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380 results on '"Tedder, T."'

7. Irish thoracic society: Proceedings of annual scientific meeting held in Cork on 5th & 6th November, 1993

Author

Chan, K. H., Singh, H. P., Aherne, T., Carabine, U., Gilliland, H., Johnston, J. R., Lowry, K. G., McGuigan, J., Cosgrove, J., Veerasingham, D., McCarthy, J., Hurley, J., Wood, A. E., Gilliland, R., McGuigan, J. A., McManus, K. G., Wilkinson, P., Johnston, L. C., MacMahon, J., Wilson, D., Austin, C., Anikin, V., McManus, K., McGuigan, J., McManus, K., Anikin, V., Gibbons, J. R. P., McGuigan, J., Sharkey, R., Long, M., Maree, A., O’Neill, S., Maguire, C. P., Hayes, J. P., Masterson, J., Fitzgerald, M. X., Hayes, M., Maguire, C. P., Hayes, J. P., Masterson, J., Fitzgerald, M. X., Quigley, C., Mofidi, A., Mofidi, R., Fitzgerald, M. X., O’Neill, M., Watson, J. B. G., O’Halloran, E. T., Shortt, C., Taylor, M., Holland, C., O’Lorcain, P., Taylor, M., Holland, C., O’Lorcain, P., Pathmakanthan, S., Sreenan, S., Power, C. K., Poulter, L. W., Burke, C. M., Reilly, D., Pathmakanthan, S., Sreenan, S., Doyle, S., Burke, C. M., Sreenan, S., Power, C., Pathmakanthan, S., Goggin, A., Burke, C. M., Poulter, L. W., Sreenan, S., Doyle, S., Pathmakanthan, S., Poulter, L. W., Burke, C. M., Sreenan, S., Debenham, P., Pathmakanthan, S., Burke, C. M., Poulter, L. W., Southey, A., O’Connor, C. M., Fitzgerald, M. X., Bourke, W. J., McDonnell, T. J., Buck, J. B., Magee, T. R. A., Lowry, R. C., Graham, A. N. J., Owens, W. A., Kelly, S. B., McGuigan, J. A., Costelloe, R. W., Ryan, J., Collins, J., Guerin, D., Rooney, D., Long, E., O’Donnell, M., O’Neill, S., Cotter, T. P., Bredin, C. P., Buick, J. B., Lowry, R. C., MacMahon, J. J., Finlay, G., Concannon, D., McDonnell, T. J., Reid, P. T., Alderdice, J., Carson, J., Sinnamon, D. G., Murphy, S., Scott, T., Keane, C. T., Walsh, J. B., Coakley, D., McKeown, D., Kelly, P., Clancy, L., Kiely, J. L., Cryan, B., Bredin, C. P., Killeen, P., Farrell, S., Kelly, P., Clancy, L., Kiely, J. L., O’Riordan, D. M., Sheehan, S., Curtain, J., Hogan, J., Bredin, C. P., Malone, A., Ahmed, S., Watson, J. B. G., Murphy, M., Fennell, W., Ahmed, S., Watson, J. B. G., Aherne, T., Keohane, C., O’Neill, M., Gleeson, C. M., McGuigan, J., Ritchie, A. J., Russell, S. E. H., Molloy, E., Keane, M., Coakley, R., Costello, R., Condron, C., Watson, R. G. W., O’Neill, S., Kelly, C., Redmond, H., Watson, W., Burke, P., Bouchier-Hayes, D., Donnelly, S. C., Haslett, C., Dransfield, I., Robertson, C. E., Carter, D. C., Ross, J. A., Grant, I. S., Tedder, T. F., Doyle, S., Sreenan, S., Pathmakanthan, S., Burke, C. M., Heaney, L. G., Cross, L. J. M., Stanford, C. F., Ennis, Madeleine, Sreenan, S., Pathmakanthan, S., Power, C., Goggin, A., Poulter, L. W., Burke, C. M., Murphy, S., Scott, T., Keane, C. T., Walsh, J. B., Coakley, D., O’Riordan, D. M., Gergely, L., Deng, N., Rose, R. M., Hennessy, T., Hickey, L., Thornton, L., Collum, C., Durity, M., Power, J., Johnson, H., Lee, B., Doherty, E., Kelly, E., McDonnell, T., McKeown, D., Kelly, P., Clancy, L., Wilkinson, P., Varghese, G., Anikin, V., Gibbons, J., McManus, K., McGuigan, J., Reid, P. T., Gower, N. H., and Rudd, R. M.

Published
1994
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13. Use of advanced magnetic resonance imaging techniques in neuromyelitis optica spectrum disorder

Author

Kremer, S. (Stephane), Renard, F. (Felix), Achard, S. (Sophie), Lana-Peixoto, M.A. (Marco A.), Palace, J. (Jacqueline), Asgari, N. (Nasrin), Klawiter, E.C. (Eric C.), Tenembaum, S. (Silvia), Banwell, B. (Brenda), Greenberg, B.M. (Benjamin M.), Bennett, J.L. (Jeffrey), Levy, M. (Michael), Villoslada, P. (Pablo), Saiz, A. (Albert Abe), Fujihara, K. (Kazuo), Chan, K.H. (Koon Ho), Schippling, S. (Sven), Paul, F. (Friedemann), Kim, H.J. (Ho Jin), De Seze, J. (Jerome), Wuerfel, J.T. (Jens T.), Cabre, P. (Philippe), Marignier, R. (Romain), Tedder, T. (Thomas), Pelt - Gravesteijn, E.D. (Daniëlle) van, Broadley, S. (Simon), Chitnis, T. (Tanuja), Wingerchuk, D. (Dean), Pandit, L. (Lekha), Leite, M.I. (M. Isabel), Apiwattanakul, M. (Metha), Kleiter, I. (Ingo), Prayoonwiwat, N. (Naraporn), Han, M. (May), Hellwig, K. (Kerstin), Van Herle, K. (Katja), John, G. (Gareth), Hooper, D.C. (D. Craig), Nakashima, I. (Ichiro), Sato, D. (Douglas), Yeaman, M.R. (Michael R.), Waubant, E. (Emmanuelle), Zamvil, S. (Scott), Stüve, O. (Olaf), Aktas, O. (Orhan), Smith, T.J. (Terry), Jacob, A. (Anu), O'Connor, K. (Kevin), Kremer, S. (Stephane), Renard, F. (Felix), Achard, S. (Sophie), Lana-Peixoto, M.A. (Marco A.), Palace, J. (Jacqueline), Asgari, N. (Nasrin), Klawiter, E.C. (Eric C.), Tenembaum, S. (Silvia), Banwell, B. (Brenda), Greenberg, B.M. (Benjamin M.), Bennett, J.L. (Jeffrey), Levy, M. (Michael), Villoslada, P. (Pablo), Saiz, A. (Albert Abe), Fujihara, K. (Kazuo), Chan, K.H. (Koon Ho), Schippling, S. (Sven), Paul, F. (Friedemann), Kim, H.J. (Ho Jin), De Seze, J. (Jerome), Wuerfel, J.T. (Jens T.), Cabre, P. (Philippe), Marignier, R. (Romain), Tedder, T. (Thomas), Pelt - Gravesteijn, E.D. (Daniëlle) van, Broadley, S. (Simon), Chitnis, T. (Tanuja), Wingerchuk, D. (Dean), Pandit, L. (Lekha), Leite, M.I. (M. Isabel), Apiwattanakul, M. (Metha), Kleiter, I. (Ingo), Prayoonwiwat, N. (Naraporn), Han, M. (May), Hellwig, K. (Kerstin), Van Herle, K. (Katja), John, G. (Gareth), Hooper, D.C. (D. Craig), Nakashima, I. (Ichiro), Sato, D. (Douglas), Yeaman, M.R. (Michael R.), Waubant, E. (Emmanuelle), Zamvil, S. (Scott), Stüve, O. (Olaf), Aktas, O. (Orhan), Smith, T.J. (Terry), Jacob, A. (Anu), and O'Connor, K. (Kevin)

Abstract

Brain parenchymal lesions are frequently observed on conventional magnetic resonance imaging (MRI) scans of patients with neuromyelitis optica (NMO) spectrum disorder, but the specific morphological and temporal patterns distinguishing them unequivocally from lesions caused by other disorders have not been identified. This literature review summarizes the literature on advanced quantitative imaging measures reported for patients with NMO spectrum disorder, including proton MR spectroscopy, diffusio

Published
2015
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15. Comparison of human eosinophil and neutrophil adhesion to endothelial cells under nonstatic conditions. Role of L-selectin

Author

Edward Knol, Tackey, F., Tedder, T. F., Klunk, D. A., Bickel, C. A., Sterbinsky, S. A., and Bochner, B. S.

Subjects
Immunology, Immunology and Allergy
Abstract

To simulate adhesion that occurs under conditions of flow, we investigated the attachment of eosinophils to endothelium under rotational conditions. Tissue-culture plates containing monolayers of HUVEC were placed on a horizontal rotator (80 revolutions per minute (rpm)), and equal numbers of purified human eosinophils or neutrophils were added to separate wells at 4 degrees C. Binding of eosinophils and neutrophils to unstimulated endothelial cells was 15 +/- 3 and 31 +/- 11 cells/four high power fields (HPF), respectively. After preincubation of HUVEC with IL-1 beta (1 ng/ml, 4 h, 37 degrees C), adhesion increased to 56 +/- 4 and 290 +/- 26 cells/four HPF, respectively (p < 0.0002 for both, n = 8-14). Eosinophils with reduced levels of L-selectin (blood eosinophils activated in vitro or eosinophils obtained from bronchoalveolar lavage (BAL) performed after segmental lung allergen challenge of allergic subjects) demonstrated reduced binding under rotating conditions. Several L-selectin Abs inhibited adhesion of eosinophils and neutrophils (e.g., LAM1-3: 43 +/- 14% vs 63 +/- 3% inhibition; LAM1-6: 73 +/- 5% vs 36 +/- 6% inhibition, respectively, n > or = 6). Interestingly, one additional L-selectin Ab, LAM1-11, inhibited eosinophil but not neutrophil adhesion (51 +/- 2% vs 1 +/- 7% inhibition, respectively, n > or = 5). We conclude that eosinophils, like neutrophils, use L-selectin to bind to activated endothelial cells under conditions of flow, although mAb LAM1-11 can selectively inhibit eosinophil attachment to stimulated endothelial cells in vitro, suggesting different functional epitopes on L-selectin among eosinophils and neutrophils.

Published
1994

16. L-Selectin Is Dispensable for T Regulatory Cell Function Postallogeneic Bone Marrow Transplantation: CD62L−/− Tregs Inhibit Acute GvHD

Author

Burgents, J. E., Panoskaltsis-Mortari, A., Fulton, L. M., Coghill, J. M., Blazar, B. R., Serody, J. S., Tedder, T. F., West, M. L., Wan, Y., and Carlson, M. J.

Subjects
surgical procedures, operative, hemic and immune systems, chemical and pharmacologic phenomena
Abstract

In murine models, the adoptive transfer of CD4+/CD25+ regulatory T cells (Tregs) inhibited graft-versus-host disease (GvHD). Previous work has indicated a critical role for the adhesion molecule L-selectin (CD62L) in the function of Tregs in preventing GvHD. Here we examined the capacity of naive wild-type (WT), CD62L−/− and ex vivo expanded CD62LLo Tregs to inhibit acute GvHD. Surprisingly, we found that CD62L−/− Tregs were potent suppressors of GvHD, whereas CD62LLo Tregs were unable to inhibit disease despite being functionally competent to suppress allo T cell responses in vitro. Concomitant with improved outcomes, WT and CD62L−/− Tregs significantly reduced liver pathology and systemic pro-inflammatory cytokine production, although CD62L−/− Tregs were less effective in reducing lung pathology. While accumulation of CD62L−/− Tregs in GvHD target organs was equivalent to WT Tregs, CD62L−/− Tregs did not migrate as well as WT Tregs to peripheral lymph nodes (PLNs) over the first 2 weeks posttransplantation. This work demonstrated that CD62L was dispensable for Treg-mediated protection from GvHD.

Published
2010
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17. Therapeutic B cell depletion impairs adaptive and autoreactive CD4+ T cell activation in mice

Author

Tisch, R. M., Wang, Y., Venturi, G. M., Yanaba, K., Bouaziz, J.-D., Poe, J. C., and Tedder, T. F.

Abstract

CD20 antibody depletion of B lymphocytes effectively ameliorates multiple T cell-mediated autoimmune diseases through mechanisms that remain unclear. To address this, a mouse CD20 antibody that depletes >95% of mature B cells in mice with otherwise intact immune systems was used to assess the role of B cells in CD4+ and CD8+ T cell activation and expansion in vivo. B cell depletion had no direct effect on T cell subsets or the activation status of CD4+ and CD8+ T cells in naive mice. However, B cell depletion impaired CD4+ T cell activation and clonal expansion in response to protein antigens and pathogen challenge, whereas CD8+ T cell activation was not affected. In vivo dendritic cell ablation, along with CD20 immunotherapy, revealed that optimal antigen-specific CD4+ T cell priming required both B cells and dendritic cells. Most importantly, B cell depletion inhibited antigen-specific CD4+ T cell expansion in both collagen-induced arthritis and autoimmune diabetes mouse models. These results provide direct evidence that B cells contribute to T cell activation and expansion in vivo and offer insights into the mechanism of action for B cell depletion therapy in the treatment of autoimmunity.

Published
2007
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18. Chronic lymphocytic leukemia and regulatory B cells share IL-10 competence and immunosuppressive function

Author

DiLillo, D J, primary, Weinberg, J B, additional, Yoshizaki, A, additional, Horikawa, M, additional, Bryant, J M, additional, Iwata, Y, additional, Matsushita, T, additional, Matta, K M, additional, Chen, Y, additional, Venturi, G M, additional, Russo, G, additional, Gockerman, J P, additional, Moore, J O, additional, Diehl, L F, additional, Volkheimer, A D, additional, Friedman, D R, additional, Lanasa, M C, additional, Hall, R P, additional, and Tedder, T F, additional

Published
2012
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19. B-cell antigens: CD21 Workshop panel report: Leucocyte typing V. White cell differentiation antigens

Author

Timens, W., Schlossman, S.F., Boumsell, L., Gilks, W., Harlan, J., Kishimoto, T., Ritz, J., Schwarting, R., Shaw, S., Silverstein, R., Springer, T., Tedder, T., Todd, R., Groningen Research Institute for Asthma and COPD (GRIAC), and Guided Treatment in Optimal Selected Cancer Patients (GUTS)

Subjects
B cell, review, artikel, CD21, B-cell, Cell Differentiation, differentiation, Antigens, cell
Published
1995

20. Pneumococcal polysaccharides localize on splenic marginal zone B-cells and follicular dendritic cells, together with complement fragment C3d, without relation to known CD21 epitopes.: Leucocyte typing V. White cell differentiation antigens

Author

Timens, W., Harms, G., Peset-Llopis, M.J., Hardonk, M., Schlossman, S.F., Boumsell, L., Gilks, W., Harlan, J., Kishimoto, T., Ritz, J., Schwarting, R., Shaw, S., Silverstein, R., Springer, T., Tedder, T., Todd, R., Research and Evaluation of Educational Effectiveness, Groningen Research Institute for Asthma and COPD (GRIAC), and Guided Treatment in Optimal Selected Cancer Patients (GUTS)

Subjects
B cell, B cells, B-cells, polysaccharides, without, artikel, B-cell, Cell Differentiation, Dendritic Cells, differentiation, and, cell, polysaccharide, splenic, CD21, cells, marginal zone, Antigens
Published
1995

21. Effects of chronic inflammation on lung fibroblasts: expression of cytokine receptors: Leucocyte typing V. White cell differentiation antigens

Author

Van Straaten, J., Postma, D.S., Coers, W., Noordhoek, J., Smith, M., Kauffman, H.F., Timens, W., Schlossman, S.F., Boumsell, L., Gilks, W., Harlan, J., Kishimoto, T., Ritz, J., Schwarting, R., Shaw, S., Silverstein, R., Springer, T., Tedder, T., Todd, R., Groningen Research Institute for Asthma and COPD (GRIAC), and Guided Treatment in Optimal Selected Cancer Patients (GUTS)

Subjects
chronic, Inflammation, effect, receptor, expression, artikel, Cell Differentiation, differentiation, Antigens, cell, effects, Fibroblasts, Lung
Published
1995

22. Expression patterns of novel integrins in human tissues, including expression patterns those of HML-1 (CD103) and beta-7 integrins that are mainly limited to hairy cell leukaemia

Author

Timens, W., Coenen, M., Boes, A., Vos, H., Schlossman, S.F., Boumsell, L., Gilks, W., Harlan, J., Kishimoto, T., Ritz, J., Schwarting, R., Shaw, S., Silverstein, R., Springer, T., Tedder, T., Todd, R., Groningen Research Institute for Asthma and COPD (GRIAC), and Guided Treatment in Optimal Selected Cancer Patients (GUTS)

Subjects
Integrins, integrin, expression, artikel, that, Cell Differentiation, tissue, differentiation, human, and, Antigens, cell, pattern
Published
1995

23. Demonstration of cytokine receptor expression in spleen and lymph nodes using immunohistochemical methods

Author

Timens, W., de Graaf, Jan, Coenen, M., Dam, A., Wiersema, J., Schlossman, S.F., Boumsell, L., Gilks, W., Harlan, J., Kishimoto, T., Ritz, J., Schwarting, R., Shaw, S., Silverstein, R., Springer, T., Tedder, T., Todd, R., Groningen Research Institute for Asthma and COPD (GRIAC), and Guided Treatment in Optimal Selected Cancer Patients (GUTS)

Subjects
receptor, artikel, Cell Differentiation, tissue, differentiation, and, cell, lymph node, normal, methods, using, immunohistochemical, expression, distribution, lymph, method, human, Lymph Nodes, Antigens, Spleen
Published
1995

26. Abstract C186: A glycoengineered anti‐CD19 antibody (MEDI‐551) is effective as monotherapy or in combination treatment in mouse models of B‐cell malignancies

Author

Ward, Beth K., primary, Mittereder, N., additional, Kuta, E., additional, Sims, G., additional, Damschroeder, M., additional, Dall'Acqua, W., additional, Bowen, M. A., additional, Wu, H., additional, Tedder, T. F., additional, Kiener, P. A., additional, Jallal, B., additional, Coyle, T., additional, and Herbst, R., additional

Published
2009
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28. Fc dependent mechanisms are necessary for ADCC and effective depletion of murine B cells by humanized anti-CD19 mAb. (131.27)

Author

Groves, Christopher J, primary, Wang, Y, additional, Sims, G P, additional, Kuta, E, additional, Rowe, D, additional, Ward, E, additional, Mittereder, N, additional, Carlesso, G, additional, Cheng, L, additional, Cook, K, additional, Tedder, T, additional, Damschroeder, M, additional, DallAcqua, W, additional, Kiener, P, additional, Herbst, R, additional, and Coyle, A J, additional

Published
2007
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