Search

Knowledge of cardiovascular health (CVH) status of a given population is mandatory to reduce the burden of vascular diseases in the region. We compared CVH of two distinct populations having similar ethnic backgrounds to understand the role of lifestyle and environment on their CVH, and to provide insights in the planning of cost-effective health strategies. CVH status was compared in two Hispanic populations living in Northern Manhattan and Atahualpa (rural coastal Ecuador) using the health metrics proposed by the American Heart Association. Both studies used similar definitions of CVH and similar inclusion criteria for participating subjects (age ≥40 years, cardiovascular disease-free status, and living at their respective localities for ≥3 months). The studied populations consisted of 1,617 Caribbean Hispanics living in Northern Manhattan (mean age 66 ± 9 years), and 616 Atahualpa residents (mean age 59 ± 13 years). Atahualpa residents had significantly better metrics than Caribbean Hispanics, with the exception of fasting glucose levels. Likewise, the odds for having 5-7 ideal metrics were also better in Atahualpa residents, irrespective of age. CVH is better in Atahualpa residents than in Caribbean Hispanics living in Northern Manhattan. These differences are likely related to a healthier lifestyle in a rural setting and provide insights for setting cardiovascular prevention priorities. [ABSTRACT FROM AUTHOR]

Background and Purpose: Atherosclerosis is a complex subclinical cardiovascular disorder with a substantial genetic component. This study sought to identify genetic loci influencing carotid plaque in 2 independent samples., Methods: B-mode ultrasound was performed to determine the presence and area of carotid plaque. Variance components analysis was used to test for linkage using 383 autosomal microsatellite markers in 1308 subjects from 100 Dominican families. Multiple linear and logistic regression models were used to investigate the association between plaque traits and 18,904 single nucleotide polymorphisms under the 1-logarithm of odds unit down regions of linkage peaks in an independent community-based data set (N = 941, 41% Dominicans) from the Northern Manhattan Study., Results: After adjustment for age, hypertension, diabetes mellitus, cigarette pack-years, body mass index, and waist-to-hip ratio, significant heritability was detected for plaque presence (h² = 0.50 ± 0.14, P < 0.0001) and plaque area (h²=0.17 ± 0.04, P < 0.0001). Quantitative and dichotomous trait linkage analyses obtained similar results and identified 4 regions with multipoint logarithm of odds scores ≥ 2.00 on 7q36, 11p15, 14q32, and 15q23. In the association analysis of the 4 linkage peaks, several single nucleotide polymorphisms in or near SOX6, FSD2, AP3S2, EFTUD1, and MYOD1 were associated with carotid plaque traits with a nominal P ≤ 0.0005 in the Northern Manhattan Study data set and with a P ≤ 0.01 in Northern Manhattan Study Dominican subset., Conclusions: Carotid plaque has considerable heritability and may be influenced by loci on chromosomes 11p15, 14q32, and 15q23. The SOX6 gene within the bone morphogenic protein pathway could be a candidate for carotid plaque. Larger independent studies are needed to validate these findings.