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Introduction: Cell phone or smart phone abuse has become a daily phenomenon, many diseases are found to be associated with cell phone overuse, it also leads to mental anxiety, mood disorder etc., Aim: To study C-Reactive Protein (CRP), Serum Uric Acid (SUA) and Serum Total Protein (STP) in cell phone addiction and depression together in the medical college campus. Materials and Methods: The present study was a case-control study in which total 150 subjects with 75 cases of depression and cell phone addiction and 75 healthy controls were involved from medical college of Uttar Pradesh, India. The diagnosis of depression and cell phone addiction was done by (Hamilton, Smart phone Addiction Scale-Short Version) scales. CRP, SUA and STP were quantified using Chem-7 Erba analyser from fasting serum samples. Data was analysed by Statistical Package for the Social Sciences (SPSS) 17.0 software. Results: Significant correlation between depression and cell phone addiction was found (p=0.023). Significant difference between cases and controls (p<0.001) was found for age, depression score, cell phone addiction score but CRP, SUA and STP were insignificant. Conclusion: Present research acknowledges many vital observations between cell phone addiction and depression with biochemical trajectories, which is novelty of this study. Youngsters are tending towards addiction and depression, which is an alarm for society and policy makers to rethink about modern gadgets advancements. It is strongly recommended to do further research in this area with more subjects and biochemical markers. [ABSTRACT FROM AUTHOR]