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Introduction: Focal lesions in the liver, due to the wide availability of modern diagnostic imaging methods are often detectable pathology of this organ. For diagnostic imaging of liver lesions are used: abdominal ultrasound examination (including Doppler-ultrasound), computed tomography, selective angiography, magnetic resonance imaging (MRI) and studies using radioactive tracers for example - positron emission tomography (PET). Fine needle aspiration biopsy (FNAB) and core needle biopsy under ultrasound control are a perfect complement to imaging studies. These procedures allow a cytological and histological examination of the collected tissues. Aim of the study: the study aimed to determine the prevalence and nature of lesions in the liver in patients hospitalized in the Department ' of Gastroenterology and Hepatology, Wroclaw Medical University in years 2004-2008. Material and methods: The analysis included the medical records of 8482 patients hospitalized in the years 2004-2008 in the Department of Gastroenterology and Hepatology, Wroclaw Medical University. From among all the hospitalized a group of patients with focal liver lesions was separated. This group was fixed on the basis of a definitive diagnosis made during the hospitalization of diagnostic tests, laboratory and imaging (ultrasound, computed tomography, magnetic resonance imaging), including the location and nature of the changes observed in focal length. Results: In the cohort of 8482 patients hospitalized in the Department of Gastroenterology and Hepatology, Wroclaw Medical University in the years 2004-2008, 535 patients (6.3%) with diagnosed focal liver lesions were isolated. In this group 414 patients (77.38%) suffered from benign lesions, including: simple cysts - found in 246 patients (59.42% of benign changes), hemangiomas - showed in 140 patients (33.82% of benign lesions), calcification - 10 patients (2.42% of benign changes), atypical cysts - abscess - in 9 patients (2.17% of benign lesions), focal nodular hyperplasia in 6 patients (1.45%), adenomas - 2 patients (0.48%). Malignant changes in the liver were diagnosed in 122 patients (22.8%). The highest percentage of malignant tumors were metastases - 108 patients (88.52%). In 11 patients the diagnose was primary hepatocellular carcinoma (9.02% of malignant tumors), while in 3 cases it was a cholangiocellular carcinoma (2.46% of malignant tumors). Conclusions: In this analysis, the most common focal liver lesions are benign simple cysts, while among malignant tumors the metastatic lesions predominated. The primary focus of cancer metastases to the liver was located most commonly in the large intestine. [ABSTRACT FROM AUTHOR]