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A reclamation project was undertaken in Zhuhai, China, covering an area of 11.35 km2 with a clay-slurry thickness of 30 m. It is interesting to find a good reinforcement method, which is more suitable for strengthening such a large-scale dredged clay-slurry ground. Evidence from engineering practice shows that vacuum preloading or vacuum preloading combined with surcharge preloading method technology has certain advantages. However, further data is required to verify their performance in the field. This paper presents a case study using the conventional vacuum preloading and vacuum preloading combined with surcharge preloading method (vacuum pressure of 90 kPa, surcharge height of 3 m) to improve the thick clay-slurry ground for a subgrade engineering project in Zhuhai, China. A series of field monitoring, in-situ tests, and laboratory tests were performed to evaluate their treatment effect by analysis of vacuum degree, ground surface settlement, layered settlement, consolidation degree, lateral displacement, excess pore water pressure dissipation, and vane shear strength. The results showed that the ground treated via vacuum preloading combined with surcharge preloading method was more effective than conventional vacuum preloading. The vacuum degree of vacuum preloading combined with surcharge preloading method was slightly lower than that of conventional vacuum preloading, decreasing with depth. The settlement is increased by 55.56%, average consolidation degree is enlarged by 40.9%, lateral displacement can be augmented by 2.4 times, pore water pressure coefficient is less than 0.6, and undrained shear strength is amplified by 22.2%. These findings can be used to guide the design of the combined preloading method of the subgrade engineering project along the east coast of China. [ABSTRACT FROM AUTHOR]