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2. Campylobacter fetus foodborne illness outbreak in the elderly

Author

Grouteau, Gaspard, primary, Mignonat, Cédric, additional, Marchou, Bruno, additional, Martin-Blondel, Guillaume, additional, Glass, Olivier, additional, Roubaud-Baudron, Claire, additional, Lansalot-Matras, Pauline, additional, Alik, Simon, additional, Balardy, Laurent, additional, De Nadaï, Thomas, additional, Bénéjat, Lucie, additional, Jehanne, Quentin, additional, Le Coustumier, Alain, additional, and Lehours, Philippe, additional

Published
2023
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3. Predominance of healthcare-associated cases among episodes of community-onset bacteraemia due to extended-spectrum β-lactamase-producing Enterobacteriaceae

Author

Aissa, Nejla, Losniewski, Alain, Henard, Sandrine, Rabaud, Christian, Janssen, Cécile, Pagani, Léonardo, Bland, Stéphane, Gaillat, Jacques, Bru, Jean Pierre, Bonnin, Pierre, Clavère, Gaelle, Vitrat, Virginie, Maulin, Laurence, Quarsaet, Luc, Roger, Helene, Euzen, Jean-Baptiste, Denes, Eric, Couve-Daecon, Elodie, Lechiche, Catherine, Lavigne, Jean-Philippe, Mondain, Véronique, Pulcini, Celine, Garnier, Veronique, Lambert, Dorothée, Hentzien, Maxime, Nguyen, Yohan, Talarmin, Jean Paul, Rameau, Pascaline, Geffroy, Françoise, Salmon-Rousseau, Arnaud, Cattoir, Vincent, Froissart, Antoine, Aberrane, Said, Legout, Laurence, Roblot, France, Beraud, Guillaume, Pavese, Patricia, Belmonte, Olivier, Traversier, Nicolas, Bellec, Laurent, Lagrange-Xelot, Marie, Moiton, Marie-Pierre, Kuli, Barbara, Longuet, Pascal, Scanvic, Agnes, Colombain, Lea, Ferreyra, Milagros, Jean, Maxime, Eden, Aurelia, Laurens, Etienne, Saada, Matthieu, Aumaitre, Hugues, Malet, Martine, Roustant, Frederique, LeMoing, Vincent, Helene, Jean-Pierre, Theodore, Jonathan, Garandeau, Caroline, Caillon, Jocelyne, Olivero, Benjamin, Boutoille, David, Lepelletier, Didier, Grandière-Perez, Lucia, Beaudron, Aurélie, Ramanantsoa, Céline, Varache, Catherine, Varache, Nicolas, Crochette, Nicolas, Hitoto, Hikombo, Blanchi, Sophie, Penn, Pascale, Louis, Bernard, Vanjak, Dominique, Escande, Marie-Christine, Patrigeon, René-Gilles, Honoré, Stéphanie, Barrelet, Audrey, Amara, Marlène, Galempoix, Jean-Marc, Réveil, Jean-Claude, Bucchiotty, Patricia, Couzigou, Carine, LeMonnier, Alban, Boidin, Emilie, Sire, Stephane, Luizy, Nelly, Bronstain, Caroline, Harbarth, Stephan, Fankhauser, Carolina, Brossier, Caroline, von Dach, Elodie, Sauve, Colette, Adam, Marie-Noelle, Hocqueloux, Laurent, Bret, Laurent, André, Marie-Hélène, Barruet, Régine, Challier, Marion, Cabié, Andre, Roze, Benoit, Plesiat, Patrick, Jeanot, Katy, Patry, Isabelle, Moreau, Joséphine, Chirouze, Catherine, Laurent, Aaron, Bachelier, Marie-Nadège, Kac, Guillaume, Farthouat, Nicolas, Feuillebois, Nicolas, Guimard, Thomas, Bourdon, Sandra, Nguyen, Sophie, Alfandari, Serge, Bentayeb, Houcine, Albertini, Mari-Thérèse, Marchou, Bruno, Gaudré, Noémie, Dubois, Damien, Guillet-Caruba, Christelle, Doucet Populaire, Florence, Fortineau, Nicolas, Escaut, Leila, Lesprit, Philippe, Fihman, Vincent, Gauzit, Rémy, Raymond, Josette, Kerneis, Solene, Leflon-Guibout, Veronique, Lefort, Agnes, Dinh, Aurelien, Roux, Anne-Laure, Abgrall, Sophie, Jauréguy, Françoise, Lucet, Jean-Christophe, Soismier, Nathalie, Lopes, Amanda, Cambau, Emmanuelle, Manceron, Veronique, Barnaud, Guilène, Zahar, Jean-Ralph, Ruckly, Stephane, Hikombo, Hitoto, Bernard, Louis, Timsit, Jean-François, and Brun-Buisson, Christian

Published
2017
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6. High Risk Features Contrast With Favorable Outcomes in HIV-associated Hodgkin Lymphoma in the Modern cART Era, ANRS CO 16 LYMPHOVIR Cohort

Author

Besson, Caroline, Lancar, Remi, Prevot, Sophie, Brice, Pauline, Meyohas, Marie-Caroline, Marchou, Bruno, Gabarre, Jean, Bonnet, Fabrice, Goujard, Cécile, Lambotte, Olivier, Boué, François, Mounier, Nicolas, Partisani, Marialuisa, Raffi, Francois, Costello, Régis, Hendel-Chavez, Houria, Algarte-Genin, Michele, Trabelsi, Selma, Marchand, Lucie, Raphael, Martine, Taoufik, Yassine, and Costagliola, Dominique

Published
2015

8. Alveolar and Blood T Lymphocyte Profiles in Pneumocystis jirovecii-Positive Patients: Effects of HIV Status

Author

Iriart, Xavier, Witkowski, Benoit, Cassaing, Sophie, Abbes, Sarah, Menard, Sandie, Fillaux, Judith, Valentin, Alexis, Linas, Marie-Denise, Tkaczuk, Jean, Huget, Françoise, Huynh, Anne, Hermant, Christophe, Escamilla, Roger, Kamar, Nassim, Cointault, Olivier, Lavayssiere, Laurence, Alvarez, Muriel, Blancher, Antoine, Marchou, Bruno, Magnaval, Jean-François, and Berry, Antoine

Published
2011
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11. Immunity, inflammation and reservoir in patients at an early stage of HIV infection on intermittent ART (ANRS 141 TIPI Trial)

Author

Piroth, Lionel, Moinot, Laetitia, Yeni, Patrick, Avettand-Fénoel, Véronique, Reynes, Jacques, Girard, Pierre-Marie, Marchou, Bruno, Georget, Aurore, Rouzioux, Christine, Autran, Brigitte, Duvillard, Laurence, Chêne, Geneviève, Fagard, Catherine, Anglaret, Xavier, Boué, François, Commoy, Marie-Josèphe, Couffin-Cadiergues, Sandrine, Diallo, Alpha, Piketty, Christophe, Préau, Marie, Taburet, Anne-Marie, Buseyne, Florence, Costagliola, Dominique, Delaugerre, Constance, Hoen, Bruno, Lortholary, Olivier, Pilorgé, Fabrice, Arvieux, Cédric, Jacomet, Christine, Sgro, Catherine, Loïodice, Laurence, Ait-Ouferoukh, Sofiane, Assuied, Alex, Colin, Céline, Couturier, Françoise, Rouch, Elodie, Soutthiphong, Anne-Aygline, and Taïeb, Audrey

Published
2016
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15. Altered CD[4.sup.+] T cell homing to the gut impairs mucosal immune reconstitution in treated HIV-infected individuals

Author

Mavigner, Maud, Cazabat, Michelle, Dubois, Martine, L'Faqihi, Fatima-Ezzahra, Requena, Mary, Pasquier, Christophe, Klopp, Pascale, Amar, Jacques, Alric, Laurent, Barange, Karl, Vinel, Jean-Pierre, Marchou, Bruno, Massip, Patrice, Izopet, Jacques, and Delobel, Pierre

Subjects
T cells -- Health aspects -- Physiological aspects -- Research, Immune response -- Physiological aspects -- Research, HIV patients -- Health aspects, Health care industry
Abstract

Depletion of CD[4.sup.+] T cells from the gut occurs rapidly during acute HIV-1 infection. This has been linked to systemic inflammation and disease progression as a result of translocation of microbial products from the gut lumen into the bloodstream. Combined antiretroviral therapy (cART) substantially restores CD[4.sup.+] T cell numbers in peripheral blood, but the gut compartment remains largely depleted of such cells for poorly understood reasons. Here, we show that a lack of recruitment of CD[4.sup.+] T cells to the gut could be involved in the incomplete mucosal immune reconstitution of cART-treated HIV-infected individuals. We investigated the trafficking of CD[4.sup.+] T cells expressing the gut-homing receptors CCR9 and integrin α4β7 and found that many of these T cells remained in the circulation rather than repopulating the mucosa of the small intestine. This is likely because expression of the CCR9 ligand CCL25 was lower in the small intestine of HIV-infected individuals. The defective gut homing of CCR[9.sup.+]β[7.sup.+] CD[4.sup.+] T cells - a population that we found included most gut-homing Th17 cells, which have a critical role in mucosal immune defense - correlated with high plasma concentrations of markers of mucosal damage, microbial translocation, and systemic T cell activation. Our results thus describe alterations in CD[4.sup.+] T cell homing to the gut that could prevent efficient mucosal immune reconstitution in HIV-infected individuals despite effective cART., Introduction The immune responses to the antigens encountered along the intestinal mucosa surfaces are mainly initiated in inductive sites of the gut-associated lymphoid tissue (GALT), Peyer's patches, and mesenteric lymph [...]

Published
2012
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16. Salmonella enterica serotype Typhi with nonclassical quinolone resistance phenotype

Author

Accou-Demartin, Marie, Gaborieau, Valerie, Song, Yajun, Roumagnac, Philippe, Marchou, Bruno, Achtman, Mark, and Weill, Francois-Xavier

Subjects
Codon -- Genetic aspects, Disease susceptibility -- Genetic aspects, Ciprofloxacin, Salmonella, Health
Abstract

Typhoid fever caused by Salmonella enterica serotype Typhi (hereafter referred to as Salmonella Typhi) remains a major health problem in the developing world (1). Treatment with appropriate antimicrobial drugs has [...]

Published
2011
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18. Outbreak of Leishmania braziliensis Cutaneous Leishmaniasis, Saul, French Guiana

Author

Martin-Blondel, Guillaume, Iriart, Xavier, Baidouri, Fouad El, Simon, Stephane, Mills, Deborah, Demar, Magalie, Pistone, Thierry, Taillandier, Thomas Le, Malvy, Denis, Gangneux, Jean-Pierre, Couppie, Pierre, Munckhof, Wendy, Marchou, Bruno, Ravel, Christophe, and Berry, Antoine

Subjects
Health
Abstract

To the Editor: New World cutaneous leishmaniasis (CL), a zoonotic disease, is increasingly seen among travelers returning from Latin American countries, particularly from Bolivia, Belize, and French Guiana (1). The [...]

Published
2015

19. Prospective evaluation of blood Epstein–Barr virus DNA load and antibody profile in HIV-related non-Hodgkin lymphomas

Author

Lupo, Julien, primary, Germi, Raphaële, additional, Lancar, Rémi, additional, Algarte-Genin, Michèle, additional, Hendel-Chavez, Houria, additional, Taoufik, Yassine, additional, Mounier, Nicolas, additional, Partisani, Marialuisa, additional, Bonnet, Fabrice, additional, Meyohas, Marie-Caroline, additional, Marchou, Bruno, additional, Filippova, Anastasiia, additional, Prevot, Sophie, additional, Costagliola, Dominique, additional, Morand, Patrice, additional, and Besson, Caroline, additional

Published
2021
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22. Immunologic and clinical responses to highly active antiretroviral therapy in patients with HIV infection aged >50 years

Author

Cuzin, Lise, Delpierre, Cyrille, Gerard, Stephane, Massip, Patrice, and Marchou, Bruno

Subjects
Aged patients -- Physiological aspects, Aged patients -- Prognosis, Highly active antiretroviral therapy -- Dosage and administration, Highly active antiretroviral therapy -- Testing, HIV testing -- Forecasts and trends, Immunological research -- Evaluation, HIV infection -- Demographic aspects, HIV infection -- Drug therapy, HIV infection -- Patient outcomes, HIV infection -- Research, Market trend/market analysis, Health, Health care industry
Published
2007

23. High-risk groups for late diagnosis of HIV infection: a need for rethinking testing policy in the general population

Author

Delpierre, Cyrille, Cuzin, Lise, Lauwers-Cances, Valerie, Marchou, Bruno, and Lang, Thierry

Subjects
France -- Health policy, HIV infection -- Diagnosis, HIV infection -- Statistics, HIV (Viruses) -- Risk factors, HIV testing -- Research, Health
Abstract

The aim of the study was to identify high-risk groups and the determinants of late HIV diagnosis in France in the era of highly active antiretroviral therapy (HAART), from January 1996 to June 2005. Informations were collected from an electronic medical record of all HIV-1-infected patients who sought care in six HIV reference centers in France, constituting a prospective multicentric cohort. Patients were defined as 'late testers' if they had presented with either symptoms of clinical AIDS or a CD4 cell count less than 200/[mm.sup.3] during the year of diagnosis, as 'nonlate' if their CD4 count was above 200, and as 'unknown' if CD4 cell count in the year at the time of diagnosis was not documented. Among the 4516 patients available for analysis, the percentage of late testing was 38% (n = 1718) and decreased after 2003 (31.5% in 2004-2005). This percentage was higher in heterosexual men (48.2%) than in homosexual men (31.7%) or heterosexual women (32.6%) and was higher for patients older than 30. Heterosexual men living in a couple with children had a higher risk of late testing (odds ratio [OR] = 1.65, 95% confidence interval [CI]: 1.03 to 2.66), while heterosexual women in a couple without children had a lower risk (OR = 0.46, 95% CI: 0.25 to 0.83). Among homosexual men, unemployment was associated with late testing (OR = 2.23, 95% CI: 1.14 to 4.36). The proportion of late testing was still high. Groups classically identified as low risk for HIV infection, particularly heterosexual men in a couple with children, were found to be at high risk for late testing. It seems necessary to improve HIV testing policy in the heterosexual population.

Published
2006

24. R5 to X4 switch of the predominant HIV-1 population in cellular reservoirs during effective highly active antiretroviral therapy

Author

Delobel, Pierre, Sandres-Saune, Karine, Cazabat, Michelle, Pasquier, Christophe, Marchou, Bruno, Massip, Patrice, and Izopet, Jacques

Subjects
HIV infection -- Care and treatment, Highly active antiretroviral therapy -- Health aspects, Health
Abstract

A longitudinal genotypic analysis of the virus found in cellular reservoirs was conducted in 32 patients with undetectable viral loads on highly active antiretroviral therapy (HAART) for investigating whether HIV-1 genetic evolution might lead to changes in virus coreceptor usage during HAART. An R5 to X4 switch in the majority virus population could occur despite of effective HAART, suggesting that potent antiretroviral therapy produces the conditions necessary for the gradual emergence of X4 variants in cellular reservoirs.

Published
2005

27. Cellular HIV-1 DNA quantification and short-term and long-term response to antiretroviral therapy

Author

Masquelier, Bernard, Taieb, Audrey, Reigadas, Sandrine, Marchou, Bruno, Cheneau, Christine, Spire, Bruno, Charpentier, Charlotte, Leport, Catherine, Raffi, François, Chêne, Geneviève, Descamps, Diane, Leport, C., Raffi, F., Chêne, G., Salamon, R., Moatti, J.-P., Pierret, J., Spire, B., Brun-Vézinet, F., Fleury, H., Masquelier, B., Peytavin, G., Garraffo, R., Costagliola, D., Dellamonica, P., Katlama, C., Meyer, L., Salmon, D., Sobel, A., Cuzin, L., Dupon, M., Duval, X., Le Moing, V., Marchou, B., May, T., Morlat, P., Rabaud, C., Waldner-Combernoux, A., Reboud, P., Couffin-Cadiergues, Sandrine, Marchand, Lucie, Bouteloup, V., Bouhnik, A. D., Brunet-François, C., Caron, V., Carrieri, M. P., Courcoul, M., Couturier, F., Hardel, L., Iordache, L., Kurkdji, P., Martiren, S., Préau, M., Protopopescu, C., Surzyn, J., Taieb, A., Villes, V., Schmit, J. L., Chennebault, J. M., Faller, J. P., Mgy-Bertrand, N., Hoen, B., Drobachef, Bouchaud, O., Dupon, M., Longy-Boursier, Morlat, P., Ragnaud, J. M., Granier, P., Garré, M., Verdon, R., Merrien, D., Devidas, A., Sobel, A., Piroth, L., Perronne, C., Froguel, E., Ceccaldi, J., Peyramond, D., Allard, C., Reynes, J., May, T., Raffi, F., Fuzibet, J. G., Dellamonica, P., Arsac, P., Bouvet, E., Bricaire, F., Bergmann, P., Cabane, J., Monsonego, J., Girard, P. M., Guillevin, L., Herson, S., Leport, C., Meyohas, M. C., Molina, J. M., Pialoux, G., Salmon, D., Roblot, P., Jaussaud, R., Michelet, C., Lucht, F., Debord, T., Rey, D., De Jaureguiberry, J. P., Marchou, B., and Bernard, L.

Published
2011
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38. Early changes in coagulation but not inflammatory biomarkers under intermittent ART: the randomized ANRS 106 WINDOW trial

Author

Gallien, Sébastien, Charreau, Isabelle, Fonsart, Julien, Mourah, Samia, Kalidi, Issa, Delobel, Pierre, Marchou, Bruno, Aboulker, Jean?Pierre, and Molina, Jean?Michel

Subjects
Antiviral agents -- Patient outcomes, Immunity -- Identification and classification -- Health aspects, AIDS (Disease) -- Research, AIDS research, HIV infection -- Development and progression -- Drug therapy, Health
Abstract

Introduction: In the SMART trial, baseline plasma hsCRP, IL6 and D‐dimer levels were strongly correlated to all‐cause mortality. A case‐control study has shown an increase of IL‐6 and D‐dimer levels after one month of antiretroviral therapy (ART) interruption, which was correlated to viral load. Restarting ART was associated to a decrease in D‐dimer but not IL‐6 or hsCRP levels. We assessed biomarkers levels up to 96 weeks in ART‐experienced adults with plasma HIV RNA levels Methods: Stored plasma for 160 participants (80 IT and 80 CT), matched by age, sex and CDC classification, were analyzed blinded for IL‐6, sCD‐14, hsCRP and D‐dimer levels at baseline, week 8 (IT group only), week 16 and week 96. Lower levels of detection for IL‐6, sCD14, hsCRP and D‐Dimer were 1.5 pg/mL, 250 ng/mL, 0.03 µg/mL and 0.21 µg/mL, respectively. The primary objective was to compare changes in IL‐6, hsCRP, sCD14 and D‐dimer plasma levels from baseline to week 8, 16 and 96 in the IT and CT arms. Biomarkers levels were log10 transformed prior to analysis. Results: At baseline, patients were mostly men (86%), with a median age of 40 years, a CD4+ T‐cell count of 768/mm[sup.3], have received a median of 4.7 years of ART and 85% had HIV RNA Compared to baseline, D‐dimer levels significantly increased 8 weeks after ART interruption in the IT arm (+23% fold change, 95% CI +9% to +39%) but reverted to baseline levels at week 16 and remained unchanged at week 96. There was no significant change from baseline in the other biomarker levels in the IT arm. Similarly, no significant change from baseline in biomarker levels was seen in the CT arm up to 96 weeks. Conclusion: Coagulation and inflammatory biomarkers levels remained stable over 96 weeks in well‐suppressed HIV‐infected patient on ART. Following ART interruption there was a significant increase in D‐dimer but not in inflammatory biomarkers levels. This increase was reversed upon reintroduction of ART. These data suggest that ART interruption increases coagulation rather than inflammatory biomarkers., Table 1: Changes in biomarkers levels in participants from the intermittent (IT) vs continuous (CT) treatment arms through 96 weeks (*p=0.002, Wilcoxon test) IL‐6(pg/mL) sCD14(ng/mL) hsCRP(#x00B5;g/mL) D‐dimer(µg/mL) IT CT IT [...]

Published
2014
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41. Epstein–Barr virus biomarkers have no prognostic value in HIV-related Hodgkin lymphoma in the modern combined antiretroviral therapy era

Author

Lupo, Julien, primary, Germi, Raphaële, additional, Lancar, Rémi, additional, Algarte-Genin, Michèle, additional, Hendel-Chavez, Houria, additional, Taoufik, Yassine, additional, Mounier, Nicolas, additional, Partisani, Marialuisa, additional, Bonnet, Fabrice, additional, Meyohas, Marie-Caroline, additional, Marchou, Bruno, additional, Semanova, Touyana, additional, Prevot, Sophie, additional, Costagliola, Dominique, additional, Morand, Patrice, additional, and Besson, Caroline, additional

Published
2019
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42. Genotypic prediction of HIV-1 subtype D tropism

Author

Chaix Marie-Laure, Delobel Pierre, Raymond Stéphanie, Cazabat Michelle, Encinas Stéphanie, Bruel Patrick, Sandres-Sauné Karine, Marchou Bruno, Massip Patrice, and Izopet Jacques

Subjects
Immunologic diseases. Allergy, RC581-607
Abstract

Abstract Background HIV-1 subtype D infections have been associated with rapid disease progression and phenotypic assays have shown that CXCR4-using viruses are very prevalent. Recent studies indicate that the genotypic algorithms used routinely to assess HIV-1 tropism may lack accuracy for non-B subtypes. Little is known about the genotypic determinants of HIV-1 subtype D tropism. Results We determined the HIV-1 coreceptor usage for 32 patients infected with subtype D by both a recombinant virus phenotypic entry assay and V3-loop sequencing to determine the correlation between them. The sensitivity of the Geno2pheno10 genotypic algorithm was 75% and that of the combined 11/25 and net charge rule was 100% for predicting subtype D CXCR4 usage, but their specificities were poor (54% and 68%). We have identified subtype D determinants in the V3 region associated with CXCR4 use and built a new simple genotypic rule for optimizing the genotypic prediction of HIV-1 subtype D tropism. We validated this algorithm using an independent GenBank data set of 67 subtype D V3 sequences of viruses of known phenotype. The subtype D genotypic algorithm was 68% sensitive and 95% specific for predicting X4 viruses in this data set, approaching the performance of genotypic prediction of HIV-1 subtype B tropism. Conclusion The genotypic determinants of HIV-1 subtype D coreceptor usage are slightly different from those for subtype B viruses. Genotypic predictions based on a subtype D-specific algorithm appear to be preferable for characterizing coreceptor usage in epidemiological and pathophysiological studies.

Published
2011
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45. Development of β-Lactam-Resistant Enterobacter cloacae in Mice

Author

Marchou, Bruno, Hamzehpour, Mehri Michea, Lucain, Christine, and Pèchere, Jean-Claude

Abstract

We compared the ability of four newer β-lactam compounds to produce resistance in an experimental model of Enterobacter cloacae infection. Mice infected intraperitoneally developed resistance depending on antibiotic treatment and the dose given. Percentages of mice in which resistance was observedwere as follows: 100% after ceftriaxone (50 mg/kg, two doses); 87% after ceftriaxone (50 mg/kg, one dose); 35% after ceftriaxone (500 mg/kg, one dose); and 21% after carumonam (25 mg/kg, two doses). No resistance occurred after therapy with either BMY 28142(25 mg/kg, two doses) or Sch 34343 (50 mg/kg, two doses). Heterogeneous resistance to 13-lactams among the cells within a given Enterobacter population accounted for these differences. The minimal concentration inhibiting the growth of the preexisting resistant variants, together with the antibiotic concentrations obtained in the peritoneal fluid, were associated with further emergence of resistance in the mouse treated with this antibiotic

Published
2017

47. A Comparison of Adult and Pediatric Measles Patients Admitted to Emergency Departments during the 2008^|^ndash;2011 Outbreak in the Midi-Pyr^|^eacute;n^|^eacute;es Region of France

Author

Marchou Bruno, Grouteau Erick, Honorat Raphaele, Casasoprana Ameline, Claudet Isabelle, CHU Toulouse [Toulouse], Embodiment, social ineQualities, lifecoUrse epidemiology, cancer and chronIc diseases, intervenTions, methodologY (Equipe 5 - EQUITY), Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées

Subjects
Microbiology (medical), Pediatrics, medicine.medical_specialty, Measles, 03 medical and health sciences, 0302 clinical medicine, Disease severity, Medicine, 030212 general & internal medicine, Young adult, ComputingMilieux_MISCELLANEOUS, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, 0303 health sciences, 030306 microbiology, business.industry, Incidence (epidemiology), Outbreak, Retrospective cohort study, General Medicine, Laboratory results, University hospital, medicine.disease, 3. Good health, Infectious Diseases, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business
Abstract

The present French and European measles outbreaks show a bimodal distribution: the two most affected populations are infants aged less than 1 year and adults older than 20 years. The purpose of this study was to determine wether there were differences in the clinical presentation and evolution of measles between adult and pediatric patients. We performed a retrospective study of adult and pediatric measles patients admitted to three tertiary-level university hospitals between January 2008 and May 2011. Data were extracted from medical charts and positive laboratory results. Collected data were age, sex, geographical origin, vaccination status, source of exposure, overseas travel before symptom onset, clinical symptoms, risk factors for complications, severity criteria on admission, type of diagnosis, biological abnormalities, complications, and treatments. A total of 305 patients (171 children and 134 adults) were included in the study. The mean age was 4.6 ± 4.4 years in children and 26.7 ± 8.1 years in adults. Children were less often hospitalized than adults (29% vs. 66%). A comparison between hospitalized pediatric (n = 49) and adult (n = 89) patients revealed that the former had a higher incidence of complications (P < 0.0001), more otorhinolaryngological complications (24% vs. 1%; P < 0.0001), and a higher incidence of severe criteria on admission (P = 0.02). Hospitalized pediatric patients differed from adults in terms of disease severity and complications.

Published
2014

50. Etablissement d'une présence endémique de la Bilharziose en Corse

Author

Berry, Antoine, Fillaux, J., Martin-Blondel, Guillaume, Boissier, Jérôme, Iriart, Xavier, Marchou, Bruno, Magnaval, J., Delobel, P., Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse], Université de Perpignan Via Domitia (UPVD), Interactions Hôtes-Pathogènes-Environnements (IHPE), and Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université de Perpignan Via Domitia (UPVD)

Subjects
[SDE.BE]Environmental Sciences/Biodiversity and Ecology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2016

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