1. Long-term diabetes risk among endometrial cancer survivors in a population-based cohort study.
- Author
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Kim, Seungmin, Park, Jihye, Chen, Yuji, Rowe, Kerry, Snyder, John, Fraser, Alison, Smith, Ken, Deshmukh, Vikrant G., Newman, Michael, Herget, Kimberley, Porucznik, Christina A., Ose, Dominik, Playdon, Mary, Gaffney, David, and Hashibe, Mia
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ENDOMETRIAL cancer , *SECONDARY primary cancer , *CANCER patients , *TYPE 2 diabetes , *DIABETES in women , *PROPORTIONAL hazards models , *HEALTH facilities - Abstract
The majority of endometrial cancer patients are overweight or obese at cancer diagnosis. Obesity is a shared risk factor for both endometrial cancer and diabetes, but it is unknown whether endometrial cancer patients have increased diabetes risks. The aim of our study was to investigate diabetes risk among endometrial cancer patients. Endometrial cancer patients diagnosed between 1997 and 2012 in Utah (n = 2,314) were identified. Women from the general population (n = 8,583) were matched to the cancer patients on birth year and birth state. Diabetes diagnoses were identified from electronic medical records and statewide healthcare facility databases. Cox proportional hazards models were used to estimate hazard ratios for diabetes after cancer diagnosis. Endometrial cancer survivors had a significantly higher risk of type II diabetes when compared to women from the general population in the first year after cancer diagnosis (HR = 5.22, 95% CI = 4.05, 6.71), >1–5 years after cancer diagnosis (HR = 1.67, 95% CI = 1.31, 2.12), and >5 years after cancer diagnosis (HR = 1.65, 95% CI = 1.29, 2.11). Endometrial cancer patients who were obese at cancer diagnosis had a three-fold increase in type II diabetes risk (HR = 2.99, 95%CI = 2.59, 3.45). Although endometrial cancer patients diagnosed at distant stage had a higher risk of diabetes, cancer treatment did not appear to contribute to any diabetes risks. In conclusion, endometrial cancer survivors had a higher risk of diabetes than women in the general population. These results suggest that long term monitoring for diabetes is indicated for endometrial cancer survivors. • Endometrial cancer survivors in all BMI groups had an increased risk of diabetes. • 29.5% of endometrial cancer patients were diagnosed with diabetes after diagnosis of endometrial cancer. • Obesity was the most important risk factor for type II diabetes among endometrial cancer survivors. • Overall, endometrial cancer survivors had a twofold higher risk of type II diabetes compared to the general population. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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