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The occurrence and seasonal variation of 50 pharmaceuticals and personal care products (PPCPs) in a wastewater treatment plant (WWTP) in Xiamen, China was investigated over a period of one year. Among the targets, 39 PPCPs were detected in the influent. The highest concentration was observed for acetaminophen, with the average concentration in the influent of 2963.5ng/L. The seasonal variation of PPCPs in the influent was observed. For most pharmaceuticals, highest concentrations were in March 2013, followed by December 2012, while the concentrations were lower in August 2012 and May 2013. Among the detected PPCPs, 14 targets could be removed more than 50% in the WWTP. The activated sludge treatment process contributed to most of PPCP removal, while the adsorption to the particles in the primary treatment and the transformation under UV radiation in the disinfection treatment also contributed to the PPCP removal. Among the detected PPCPs in the influent, 36 PPCPs could be detected in the final effluent of the WWTP. Significantly higher concentrations of PPCPs were observed in effluent samples collected in March 2013 compared to other seasons, suggesting higher concentrations of PPCPs could be discharged into the surrounding seawater during this period. [ABSTRACT FROM AUTHOR]