemic symptoms (DRESS). However, there is currently no established association between PPIs and DRESS., Aim: This research aimed to identify the associations between PPIs and DRESS using the US Food and Drug Administration Adverse Events Reporting System (FAERS) database., Method: A retrospective investigation of DRESS associated with six PPIs used FAERS data from Q1 2004 to Q3 2023. Data mining algorithms were used to identify adverse events in the FAERS database that met the following criteria: (1) proportional reporting ratio (PRR) ≥ 2; (2) reporting odds ratio (ROR) > 1; (3) 95% confidence interval (CI) of ROR > 1; (4) Chi-square (χ 2 ) ≥ 4 and case count ≥ 3., Results: There were 495 reports of PPI-related DRESS, including pantoprazole (174, 35.2%), omeprazole (103, 20.8%), lansoprazole (103, 20.8%), esomeprazole (101, 20.4%), rabeprazole (8, 1.6%), and dexlansoprazole (6, 1.2%). The results indicated a significant association of three PPIs (pantoprazole, omeprazole, and lansoprazole) with DRESS. The sensitivity analysis demonstrated that only pantoprazole remained significantly associated with DRESS after 10 concomitant drugs had been removed (ROR: 3.00, PRR: 2.99, and information component [IC]: 1.57)., Conclusion: This study identified the signals suggesting a potential association between DRESS and six PPIs. However, more investigation of epidemiological data is required to validate of these conclusions., Competing Interests: Conflicts of interest The authors have not disclosed any competing interests., (© 2024. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)

Childhood-onset essential hypertension (COEH) is an uncommon form of hypertension that manifests in childhood or adolescence and, in the United States, disproportionately affects children of African ancestry. The etiology of COEH is unknown, but its childhood onset, low prevalence, high heritability, and skewed ancestral demography suggest the potential to identify rare genetic variation segregating in a Mendelian manner among affected individuals and thereby implicate genes important to disease pathogenesis. However, no COEH genes have been reported to date. Here, we identify recessive segregation of rare and putatively damaging missense variation in the spectrin domain of spectrin repeat containing nuclear envelope protein 1 (SYNE1), a cardiovascular candidate gene, in 3 of 16 families with early-onset COEH without an antecedent family history. By leveraging exome sequence data from an additional 48 COEH families, 1,700 in-house trios, and publicly available data sets, we demonstrate that compound heterozygous SYNE1 variation in these COEH individuals occurred more often than expected by chance and that this class of biallelic rare variation was significantly enriched among individuals of African genetic ancestry. Using in vitro shRNA knockdown of SYNE1, we show that reduced SYNE1 expression resulted in a substantial decrease in the elasticity of smooth muscle vascular cells that could be rescued by pharmacological inhibition of the downstream RhoA/Rho-associated protein kinase pathway. These results provide insights into the molecular genetics and underlying pathophysiology of COEH and suggest a role for precision therapeutics in the future.

With increasing evidence that ferroptosis is associated with diverse neurological disorders, targeting ferroptosis offers a promising avenue for developing effective pharmaceutical agents for neuroprotection. In this study, we identified ferroptosis inhibitors as neuroprotective agents from US Food and Drug Administration (FDA)-approved drugs. 1176 drugs have been screened against erastin-induced ferroptosis in HT22 cells, resulting in 89 ferroptosis inhibitors. Among them, 26 drugs showed significant activity with EC 50 below10 μM. The most active ferroptosis inhibitor is lumateperone tosylate at nanomolar level. 11 drugs as ferroptosis inhibitors were not reported previously. Further mechanistic studies revealed that their mechanisms of actions involve free radical scavenging, Fe 2+ chelation, and 15-lipoxygenase inhibition. Notably, the active properties of some drugs were firstly revealed here. These ferroptosis inhibitors increase the chemical diversity of ferroptosis inhibitors, and offer new therapeutic possibilities for the treatments of related neurological diseases., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Inc. All rights reserved.)

Data on incidence rates of myeloid malignancies for subtypes based on the World Health Organization (WHO) classification are lacking in Asian populations. We compared age-adjusted incidence rates for 27 myeloid malignancy WHO-defined subtypes in Hong Kong (HK) (2014-2016) with those for Asian and white individuals living in the United States (U.S.) (2010-2016). Except for overall acute myeloid leukemia (AML) (2.23 cases per 100,000) and myeloproliferative neoplasms (MPNs) (2.10 cases per 100,000), rates of all subtypes were <1 case per 100,000 person-years in HK. Overall rates of AML, myelodysplastic syndrome (MDS), and MDS/MPN were lower in HK compared to white and Asian individuals in the U.S., but the patterns by specific subtype varied. For these three broad groupings of myeloid malignancies, rates in U.S. Asians were intermediate to those in HK and white individuals in the U.S. These results suggest the possibility of a multifactorial etiology for specific myeloid malignancy subtypes that should be evaluated in future epidemiological studies.

Understanding the sectoral contribution of emissions to fine particulate matter (PM 2.5 ) offers information for air quality management, and for investigation of association with health outcomes. This study evaluates the contribution of different emission sectors to PM 2.5 in 2013 for Canada using the GEOS-Chem chemical transport model, downscaled with satellite-based PM 2.5 . Despite the low population-weighted PM 2.5 concentrations of 5.5 μg m -3 across Canada, we find that over 70% of population-weighted PM 2.5 originates from Canadian sources followed by 30% from the contiguous United States. The three leading sectoral contributors to population-weighted PM 2.5 over Canada are wildfires with 1.0 μg m -3 (17%), transportation with 0.96 μg m -3 (16%), and residential combustion with 0.91 μg m -3 (15%). The relative contribution to population-weighted PM 2.5 of different sectors varies regionally with residential combustion as the leading contributor in Central Canada (19%), while wildfires dominate over Northern Canada (59%), Atlantic Canada (34%), and Western Canada (18%). The contribution from U.S. sources is larger over Central Canada (33%) than over Western Canada (17%), Atlantic Canada (17%), and Northern Canada (<2%). Sectoral trend analysis showed that the contribution from anthropogenic sources to population-weighted PM 2.5 decreased from 7.1 μg m -3 to 3.4 μg m -3 over the past two decades.

The association between socioeconomic status (SES) and health has been widely documented. However, the role of occupation in this association is not clear because occupation is less often used than income and education as an indicator of SES, especially in the United States. This may be caused by the ambiguity in what occupation represents: both health-enhancing resources (e.g., self-affirmation) and health-damaging hazards (e.g., job stress). SES has two aspects: resources and status. While income and education represent resources and imply status, occupational prestige is an explicit indicator of the social status afforded by one's occupation. Using data from the US General Social Survey in 2002 and 2006 (n = 3151), we examine whether occupational prestige has a significant association with self-rated health independent from other SES indicators (income, education), occupational categories (e.g., managerial, professional, technical, service), and previously established work-related health determinants (job strain, work place social support, job satisfaction). After all covariates were included in the multiple logistic regression model, higher occupational prestige was associated with lower odds of reporting poor/fair self-rated health. We discuss potential mechanisms through which occupational prestige may impact health. Our findings not only suggest multiple ways that occupation is associated with health, but also highlight the utility of occupational prestige as an SES indicator that explicitly represents social standing., (Published by Elsevier Ltd.)

Research has demonstrated that certain genotypes are expressed in different forms, depending on input from the social environment. To examine sensitivity to cultural norms regarding emotional support seeking as a type of social environment, we explored the behavioral expression of oxytocin receptor polymorphism (OXTR) rs53576, a gene previously related to socio-emotional sensitivity. Seeking emotional support in times of distress is normative in American culture but not in Korean culture. Consequently, we predicted a three-way interaction of culture, distress, and OXTR genotype on emotional support seeking. Korean and American participants (n = 274) completed assessments of psychological distress and emotional support seeking and were genotyped for OXTR. We found the predicted three-way interaction: among distressed American participants, those with the GG/AG genotypes reported seeking more emotional social support, compared with those with the AA genotype, whereas Korean participants did not differ significantly by genotype; under conditions of low distress, OXTR groups did not differ significantly in either cultural group. These findings suggest that OXTR rs53576 is sensitive to input from the social environment, specifically cultural norms regarding emotional social support seeking. These findings also indicate that psychological distress and culture are important moderators that shape behavioral outcomes associated with OXTR genotypes.

Recently, active and proposed US medical insurance programs are taking steps to address the problems of organ availability, long waiting times, and high medical and surgical costs by promoting transplant tourism. Such programs are created explicitly to encourage policy holders to travel to a foreign country for the purpose of obtaining a transplant. Some medical insurance programs have gone as far as to bundle exotic travel and healthcare-transplantation not excluded-into one package. This article details some of the safety and ethics issues with these programs.

Over the last decade, the introduction of microarray technology has had a profound impact on gene expression research. The publication of studies with dissimilar or altogether contradictory results, obtained using different microarray platforms to analyze identical RNA samples, has raised concerns about the reliability of this technology. The MicroArray Quality Control (MAQC) project was initiated to address these concerns, as well as other performance and data analysis issues. Expression data on four titration pools from two distinct reference RNA samples were generated at multiple test sites using a variety of microarray-based and alternative technology platforms. Here we describe the experimental design and probe mapping efforts behind the MAQC project. We show intraplatform consistency across test sites as well as a high level of interplatform concordance in terms of genes identified as differentially expressed. This study provides a resource that represents an important first step toward establishing a framework for the use of microarrays in clinical and regulatory settings.