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280 results on '"Lei, Shaohua"'

1. Genomic profiling of circulating tumor DNA for childhood cancers

Author

Lei, Shaohua, Jia, Sujuan, Takalkar, Sunitha, Chang, Ti-Cheng, Ma, Xiaotu, Szlachta, Karol, Xu, Ke, Cheng, Zhongshan, Hui, Yawei, Koo, Selene C., Mead, Paul E., Gao, Qingsong, Kumar, Priyadarshini, Bailey, Colin P., Sunny, Jobin, Pappo, Alberto S., Federico, Sara M., Robinson, Giles W., Gajjar, Amar, Rubnitz, Jeffrey E., Jeha, Sima, Pui, Ching-Hon, Inaba, Hiroto, Wu, Gang, Klco, Jeffery M., Tatevossian, Ruth G., and Mullighan, Charles G.

Published
2024
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8. The genomic landscape of acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21

Author

Gao, Qingsong, Ryan, Sarra L., Iacobucci, Ilaria, Ghate, Pankaj S., Cranston, Ruth E., Schwab, Claire, Elsayed, Abdelrahman H., Shi, Lei, Pounds, Stanley, Lei, Shaohua, Baviskar, Pradyuamna, Pei, Deqing, Cheng, Cheng, Bashton, Matthew, Sinclair, Paul, Bentley, David R., Ross, Mark T., Kingsbury, Zoya, James, Terena, Roberts, Kathryn G., Devidas, Meenakshi, Fan, Yiping, Chen, Wenan, Chang, Ti-Cheng, Wu, Gang, Carroll, Andrew, Heerema, Nyla, Valentine, Virginia, Valentine, Marcus, Yang, Wenjian, Yang, Jun J., Moorman, Anthony V., Harrison, Christine J., and Mullighan, Charles G.

Published
2023
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12. A 35-Year Analysis of Vegetation Cover in Rare-Earth Mining Areas Using Landsat Data.

Author

Zheng, Zhubin, Liu, Yuqing, Chen, Na, Liu, Ge, Lei, Shaohua, Xu, Jie, Li, Jianzhong, Ren, Jingli, and Huang, Chao

Subjects
ENVIRONMENTAL protection, MULTISPECTRAL imaging, GROUND vegetation cover, SOIL conservation, LANDSAT satellites
Abstract

Fractional vegetation cover (FVC) plays a significant role in assessing ecological quality and protection, as well as soil and water conservation. As a typical rare-earth resource county in China, Dingnan County has experienced rapid development due to rare-earth mining, resulting in significant alterations to vegetation cover. To elucidate the spatio-temporal changes in vegetation within Dingnan County over the past 35 years and the effects of natural and human factors on these changes, the spatial and temporal variations in FVC were analyzed using Landsat-TM/OLI multispectral images taken in 1988, 1995, 1997, 2002, 2006, 2013, 2017, and 2023. The findings indicate that (1) vegetation coverage in Dingnan County decreased from 1988 to 2002, followed by a gradual increase; (2) high vegetation cover is predominantly found in forested areas that maintain their natural state, while the central town and mining areas exhibit generally low coverage; (3) there are regional differences in the relationship between vegetation cover and environmental factors in Dingnan County. This research facilitates the alignment of ion-type rare-earth mining with ecological protection, thereby promoting the sustainable development of the mining area and providing scientific guidance for local governments to formulate more effective management and protection strategies for the mining ecosystem. Additionally, this research offers a scientific foundation for mining areas globally to develop sustainable policies and informed decision-making regarding environmental protection and sustainable development. [ABSTRACT FROM AUTHOR]

Published
2024
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21. LOD2-Level+ Low-Rise Building Model Extraction Method for Oblique Photography Data Using U-NET and a Multi-Decision RANSAC Segmentation Algorithm.

Author

He, Yufeng, Wu, Xiaobian, Pan, Weibin, Chen, Hui, Zhou, Songshan, Lei, Shaohua, Gong, Xiaoran, Xu, Hanzeyu, and Sheng, Yehua

Subjects
ARCHITECTURAL details, DIGITAL elevation models, POINT cloud, PHOTOGRAPHY, ALGORITHMS
Abstract

Oblique photography is a regional digital surface model generation technique that can be widely used for building 3D model construction. However, due to the lack of geometric and semantic information about the building, these models make it difficult to differentiate more detailed components in the building, such as roofs and balconies. This paper proposes a deep learning-based method (U-NET) for constructing 3D models of low-rise buildings that address the issues. The method ensures complete geometric and semantic information and conforms to the LOD2 level. First, digital orthophotos are used to perform building extraction based on U-NET, and then a contour optimization method based on the main direction of the building and the center of gravity of the contour is used to obtain the regular building contour. Second, the pure building point cloud model representing a single building is extracted from the whole point cloud scene based on the acquired building contour. Finally, the multi-decision RANSAC algorithm is used to segment the building detail point cloud and construct a triangular mesh of building components, followed by a triangular mesh fusion and splicing method to achieve monolithic building components. The paper presents experimental evidence that the building contour extraction algorithm can achieve a 90.3% success rate and that the resulting single building 3D model contains LOD2 building components, which contain detailed geometric and semantic information. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Coptisine Improves Anxiety-Like Behaviors by Regulating the Warburg Effect in Microglia Via Pkm2

Author

Qi, Yiyu, primary, Zhao, Xin, additional, Wu, Weizhen, additional, Wang, Ningjing, additional, Ge, Pingyuan, additional, Guo, Siqi, additional, Lei, Shaohua, additional, Zhou, Peng, additional, Zhao, Li, additional, Tang, Zhi-Shu, additional, Duan, Jin-Ao, additional, Yang, Nianyun, additional, Guo, Rui, additional, Chai, Xin, additional, Zhang, Qi-chun, additional, Snijders, Antoine M., additional, and Zhu, Huaxu, additional

Published
2024
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30. Coptisine Improves Anxiety-Like Behaviors by Regulating the Warburg Effect in Microglia Via Pkm2

Author

Qi, Yi-yu, primary, Zhao, Xin, additional, Wu, Weizhen, additional, Wang, Ningjing, additional, Ge, Pingyuan, additional, Guo, Siqi, additional, Lei, Shaohua, additional, Zhou, Peng, additional, Zhao, Li, additional, Tang, Zhi-Shu, additional, Duan, Jin-Ao, additional, Yang, Nianyun, additional, Guo, Rui, additional, Chai, Xin, additional, Zhang, Qi-chun, additional, Snijders, Antoine M., additional, and Zhu, Huaxu, additional

Published
2024
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39. An Exosome-Based Therapeutic Strategy Targeting Neuroinflammation in Alzheimer’s Disease with Berberine and Palmatine

Author

Zhao, Xin, primary, Ge, Pingyuan, additional, Lei, Shaohua, additional, Guo, Siqi, additional, Zhou, Peng, additional, Zhao, Li, additional, Qi, Yiyu, additional, Wei, Xiaotong, additional, Wu, Weizhen, additional, Wang, Ningjing, additional, Guo, Rui, additional, Yang, Nianyun, additional, Xiao, Qingqing, additional, Zhang, Qichun, additional, and Zhu, Huaxu, additional

Published
2023
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40. Pan-neuroblastoma analysis reveals age- and signature-associated driver alterations

Author

Brady, Samuel W., Liu, Yanling, Ma, Xiaotu, Gout, Alexander M., Hagiwara, Kohei, Zhou, Xin, Wang, Jian, Macias, Michael, Chen, Xiaolong, Easton, John, Mulder, Heather L., Rusch, Michael, Wang, Lu, Nakitandwe, Joy, Lei, Shaohua, Davis, Eric M., Naranjo, Arlene, Cheng, Cheng, Maris, John M., Downing, James R., Cheung, Nai-Kong V., Hogarty, Michael D., Dyer, Michael A., and Zhang, Jinghui

Published
2020
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42. List of Contributors

Author

Abbasnezhad, Amir, primary, Acosta, Andrés, additional, Arunima, Aryashree, additional, Azagra-Boronat, Ignasi, additional, Baliga, Manjeshwar Shrinath, additional, Bayir, Ayse Gunes, additional, Bernhardt, Cassandra, additional, Bhagatwala, Jigar, additional, Biswas, Debabrata, additional, Calderón, Gerardo, additional, Camps-Bossacoma, Mariona, additional, Carrion, Michael, additional, Castell, Margarida, additional, Choghakhori, Razieh, additional, Coppola, Vincenzo, additional, Das, Jugal Kishore, additional, Day, Andrew S., additional, DemirkesenBiçak, Hilal, additional, Doğan, Murat, additional, Fayad, Raja, additional, Ferreira, Adaliene Versiani Matos, additional, Fiagbor, Rita, additional, George, Thomas, additional, Gyawali, Rabin, additional, Hekmatdoost, Azita, additional, Hutson, J.M., additional, Ibrahim, Salam A., additional, Issa, Aseel T., additional, Kalekhan, Faizan, additional, Kaur, Kamaljit, additional, Kearsey, I., additional, Kiziltan, Huriye Senay, additional, Kocyigit, Abdurrahim, additional, Kuda, Takashi, additional, Lei, Shaohua, additional, Massot-Cladera, Malen, additional, McRorie, Johnson W., additional, Mokhtari, Zeinab, additional, Nagarajan, Vinod, additional, Newman, Robert H., additional, Nwamaioha, Nwadiuto, additional, Patel, Puja, additional, Peng, Mengfei, additional, Pérez-Cano, Francisco J., additional, Rao, Suresh, additional, Rodríguez-Lagunas, Maria José, additional, Saldanha, Elroy, additional, Saxena, Arpit, additional, Scarpato, Elena, additional, Sharma, Amol, additional, Shomali, T., additional, Silveira, Ana Letícia Malheiros, additional, Southwell, B.R., additional, Staiano, Annamaria, additional, Suar, Mrutyunjay, additional, Tahergorabi, Reza, additional, Teixeira, Mauro Martins, additional, Tekiner, İsmail Hakkı, additional, Venkatesh, Ponemone, additional, Yari, Zahra, additional, Yik, Y.I., additional, Yuan, Lijuan, additional, Zhong, Wei, additional, Zhou, Zhanxiang, additional, and Zimmerman, Tahl, additional

Published
2019
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44. Data from St. Jude Cloud: A Pediatric Cancer Genomic Data-Sharing Ecosystem

Author

McLeod, Clay, primary, Gout, Alexander M., primary, Zhou, Xin, primary, Thrasher, Andrew, primary, Rahbarinia, Delaram, primary, Brady, Samuel W., primary, Macias, Michael, primary, Birch, Kirby, primary, Finkelstein, David, primary, Sunny, Jobin, primary, Mudunuri, Rahul, primary, Orr, Brent A., primary, Treadway, Madison, primary, Davidson, Bob, primary, Ard, Tracy K., primary, Chiao, Arthur, primary, Swistak, Andrew, primary, Wiggins, Stephanie, primary, Foy, Scott, primary, Wang, Jian, primary, Sioson, Edgar, primary, Wang, Shuoguo, primary, Michael, J. Robert, primary, Liu, Yu, primary, Ma, Xiaotu, primary, Patel, Aman, primary, Edmonson, Michael N., primary, Wilkinson, Mark R., primary, Frantz, Andrew M., primary, Chang, Ti-Cheng, primary, Tian, Liqing, primary, Lei, Shaohua, primary, Islam, S.M. Ashiqul, primary, Meyer, Christopher, primary, Thangaraj, Naina, primary, Tater, Pamella, primary, Kandali, Vijay, primary, Ma, Singer, primary, Nguyen, Tuan, primary, Serang, Omar, primary, McGuire, Irina, primary, Robison, Nedra, primary, Gentry, Darrell, primary, Tang, Xing, primary, Palmer, Lance E., primary, Wu, Gang, primary, Suh, Ed, primary, Tanner, Leigh, primary, McMurry, James, primary, Lear, Matthew, primary, Pappo, Alberto S., primary, Wang, Zhaoming, primary, Wilson, Carmen L., primary, Cheng, Yong, primary, Meshinchi, Soheil, primary, Alexandrov, Ludmil B., primary, Weiss, Mitchell J., primary, Armstrong, Gregory T., primary, Robison, Leslie L., primary, Yasui, Yutaka, primary, Nichols, Kim E., primary, Ellison, David W., primary, Bangur, Chaitanya, primary, Mullighan, Charles G., primary, Baker, Suzanne J., primary, Dyer, Michael A., primary, Miller, Geralyn, primary, Newman, Scott, primary, Rusch, Michael, primary, Daly, Richard, primary, Perry, Keith, primary, Downing, James R., primary, and Zhang, Jinghui, primary

Published
2023
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45. Supplementary Tables from St. Jude Cloud: A Pediatric Cancer Genomic Data-Sharing Ecosystem

Author

McLeod, Clay, primary, Gout, Alexander M., primary, Zhou, Xin, primary, Thrasher, Andrew, primary, Rahbarinia, Delaram, primary, Brady, Samuel W., primary, Macias, Michael, primary, Birch, Kirby, primary, Finkelstein, David, primary, Sunny, Jobin, primary, Mudunuri, Rahul, primary, Orr, Brent A., primary, Treadway, Madison, primary, Davidson, Bob, primary, Ard, Tracy K., primary, Chiao, Arthur, primary, Swistak, Andrew, primary, Wiggins, Stephanie, primary, Foy, Scott, primary, Wang, Jian, primary, Sioson, Edgar, primary, Wang, Shuoguo, primary, Michael, J. Robert, primary, Liu, Yu, primary, Ma, Xiaotu, primary, Patel, Aman, primary, Edmonson, Michael N., primary, Wilkinson, Mark R., primary, Frantz, Andrew M., primary, Chang, Ti-Cheng, primary, Tian, Liqing, primary, Lei, Shaohua, primary, Islam, S.M. Ashiqul, primary, Meyer, Christopher, primary, Thangaraj, Naina, primary, Tater, Pamella, primary, Kandali, Vijay, primary, Ma, Singer, primary, Nguyen, Tuan, primary, Serang, Omar, primary, McGuire, Irina, primary, Robison, Nedra, primary, Gentry, Darrell, primary, Tang, Xing, primary, Palmer, Lance E., primary, Wu, Gang, primary, Suh, Ed, primary, Tanner, Leigh, primary, McMurry, James, primary, Lear, Matthew, primary, Pappo, Alberto S., primary, Wang, Zhaoming, primary, Wilson, Carmen L., primary, Cheng, Yong, primary, Meshinchi, Soheil, primary, Alexandrov, Ludmil B., primary, Weiss, Mitchell J., primary, Armstrong, Gregory T., primary, Robison, Leslie L., primary, Yasui, Yutaka, primary, Nichols, Kim E., primary, Ellison, David W., primary, Bangur, Chaitanya, primary, Mullighan, Charles G., primary, Baker, Suzanne J., primary, Dyer, Michael A., primary, Miller, Geralyn, primary, Newman, Scott, primary, Rusch, Michael, primary, Daly, Richard, primary, Perry, Keith, primary, Downing, James R., primary, and Zhang, Jinghui, primary

Published
2023
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46. Supplementary Data from St. Jude Cloud: A Pediatric Cancer Genomic Data-Sharing Ecosystem

Author

McLeod, Clay, primary, Gout, Alexander M., primary, Zhou, Xin, primary, Thrasher, Andrew, primary, Rahbarinia, Delaram, primary, Brady, Samuel W., primary, Macias, Michael, primary, Birch, Kirby, primary, Finkelstein, David, primary, Sunny, Jobin, primary, Mudunuri, Rahul, primary, Orr, Brent A., primary, Treadway, Madison, primary, Davidson, Bob, primary, Ard, Tracy K., primary, Chiao, Arthur, primary, Swistak, Andrew, primary, Wiggins, Stephanie, primary, Foy, Scott, primary, Wang, Jian, primary, Sioson, Edgar, primary, Wang, Shuoguo, primary, Michael, J. Robert, primary, Liu, Yu, primary, Ma, Xiaotu, primary, Patel, Aman, primary, Edmonson, Michael N., primary, Wilkinson, Mark R., primary, Frantz, Andrew M., primary, Chang, Ti-Cheng, primary, Tian, Liqing, primary, Lei, Shaohua, primary, Islam, S.M. Ashiqul, primary, Meyer, Christopher, primary, Thangaraj, Naina, primary, Tater, Pamella, primary, Kandali, Vijay, primary, Ma, Singer, primary, Nguyen, Tuan, primary, Serang, Omar, primary, McGuire, Irina, primary, Robison, Nedra, primary, Gentry, Darrell, primary, Tang, Xing, primary, Palmer, Lance E., primary, Wu, Gang, primary, Suh, Ed, primary, Tanner, Leigh, primary, McMurry, James, primary, Lear, Matthew, primary, Pappo, Alberto S., primary, Wang, Zhaoming, primary, Wilson, Carmen L., primary, Cheng, Yong, primary, Meshinchi, Soheil, primary, Alexandrov, Ludmil B., primary, Weiss, Mitchell J., primary, Armstrong, Gregory T., primary, Robison, Leslie L., primary, Yasui, Yutaka, primary, Nichols, Kim E., primary, Ellison, David W., primary, Bangur, Chaitanya, primary, Mullighan, Charles G., primary, Baker, Suzanne J., primary, Dyer, Michael A., primary, Miller, Geralyn, primary, Newman, Scott, primary, Rusch, Michael, primary, Daly, Richard, primary, Perry, Keith, primary, Downing, James R., primary, and Zhang, Jinghui, primary

Published
2023
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47. An Exosome-Based Therapeutic Strategy Targeting Neuroinflammation in Alzheimer’s Disease with Berberine and Palmatine

Author

Zhao,Xin, Ge,Pingyuan, Lei,Shaohua, Guo,Siqi, Zhou,Peng, Zhao,Li, Qi,Yiyu, Wei,Xiaotong, Wu,Weizhen, Wang,Ningjing, Guo,Rui, Yang,Nianyun, Xiao,Qingqing, Zhang,Qichun, Zhu,Huaxu, Zhao,Xin, Ge,Pingyuan, Lei,Shaohua, Guo,Siqi, Zhou,Peng, Zhao,Li, Qi,Yiyu, Wei,Xiaotong, Wu,Weizhen, Wang,Ningjing, Guo,Rui, Yang,Nianyun, Xiao,Qingqing, Zhang,Qichun, and Zhu,Huaxu

Abstract

Xin Zhao,1,* Pingyuan Ge,1,* Shaohua Lei,1 Siqi Guo,1 Peng Zhou,1 Li Zhao,1 Yiyu Qi,1 Xiaotong Wei,2 Weizhen Wu,2 Ningjing Wang,2 Rui Guo,3 Nianyun Yang,1 Qingqing Xiao,1 Qichun Zhang,1,2 Huaxu Zhu1 1Department of Traditional Chinese Medicine Processing and Preparation, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People’s Republic of China; 2Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China; 3School of Medicine and Holistic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qichun Zhang; Huaxu Zhu, Email zhangqichun@njucm.edu.cn; zhuhx@njucm.edu.cnIntroduction: Neuroinflammation is one of the major pathogeneses in Alzheimer’s disease (AD) and mainly involves abnormal inflammatory activation of microglia by multiple pathological stimuli. The treatment of AD remains a major challenge due to the multifactorial characterization of AD and the inefficient ability of therapeutic drugs to permeate through the blood‒brain barrier (BBB). Accordingly, drug combination treatment and drug carrier delivery have become important therapeutic tools for the treatment of multifactorial diseases, especially AD.Methods: Inflammatory cytokine levels in microglia, including NO, TNF-α, IL-1β, IL-4, and IL-10, were detected. The Morris water maze and object location task were used to investigate the learning and memory functions of APP/PS1 mice in different treatment groups. The number of neurons and plasticity of synapses were evaluated by immunofluorescence double labelling. Additionally, the ratio of β-amyloid plaques and the number of activated microglia were evaluated by immunofluorescence staining. The concentrations of β-amyloid plaques and inflammatory factors in the hippocampus were determin

Published
2023

48. Estimating Effects of Natural and Anthropogenic Activities on Trophic Level of Inland Water : Analysis of Poyang Lake Basin, China, with Landsat-8 Observations

Author

Li, Jianzhong, Zheng, Zhubin, Liu, Ge, Chen, Na, Lei, Shaohua, Du, Chao, Xu, Jie, Li, Yuan, Zhang, Runfei, Huang, Chao, Li, Jianzhong, Zheng, Zhubin, Liu, Ge, Chen, Na, Lei, Shaohua, Du, Chao, Xu, Jie, Li, Yuan, Zhang, Runfei, and Huang, Chao

Abstract

The intensification of anthropogenic activities has led to the infiltration of enormous quantities of pollutants into rivers and lakes, resulting in significant deterioration in water quality and a more prominent occurrence of eutrophication. Poyang Lake, the largest freshwater lake in China, is facing a severe challenge related to eutrophication, which seriously threatens the delivery of the ecosystem service and the safety of drinking water. To address this challenge, Landsat-8 Operational Land Imager (OLI) data for the Poyang Lake Basin (PLB) from May 2013 to December 2020 were used. Since inland water bodies with complex optical characteristics, we developed a semi-analytical algorithm to assess the trophic state of the water based on two cruise field measurements in 2016 and 2019. Combining the semi-analytical trophic level index (TLI) with an atmospheric correction model is the most suitable model for OLI images of the PLB, this model was then applied to Landsat-8 time series observations. The trends of the trophic state of water bodies in PLB were revealed, and the annual, quarterly and monthly percentages of eutrophic water bodies were calculated. Natural and anthropogenic factors were then used to explain the changes in the trophic state of the PLB waters. The main findings are as follows: (1) From the 8-year observation results, it can be seen that the variation of trophic level of water in PLB showed obviously spatial and temporal variations, characterized by higher in the north than in the south and higher in winter than in summer. (2) Temperature promoted the growth of harmful algae and plays an essential role in affecting changes in the trophic level of the water. (3) Changes in the trophic level of water bodies in PLB were mainly affected by human activities. The results of spatial and temporal variation of the trophic level of water and the driving factors in PLB can extend our knowledge of water quality degradation and provide essential references f

Published
2023

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