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328 results on '"Su, Yuling"'

3. Exploring Taiwanese Preschool Children's Perspectives on the Value of Caring

Author

Su, Yuling and Chung, Ya-hui

Abstract

The current study explores Taiwanese preschool children's understanding of the value of caring in school. This study offers researchers and practitioners opportunities to study children's perspectives in a particular cultural setting and discuss the connectedness of culture and children's views on caring. Participatory research and qualitative methods were used, encompassing the collecting of children's speech, photography, and drawings. The findings regarding the understanding of caring indicated the following: (1) Children interpret caring among peers and from school surroundings; (2) children perceive teacher care in daily classroom routines; (3) children learn about values when outdoors, in learning areas, and during transition times; and (4) children exhibit the ability to distinguish non-caring behaviour. This study shows that for children caring was most frequently defined as helping others in need and as teacher care in daily routines. The children's views on caring were influenced by culture, and they created meanings for caring.

Published
2023
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13. A new family of disorder-free Rare-Earth-based kagom\'e lattice magnets: structure and magnetic characterizations of RE3BWO9 (RE=Pr, Nd, Gd-Ho) Boratotungstates

Author

Ashtar, Malik, Guo, Jinjin, Wan, Zongtang, Wang, Yongqiang, Gong, Gaoshang, Liu, Yong, Su, Yuling, and Tian, Zhaoming

Subjects
Condensed Matter - Materials Science, Condensed Matter - Strongly Correlated Electrons
Abstract

Exploration of rare-earth (RE)-based Kagome lattice magnets with spin-orbital entangled jeff=1/2 moments will provide new platform for investigating the exotic magnetic phases. Here, we report a new family of RE3BWO9 (RE=Pr,Nd,Gd-Ho) boratotungstates with magnetic RE3+ ions arranged on Kagome lattice, and perform its structure and magnetic characterizations. This serial compounds crystallize in hexagonal coordinated structure with space group P63 (No.173), where magnetic RE3+ ions have distorted Kagom\'e lattice connections within the ab plane and stacked in a AB-type fashion along c axis. The interlayer RE-RE separation is comparable with that of intralayer distance, forming 3-dimensional (3D) exchange coupled magnetic framework of RE3+ ions. The magnetic susceptibility data of RE3BWO9 (RE=Pr, Nd, Gd-Ho) reveal dominant antiferromagnetic interactions between magnetic RE3+ ions, but without visible magnetic ordering down to 2 K. The magnetization analyses for different RE3+ ions show diverse anisotropic behaviors, make RE3BWO9 as an appealing Kagome-lattice antiferromagnet to explore exotic magnetic phases., Comment: 17 pages, 6 fiugures

Published
2020

47. Spinster homolog 2 reduces malignancies of glioblastoma via PTEN/PI3K/AKT pathway.

Author

Liang, Weiye, Liu, Mingkai, Su, Yuling, Wen, Yulin, Wang, Lili, Shan, Jiajie, Zhao, Jie, Xie, Keping, and Wang, Jian

Subjects
GLIOBLASTOMA multiforme, DISEASE risk factors, GLIOMAS, EPITHELIAL-mesenchymal transition, CELL physiology, IMMUNOCOMPUTERS
Abstract

The molecular mechanisms of glioblastoma (GBM) are unclear, and the prognosis is poor. Spinster homolog 2 (SPNS2) is reportedly involved in pathological processes such as immune response, vascular development, and cancer. However, the biological function and molecular role of SPNS2 in GBM are unclear. SPNS2 is aberrantly low expressed in glioma. Survival curves, risk scores, prognostic nomograms, and univariate and multifactorial Cox regression analyses showed that SPNS2 is an independent prognostic indicator significantly associated with glioma progression and prognosis. Cell function assays and in vivo xenograft transplantation were performed that downregulation of SPNS2 promoted GBM cell growth, migration, invasion, epithelial–mesenchymal transition (EMT), anti‐apoptosis, drug resistance, and stemness, while overexpression of SPNS2 had the opposite effect. Meanwhile, the functional enrichment and signaling pathways of SPNS2 in the Cancer Genome Atlas (TCGA), Chinese Glioma Genome Atlas (CGGA), and RNA sequencing were analyzed by Gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and Gene set enrichment analysis (GSEA). The above results were related to the inhibition of the PTEN/PI3K/AKT pathway by SPNS2. In addition, we predicted that SPNS2 is closely associated with immune infiltration in the tumor microenvironment by four immune algorithms, ESTIMATE, TIMER, CIBERSORT, and QUANTISEQ. In particular, SPNS2 was negatively correlated with the infiltration of most immune cells, immunomodulators, and chemokines. Finally, single‐cell sequencing analysis also revealed that SPNS2 was remarkably correlated with macrophages, and downregulation of SPNS2 promotes the expression of M2‐like macrophages. This study provides new evidence that SPNS2 inhibits malignant progression, stemness, and immune infiltration of GBM cells through PTEN/PI3K/AKT pathway. SPNS2 may become a new diagnostic indicator and potential immunotherapeutic target for glioma. [ABSTRACT FROM AUTHOR]

Published
2024
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