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4. A whole-brain model of the neural entropy increase elicited by psychedelic drugs.

Author

Herzog, Rubén, Mediano, Pedro AM, Rosas, Fernando E, Lodder, Paul, Carhart-Harris, Robin, Perl, Yonatan Sanz, Tagliazucchi, Enzo, and Cofre, Rodrigo

Subjects
Brain, Lysergic Acid Diethylamide, Hallucinogens, Consciousness, Entropy, Brain Disorders, Neurosciences, 1.1 Normal biological development and functioning, Underpinning research, 1.2 Psychological and socioeconomic processes, Mental health, Neurological
Abstract

Psychedelic drugs, including lysergic acid diethylamide (LSD) and other agonists of the serotonin 2A receptor (5HT2A-R), induce drastic changes in subjective experience, and provide a unique opportunity to study the neurobiological basis of consciousness. One of the most notable neurophysiological signatures of psychedelics, increased entropy in spontaneous neural activity, is thought to be of relevance to the psychedelic experience, mediating both acute alterations in consciousness and long-term effects. However, no clear mechanistic explanation for this entropy increase has been put forward so far. We sought to do this here by building upon a recent whole-brain model of serotonergic neuromodulation, to study the entropic effects of 5HT2A-R activation. Our results reproduce the overall entropy increase observed in previous experiments in vivo, providing the first model-based explanation for this phenomenon. We also found that entropy changes were not uniform across the brain: entropy increased in all regions, but the larger effect were localised in visuo-occipital regions. Interestingly, at the whole-brain level, this reconfiguration was not well explained by 5HT2A-R density, but related closely to the topological properties of the brain's anatomical connectivity. These results help us understand the mechanisms underlying the psychedelic state and, more generally, the pharmacological modulation of whole-brain activity.

Published
2023

10. Quantifiers satisfying semantic universals are simpler

Author

van de Pol, Iris, Lodder, Paul, van Maanen, Leendert, Steinert-Threlkeld, Shane, and Szymanik, Jakub

Subjects
cognitive science
Abstract

Despite wide variation among natural languages, there are linguistic properties thought to be universal to all or almost all natural languages. Here, we consider universals at the semantic level, in the domain of quantifiers, which are given by the properties of monotonicity, quantity, and conservativity. We investigate whether these universals might be explained by differences in complexity. We generate a large collection of quantifiers, based on a simple yet expressive grammar, and compute both their complexities and whether they adhere to these universal properties. We find that quantifiers satisfying semantic universals are less complex: they have a shorter minimal description length.

Published
2021

14. Type D personality as a risk factor for adverse outcome in patients with cardiovascular disease: an individual patient data meta-analysis

Author

Lodder, Paul, Wicherts, Jelte M., Antens, Marijn, Albus, Christian, Bessonov, Ivan S., Condén, Emelie, Dulfer, Karolijn, Gostoli, Sara, Grande, Gesine, Hedberg, Pär, Herrmann-Lingen, Christoph, Jaarsma, Tiny, Koo, Malcolm, Lin, Ping, Lin, Tin-Kwang, Meyer, Thomas, Pushkarev, Georgiy, Rafanelli, Chiara, Raykh, Olga I., de Quadros, Alexandre Schaan, Schmidt, Marcia, Sumin, Alexei N., Utens, Elisabeth M.W.J., van Veldhuisen, Dirk J., Wang, Yini, and Kupper, Nina

Published
2023
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23. Gender roles and gender norms associated with psychological distress in women and men among the Dutch general population.

Author

Mommersteeg, Paula MC, van Valkengoed, Irene, Lodder, Paul, Juster, Robert-Paul, and Kupper, Nina

Subjects
MENTAL depression risk factors, GENDER role, CROSS-sectional method, RISK assessment, PSYCHOLOGICAL distress, CAUSAL models, RESEARCH funding, SEX distribution, MULTIPLE regression analysis, MASCULINITY, FEMININITY, PSYCHOLOGY of women, PSYCHOLOGY of men, ANXIETY, PSYCHOLOGICAL stress, WELL-being
Abstract

Women report more psychological distress than men, which may be related to both biological sex and socio-cultural gender. We tested whether associations between gender and distress differ for women and men. The cross-sectional sample consisted of 678 Dutch people (54% women). Gender roles were assessed as masculinity and femininity. A composite gender norm score was calculated by summing gendered sociodemographics. Multivariate regressions examined sex, gender, and their interaction for depressive symptoms, anxiety, and perceived stress, additionally adjusted. Women reported more psychological distress. People scoring higher on masculine gender roles, but not feminine gender roles, reported lower psychological distress. A higher gender norm score was related to more depressive symptoms and perceived stress. This association was only present in men and was explained by health-related covariates. This research shows that there is a need to further elaborate on the discrepancies between sex and gender in health psychology research to better understand individual differences. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Vertebroplasty versus Active Control Intervention for Chronic Osteoporotic Vertebral Compression Fractures: The VERTOS V Randomized Controlled Trial

Author

Carli, Dennis, primary, Venmans, Alexander, additional, Lodder, Paul, additional, Donga, Esther, additional, van Oudheusden, Thijs, additional, Boukrab, Issam, additional, Schoemaker, Kees, additional, Smeets, Albert, additional, Schonenberg, Catharina, additional, Hirsch, Joshua, additional, de Vries, Jolanda, additional, and Lohle, Paul, additional

Published
2023
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42. Quantifiers satisfying semantic universals have shorter minimal description length

Author

Leerstoel Stigchel, Helmholtz Institute, Experimental Psychology (onderzoeksprogramma PF), van de Pol, Iris, Lodder, Paul, van Maanen, Leendert, Steinert-Threlkeld, Shane, Szymanik, Jakub, Leerstoel Stigchel, Helmholtz Institute, Experimental Psychology (onderzoeksprogramma PF), van de Pol, Iris, Lodder, Paul, van Maanen, Leendert, Steinert-Threlkeld, Shane, and Szymanik, Jakub

Published
2023

43. A many-analysts approach to the relation between religiosity and well-being

Author

Hoogeveen, Suzanne, Sarafoglou, Alexandra, Aczel, Balazs, Aditya, Yonathan, Alayan, Alexandra J., Allen, Peter J., Altay, Sacha, Alzahawi, Shilaan, Amir, Yulmaida, Anthony, Francis-Vincent, Appiah, Obed Kwame, Atkinson, Quentin D., Baimel, Adam, Balkaya-Ince, Merve, Balsamo, Michela, Banker, Sachin, Bartos, Frantisek, Becerra, Mario, Beffara, Bertrand, Beitner, Julia, Bendixen, Theiss, Berkessel, Jana B., Berniunas, Renatas, Billet, Matthew, Billingsley, Joseph, Bortolini, Tiago, Breitsohl, Heiko, Bret, Amelie, Brown, Faith L., Brown, Jennifer, Brumbaugh, Claudia C., Buczny, Jacek, Bulbulia, Joseph, Caballero, Saul, Carlucci, Leonardo, Carmichael, Cheryl L., Cattaneo, Marco E. G., Charles, Sarah J., Claessens, Scott, Panagopoulos, Maxinne C., Costa, Angelo Brandelli, Crone, Damien L., Czoschke, Stefan, Czymara, Christian, D'Urso, E. Damiano, Dahlstrom, Orjan, Dalla Rosa, Anna, Danielsson, Henrik, De Ron, Jill, de Vries, Ymkje Anna, Dean, Kristy K., Dik, Bryan J., Disabato, David J., Doherty, Jaclyn K., Draws, Tim, Drouhot, Lucas, Dujmovic, Marin, Dunham, Yarrow, Ebert, Tobias, Edelsbrunner, Peter A., Eerland, Anita, Elbaek, Christian T., Farahmand, Shole, Farahmand, Hooman, Farias, Miguel, Feliccia, Abrey A., Fischer, Kyle, Fischer, Ronald, Fisher-Thompson, Donna, Francis, Zoe, Frick, Susanne, Frisch, Lisa K., Geraldes, Diogo, Gerdin, Emily, Geven, Linda, Ghasemi, Omid, Gielens, Erwin, Gligoric, Vukasin, Hagel, Kristin, Hajdu, Nandor, Hamilton, Hannah R., Hamzah, Imaduddin, Hanel, Paul H. P., Hawk, Christopher E., Himawan, Karel K., Holding, Benjamin C., Homman, Lina E., Ingendahl, Moritz, Inkila, Hilla, Inman, Mary L., Islam, Chris-Gabriel, Isler, Ozan, Izydorczyk, David, Jaeger, Bastian, Johnson, Kathryn A., Jong, Jonathan, Karl, Johannes A., Kaszubowski, Erikson, Katz, Benjamin A., Keefer, Lucas A., Kelchtermans, Stijn, Kelly, John M., Klein, Richard A., Kleinberg, Bennett, Knowles, Megan L., Kolczynska, Marta, Koller, Dave, Krasko, Julia, Kritzler, Sarah, Krypotos, Angelos-Miltiadis, Kyritsis, Thanos, Landes, Todd L., Laukenmann, Ruben, Forsyth, Guy A. Lavender, Lazar, Aryeh, Lehman, Barbara J., Levy, Neil, Lo, Ronda F., Lodder, Paul, Lorenz, Jennifer, Lowicki, Pawel, Ly, Albert L., Maassen, Esther, Magyar-Russell, Gina M., Maier, Maximilian, Marsh, Dylan R., Martinez, Nuria, Martinie, Marcellin, Martoyo, Ihan, Mason, Susan E., Mauritsen, Anne Lundahl, McAleer, Phil, McCauley, Thomas, McCullough, Michael, McKay, Ryan, McMahon, Camilla M., McNamara, Amelia A., Means, Kira K., Mercier, Brett, Mitkidis, Panagiotis, Monin, Benoit, Moon, Jordan W., Moreau, David, Morgan, Jonathan, Murphy, James, Muscatt, George, Nagel, Christof, Nagy, Tamas, Nalborczyk, Ladislas, Nilsonne, Gustav, Noack, Pamina, Norenzayan, Ara, Nuijten, Michele B., Olsson-Collentine, Anton, Oviedo, Lluis, Pavlov, Yuri G., Pawelski, James O., Pearson, Hannah, Pedder, Hugo, Peetz, Hannah K., Pinus, Michael, Pirutinsky, Steven, Polito, Vince, Porubanova, Michaela, Poulin, Michael J., Prenoveau, Jason M., Prince, Mark A., Protzko, John, Pryor, Campbell, Purzycki, Benjamin G., Qiu, Lin, Putter, Julian Quevedo, Rabelo, Andre, Radell, Milen L., Ramsay, Jonathan E., Reid, Graham, Roberts, Andrew J., Luna, Lindsey M. Root, Ross, Robert M., Roszak, Piotr, Roy, Nirmal, Saarelainen, Suvi-Maria K., Sasaki, Joni Y., Schaumans, Catherine, Schivinski, Bruno, Schmitt, Marcel C., Schnitker, Sarah A., Schnuerch, Martin, Schreiner, Marcel R., Schuttengruber, Victoria, Sebben, Simone, Segerstrom, Suzanne C., Seryczynska, Berenika, Shjoedt, Uffe, Simsek, Muge, Sleegers, Willem W. A., Smith, Eliot R., Sowden, Walter J., Spath, Marion, Sporlein, Christoph, Stedden, William, Stoevenbelt, Andrea H., Stuber, Simon, Sulik, Justin, Suwartono, Christiany, Syropoulos, Stylianos, Szaszi, Barnabas, Szecsi, Peter, Tappin, Ben M., Tay, Louis, Thibault, Robert T., Thompson, Burt, Thurn, Christian M., Torralba, Josefa, Tuthill, Shelby D., Ullein, Ann-Marie, Van Aert, Robbie C. M., van Assen, Marcel A. L. M., Van Cappellen, Patty, van den Akker, Olmo R., Van der Cruyssen, Ine, Van der Noll, Jolanda, van Dongen, Noah N. N., Van Lissa, Caspar J., van Mulukom, Valerie, van Ravenzwaaij, Don, van Zyl, Casper J. J., Vaughn, Leigh Ann, Verschuere, Bruno, Vianello, Michelangelo, Vilanova, Felipe, Vishkin, Allon, Vogel, Vera, Vogelsmeier, Leonie V. D. E., Watanabe, Shoko, White, Cindel J. M., Wiebels, Kristina, Wiechert, Sera, Willett, Zachary Z., Witkowiak, Maciej, Witvliet, Charlotte V. O., Wiwad, Dylan, Wuyts, Robin, Xygalatas, Dimitris, Yang, Xin, Yeo, Darren J., Yilmaz, Onurcan, Zarzeczna, Natalia, Zhao, Yitong, Zijlmans, Josjan, van Elk, Michiel, Wagenmakers, Eric-Jan, Hoogeveen, Suzanne, Sarafoglou, Alexandra, Aczel, Balazs, Aditya, Yonathan, Alayan, Alexandra J., Allen, Peter J., Altay, Sacha, Alzahawi, Shilaan, Amir, Yulmaida, Anthony, Francis-Vincent, Appiah, Obed Kwame, Atkinson, Quentin D., Baimel, Adam, Balkaya-Ince, Merve, Balsamo, Michela, Banker, Sachin, Bartos, Frantisek, Becerra, Mario, Beffara, Bertrand, Beitner, Julia, Bendixen, Theiss, Berkessel, Jana B., Berniunas, Renatas, Billet, Matthew, Billingsley, Joseph, Bortolini, Tiago, Breitsohl, Heiko, Bret, Amelie, Brown, Faith L., Brown, Jennifer, Brumbaugh, Claudia C., Buczny, Jacek, Bulbulia, Joseph, Caballero, Saul, Carlucci, Leonardo, Carmichael, Cheryl L., Cattaneo, Marco E. G., Charles, Sarah J., Claessens, Scott, Panagopoulos, Maxinne C., Costa, Angelo Brandelli, Crone, Damien L., Czoschke, Stefan, Czymara, Christian, D'Urso, E. Damiano, Dahlstrom, Orjan, Dalla Rosa, Anna, Danielsson, Henrik, De Ron, Jill, de Vries, Ymkje Anna, Dean, Kristy K., Dik, Bryan J., Disabato, David J., Doherty, Jaclyn K., Draws, Tim, Drouhot, Lucas, Dujmovic, Marin, Dunham, Yarrow, Ebert, Tobias, Edelsbrunner, Peter A., Eerland, Anita, Elbaek, Christian T., Farahmand, Shole, Farahmand, Hooman, Farias, Miguel, Feliccia, Abrey A., Fischer, Kyle, Fischer, Ronald, Fisher-Thompson, Donna, Francis, Zoe, Frick, Susanne, Frisch, Lisa K., Geraldes, Diogo, Gerdin, Emily, Geven, Linda, Ghasemi, Omid, Gielens, Erwin, Gligoric, Vukasin, Hagel, Kristin, Hajdu, Nandor, Hamilton, Hannah R., Hamzah, Imaduddin, Hanel, Paul H. P., Hawk, Christopher E., Himawan, Karel K., Holding, Benjamin C., Homman, Lina E., Ingendahl, Moritz, Inkila, Hilla, Inman, Mary L., Islam, Chris-Gabriel, Isler, Ozan, Izydorczyk, David, Jaeger, Bastian, Johnson, Kathryn A., Jong, Jonathan, Karl, Johannes A., Kaszubowski, Erikson, Katz, Benjamin A., Keefer, Lucas A., Kelchtermans, Stijn, Kelly, John M., Klein, Richard A., Kleinberg, Bennett, Knowles, Megan L., Kolczynska, Marta, Koller, Dave, Krasko, Julia, Kritzler, Sarah, Krypotos, Angelos-Miltiadis, Kyritsis, Thanos, Landes, Todd L., Laukenmann, Ruben, Forsyth, Guy A. Lavender, Lazar, Aryeh, Lehman, Barbara J., Levy, Neil, Lo, Ronda F., Lodder, Paul, Lorenz, Jennifer, Lowicki, Pawel, Ly, Albert L., Maassen, Esther, Magyar-Russell, Gina M., Maier, Maximilian, Marsh, Dylan R., Martinez, Nuria, Martinie, Marcellin, Martoyo, Ihan, Mason, Susan E., Mauritsen, Anne Lundahl, McAleer, Phil, McCauley, Thomas, McCullough, Michael, McKay, Ryan, McMahon, Camilla M., McNamara, Amelia A., Means, Kira K., Mercier, Brett, Mitkidis, Panagiotis, Monin, Benoit, Moon, Jordan W., Moreau, David, Morgan, Jonathan, Murphy, James, Muscatt, George, Nagel, Christof, Nagy, Tamas, Nalborczyk, Ladislas, Nilsonne, Gustav, Noack, Pamina, Norenzayan, Ara, Nuijten, Michele B., Olsson-Collentine, Anton, Oviedo, Lluis, Pavlov, Yuri G., Pawelski, James O., Pearson, Hannah, Pedder, Hugo, Peetz, Hannah K., Pinus, Michael, Pirutinsky, Steven, Polito, Vince, Porubanova, Michaela, Poulin, Michael J., Prenoveau, Jason M., Prince, Mark A., Protzko, John, Pryor, Campbell, Purzycki, Benjamin G., Qiu, Lin, Putter, Julian Quevedo, Rabelo, Andre, Radell, Milen L., Ramsay, Jonathan E., Reid, Graham, Roberts, Andrew J., Luna, Lindsey M. Root, Ross, Robert M., Roszak, Piotr, Roy, Nirmal, Saarelainen, Suvi-Maria K., Sasaki, Joni Y., Schaumans, Catherine, Schivinski, Bruno, Schmitt, Marcel C., Schnitker, Sarah A., Schnuerch, Martin, Schreiner, Marcel R., Schuttengruber, Victoria, Sebben, Simone, Segerstrom, Suzanne C., Seryczynska, Berenika, Shjoedt, Uffe, Simsek, Muge, Sleegers, Willem W. A., Smith, Eliot R., Sowden, Walter J., Spath, Marion, Sporlein, Christoph, Stedden, William, Stoevenbelt, Andrea H., Stuber, Simon, Sulik, Justin, Suwartono, Christiany, Syropoulos, Stylianos, Szaszi, Barnabas, Szecsi, Peter, Tappin, Ben M., Tay, Louis, Thibault, Robert T., Thompson, Burt, Thurn, Christian M., Torralba, Josefa, Tuthill, Shelby D., Ullein, Ann-Marie, Van Aert, Robbie C. M., van Assen, Marcel A. L. M., Van Cappellen, Patty, van den Akker, Olmo R., Van der Cruyssen, Ine, Van der Noll, Jolanda, van Dongen, Noah N. N., Van Lissa, Caspar J., van Mulukom, Valerie, van Ravenzwaaij, Don, van Zyl, Casper J. J., Vaughn, Leigh Ann, Verschuere, Bruno, Vianello, Michelangelo, Vilanova, Felipe, Vishkin, Allon, Vogel, Vera, Vogelsmeier, Leonie V. D. E., Watanabe, Shoko, White, Cindel J. M., Wiebels, Kristina, Wiechert, Sera, Willett, Zachary Z., Witkowiak, Maciej, Witvliet, Charlotte V. O., Wiwad, Dylan, Wuyts, Robin, Xygalatas, Dimitris, Yang, Xin, Yeo, Darren J., Yilmaz, Onurcan, Zarzeczna, Natalia, Zhao, Yitong, Zijlmans, Josjan, van Elk, Michiel, and Wagenmakers, Eric-Jan

Abstract

The relation between religiosity and well-being is one of the most researched topics in the psychology of religion, yet the directionality and robustness of the effect remains debated. Here, we adopted a many-analysts approach to assess the robustness of this relation based on a new cross-cultural dataset (N = 10, 535 participants from 24 countries). We recruited 120 analysis teams to investigate (1) whether religious people self-report higher well-being, and (2) whether the relation between religiosity and self-reported well-being depends on perceived cultural norms of religion (i.e., whether it is considered normal and desirable to be religious in a given country). In a two-stage procedure, the teams first created an analysis plan and then executed their planned analysis on the data. For the first research question, all but 3 teams reported positive effect sizes with credible/confidence intervals excluding zero (median reported beta = 0.120). For the second research question, this was the case for 65% of the teams (median reported beta = 0.039). While most teams applied (multilevel) linear regression models, there was considerable variability in the choice of items used to construct the independent variables, the dependent variable, and the included covariates.

Published
2023

44. Medical psychometrics: A psychometric evaluation of Type D personality and its predictive value in medical research

Author

Lodder, Paul and Lodder, Paul

Abstract

Type D personality–a combination of high negative affectivity and high social inhibition–has been identified as a risk factor for adverse outcome in various patient populations. However, common methods used to establish the predictive value of Type D personality have been criticized and several recent studies were not able to replicate previous findings. To explain these inconsistencies, this interdisciplinary dissertation brings together experts from the fields of medical psychology and psychometrics. It presents a psychometric evaluation of the construct Type D personality and illustrates how it can best be modeled in medical and psychological research. Based on thousands of computer-simulated datasets, as well as empirical data from patients with various types of diseases, this dissertation shows why most published research testing a Type D personality effect should be reanalyzed using modern psychometric and statistical methods. It also presents a first attempt at this endeavor by reanalyzing various earlier published datasets, showing that coronary artery disease patients with Type D personality are at increased risk for adverse outcome.

Published
2023

45. Antenatal anxiety and depressive symptoms and physiological birth

Author

Hulsbosch, Lianne P., Boekhorst, Myrthe G.B.M., Lodder, Paul, Potharst, Eva S., Nyklíček, Ivan, Bergink, Veerle, Oei, Swan Guid, Verhoeven, Corine J.M., Pop, Victor J.M., Hulsbosch, Lianne P., Boekhorst, Myrthe G.B.M., Lodder, Paul, Potharst, Eva S., Nyklíček, Ivan, Bergink, Veerle, Oei, Swan Guid, Verhoeven, Corine J.M., and Pop, Victor J.M.

Abstract

A comment on the recently published letter by Grogan and Srinivasan: The effect of antenatal depressive and anxious symptoms on the rate of physiological births.

Published
2023

46. Vertebroplasty versus active control intervention for chronic osteoporotic vertebral compression fractures: The VERTOS V randomized controlled trial

Author

Carli, Dennis, Venmans, Alexander, Lodder, Paul, Donga, Esther, van Oudheusden, Thijs, Boukrab, Issam, Schoemaker, Kees, Smeets, Albert, Schonenberg, Catharina, Hirsch, Joshua, de Vries, Jolanda, Lohle, Paul, Carli, Dennis, Venmans, Alexander, Lodder, Paul, Donga, Esther, van Oudheusden, Thijs, Boukrab, Issam, Schoemaker, Kees, Smeets, Albert, Schonenberg, Catharina, Hirsch, Joshua, de Vries, Jolanda, and Lohle, Paul

Abstract

Background Evidence regarding percutaneous vertebroplasty (PV) for chronic painful osteoporotic vertebral compression fractures (OVCFs) remains limited. Purpose To compare pain relief, quality of life, and disability between PV and active control (anesthetic infiltration) interventions for chronic OVCF. Materials and Methods This prospective randomized clinical trial was conducted between May 2013 and June 2019 in participants with pain due to OVCF lasting longer than 3 months with bone marrow edema present at MRI. Study participants were randomly assigned to undergo PV ( n = 40) or active control intervention ( n = 40). The primary outcome was pain severity, assessed with the visual analog scale (VAS) (range, 0-10) during 12 months after treatment. Secondary outcomes included Quality of Life Questionnaire of the European Foundation for Osteoporosis (QUALEFFO) score (range, 0-100) and Roland Morris Disability Questionnaire (RMDQ) score (range, 0-100). Outcomes were analyzed according to a longitudinal multilevel model used to test the difference between groups in change from baseline across follow-up. Results The mean age of the 80 participants (54 women) was 69 years ± 10 (SD) in the PV group and 71 years ± 10 in the active control group. VAS score was 7.6 (95% CI: 7.0, 8.2) in the PV group and 7.3 (95% CI: 6.9, 7.8) in the active control group at baseline ( P = .47) and 3.9 (95% CI: 3.1, 4.8) and 5.1 (95% CI: 4.3, 6.0), respectively, at month 12 ( P = .045). At month 12, the group difference from baseline was 1.3 (95% CI: 0.1, 2.6; P = .02) for VAS, 5.2 (95% CI: 0.9, 9.4; P = .02) for QUALEFFO, and 7.1 (95% CI: -3.3, 17.5; P = .18) for RMDQ, favoring the PV group. Conclusion In the treatment of pain caused by chronic OVCFs, PV is more effective for pain relief and quality of life improvement than anesthetic injection alone, with similar improvement for disability between the groups.

Published
2023

47. CBT-based Online Self-help Training to Reduce Fear and Distress After Cancer (CAREST Randomized Trial): 24 Months Follow-up Using Latent Growth Models and Latent Class Analysis.

Author

Helmondt, Sanne Jasperine van, Lodder, Paul, Woezik, Rosalie van, Vries, Jolanda de, and Lee, Marije Liesbeth van der

Subjects
*ONLINE education, *PSYCHOLOGICAL distress, *CANCER relapse, *COGNITIVE therapy, *RANDOMIZED controlled trials, *BIBLIOTHERAPY
Abstract

Background Psychological distress (PD) and fear of cancer recurrence (FCR) are common consequences of surviving cancer. Online self-help training could help many cancer survivors deal with PD and FCR at low costs. Purpose To evaluate the long-term effectiveness of the CAncer REcurrence Self-help Training (CAREST trial) to reduce PD and FCR. Moreover, to evaluate the relation between FCR and PD across time and identify subgroups representing different change trajectories in FCR over time and their predictors. Methods This multicenter randomized controlled trial included 262 female breast cancer survivors, assigned to online self-help training or care as usual. Participants completed questionnaires at baseline and four times during the 24-month follow-up. The primary outcomes were PD and FCR (Fear of Cancer Recurrence Inventory). Latent growth curve modeling (LGCM) and repeated measures latent class analysis (RMLCA) were performed, both according to the intention‐to‐treat principle. Results LGCM showed no differences between the average latent slope in both groups for both PD and FCR. The correlation between FCR and PD at baseline was moderate for the intervention group and strong for the CAU group and did not significantly decrease over time in both groups. RMLCA revealed five latent classes and several predictors of class membership. Conclusions We did not find a long-term effect of the CBT‐based online self-help training in reducing PD or FCR, nor in their relation. Therefore, we recommend adding professional support to online interventions for FCR. Information about FCR classes and predictors may contribute to improvement of FCR interventions. [ABSTRACT FROM AUTHOR]

Published
2023
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