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Reverse link capacity of a direct-sequence code-division multiple-access (DS-CDMA) system in a multicell environment has been studied recently, and significant capacity improvements due to the use of beamforming have been observed. However, system performance with beamforming will be affected by several impairments, such as direction of arrival estimation errors, array perturbations, mutual coupling, and signal spatial spreads. In this paper, reverse link performance of CDMA systems with beamforming under these impairments (imperfect beamforming) is investigated. A simplified beamforming model is developed to evaluate the system performance in terms of user capacity, bit-error rates (BER), and outage probabilities. Both signal-to-interference-ratio-based power control and strength-based power control are considered in this paper. The capacity and BER degradations due to different impairments are shown, and outage probabilities under different power control schemes are examined. [ABSTRACT FROM AUTHOR]

Do contexts of greater income inequality spur the disadvantaged to achieve a class consciousness vital to contesting the fairness of the economic system and demanding more redistribution? One prominent recent publication, the 2015 study by Newman, Johnston, and Lown, argues that simple exposure to higher levels of local income inequality lead low-income people to view the United States as divided into haves and have-nots and to see themselves as among the have-nots, that is, to become more likely to achieve such a class consciousness. Here, we show that this sanguine conclusion is at best supported only in analyses of the single survey presented in that study. There is no evidence that higher levels of income inequality produce greater class consciousness among those with low incomes in other similar but neglected surveys. [ABSTRACT FROM AUTHOR]

Ceftriaxone, an FDA-approved third-generation cephalosporin antibiotic, has antimicrobial activity against both gram-positive and gram-negative organisms. Generally, ceftriaxone is used for a variety of infections such as community-acquired pneumonia, meningitis and gonorrhea. Its primary molecular targets are the penicillin-binding proteins. However, other activities of ceftriaxone remain unknown. Herein, we report for the first time that ceftriaxone has antitumor activity in vitro and in vivo. Kinase profiling results predicted that Aurora B might be a potential ‘off’ target of ceftriaxone. Pull-down assay data confirmed that ceftriaxone could bind with Aurora B in vitro and in A549 cells. Furthermore, ceftriaxone (500 µM) suppressed anchorage-independent cell growth by targeting Aurora B in A549, H520 and H1650 lung cancer cells. Importantly, in vivo xenograft animal model results showed that ceftriaxone effectively suppressed A549 and H520 lung tumor growth by inhibiting Aurora B. These data suggest the anticancer efficacy of ceftriaxone for the treatment of lung cancers through its inhibition of Aurora B. [ABSTRACT FROM PUBLISHER]