1. Neuroprotective Metabolites from Vietnamese Marine Derived Fungi of Aspergillus and Penicillium Genera.
- Author
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Girich EV, Yurchenko AN, Smetanina OF, Trinh PTH, Ngoc NTD, Pivkin MV, Popov RS, Pislyagin EA, Menchinskaya ES, Chingizova EA, Afiyatullov SS, and Yurchenko EA
- Subjects
- Animals, Antiparkinson Agents isolation & purification, Cell Line, Tumor, Cell Survival drug effects, Mice, Molecular Structure, Neurons metabolism, Neurons pathology, Neuroprotective Agents isolation & purification, Oxidative Stress drug effects, Paraquat toxicity, Parkinson Disease metabolism, Parkinson Disease pathology, Reactive Oxygen Species metabolism, Rotenone toxicity, Secondary Metabolism, Structure-Activity Relationship, Vietnam, Antiparkinson Agents pharmacology, Aspergillus metabolism, Neurons drug effects, Neuroprotective Agents pharmacology, Parkinson Disease drug therapy, Penicillium metabolism
- Abstract
Low molecular weight secondary metabolites of marine fungi Aspergillus flocculosus , Aspergillus terreus and Penicillium sp. from Van Phong and Nha Trang Bays (Vietnam) were studied and a number of polyketides, bis-indole quinones and terpenoids were isolated. The structures of the isolated compounds were determined by 1D and 2D NMR and HR-ESI-MS techniques. Stereochemistry of some compounds was established based on ECD data. A chemical structure of asterriquinone F ( 6 ) was thoroughly described for the first time. Anthraquinone ( 13 ) was firstly obtained from a natural source. Neuroprotective influences of the isolated compounds against 6-OHDA, paraquat and rotenone toxicity were investigated. 4-Hydroxyscytalone ( 1 ), 4-hydroxy-6-dehydroxyscytalone ( 2 ) and demethylcitreoviranol ( 3 ) have shown significant increasing of paraquat- and rotenone-treated Neuro-2a cell viability and anti-ROS activity.
- Published
- 2020
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