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Background: We aimed to evaluate the incidence, mortality and survival outcome for patients with pancreatic neuroendocrine neoplasms (pNEN). Methods: Patients with pNEN were collected from the Surveillance, Epidemiology, and End Results (SEER) database. Incidence, mortality and average annual percentage change (AAPC) were calculated using SEER stat 8.3.6 and Joinpoint software. Survival outcome was estimated using Kaplan-Meier and Cox proportional hazard model. Results: During 2000-2016, the incidence of pNEN significantly rose from 0.2647 to 1.0618 per 100,000 persons with an AAPC of 9.4; AAPC of mortality was 6.7. Prognostic improvement was revealed in 2010-2016, but not for late-stage pNEN, which had the highest risk of death. Conclusion: Efforts to improve prognosis of pNEN patients must focus on not only early detection, but also on improving therapy for late-stage disease. [ABSTRACT FROM AUTHOR]

Background: Colorectal cancer (CRC) treatment and patient survival improved greatly. Consequently an increased incidence of non-cancer-related deaths is observed. This study analyzed the causes of non-cancer death for people suffering from CRC based on the year of diagnosis, follow-up time, and patient's age., Methods: The data from patients diagnosed with CRC in the years 2000-2016 were taken from the Surveillance, Epidemiology, and End Results 18 database. Patients were categorized according to: death from CRC, non-CRC cancer, and non-cancer. Constituent ratios and standardized mortality ratios (SMRs) were calculated to describe the death causes distribution and relative death risks., Results: Between 2000 and 2016, a stable and rapid drop for the original diagnosis as death cause for CRC patients was observed (70.19% to 49.35%). This was coupled to an increase in non-cancer-associated death reasons (23.38% to 40.00%). The most common non-cancer death cause was heart disease, especially for elderly patients. However, deaths from accidents and adverse effects were frequent in younger CRC patients. Patients died from septicemia more often within the first follow-up year; however, a 6-fold increase in death from Alzheimer's disease was found for after at least 180 months follow-up time. The SMRs of all 25 non-cancer death causes initially decreased in all CRC subgroups, followed by an increase with follow-up times. Gradually decreasing SMR values were observed with increasing age of CRC patients., Conclusions: These findings could help modify and sharpen preventive measures and clinical management and raise physician's awareness to potential non-CRC death risk factors for CRC patients., (© 2020 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.)