1. Two new cytotoxic chalcones from Calythropsis aurea.
- Author
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Beutler JA, Cardellina JH 2nd, Gray GN, Prather TR, Shoemaker RH, Boyd MR, Lin CM, Hamel E, and Cragg GM
- Subjects
- Animals, Antineoplastic Agents, Phytogenic pharmacology, Chalcone isolation & purification, Chalcone pharmacology, Drug Screening Assays, Antitumor, Humans, Leukemia L1210 drug therapy, Mitosis drug effects, Plant Extracts analysis, Propiophenones pharmacology, Tubulin metabolism, Western Australia, Antineoplastic Agents, Phytogenic isolation & purification, Chalcone analogs & derivatives, Plants, Medicinal chemistry, Propiophenones isolation & purification
- Abstract
The crude extract of Calythropsis aurea (Myrtaceae) produced a pattern of differential cytotoxicity in the NCI 60 cell line assay which was similar to those of known tubulin-interactive compounds. Cytotoxicity-guided fractionation led to the isolation of two new chalcones, calythropsin [1] and dihydrocalythropsin [2], which were responsible for the activity. Calythropsin was demonstrated to have a weak effect on mitosis, and presumably also on tubulin polymerization.
- Published
- 1993
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