1. Antiviral effect of cetylpyridinium chloride in mouthwash on SARS-CoV-2.
- Author
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Takeda, Ryo, Sawa, Hirofumi, Sasaki, Michihito, Orba, Yasuko, Maishi, Nako, Tsumita, Takuya, Ushijima, Natsumi, Hida, Yasuhiro, Sano, Hidehiko, Kitagawa, Yoshimasa, and Hida, Kyoko
- Subjects
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CETYLPYRIDINIUM chloride , *MOUTHWASHES , *SARS-CoV-2 , *QUATERNARY ammonium compounds , *ELECTRON density , *MICROSCOPY - Abstract
Cetylpyridinium chloride (CPC), a quaternary ammonium compound, which is present in mouthwash, is effective against bacteria, fungi, and enveloped viruses. This study was conducted to explore the antiviral effect of CPC on SARS-CoV-2. There are few reports on the effect of CPC against wild-type SARS-CoV-2 at low concentrations such as 0.001%–0.005% (10–50 µg/mL). Interestingly, we found that low concentrations of CPC suppressed the infectivity of human isolated SARS-CoV-2 strains (Wuhan, Alpha, Beta, and Gamma) even in saliva. Furthermore, we demonstrated that CPC shows anti-SARS-CoV-2 effects without disrupting the virus envelope, using sucrose density analysis and electron microscopic examination. In conclusion, this study provided experimental evidence that CPC may inhibit SARS-CoV-2 infection even at lower concentrations. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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