1. Associations between six common per- and polyfluoroalkyl substances and estrogens in neonates of China.
- Author
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Liu, Hongxiu, Pan, Yitao, Jin, Shuna, Sun, Xiaojie, Jiang, Yangqian, Wang, Yuyan, Ghassabian, Akhgar, Li, Yuanyuan, Xia, Wei, Cui, Qianqian, Zhang, Bin, Zhou, Aifen, Dai, Jiayin, and Xu, Shunqing
- Subjects
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NEWBORN infants , *PERFLUOROOCTANE sulfonate , *ESTROGEN , *ESTRIOL , *QUANTILE regression , *ESTRADIOL - Abstract
Experimental studies suggested per- and polyfluoroalkyl substances (PFASs) may disrupt estrogens in animals, however, the epidemiological evidence on the associations of PFASs with estrogens is sparse. We investigated the associations of legacy PFASs and their alternatives, including F-53B, the perfluorooctane sulfonate (PFOS) replacement that is specifically and commonly used in China, with estrogen concentrations in newborns. We quantified six PFASs and three estrogens in the cord sera of 942 newborns from a birth cohort in Wuhan, China, between 2013 and 2014. After adjusting for confounders and correcting for multiple comparisons, we observed that both legacy PFASs and their alternatives were associated with higher serum levels of estradiol (E2). Some of the PFASs were associated with increasing levels of estrone (E1) and estriol (E3). Analysis of PFASs in mixture using weighted quantile sum regressions showed that F-53B contributed 20.1% and 48.5% to the associations between PFASs and E1 and E2, respectively. This study provided epidemiological data on the associations between common PFAS exposures and estrogens in newborns. Additional toxicology studies are needed to fully understand the effects of PFASs on estrogens and the mechanisms. ga1 • 6:2 Cl-PFESA, trade name F-53B, is a PFOS alternative specifically used in China. • 6:2 Cl-PFESA has ranked as 3rd highest PFASs exposed Chinese neonates. • Associations between 6 PFASs and 3 estrogen levels in neonates were assessed. • Both legacy PFASs and the alternatives were related to higher estrogen levels in cord sera. • 6:2 Cl-PFESA weighted more than PFOS and PFOA in association with estradiol in neonates. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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