1. Anti-inflammatory sesquiterpene lactones from Lourteigia ballotaefolia.
- Author
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Rosas-Romero A, Manchado CM, Crescente O, Acosta M, Curini M, Epifano F, Marcotullio MC, Rosati O, Tubaro A, and Sosa S
- Subjects
- Animals, Anti-Inflammatory Agents, Non-Steroidal chemistry, Anti-Inflammatory Agents, Non-Steroidal isolation & purification, Croton Oil pharmacology, Disease Models, Animal, Indomethacin pharmacology, Inflammation chemically induced, Inflammation drug therapy, Lactones chemistry, Lactones isolation & purification, Magnetic Resonance Spectroscopy, Male, Mice, Molecular Structure, Phytotherapy, Plant Extracts chemistry, Plant Extracts isolation & purification, Plant Extracts pharmacology, Plant Leaves chemistry, Sesquiterpenes chemistry, Sesquiterpenes isolation & purification, Venezuela, Anti-Inflammatory Agents, Non-Steroidal pharmacology, Asteraceae, Lactones pharmacology, Sesquiterpenes pharmacology
- Abstract
Three sesquiterpene lactones were isolated from Lourteigia ballotaefolia (H. B. K.). 9beta-hydroxy-atripliciolide-8- O-tiglate ( 1) was isolated for the first time from this plant and was previously reported in Conocliniopsis prasiifolia (DC) K. et R., 9beta-hydroxy-atripliciolide-8- O-(5'-acetoxytiglate) ( 2) had been already reported in this species. The minor component, 9beta-(tigloyloxy)-atripliciolide, is a new compound. The anti-inflammatory activity of compounds 1 and 2 was evaluated using the croton oil ear test in mice.
- Published
- 2002
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