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We aimed to generate an unbiased estimate of the incidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in 4 urban counties in Utah, USA. We used a multistage sampling design to randomly select community-representative participants >12 years of age. During May 4-June 30, 2020, we collected serum samples and survey responses from 8,108 persons belonging to 5,125 households. We used a qualitative chemiluminescent microparticle immunoassay to detect SARS-CoV-2 IgG in serum samples. We estimated the overall seroprevalence to be 0.8%. The estimated seroprevalence-to-case count ratio was 2.5, corresponding to a detection fraction of 40%. Only 0.2% of participants from whom we collected nasopharyngeal swab samples had SARS-CoV-2-positive reverse transcription PCR results. SARS-CoV-2 antibody prevalence during the study was low, and prevalence of PCR-positive cases was even lower. The comparatively high SARS-CoV-2 detection rate (40%) demonstrates the effectiveness of Utah's testing strategy and public health response. [ABSTRACT FROM AUTHOR]

Aim A new deceased donor kidney allocation system (KAS) was implemented by UNOS on December 4, 2014. One key goal was to change the algorithm to better assist the previously disadvantaged highly sensitized population in receiving organ offers, regardless of the originating center’s geographical region. Candidate recipients with an allosensitization of 99% or 100% cPRA have been awarded an additional 50, and 202 points, respectively, to the waitlist score, thus giving them the highest priority for each kidney offer nationwide. One-year OPTN data indicate that overall in the US, the proportion of transplants occurring in the most highly sensitized patients has increased dramatically compared to the previous year. The goal of this study was to evaluate, and compare data from Utah to the national average. Method We reviewed and analyzed the annual rate of transplants in Utah based on recipient cPRA scores from 2011 through April 2016 and compared it to the OPTN data. Results One year prior to the implementation of the new KAS, in 2014 only two 99–100% cPRA patients were transplanted. In 2015, the first full year following implementation of the new KAS, a total of seven 99–100% cPRA patients were transplanted. Although comparison of the 1-year before versus after implementation of the new KAS suggests a 3.5 fold increase in the number of transplanted highly sensitized patients (cPRA 99–100%), this increase is more modest, only 2.3 fold if we compare it to the average number (3 per year) of highly sensitized recipients transplanted between 2011 and 2014. Conclusions The increase in transplant rates for 99–100% cPRA patients was more modest in Utah, compared to the national average. Possible reasons include that under the old KAS, local candidates were favored more heavily, and due to shorter overall wait times in Utah, highly sensitized patients may have had more offers compared to the national average. Other factors that may affect current transplant rates include a lower percentage of highly sensitized recipients locally, the EPTS of the local recipient pool, and the KDPI of donors. Although 2016 promises a greater rate of highly sensitized recipient transplants (4 performed through April), more data are needed to determine if the new KAS has a significant impact on the highly sensitized recipient transplant rate in Utah. [ABSTRACT FROM AUTHOR]