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Diagnostic investigation has an important role in risk stratification and clinical decision making of patients with suspected and documented Coronary Artery Disease (CAD). However, the majority of existing tools are primarily focused on the selection of gatekeeper tests, whereas only a handful of systems contain information regarding the downstream testing or treatment. We propose a multi-task deep learning model to support risk stratification and down-stream test selection for patients undergoing Coronary Computed Tomography Angiography (CCTA). The analysis included 14,021 patients who underwent CCTA between 2006 and 2017. Our novel multitask deep learning framework extends the state-of-the art Perceiver model to deal with real-world CCTA report data. Our model achieved an Area Under the receiver operating characteristic Curve (AUC) of 0.76 in CAD risk stratification, and 0.72 AUC in predicting downstream tests. Our proposed deep learning model can accurately estimate the likelihood of CAD and provide recommended downstream tests based on prior CCTA data. In clinical practice, the utilization of such an approach could bring a paradigm shift in risk stratification and downstream management. Despite significant progress using deep learning models for tabular data, they do not outperform gradient boosting decision trees, and further research is required in this area. However, neural networks appear to benefit more readily from multi-task learning than tree-based models. This could offset the shortcomings of using single task learning approach when working with tabular data.

We explore two differentiable deep declarative layers, namely least squares on sphere (LESS) and implicit eigen decomposition (IED), for learning the principal matrix features (PMaF). It can be used to represent data features with a low-dimensional vector containing dominant information from a high-dimensional matrix. We first solve the problems with iterative optimization in the forward pass and then backpropagate the solution for implicit gradients under a bi-level optimization framework. Particularly, adaptive descent steps with the backtracking line search method and descent decay in the tangent space are studied to improve the forward pass efficiency of LESS. Meanwhile, exploited data structures are used to greatly reduce the computational complexity in the backward pass of LESS and IED. Empirically, we demonstrate the superiority of our layers over the off-the-shelf baselines by comparing the solution optimality and computational requirements., Comment: 16 pages, 7 figures, 10 tables, accepted to the differentiable almost everything workshop, ICML, 2023

We explore conditions for when the gradient of a deep declarative node can be approximated by ignoring constraint terms and still result in a descent direction for the global loss function. This has important practical application when training deep learning models since the approximation is often computationally much more efficient than the true gradient calculation. We provide theoretical analysis for problems with linear equality constraints and normalization constraints, and show examples where the approximation works well in practice as well as some cautionary tales for when it fails., Comment: 10 pages, 4 figures, ICML 2023 workshop on Differentiable Almost Everything

Multimodal alignment facilitates the retrieval of instances from one modality when queried using another. In this paper, we consider a novel setting where such an alignment is between (i) instruction steps that are depicted as assembly diagrams (commonly seen in Ikea assembly manuals) and (ii) video segments from in-the-wild videos; these videos comprising an enactment of the assembly actions in the real world. To learn this alignment, we introduce a novel supervised contrastive learning method that learns to align videos with the subtle details in the assembly diagrams, guided by a set of novel losses. To study this problem and demonstrate the effectiveness of our method, we introduce a novel dataset: IAW for Ikea assembly in the wild consisting of 183 hours of videos from diverse furniture assembly collections and nearly 8,300 illustrations from their associated instruction manuals and annotated for their ground truth alignments. We define two tasks on this dataset: First, nearest neighbor retrieval between video segments and illustrations, and, second, alignment of instruction steps and the segments for each video. Extensive experiments on IAW demonstrate superior performances of our approach against alternatives., Comment: Project website: https://academic.davidz.cn/en/publication/zhang-cvpr-2023/

The long-tailed recognition (LTR) is the task of learning high-performance classifiers given extremely imbalanced training samples between categories. Most of the existing works address the problem by either enhancing the features of tail classes or re-balancing the classifiers to reduce the inductive bias. In this paper, we try to look into the root cause of the LTR task, i.e., training samples for each class are greatly imbalanced, and propose a straightforward solution. We split the categories into three groups, i.e., many, medium and few, according to the number of training images. The three groups of categories are separately predicted to reduce the difficulty for classification. This idea naturally arises a new problem of how to assign a given sample to the right class groups? We introduce a mutual exclusive modulator which can estimate the probability of an image belonging to each group. Particularly, the modulator consists of a light-weight module and learned with a mutual exclusive objective. Hence, the output probabilities of the modulator encode the data volume clues of the training dataset. They are further utilized as prior information to guide the prediction of the classifier. We conduct extensive experiments on multiple datasets, e.g., ImageNet-LT, Place-LT and iNaturalist 2018 to evaluate the proposed approach. Our method achieves competitive performance compared to the state-of-the-art benchmarks.

We present NeRFEditor, an efficient learning framework for 3D scene editing, which takes a video captured over 360{\deg} as input and outputs a high-quality, identity-preserving stylized 3D scene. Our method supports diverse types of editing such as guided by reference images, text prompts, and user interactions. We achieve this by encouraging a pre-trained StyleGAN model and a NeRF model to learn from each other mutually. Specifically, we use a NeRF model to generate numerous image-angle pairs to train an adjustor, which can adjust the StyleGAN latent code to generate high-fidelity stylized images for any given angle. To extrapolate editing to GAN out-of-domain views, we devise another module that is trained in a self-supervised learning manner. This module maps novel-view images to the hidden space of StyleGAN that allows StyleGAN to generate stylized images on novel views. These two modules together produce guided images in 360{\deg}views to finetune a NeRF to make stylization effects, where a stable fine-tuning strategy is proposed to achieve this. Experiments show that NeRFEditor outperforms prior work on benchmark and real-world scenes with better editability, fidelity, and identity preservation., Comment: Project page: https://chuny1.github.io/NeRFEditor/nerfeditor.html

Generative models such as generative adversarial networks and autoencoders have gained a great deal of attention in the medical field due to their excellent data generation capability. This paper provides a comprehensive survey of generative models for three-dimensional (3D) volumes, focusing on the brain and heart. A new and elaborate taxonomy of unconditional and conditional generative models is proposed to cover diverse medical tasks for the brain and heart: unconditional synthesis, classification, conditional synthesis, segmentation, denoising, detection, and registration. We provide relevant background, examine each task and also suggest potential future directions. A list of the latest publications will be updated on Github to keep up with the rapid influx of papers at https://github.com/csyanbin/3D-Medical-Generative-Survey., Comment: Accepted at ACM Computing Surveys (CSUR) 2023

The generation of three-dimensional (3D) medical images has great application potential since it takes into account the 3D anatomical structure. Two problems prevent effective training of a 3D medical generative model: (1) 3D medical images are expensive to acquire and annotate, resulting in an insufficient number of training images, and (2) a large number of parameters are involved in 3D convolution. Methods: We propose a novel GAN model called 3D Split&Shuffle-GAN. To address the 3D data scarcity issue, we first pre-train a two-dimensional (2D) GAN model using abundant image slices and inflate the 2D convolution weights to improve the initialization of the 3D GAN. Novel 3D network architectures are proposed for both the generator and discriminator of the GAN model to significantly reduce the number of parameters while maintaining the quality of image generation. Several weight inflation strategies and parameter-efficient 3D architectures are investigated. Results: Experiments on both heart (Stanford AIMI Coronary Calcium) and brain (Alzheimer's Disease Neuroimaging Initiative) datasets show that our method leads to improved 3D image generation quality (14.7 improvements on Fr\'echet inception distance) with significantly fewer parameters (only 48.5% of the baseline method). Conclusions: We built a parameter-efficient 3D medical image generation model. Due to the efficiency and effectiveness, it has the potential to generate high-quality 3D brain and heart images for real use cases., Comment: Published at Computer Methods and Programs in Biomedicine (CMPB) 2023

Unsupervised anomaly detection (AD) is a challenging task in realistic applications. Recently, there is an increasing trend to detect anomalies with deep neural networks (DNN). However, most popular deep AD detectors cannot protect the network from learning contaminated information brought by anomalous data, resulting in unsatisfactory detection performance and overfitting issues. In this work, we identify one reason that hinders most existing DNN-based anomaly detection methods from performing is the wide adoption of the Empirical Risk Minimization (ERM). ERM assumes that the performance of an algorithm on an unknown distribution can be approximated by averaging losses on the known training set. This averaging scheme thus ignores the distinctions between normal and anomalous instances. To break through the limitations of ERM, we propose a novel Diminishing Empirical Risk Minimization (DERM) framework. Specifically, DERM adaptively adjusts the impact of individual losses through a well-devised aggregation strategy. Theoretically, our proposed DERM can directly modify the gradient contribution of each individual loss in the optimization process to suppress the influence of outliers, leading to a robust anomaly detector. Empirically, DERM outperformed the state-of-the-art on the unsupervised AD benchmark consisting of 18 datasets., Comment: 8 pages, 4 figures, to be published in IJCNN at IEEE WCCI 2022

Optimal transport is a machine learning problem with applications including distribution comparison, feature selection, and generative adversarial networks. In this paper, we propose feature-robust optimal transport (FROT) for high-dimensional data, which solves high-dimensional OT problems using feature selection to avoid the curse of dimensionality. Specifically, we find a transport plan with discriminative features. To this end, we formulate the FROT problem as a min--max optimization problem. We then propose a convex formulation of the FROT problem and solve it using a Frank--Wolfe-based optimization algorithm, whereby the subproblem can be efficiently solved using the Sinkhorn algorithm. Since FROT finds the transport plan from selected features, it is robust to noise features. To show the effectiveness of FROT, we propose using the FROT algorithm for the layer selection problem in deep neural networks for semantic correspondence. By conducting synthetic and benchmark experiments, we demonstrate that the proposed method can find a strong correspondence by determining important layers. We show that the FROT algorithm achieves state-of-the-art performance in real-world semantic correspondence datasets.

Estimating mutual information is an important statistics and machine learning problem. To estimate the mutual information from data, a common practice is preparing a set of paired samples $\{(\mathbf{x}_i,\mathbf{y}_i)\}_{i=1}^n \stackrel{\mathrm{i.i.d.}}{\sim} p(\mathbf{x},\mathbf{y})$. However, in many situations, it is difficult to obtain a large number of data pairs. To address this problem, we propose the semi-supervised Squared-loss Mutual Information (SMI) estimation method using a small number of paired samples and the available unpaired ones. We first represent SMI through the density ratio function, where the expectation is approximated by the samples from marginals and its assignment parameters. The objective is formulated using the optimal transport problem and quadratic programming. Then, we introduce the Least-Squares Mutual Information with Sinkhorn (LSMI-Sinkhorn) algorithm for efficient optimization. Through experiments, we first demonstrate that the proposed method can estimate the SMI without a large number of paired samples. Then, we show the effectiveness of the proposed LSMI-Sinkhorn algorithm on various types of machine learning problems such as image matching and photo album summarization. Code can be found at https://github.com/csyanbin/LSMI-Sinkhorn., Comment: ECML/PKDD 2021