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In the global context of climate change and frequent occurrence of extreme temperature variations, the impact of harsh climates on the outdoor thermal environment in remote, cold, mountainous villages is particularly pronounced, leading to many negative effects. The geoorphology of the village sites and their building layouts are important factors affecting the outdoor thermal environment. Therefore, exploring the spatiotemporal characteristics of these factors is significant for optimizing village construction and improving living environments. In this study, taking Fangjialiang Village in a cold mountainous area as an example, we analysed the outdoor thermal environment from a spatiotemporal perspective through comprehensive field investigations and measurements. The findings obtained are summarized as follows: (1) Landform elements were limited by boundary and azimuth constraints (difference in time temperature decay rate between the valley interior and valley edge area: ΔK = 0.48°C/m). (2) The temperature inversion phenomenon in the valley was significant (the average rate of temperature increase with elevation was 0.037°C/m). (3) The vertical distribution of the temperature was more susceptible to the influence of the difference in elevation inside the village (ρ≈–0.48). The average rate of temperature decrease with elevation is 0.489°C/m. (4) A compact building layout could sustainably weaken the effects of topographic elements (e.g. the average temperature sequenced as: closed internal courtyard (Avg = 14.60°C)> semi-open horizontal village street (Avg = 13.58°C)> fully open space (Avg = 13.11°C)). Therefore, the results of the study further revealed the coordinated relationship between the natural environment and rural settlements, proved the integrated effects of village siting and building layout, and provided useful insights for the construction and living environment optimization of mountain villages.

Vehicle edge computing enhances the computational capabilities of vehicles by offloading computations. The existing task offloading strategies do not simultaneously consider data security, priority of offloading tasks, computation resource release, and incentivizing vehicle to share computation resources, making it difficult to adapt to dynamic vehicle environments. To address these problems, this paper investigates the distributed vehicle-to-vehicle (V2V) computation offloading problem, establishes a Markov decision process, and designs a deep reinforcement learning-based optimal task allocation strategy for computation offloading. This paper utilizes dynamic pricing to incentivize vehicle to share computation resources while considering task priorities and computation resource release mechanisms. Additionally, this paper embeds the offloading scheme into the blockchain, employs the vehicles blockchain with identity authentication mechanisms to encrypt sensitive information such as vehicle information, task information, and transaction information, thus ensuring data security. Simulation experimental results validate the performance of the proposed method. Compared with other algorithms, the average efficiency of the system is improved by at least 9.58% while the training time is saved by 10.28%.

Background Traditionally, open reduction with Kirschner wire fixation (ORKF) is used to treat paediatric patients with significantly displaced lateral humeral condyle fractures. However, in recent years, the use of closed reduction percutaneous pinning (CRPP) to treat lateral humeral condyle fractures in children has been increasingly reported. However, there is some controversy as to which surgical technique is more effective and safe. Objective To evaluate the efficacy and safety of CRPP and ORKF in paediatric patients with lateral humeral condyle fractures. Methods Chinese databases including CNKI, Wanfang Data, VIP and CBM and English databases including PubMed, Embase, Cochrane Library and Web of Science were searched from inception to 2023-01-01 for the case-control studies of CRPP and ORKF to treat the lateral humeral condyle fractures, the quality of the literature was evaluated and data were extracted. RevMan 5.3 software was performed to conduct a meta-analysis comparing the relevant efficacy and safety indexes of the two surgical techniques. Results A total of 16 studies involving 1 165 cases were included for this meta-analysis. The results of meta-analysis indicated that CRPP was superior in status of surgical time (MD=-11.81, 95%CI=-15.04 to -8.58, P0.05) . Conclusion CRPP was superior to ORKF in the treatment of pediatric lateral humeral condyle fractures, both in terms of efficacy and overall complications, but more high-quality studies are needed to further validate CRPP in terms of specific complications.

The demand for advanced camouflage technology is increasing in modern military warfare. Multispectral compatibility and adaptive capabilities are increasingly desired features in camouflage materials. However, due to the strong wavelength dependence and limited tunability of electromagnetic wave responses, achieving simultaneous multispectral compatibility and adaptive capability in a single structure or device remains a challenge. By integrating coding metamaterials with infrared (IR) electrochromic devices, we demonstrate a highly integrated multispectral metal-based electro-optical metadevice. The fabricated metadevices enable the reversible tunability of IR emissivity (0.58 at 3–5 µm, 0.50 at 7.5–13 µm) and wideband microwave scattering reduction (>10 dB at 10–20 GHz). The excellent integration performance is attributed to the remarkable electromagnetic control capabilities of the coding metamaterials in a chessboard-like configuration and the IR electrochromic devices based on metal reversible electrodeposition. Furthermore, the monolithic integrated design with shared barium fluoride substrate and electrodes allows the metadevices to have a simple architecture, and the careful design avoids coupling between functions. Our approach is general enough for the design of various electrochromic devices and metamaterials for multispectral camouflage, offering valuable insights for the development of advanced adaptive multispectral camouflage systems.

Public trust in medical institutions is essential for ensuring compliance with medical directives. However, the politicization of public health issues and the polarized nature of major news outlets suggest that partisanship and news consumption habits can influence medical trust. This study employed a survey with 858 participants and used regression analysis to assesses how news consumption habits and information assessment traits (IATs) influence trust in medical scientists. IATs included were conscientiousness, openness, need for cognitive closure (NFCC), and cognitive reflective thinking (CRT). News sources were classified on the basis of factuality and political bias. Initially, readership of liberally biased news was positively associated with medical trust (p < 0.05). However, this association disappeared when controlling for the news source's factuality (p = 0.28), while CRT (p < 0.05) was positively associated with medical trust. When controlling for conservatively biased news sources, factuality of the news source (p < 0.05) and NFCC (p < 0.05) were positively associated with medical trust. While partisan media bias may influence medical trust, these results suggest that those who have higher abilities to assess information and who prefer more credible news sources have a greater trust in medical scientists.

Abstract Background Myopia is the most prevalent refractive error and a growing global health concern that significantly affects visual function. Researchers have recently emphasized considerably on the influence of lifestyle on myopia incidence and development. This study investigates the relationship between leisure sedentary behaviors (LSB)/physical activity (PA)/sleep traits and myopia. Methods LSB, PA, and sleep trait-associated genetic variants were used as instrument variables in a Mendelian randomization (MR) study to examine their causal effects on myopia. Summary genome-wide association studies (GWASs) statistical data for LSB and PA were obtained from UK Biobank, and the data of sleep traits was obtained from UK Biobank, UK Biobank and 23andMe, and FinnGen. We used summary statistics data for myopia from MRC IEU. The MR analyses was performed using the inverse variance-weighted (IVW), MR-Egger, weighted median, and MR Pleiotropy RESidual Sum and Outlier methods. Results Computer use was genetically predicted to increase the myopia risk [IVW odds ratio (OR) = 1.057; 95% confidence interval (CI), 1.038–1.078; P = 7.04 × 10− 9]. The self-reported moderate-to-vigorous physical activity (MVPA) (IVW OR = 0.962; 95% CI, 0.932–0.993; P = 1.57 × 10− 2) and television watching (IVW OR = 0.973; 95% CI, 0.961–0.985, P = 1.93 × 10− 5) were significantly associated with a lower myopia risk. However, genetically predicted sleep traits or accelerometer-measured physical activity had no significant associations with myopia. Conclusion Our results indicated that computer use is a risk factor for myopia, whereas television watching and MVPA may protect against myopia. These findings shed new light on possible strategies for reducing the prevalence of myopia.

AIM: To explore the clinical efficacy and safety of stromal lenticule addition keratoplasty (SLAK) with corneal crosslinking (CXL) on patients with corneal ectasia secondary to femtosecond laser-assisted in situ keratomileusis (FS-LASIK). METHODS: A series of 5 patients undertaking SLAK with CXL for the treatment of corneal ectasia secondary to FS-LASIK were followed for 4-9mo. The lenticules were collected from patients undertaking small incision lenticule extraction (SMILE) for the correction of myopia. Adding a stromal lenticule was aimed at improving the corneal thickness for the safe application of crosslinking and compensating for the thin cornea to improve its mechanical strength. RESULTS: All surgeries were conducted successfully with no significant complications. Their best corrected visual acuity (BCVA) ranged from 0.05 to 0.8-2 before surgery. The pre-operational total corneal thickness ranged from 345-404 μm and maximum keratometry (Kmax) ranged from 50.8 to 86.3. After the combination surgery, both the corneal keratometry (range 55.9 to 92.8) and total corneal thickness (range 413-482 μm) significantly increased. Four out of 5 patients had improvement of corneal biomechanical parameters (reflected by stiffness parameter A1 in Corvis ST). However, 3 patients showed decreased BCVA after surgery due to the development of irregular astigmatism and transient haze. Despite the onset of corneal edema right after SLAK, the corneal topography and thickness generally stabilized after 3mo. CONCLUSION: SLAK with CXL is a potentially beneficial and safe therapy for advanced corneal ectasia. Future work needs to address the poor predictability of corneal refractometry and compare the outcomes of different surgical modes.

Abstract Fat-forming solitary fibrous tumor is a rare and specific subtype of solitary fibrous tumor. In this case, a mass of 8.3 cm in diameter was found in a 59-year-old male patient’s right retroperitoneum, as revealed by abdominal contrast-enhanced computed tomography (CT) images. The tumor exhibited a well-circumscribed nature and histological features characterized by a combination of hemangiopericytomatous vasculature and mature adipose tissue, comprising around 70% of the total tumor composition. Immunohistochemistry staining revealed diffuse positive expression of STAT6 and CD34 in the tumor cells. Based on these findings, the final diagnosis was determined to be a fat-forming solitary fibrous tumor located in the retroperitoneum. It is important to consider other potential differential diagnoses, including angiomyolipoma, dedifferentiated liposarcoma, spindle cell lipoma, and atypical lipomatous tumor/well-differentiated liposarcoma.

Nonalcoholic fatty liver disease (NAFLD) is marked by hepatic steatosis accompanied by an inflammatory response. At present, there are no approved therapeutic agents for NAFLD. Dendrobium Huoshanense polysaccharide (DHP), an active ingredient extracted from the stems of Dendrobium Huoshanense, and exerts a protective effect against liver injury. However, the therapeutic effects and mechanisms of action DHP against NAFLD remain unclear. DHP was extracted, characterized, and administered to mice in which NAFLD had been induced with a high-fat and high-fructose drinking (HFHF) diet. Our results showed that DHP used in this research exhibits the characteristic polysaccharide peak with a molecular weight of 179.935 kDa and is composed primarily of Man and Glc in a molar ratio of 68.97:31.03. DHP treatment greatly ameliorated NAFLD by significantly reducing lipid accumulation and the levels of liver function markers in HFHF-induced NAFLD mice, as evidenced by decreased serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), total cholesterol (TC) and total triglyceride (TG). Furthermore, DHP administration reduced hepatic steatosis, as shown by H&E and Oil red O staining. DHP also inhibited the Toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-κB) signaling pathway expression, thereby reducing levels of hepatic proinflammatory cytokines. Besides, untargeted metabolomics further indicated that 49 metabolites were affected by DHP. These metabolites are strongly associated the metabolism of glycine, serine, threonine, nicotinate and nicotinamide, and arachidonic acid. In conclusion, DHP has a therapeutic effect against NAFLD, whose underlying mechanism may involve the modulation of TLR4/NF-κB, reduction of inflammation, and regulation of the metabolism of glycine, serine, threonine, nicotinate and nicotinamide metabolism, and arachidonic acid metabolism.

Tea plants are a perennial crop with significant economic value. Chlorophyll, a key factor in tea leaf color and photosynthetic efficiency, is affected by the photoperiod and usually exhibits diurnal and seasonal variations. In this study, high-throughput transcriptomic analysis was used to study the chlorophyll metabolism, under different photoperiods, of tea plants. We conducted a time-series sampling under a skeleton photoperiod (6L6D) and continuous light conditions (24 L), measuring the chlorophyll and carotenoid content at a photoperiod interval of 3 h (24 h). Transcriptome sequencing was performed at six time points across two light cycles, followed by bioinformatics analysis to identify and annotate the differentially expressed genes (DEGs) involved in chlorophyll metabolism. The results revealed distinct expression patterns of key genes in the chlorophyll biosynthetic pathway. The expression levels of CHLE (magnesium-protoporphyrin IX monomethyl ester cyclase gene), CHLP (geranylgeranyl reductase gene), CLH (chlorophyllase gene), and POR (cytochrome P450 oxidoreductase gene), encoding enzymes in chlorophyll synthesis, were increased under continuous light conditions (24 L). At 6L6D, the expression levels of CHLP1.1, POR1.1, and POR1.2 showed an oscillating trend. The expression levels of CHLP1.2 and CLH1.1 showed the same trend, they both decreased under light treatment and increased under dark treatment. Our findings provide potential insights into the molecular basis of how photoperiods regulate chlorophyll metabolism in tea plants.