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With the acceleration of China's urbanization and industrialization, air pollution has become a major environmental problem. Retrospective data analysis of 6564 patients who underwent IVF-ET in the center for reproductive medicine of the First Affiliated Hospital of Zhengzhou University from 2015 to 2020. Different stages were selected from 90 days before oocyte retrieval to 35 days after transfer and divided into five exposure periods. Multivariate logistic regression was used to analyze the relationship between six ambient air pollutants (PM 2.5 , PM 10 , NO 2 , SO 2 , CO and O 3) and the IVF-ET pregnancy outcome. The results showed that air pollutants can significantly affect the IVF pregnancy outcome. The harmful effects of ambient air pollutants are more obvious in the patients aged < 35 years, single embryo transfer and cleavage stage embryo transfer. • Air pollution can affect the pregnancy outcome of in vitro fertilization. • Female younger than 35 years old are more vulnerable to ambient air pollutants. • Single-embryo-transfer patients are sensitive in endometrial transformation period. • Pregnancy outcome are less likely to be affected in blastocyst-transfer patients. • Different protection strategies should be considered for different population. [ABSTRACT FROM AUTHOR]