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2. Multicenter comparison of transcatheter aortic valve implantation with the self-expanding ACURATE neo2 versus Evolut PRO transcatheter heart valves

Author

Rheude, Tobias, Pellegrini, Costanza, Landt, Martin, Bleiziffer, Sabine, Wolf, Alexander, Renker, Matthias, Neuser, Jonas, Dörr, Oliver, Allali, Abdelhakim, Rudolph, Tanja K., Wambach, Jan Martin, Widder, Julian D., Singh, Parminder, Berliner, Dominik, Alvarez-Covarrubias, Hector A., Richardt, Gert, Xhepa, Erion, Kim, Won-Keun, and Joner, Michael

Published
2024
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4. Simple and safe digitoxin dosing in heart failure based on data from the DIGIT-HF trial

Author

Bavendiek, Udo, Großhennig, Anika, Schwab, Johannes, Berliner, Dominik, Liu, Xiaofei, Maier, Lars, Gaspar, Thomas, Rieth, Andreas, Philipp, Sebastian, Hambrecht, Rainer, Westenfeld, Ralf, Münzel, Thomas, Winkler, Sebastian, Hülsmann, Martin, Westermann, Dirk, Zdravkovic, Marja, Lichtinghagen, Ralf, von der Leyen, Heiko, Zimmermann, Silke, Veltmann, Christian, Böhm, Michael, Störk, Stefan, Koch, Armin, and Bauersachs, Johann

Published
2023
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5. Kardiomyopathien

Author

Berliner, Dominik, Sonnenschein, Kristina, Bauersachs, Johann, Marx, Nikolaus, editor, and Erdmann, Erland, editor

Published
2023
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7. Kardiomyopathien

Author

Berliner, Dominik, primary, Sonnenschein, Kristina, additional, and Bauersachs, Johann, additional

Published
2023
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10. Reassessing Pulmonary Hypertension Classification: Utilizing Criteria for Heart Failure with Preserved Ejection Fraction Instead of Pulmonary Arterial Wedge Pressure.

Author

Park, Da-Hee, Fuge, Jan, Kamp, Jan Christopher, Harrigfeld, Britta, Berliner, Dominik, Hoeper, Marius M., and Olsson, Karen M.

Subjects
PULMONARY arterial hypertension, HEART diseases, PULMONARY hypertension, IDIOPATHIC diseases, HEART failure
Abstract

Background: The current classification of pulmonary hypertension (PH) distinguishes between pre-capillary (PAWP ≤ 15 mmHg) and post-capillary (PAWP > 15 mmHg) forms, with left heart disease, especially heart failure with preserved ejection fraction (HFpEF), being a common cause of PH. We investigated the suitability of an HFpEF diagnosis instead of PAWP in diagnosing PH associated with HFpEF. Methods: In a retrospective, single-center analysis, we reviewed diagnoses from our database, focusing on patients initially diagnosed with idiopathic pulmonary arterial hypertension (IPAH) or PH associated with HFpEF (PH-HFpEF) based on their PAWP. These patients were reclassified, distinguishing between HFpEF and non-HFpEF cases. Patients with PH-HFpEF were further stratified by PAWP (≤15 mmHg or >15 mmHg). Results: The study included 350 patients: 214 (61.1%) with PAWP ≤ 15 mmHg and 136 (38.9%) with PAWP > 15 mmHg. Replacing the PAWP criterion with the HFpEF criterion resulted in the reclassification of 121 of 350 (34.6%) patients (115 of 214 [53.7%] from IPAH to PH-HFpEF and 6 of 136 [4.4%] from PH-HFpEF to IPAH). The final disposition was IPAH (n = 105, 30%), PH-HFpEF with PAWP ≤ 15 mmHg (n = 115, 32.9%), and PH-HFpEF with PAWP > 15 mmHg (n = 130, 37.1%). Characteristics such as age distribution, functional impairment, co-morbidities, echocardiographic indices of HFpEF, pulmonary vascular resistance, response to PH medications, and unadjusted survival were comparable between the two HFpEF cohorts but differed substantially from those with IPAH. Conclusions: PH-HFpEF patients with PAWP ≤ 15 mmHg resemble those with PAWP > 15 mmHg but differ from IPAH cases. Incorporating non-invasive HFpEF criteria could refine PH diagnostic classification. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Characteristics of hospital admission during checkpoint-inhibition therapy.

Author

Fröhlich, Tabea Constanze, primary, Wiegmann, Jonas Paul, additional, Möhn, Nora, additional, Mahjoub, Susann, additional, Duzzi, Laura, additional, Narte, Emily, additional, Aurich, Johanna, additional, Berliner, Dominik, additional, Wirth, Thomas, additional, Golpon, Heiko, additional, von Wasielewski, Imke, additional, Heidel, Florian, additional, Skripuletz, Thomas, additional, Gutzmer, Ralf, additional, Beutel, Gernot, additional, and Ivanyi, Philipp, additional

Published
2024
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15. Increased Cancer Prevalence in Peripartum Cardiomyopathy

Author

Pfeffer, Tobias J., Schlothauer, Stella, Pietzsch, Stefan, Schaufelberger, Maria, Auber, Bernd, Ricke-Hoch, Melanie, List, Manuel, Berliner, Dominik, Abou Moulig, Valeska, König, Tobias, Arany, Zolt, Sliwa, Karen, Bauersachs, Johann, and Hilfiker-Kleiner, Denise

Published
2019
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17. Hypoxia Attenuates Pressure Overload‐Induced Heart Failure

Author

Froese, Natali, primary, Szaroszyk, Malgorzata, additional, Galuppo, Paolo, additional, Visker, Joseph R., additional, Werlein, Christopher, additional, Korf‐Klingebiel, Mortimer, additional, Berliner, Dominik, additional, Reboll, Marc R., additional, Hamouche, Rana, additional, Gegel, Simona, additional, Wang, Yong, additional, Hofmann, Winfried, additional, Tang, Ming, additional, Geffers, Robert, additional, Wende, Adam R., additional, Kühnel, Mark P., additional, Jonigk, Danny D., additional, Hansmann, Georg, additional, Wollert, Kai C., additional, Abel, E. Dale, additional, Drakos, Stavros G., additional, Bauersachs, Johann, additional, and Riehle, Christian, additional

Published
2024
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25. Echocardiographic parameters indicating left atrial reverse remodeling after catheter ablation for atrial fibrillation

Author

Angelini, Eleonora, primary, Sieweke, Jan-Thorben, additional, Berliner, Dominik, additional, Biber, Saskia, additional, Hohmann, Stephan, additional, Oldhafer, Maximiliane, additional, Schallhorn, Sven, additional, Duncker, David, additional, Veltmann, Christian, additional, Bauersachs, Johann, additional, and Bavendiek, Udo, additional

Published
2023
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27. Effects of six month personalized endurance training on work ability in middle-aged sedentary women: a secondary analysis of a randomized controlled trial

Author

Stenner, Hedwig T., Eigendorf, Julian, Kerling, Arno, Kueck, Momme, Hanke, Alexander A., Boyen, Johanna, Nelius, Anne-Katrin, Melk, Anette, Boethig, Dietmar, Bara, Christoph, Hilfiker, Andres, Berliner, Dominik, Bauersachs, Johann, Hilfiker-Kleiner, Denise, Eberhard, Jörg, Stiesch, Meike, Schippert, Cordula, Haverich, Axel, Tegtbur, Uwe, and Haufe, Sven

Published
2020
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30. Bromocriptine treatment in patients with peripartum cardiomyopathy and right ventricular dysfunction

Author

Haghikia, Arash, Schwab, Johannes, Vogel-Claussen, Jens, Berliner, Dominik, Pfeffer, Tobias, König, Tobias, Zwadlo, Carolin, Moulig, Valeska Abou, Franke, Annegret, Schwarzkopf, Marziel, Ehlermann, Philipp, Pfister, Roman, Michels, Guido, Westenfeld, Ralf, Stangl, Verena, Kühl, Uwe, Podewski, Edith, Kindermann, Ingrid, Böhm, Michael, Sliwa, Karen, Hilfiker-Kleiner, Denise, and Bauersachs, Johann

Published
2019
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33. Navigating between Scylla and Charybdis: Diuretics during pregnancy – as much as needed, but the least possible.

Author

Bauersachs, Johann and Berliner, Dominik

Subjects
*HEART failure, *PERIPARTUM cardiomyopathy, *DIURETICS, *PREGNANCY, *HEART valve diseases
Abstract

The article discusses the use of diuretics during pregnancy for women with heart failure and/or congenital heart and/or valvular heart disease. The care of these patients during pregnancy is largely based on expert opinion rather than evidence-based studies. The article presents data from the ESC Registry of Pregnancy and Cardiac Disease, showing that diuretics can be used during pregnancy when clearly indicated based on the mother's disease. The data mainly refer to the loop diuretic furosemide, and other diuretic medications were used less frequently. The article emphasizes the need for an individualized patient-centered approach and collaboration between cardiologists and obstetricians in the care of pregnant women with cardiac diseases. [Extracted from the article]

Published
2024
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34. Anterior mitral leaflet laceration using the MitraCut technique for transapical transcatheter Tendyne implantation after unsuccessful Carillon indirect annuloplasty: a case report.

Author

Manna, Nunzio Davide de, Martens, Andreas, Jüttner, Marieke, Berliner, Dominik, Bauersachs, Johann, Ruhparwar, Arjang, Kempf, Tibor, and Ius, Fabio

Subjects
MITRAL valve insufficiency, VENTRICULAR outflow obstruction, MITRAL valve, CARDIAC surgery, HEART beat
Abstract

Background The introduction of a transapical transcatheter beating heart replacement system has significantly expanded therapeutic options for patients with severely diseased mitral valves, particularly those ineligibles for traditional surgery or transcatheter repair. However, challenges, such as left ventricular outflow tract obstruction (LVOT-O) and the risk of dynamic systolic anterior motion (SAM) in cases with elongated anterior mitral leaflet (AML) post-prosthesis implantation, impede the widespread adoption of transcatheter mitral valve replacement (TMVR). Case summary In 2022, a 75-year-old male with severe mixed-genesis mitral regurgitation (MR) underwent Carillon Mitral Contour System annuloplasty. Recurrent heart failure admissions (New York Heart Association IV) and prohibitive risk for open-heart surgery (European System for Cardiac Operative Risk Evaluation II 8.27%) prompted evaluation for Tendyne TMVR with the MitraCut technique. This beating heart transapical approach involved scissor-mediated splitting of the elongated 27 mm AML, essential for mitigating LVOT-O risk and dynamic SAM. The screening echocardiogram revealed the poorly tethered AML near the thickened septum at the simulated neo-LVOT site. Discussion This case underscores the intricate management challenges associated with severe MR, highlighting the successful application of the MitraCut technique as a viable alternative in high-risk scenarios. The imperative for further research and clinical studies is emphasized to comprehensively elucidate outcomes and safety parameters, providing valuable insights for refining TMVR applications within this context. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Impact of intrapulmonary vascular dilatations and hepatopulmonary syndrome on the clinical course of patients after transjugular intrahepatic portosystemic shunt insertion

Author

Mauz, Jim Benjamin, primary, Schneider, Hannah, additional, Berliner, Dominik, additional, Tiede, Anja, additional, Stockhoff, Lena, additional, Hinrichs, Jan, additional, Wedemeyer, Heiner, additional, Meyer, Bernhard, additional, Olsson, Karen, additional, Maasoumy, Benjamin, additional, and Tergast, Tammo Lambert, additional

Published
2023
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42. Cabergoline treatment promotes myocardial recovery in peripartum cardiomyopathy

Author

Pfeffer, Tobias J., primary, Mueller, Julia H., additional, Haebel, Lea, additional, Erschow, Sergej, additional, Yalman, Kuebra C., additional, Talbot, Steven R., additional, Koenig, Tobias, additional, Berliner, Dominik, additional, Zwadlo, Carolin, additional, Scherr, Michaela, additional, Hilfiker‐Kleiner, Denise, additional, Bauersachs, Johann, additional, and Ricke‐Hoch, Melanie, additional

Published
2022
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48. Clinical characteristics and long‐term outcomes in patients with peripartum cardiomyopathy (PPCM) receiving left ventricular assist devices (LVAD)

Author

Berliner, Dominik, primary, Li, Tong, additional, Mariani, Silvia, additional, Hamdan, Righab, additional, Hanke, Jasmin, additional, König, Tobias, additional, Pfeffer, Tobias Jonathan, additional, Abou‐Moulig, Valeska, additional, Dogan, Günes, additional, Hilfiker‐Kleiner, Denise, additional, Haverich, Axel, additional, Bauersachs, Johann, additional, and Schmitto, Jan D., additional

Published
2022
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49. Outcome in German and South African peripartum cardiomyopathy cohorts associates with medical therapy and fibrosis markers

Author

Azibani, Feriel, Pfeffer, Tobias J., Ricke-Hoch, Melanie, Dowling, Wentzel, Pietzsch, Stefan, Briton, Olivia, Baard, Johann, Abou Moulig, Valeska, König, Tobias, Berliner, Dominik, Libhaber, Elena, Schlothauer, Stella, Anthony, John, Lichtinghagen, Ralf, Bauersachs, Johann, Sliwa, Karen, and Hilfiker-Kleiner, Denise

Subjects
Cardiac function curve, medicine.medical_specialty, Peripartum cardiomyopathy, Pregnancy Complications, Cardiovascular, 030204 cardiovascular system & hematology, Ventricular Function, Left, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Fibrosis, Germany, Original Research Articles, Internal medicine, Peripartum Period, Humans, Medicine, Diseases of the circulatory (Cardiovascular) system, Original Research Article, 030212 general & internal medicine, Outcome, Ejection fraction, business.industry, Stroke Volume, Biomarker, medicine.disease, Bromocriptine, Procollagen peptidase, Heart failure, RC666-701, Biomarker (medicine), Female, Therapy, Cardiomyopathies, Cardiology and Cardiovascular Medicine, business, Biomarkers, medicine.drug
Abstract

Aims This study aims to compare the clinical course of peripartum cardiomyopathy (PPCM) cohorts from Germany (G‐PPCM) and South Africa (SA‐PPCM) with fibrosis‐related markers to get insights into novel pathomechanisms of PPCM. Methods and results G‐PPCM (n = 79) and SA‐PPCM (n = 72) patients and healthy pregnancy‐matched women from Germany (n = 56) and South Africa (n = 40) were enrolled. Circulating levels of procollagen type‐I (PINP) and type‐III (PIIINP) N‐terminal propeptides, soluble ST2, galectin‐3, and full‐length and cleaved osteopontin (OPN) were measured at diagnosis (baseline) and 6 months of follow‐up. Both cohorts received standard heart failure therapy while anticoagulation therapy was applied in 100% of G‐PPCM but only in 7% of SA‐PPCM patients. In G‐PPCM patients, baseline left ventricular ejection fraction (LVEF) was lower, and outcome was better (baseline LVEF, 24 ± 8%, full recovery: 52%, mortality: 0%) compared with SA‐PPCM patients (baseline LVEF: 30 ± 9%, full recovery: 32%, mortality: 11%; P < 0.05). At baseline, PINP/PIIINP ratio was lower in SA‐PPCM and higher in G‐PPCM compared with respective controls, whereas total OPN was elevated in both collectives. Cleaved OPN, which increases PIIINP levels, is generated by thrombin and was reduced in patients receiving anticoagulation therapy. High baseline galectin‐3, soluble ST2, and OPN levels were associated with poor outcome in all PPCM patients. Conclusions SA‐PPCM patients displayed a more profibrotic biomarker profile, which was associated with a less favourable outcome despite better cardiac function at baseline, compared with G‐PPCM patients. Use of bromocriptine and anticoagulation therapy in G‐PPCM may counteract fibrosis and may in part be responsible for their better outcome.

Published
2020

50. Diastolic dysfunction is associated with cardiac decompensation after transjugular intrahepatic portosystemic shunt in patients with liver cirrhosis

Author

Schneider, Hannah, Berliner, Dominik, Stockhoff, Lena, Reincke, Marlene, Mauz, Jim B., Meyer, Bernhard, Bauersachs, Johann, Wedemeyer, Heiner, Wacker, Frank, Bettinger, Dominik, Hinrichs, Jan B., and Maasoumy, Benjamin

Abstract

About 20% of patients develop cardiac decompensation within the first year after transjugular intrahepatic portosystemic shunt (TIPS) insertion. However, risk factors for cardiac decompensation remain poorly defined. We aimed to evaluate predictors of cardiac decompensation after TIPS insertion in a large, well‐defined cohort of patients with liver cirrhosis. 234 cirrhotic patients who received a TIPS at Hannover Medical School were retrospectively followed up for one year to assess the incidence of cardiac decompensation. Echocardiographic parameters and established diagnostic criteria for cardiac impairment (e.g. by the American Society of Echocardiography/ European Association of Cardiovascular Imaging (ASE/EACVI)) were investigated for an association with cardiac decompensation in a competing risk analysis. Survival was analyzed using a multivariable cox regression analysis adjusting for Freiburg index of post‐TIPS survival. Predominant TIPS indication was ascites (83%). Median age was 59 years, median MELD‐score 12% and 58% were male. Overall, 41 patients (18%) developed cardiac decompensation within one year after TIPS insertion. Diastolic dysfunction according to the ASE/EACVI was diagnosed in 26% of patients at baseline and was linked to a significantly higher risk for cardiac decompensation (p= 0.025) after TIPS. When investigating individual echocardiographic baseline parameters, only pathological E/A (<0.8 or >2) was identified as a risk factor for cardiac decompensation (p= 0.015). Mortality and liver transplantation (n= 50) were significantly higher among patients who developed cardiac decompensation (HR = 5.29, p< 0.001) as well as in patients with a pathological E/A (HR = 2.34, p= 0.006). Cardiac high‐risk status (44% of patients) was strongly linked to cardiac decompensation (HR = 2.93, p= 0.002) and mortality (HR = 2.24, p= 0.012). Cardiac decompensation after TIPS is a frequent and important complication and is associated with reduced survival. American Society of Echocardiography/EACVI criteria and E/A seem to be the best parameters to predict the cardiac risk in cirrhotic patients undergoing TIPS insertion.

Published
2023
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