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384 results on '"Scarsella, Marco"'

1. Combining ERAP1 silencing and entinostat therapy to overcome resistance to cancer immunotherapy in neuroblastoma

Author

Tempora, Patrizia, D’Amico, Silvia, Gragera, Paula, Damiani, Verena, Krol, Kamila, Scaldaferri, Valentina, Pandey, Kirti, Chung, Shanzou, Lucarini, Valeria, Giorda, Ezio, Scarsella, Marco, Volpe, Gabriele, Pezzullo, Marco, De Stefanis, Cristiano, D’Oria, Valentina, De Angelis, Lorenzo, Giovannoni, Roberto, De Ioris, Maria Antonietta, Melaiu, Ombretta, Purcell, Anthony W., Locatelli, Franco, and Fruci, Doriana

Published
2024
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3. Defective peripheral B cell selection in common variable immune deficiency patients with autoimmune manifestations

Author

Friman, Vanda, Quinti, Isabella, Davydov, Alexey N., Shugay, Mikhail, Farroni, Chiara, Engström, Erik, Pour Akaber, Shirin, Barresi, Sabina, Mohamed, Ahmed, Pulvirenti, Federica, Milito, Cinzia, Granata, Guido, Giorda, Ezio, Ahlström, Sara, Karlsson, Johanna, Marasco, Emiliano, Marcellini, Valentina, Bocci, Chiara, Cascioli, Simona, Scarsella, Marco, Phad, Ganesh, Tilevik, Andreas, Tartaglia, Marco, Bemark, Mats, Chudakov, Dmitriy M., Carsetti, Rita, and Grimsholm, Ola

Published
2023
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6. Persistent B cell memory after SARS-CoV-2 vaccination is functional during breakthrough infections

Author

Terreri, Sara, Piano Mortari, Eva, Vinci, Maria Rosaria, Russo, Cristina, Alteri, Claudia, Albano, Christian, Colavita, Francesca, Gramigna, Giulia, Agrati, Chiara, Linardos, Giulia, Coltella, Luana, Colagrossi, Luna, Deriu, Gloria, Ciofi Degli Atti, Marta, Rizzo, Caterina, Scarsella, Marco, Brugaletta, Rita, Camisa, Vincenzo, Santoro, Annapaola, Roscilli, Giuseppe, Pavoni, Emiliano, Muzi, Alessia, Magnavita, Nicola, Scutari, Rossana, Villani, Alberto, Raponi, Massimiliano, Locatelli, Franco, Perno, Carlo Federico, Zaffina, Salvatore, and Carsetti, Rita

Published
2022
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9. Combined mitoxantrone and anti-TGFβ treatment with PD-1 blockade enhances antitumor immunity by remodelling the tumor immune landscape in neuroblastoma

Author

Lucarini, Valeria, Melaiu, Ombretta, D’Amico, Silvia, Pastorino, Fabio, Tempora, Patrizia, Scarsella, Marco, Pezzullo, Marco, De Ninno, Adele, D’Oria, Valentina, Cilli, Michele, Emionite, Laura, Infante, Paola, Di Marcotullio, Lucia, De Ioris, Maria Antonietta, Barillari, Giovanni, Alaggio, Rita, Businaro, Luca, Ponzoni, Mirco, Locatelli, Franco, and Fruci, Doriana

Published
2022
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10. Correction to: Focal adhesion kinase inhibitor TAE226 combined with Sorafenib slows down hepatocellular carcinoma by multiple epigenetic effects

Author

Romito, Ilaria, Porru, Manuela, Braghini, Maria Rita, Pompili, Luca, Panera, Nadia, Crudele, Annalisa, Gnani, Daniela, De Stefanis, Cristiano, Scarsella, Marco, Pomella, Silvia, Mortera, Stefano Levi, de Billy, Emmanuel, Conti, Adrian Libenzio, Marzano, Valeria, Putignani, Lorenza, Vinciguerra, Manlio, Balsano, Clara, Pastore, Anna, Rota, Rossella, Tartaglia, Marco, Leonetti, Carlo, and Alisi, Anna

Published
2022
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12. Optimization of Pyrolysis Parameters by Design of Experiment for the Production of Biochar from Sewage Sludge.

Author

Cedrone, Giacomo, Bracciale, Maria Paola, Cafiero, Lorenzo, Langone, Michela, Mattioli, Davide, Scarsella, Marco, and Tuffi, Riccardo

Subjects
CARBON dioxide adsorption, SEWAGE sludge, SLUDGE management, SOIL pollution, ADSORPTION capacity
Abstract

Sewage sludge management is a key concern in today's world. Improper disposal can lead to various environmental issues including air, water and soil pollution. Among the available technologies, thermal treatments, particularly pyrolysis, are gaining interest for their ability to reduce sewage sludge volume and to recover materials and energy from it. This study explored the influence of some relevant parameters in the thermal pyrolysis process. The design of experiment, named central composite design, was accounted to optimize temperature, heating rate and residence time in order to maximize the biochar yield and its CO2 adsorption capacity. A two-factor interaction model provided a satisfactory interpretation of the results. Within the studied ranges, maximum values of 47.8 wt% and 0.514 mol CO2/kg were obtained for the yield and CO2 adsorption capacity, respectively. Two significant experiments were repeated in a different pyrolysis system highlighting how other factors (e.g., reactor geometry, granulometry, etc.) can influence the quantity and the quality of produced biochar. The biochar obtained under the best pyrolysis conditions was characterized by a surface area of 124 m2/g and an ash content of 61 wt%. Lastly, the theoretical energy balance showed that the drying process is the main energy-intensive step in the pyrolysis of sewage sludge. [ABSTRACT FROM AUTHOR]

Published
2024
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16. The Interplay between CD27dull and CD27bright B Cells Ensures the Flexibility, Stability, and Resilience of Human B Cell Memory

Author

Grimsholm, Ola, Piano Mortari, Eva, Davydov, Alexey N., Shugay, Mikhail, Obraztsova, Anna S., Bocci, Chiara, Marasco, Emiliano, Marcellini, Valentina, Aranburu, Alaitz, Farroni, Chiara, Silvestris, Domenico Alessandro, Cristofoletti, Cristina, Giorda, Ezio, Scarsella, Marco, Cascioli, Simona, Barresi, Sabina, Lougaris, Vassilios, Plebani, Alessandro, Cancrini, Caterina, Finocchi, Andrea, Moschese, Viviana, Valentini, Diletta, Vallone, Cristina, Signore, Fabrizio, de Vincentiis, Giovanni, Zaffina, Salvatore, Russo, Giandomenico, Gallo, Angela, Locatelli, Franco, Tozzi, Alberto E., Tartaglia, Marco, Chudakov, Dmitriy M., and Carsetti, Rita

Published
2020
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17. A novel flow cytometry panel to identify prognostic markers for steroid-sensitive forms of idiopathic nephrotic syndrome in childhood

Author

Riganati, Martina, primary, Zotta, Federica, additional, Candino, Annalisa, additional, Conversano, Ester, additional, Gargiulo, Antonio, additional, Scarsella, Marco, additional, Lo Russo, Anna, additional, Bettini, Chiara, additional, Emma, Francesco, additional, Vivarelli, Marina, additional, and Colucci, Manuela, additional

Published
2024
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20. Focal adhesion kinase inhibitor TAE226 combined with Sorafenib slows down hepatocellular carcinoma by multiple epigenetic effects

Author

Romito, Ilaria, Porru, Manuela, Braghini, Maria Rita, Pompili, Luca, Panera, Nadia, Crudele, Annalisa, Gnani, Daniela, De Stefanis, Cristiano, Scarsella, Marco, Pomella, Silvia, Levi Mortera, Stefano, de Billy, Emmanuel, Conti, Adrian Libenzio, Marzano, Valeria, Putignani, Lorenza, Vinciguerra, Manlio, Balsano, Clara, Pastore, Anna, Rota, Rossella, Tartaglia, Marco, Leonetti, Carlo, and Alisi, Anna

Published
2021
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30. Supplementary Table 1 from Reversible Dysfunction of Wild-Type p53 following Homeodomain-Interacting Protein Kinase-2 Knockdown

Author

Puca, Rosa, primary, Nardinocchi, Lavinia, primary, Gal, Hilah, primary, Rechavi, Gideon, primary, Amariglio, Ninette, primary, Domany, Eytan, primary, Notterman, Daniel A., primary, Scarsella, Marco, primary, Leonetti, Carlo, primary, Sacchi, Ada, primary, Blandino, Giovanni, primary, Givol, David, primary, and D'Orazi, Gabriella, primary

Published
2023
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31. Removal of PFAS from wastewater by bio-waste adsorbent: material characterization and adsorption kinetic study

Author

Irene Bavasso, M.Paola Bracciale, Francesca Sbardella, Luca Di Palma, and Scarsella Marco

Abstract

Per- and polyfluoroalkyl substances (PFAS) are considered emerging contaminants and have been increased their attention due to their distribution in water body. These compounds are acid and characterized by a thermal stability to make them resistant to degradation processes. Activities such as tannery, paper and cardboard production, waterproof cloths, produce wastewater rich in PFAS and heavy metals. There are currently no Maximum Contaminant Levels established for PFAS chemicals and the Environmental Protection Agency is working on the definition of a technical guidance providing information on health effects and methods for the treatment of drinking water. The adsorption process is one of the technologies used for the treatment of wastewater and food residues are getting increased attention as bio-adsorbent because they can be found easily as wastes or by-products and at almost no cost. In this work the removal of PFAS was performed by using food waste such as Yerba Mate (YM) as bio-adsorbent. Adsorption tests were performed at different pH condition (from 3 to 10) and temperature (from 10 °C to 40 °C). The concentration of pollutants was determined by HPLC, UV-VIS and TOC analysis. SEM-EDS, XRD, FT-IR and BET were done to achieve a characterization of the adsorbent material.

Published
2022
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35. Nanotechnologies to use bisphosphonates as potent anticancer agents: the effects of zoledronic acid encapsulated into liposomes

Author

Marra, Monica, Salzano, Giuseppina, Leonetti, Carlo, Tassone, Pierfrancesco, Scarsella, Marco, Zappavigna, Silvia, Calimeri, Teresa, Franco, Renato, Liguori, Giuseppina, Cigliana, Giovanni, Ascani, Roberta, La Rotonda, Maria Immacolata, Abbruzzese, Alberto, Tagliaferri, Pierosandro, Caraglia, Michele, and De Rosa, Giuseppe

Published
2011
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36. Additional file 3 of Correction to: Focal adhesion kinase inhibitor TAE226 combined with Sorafenib slows down hepatocellular carcinoma by multiple epigenetic effects

Author

Romito, Ilaria, Porru, Manuela, Braghini, Maria Rita, Pompili, Luca, Panera, Nadia, Crudele, Annalisa, Gnani, Daniela, De Stefanis, Cristiano, Scarsella, Marco, Pomella, Silvia, Mortera, Stefano Levi, de Billy, Emmanuel, Conti, Adrian Libenzio, Marzano, Valeria, Putignani, Lorenza, Vinciguerra, Manlio, Balsano, Clara, Pastore, Anna, Rota, Rossella, Tartaglia, Marco, Leonetti, Carlo, and Alisi, Anna

Subjects
Data_FILES
Abstract

Additional file 8.

Published
2022
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37. Additional file 2 of Correction to: Focal adhesion kinase inhibitor TAE226 combined with Sorafenib slows down hepatocellular carcinoma by multiple epigenetic effects

Author

Romito, Ilaria, Porru, Manuela, Braghini, Maria Rita, Pompili, Luca, Panera, Nadia, Crudele, Annalisa, Gnani, Daniela, De Stefanis, Cristiano, Scarsella, Marco, Pomella, Silvia, Mortera, Stefano Levi, de Billy, Emmanuel, Conti, Adrian Libenzio, Marzano, Valeria, Putignani, Lorenza, Vinciguerra, Manlio, Balsano, Clara, Pastore, Anna, Rota, Rossella, Tartaglia, Marco, Leonetti, Carlo, and Alisi, Anna

Subjects
Data_FILES
Abstract

Additional file 7.

Published
2022
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38. Additional file 1 of Correction to: Focal adhesion kinase inhibitor TAE226 combined with Sorafenib slows down hepatocellular carcinoma by multiple epigenetic effects

Author

Romito, Ilaria, Porru, Manuela, Braghini, Maria Rita, Pompili, Luca, Panera, Nadia, Crudele, Annalisa, Gnani, Daniela, De Stefanis, Cristiano, Scarsella, Marco, Pomella, Silvia, Mortera, Stefano Levi, de Billy, Emmanuel, Conti, Adrian Libenzio, Marzano, Valeria, Putignani, Lorenza, Vinciguerra, Manlio, Balsano, Clara, Pastore, Anna, Rota, Rossella, Tartaglia, Marco, Leonetti, Carlo, and Alisi, Anna

Subjects
Data_FILES
Abstract

Additional file 6.

Published
2022
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39. Additional file 1 of Combined mitoxantrone and anti-TGFβ treatment with PD-1 blockade enhances antitumor immunity by remodelling the tumor immune landscape in neuroblastoma

Author

Lucarini, Valeria, Melaiu, Ombretta, D’Amico, Silvia, Pastorino, Fabio, Tempora, Patrizia, Scarsella, Marco, Pezzullo, Marco, De Ninno, Adele, D’Oria, Valentina, Cilli, Michele, Emionite, Laura, Infante, Paola, Di Marcotullio, Lucia, De Ioris, Maria Antonietta, Barillari, Giovanni, Alaggio, Rita, Businaro, Luca, Ponzoni, Mirco, Locatelli, Franco, and Fruci, Doriana

Abstract

Additional file 1: Fig. S1. Flow-cytometry analysis of tumor-infiltrating immune cells in mouse NB models. Fig. S2. Immune content of cisplatin- and vincristine-treated 975A2 tumors. Fig. S3. Immune content of drug-treated 975A2 tumors. Fig. S4. Effect of anti-TGFβ treatment on immune content of 975A2 tumors. Fig. S5. Effect of combined drug treatment on the recall and activation of CD8+ T cells and NK cells. Fig. S6. Treatment of mitoxantrone in combination with TGFβ and PD-1 blockade delays growth of subcutaneously transplanted 975A2 tumors and reshapes intratumoral immune infiltrate. Fig. S7. Tumor growth of drug-treated 975A2 and 9464D. Fig. S8. Expression of calreticulin in 9464D tumors. Fig. S9. Immune content of drug-treated 9464D and 975A2 tumors. Fig. S10. Immune content of drug-treated 9464D grown in the adrenal gland. Fig. S11. Mitoxantrone recalls activated CD8+ T cells and NK cells in some PDOTS when combined with TGFβ and PD-1 blockade. Fig. S12. Mitoxantrone TME of drug-treated 9464D grown in the adrenal gland. Table S1. List of antibodies. Table S2. Clinical and genetic characteristics of 7 newly diagnosed NB patients.

Published
2022
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41. Focal adhesion kinase inhibitor TAE226 combined with Sorafenib slows down hepatocellular carcinoma by multiple epigenetics effects

Author

Romito, Ilaria, primary, Porru, Manuela, additional, Braghini, Maria Rita, additional, Pompili, Luca, additional, Panera, Nadia, additional, Crudele, Annalisa, additional, Gnani, Daniela, additional, De Stefanis, Cristiano, additional, Scarsella, Marco, additional, Pomella, Silvia, additional, Mortera, Stefano Levi, additional, de Billy, Emmanuel, additional, Conti, Libenzio Adrian, additional, Marzano, Valeria, additional, Putignani, Lorenza, additional, Vinciguerra, Manlio, additional, Balsano, Clara, additional, Pastore, Anna, additional, Rota, Rossella, additional, Tartaglia, Marco, additional, Leonetti, Carlo, additional, and Alisi, Anna, additional

Published
2021
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42. Additional file 7 of Focal adhesion kinase inhibitor TAE226 combined with Sorafenib slows down hepatocellular carcinoma by multiple epigenetic effects

Author

Romito, Ilaria, Porru, Manuela, Braghini, Maria Rita, Pompili, Luca, Panera, Nadia, Crudele, Annalisa, Gnani, Daniela, De Stefanis, Cristiano, Scarsella, Marco, Pomella, Silvia, Levi Mortera, Stefano, de Billy, Emmanuel, Conti, Adrian Libenzio, Marzano, Valeria, Putignani, Lorenza, Vinciguerra, Manlio, Balsano, Clara, Pastore, Anna, Rota, Rossella, Tartaglia, Marco, Leonetti, Carlo, and Alisi, Anna

Subjects
digestive system diseases
Abstract

Additional file 7: Figure S2. Evaluation of the IC50 values of TAE226 and SOR on HCC cell viability after 2 and 5 days. Cell viability, measured by XTT assay, after 2 and 5 days from treatment with TAE226 or SOR, in HepG2 and Huh7 cells. Values are the mean OD �� SD of three independent experiments repeated at least in duplicate. Data were analysed by ANOVA. ***p

Published
2021
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43. Additional file 6 of Focal adhesion kinase inhibitor TAE226 combined with Sorafenib slows down hepatocellular carcinoma by multiple epigenetic effects

Author

Romito, Ilaria, Porru, Manuela, Braghini, Maria Rita, Pompili, Luca, Panera, Nadia, Crudele, Annalisa, Gnani, Daniela, De Stefanis, Cristiano, Scarsella, Marco, Pomella, Silvia, Levi Mortera, Stefano, de Billy, Emmanuel, Conti, Adrian Libenzio, Marzano, Valeria, Putignani, Lorenza, Vinciguerra, Manlio, Balsano, Clara, Pastore, Anna, Rota, Rossella, Tartaglia, Marco, Leonetti, Carlo, and Alisi, Anna

Subjects
digestive system diseases
Abstract

Additional file 6: Figure S1. FAK phosphorylation in HCC cells after IC50 values of treatments. Quantitative analysis of pTyr397FAK expression after 48 h of treatment with the different drugs, in HepG2 and Huh7 cells. Values are the mean arbitrary units �� SD of at least three independent experiments. Data were analysed by 2-tailed Student���s t test. *p

Published
2021
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44. Additional file 10 of Focal adhesion kinase inhibitor TAE226 combined with Sorafenib slows down hepatocellular carcinoma by multiple epigenetic effects

Author

Romito, Ilaria, Porru, Manuela, Braghini, Maria Rita, Pompili, Luca, Panera, Nadia, Crudele, Annalisa, Gnani, Daniela, De Stefanis, Cristiano, Scarsella, Marco, Pomella, Silvia, Levi Mortera, Stefano, de Billy, Emmanuel, Conti, Adrian Libenzio, Marzano, Valeria, Putignani, Lorenza, Vinciguerra, Manlio, Balsano, Clara, Pastore, Anna, Rota, Rossella, Tartaglia, Marco, Leonetti, Carlo, and Alisi, Anna

Abstract

Additional file 10: Figure S5. Analysis of FAK nuclear interaction with specific epigenetics regulators. (A) Coomassie-stained 1D SDS-PAGE gels used for the in-gel digestions of nuclear immunoprecipitates of FAK in HCC cells. The photographs showed gel lanes excision into 10 bands for mass spectrometry characterization of FAK nuclear interactors. (B) Pipeline employed for the analysis of proteomics data.

Published
2021
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45. Additional file 2 of Focal adhesion kinase inhibitor TAE226 combined with Sorafenib slows down hepatocellular carcinoma by multiple epigenetic effects

Author

Romito, Ilaria, Porru, Manuela, Braghini, Maria Rita, Pompili, Luca, Panera, Nadia, Crudele, Annalisa, Gnani, Daniela, De Stefanis, Cristiano, Scarsella, Marco, Pomella, Silvia, Levi Mortera, Stefano, de Billy, Emmanuel, Conti, Adrian Libenzio, Marzano, Valeria, Putignani, Lorenza, Vinciguerra, Manlio, Balsano, Clara, Pastore, Anna, Rota, Rossella, Tartaglia, Marco, Leonetti, Carlo, and Alisi, Anna

Abstract

Additional file 2: Table S2. In vivo antitumor efficacy of TAE226>SOR combination on orthotopic liver tumour.

Published
2021
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46. Additional file 9 of Focal adhesion kinase inhibitor TAE226 combined with Sorafenib slows down hepatocellular carcinoma by multiple epigenetic effects

Author

Romito, Ilaria, Porru, Manuela, Braghini, Maria Rita, Pompili, Luca, Panera, Nadia, Crudele, Annalisa, Gnani, Daniela, De Stefanis, Cristiano, Scarsella, Marco, Pomella, Silvia, Levi Mortera, Stefano, de Billy, Emmanuel, Conti, Adrian Libenzio, Marzano, Valeria, Putignani, Lorenza, Vinciguerra, Manlio, Balsano, Clara, Pastore, Anna, Rota, Rossella, Tartaglia, Marco, Leonetti, Carlo, and Alisi, Anna

Abstract

Additional file 9: Figure S4. Pilot study for quantitative setting of TAE226 concentration in a heterotopic HepG2 xenograft model of HCC. (A) Quantitative analysis of tumour weight at various time points in NT animals or after TAE226 treatments. P values were calculated at day 12 using an unpaired two-tailed t-test, between treated and untreated tumours. **** p

Published
2021
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47. Additional file 3 of Focal adhesion kinase inhibitor TAE226 combined with Sorafenib slows down hepatocellular carcinoma by multiple epigenetic effects

Author

Romito, Ilaria, Porru, Manuela, Braghini, Maria Rita, Pompili, Luca, Panera, Nadia, Crudele, Annalisa, Gnani, Daniela, De Stefanis, Cristiano, Scarsella, Marco, Pomella, Silvia, Levi Mortera, Stefano, de Billy, Emmanuel, Conti, Adrian Libenzio, Marzano, Valeria, Putignani, Lorenza, Vinciguerra, Manlio, Balsano, Clara, Pastore, Anna, Rota, Rossella, Tartaglia, Marco, Leonetti, Carlo, and Alisi, Anna

Abstract

Additional file 3: Table S3. Common up- and down-regulated genes.

Published
2021
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48. Additional file 5 of Focal adhesion kinase inhibitor TAE226 combined with Sorafenib slows down hepatocellular carcinoma by multiple epigenetic effects

Author

Romito, Ilaria, Porru, Manuela, Braghini, Maria Rita, Pompili, Luca, Panera, Nadia, Crudele, Annalisa, Gnani, Daniela, De Stefanis, Cristiano, Scarsella, Marco, Pomella, Silvia, Levi Mortera, Stefano, de Billy, Emmanuel, Conti, Adrian Libenzio, Marzano, Valeria, Putignani, Lorenza, Vinciguerra, Manlio, Balsano, Clara, Pastore, Anna, Rota, Rossella, Tartaglia, Marco, Leonetti, Carlo, and Alisi, Anna

Subjects
Data_FILES
Abstract

Additional file 5: Table S5. GO annotations.

Published
2021
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49. Additional file 8 of Focal adhesion kinase inhibitor TAE226 combined with Sorafenib slows down hepatocellular carcinoma by multiple epigenetic effects

Author

Romito, Ilaria, Porru, Manuela, Braghini, Maria Rita, Pompili, Luca, Panera, Nadia, Crudele, Annalisa, Gnani, Daniela, De Stefanis, Cristiano, Scarsella, Marco, Pomella, Silvia, Levi Mortera, Stefano, de Billy, Emmanuel, Conti, Adrian Libenzio, Marzano, Valeria, Putignani, Lorenza, Vinciguerra, Manlio, Balsano, Clara, Pastore, Anna, Rota, Rossella, Tartaglia, Marco, Leonetti, Carlo, and Alisi, Anna

Abstract

Additional file 8: Figure S3. IGF-1R in HCC cells after treatment with TAE226 > SOR compared to single treatments. Representative immunoblot and quantitative analysis of phosphorylated IGF-1R after 48 h from treatment with the different drugs, in HepG2 (A) and Huh7 cells (B). ��Tubulin served as loading control. Values are the mean arbitrary units �� SD of at least three independent experiments. Data were analysed by 2-tailed Student���s t test. **p

Published
2021
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50. Evolution of Human Memory B Cells From Childhood to Old Age

Author

Ciocca, Michela, primary, Zaffina, Salvatore, additional, Fernandez Salinas, Ane, additional, Bocci, Chiara, additional, Palomba, Patrizia, additional, Conti, Maria Giulia, additional, Terreri, Sara, additional, Frisullo, Giuseppe, additional, Giorda, Ezio, additional, Scarsella, Marco, additional, Brugaletta, Rita, additional, Vinci, Maria Rosaria, additional, Magnavita, Nicola, additional, Carsetti, Rita, additional, and Piano Mortari, Eva, additional

Published
2021
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