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3. COVID-19 and Mixed Cryoglobulinemia Syndrome: Long-Term Survey Study on the Prevalence and Outcome, Vaccine Safety, and Immunogenicity

Author

Gragnani, Laura, Visentini, Marcella, Lorini, Serena, Santini, Stefano Angelo, Lauletta, Gianfranco, Mazzaro, Cesare, Urraro, Teresa, Quartuccio, Luca, Cacciapaglia, Fabio, Ruscitti, Piero, Tavoni, Antonio, Marri, Silvia, Cusano, Giuseppina, Petraccia, Luisa, Naclerio, Caterina, Treppo, Elena, del Frate, Giulia, Di Cola, Ilenia, Raimondo, Vincenzo, Scorpiniti, Daniela, Monti, Monica, Puccetti, Lorenzo, Elia, Giusy, Fallahi, Poupak, Basili, Stefania, Scarpato, Salvatore, Iannone, Florenzo, Casato, Milvia, Antonelli, Alessandro, Zignego, Anna Linda, and Ferri, Clodoveo

Published
2023
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4. Impact of COVID-19 and vaccination campaign on 1,755 systemic sclerosis patients during first three years of pandemic. Possible risks for individuals with impaired immunoreactivity to vaccine, ongoing immunomodulating treatments, and disease-related lung involvement during the next pandemic phase

Author

Ferri, Clodoveo, Raimondo, Vincenzo, Giuggioli, Dilia, Gragnani, Laura, Lorini, Serena, Dagna, Lorenzo, Bosello, Silvia Laura, Foti, Rosario, Riccieri, Valeria, Guiducci, Serena, Cuomo, Giovanna, Tavoni, Antonio, De Angelis, Rossella, Cacciapaglia, Fabio, Zanatta, Elisabetta, Cozzi, Franco, Murdaca, Giuseppe, Cavazzana, Ilaria, Romeo, Nicoletta, Codullo, Veronica, Pellegrini, Roberta, Varcasia, Giuseppe, De Santis, Maria, Selmi, Carlo, Abignano, Giuseppina, Caminiti, Maurizio, L'Andolina, Massimo, Olivo, Domenico, Lubrano, Ennio, Spinella, Amelia, Lumetti, Federica, De Luca, Giacomo, Ruscitti, Piero, Urraro, Teresa, Visentini, Marcella, Bellando-Randone, Silvia, Visalli, Elisa, Testa, Davide, Sciascia, Gabriella, Masini, Francesco, Pellegrino, Greta, Saccon, Francesca, Balestri, Eugenia, Elia, Giusy, Ferrari, Silvia Martina, Tonutti, Antonio, Dall’Ara, Francesca, Pagano Mariano, Giuseppa, Pettiti, Giorgio, Zanframundo, Giovanni, Brittelli, Raffaele, Aiello, Vincenzo, Dal Bosco, Ylenia, Foti, Roberta, Di Cola, Ilenia, Scorpiniti, Daniela, Fusaro, Enrico, Ferrari, Tommaso, Gigliotti, Pietro, Campochiaro, Corrado, Francioso, Francesca, Iandoli, Carlo, Caira, Virginia, Zignego, Anna Linda, D'Angelo, Salvatore, Franceschini, Franco, Matucci-Cerinic, Marco, Giacomelli, Roberto, Doria, Andrea, Santini, Stefano Angelo, Fallahi, Poupak, Iannone, Florenzo, and Antonelli, Alessandro

Published
2023
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5. Breakthrough infections after COVID-19 vaccinations do not elicit platelet hyperactivation and are associated with high platelet–lymphocyte and low platelet–neutrophil aggregates

Author

Maiorca, Francesca, Lombardi, Ludovica, Marrapodi, Ramona, Pallucci, Davide, Sabetta, Annamaria, Zingaropoli, Maria Antonella, Perri, Valentina, Flego, Davide, Romiti, Giulio Francesco, Corica, Bernadette, Miglionico, Marzia, Russo, Gianluca, Pasculli, Patrizia, Ciardi, Maria Rosa, Mastroianni, Claudio M., Ruberto, Franco, Pugliese, Francesco, Pulcinelli, Fabio, Raparelli, Valeria, Cangemi, Roberto, Visentini, Marcella, Basili, Stefania, and Stefanini, Lucia

Published
2023
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6. Management of mixed cryoglobulinemia with rituximab: evidence and consensus-based recommendations from the Italian Study Group of Cryoglobulinemia (GISC)

Author

Quartuccio, Luca, Bortoluzzi, Alessandra, Scirè, Carlo Alberto, Marangoni, Antonio, Del Frate, Giulia, Treppo, Elena, Castelnovo, Laura, Saccardo, Francesco, Zani, Roberta, Candela, Marco, Fraticelli, Paolo, Mazzaro, Cesare, Renoldi, Piero, Scaini, Patrizia, Filippini, Davide Antonio, Visentini, Marcella, Scarpato, Salvatore, Giuggioli, Dilia, Mascia, Maria Teresa, Sebastiani, Marco, Zignego, Anna Linda, Lauletta, Gianfranco, Fiorilli, Massimo, Casato, Milvia, Ferri, Clodoveo, Pietrogrande, Maurizio, Pioltelli, Pietro Enrico, De Vita, Salvatore, Monti, Giuseppe, and Galli, Massimo

Published
2023
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9. Systemic syndromes of rheumatological interest with onset after COVID-19 vaccine administration: a report of 30 cases

Author

Ursini, Francesco, Ruscitti, Piero, Raimondo, Vincenzo, De Angelis, Rossella, Cacciapaglia, Fabio, Pigatto, Erika, Olivo, Domenico, Di Cola, Ilenia, Galluccio, Felice, Francioso, Francesca, Foti, Rosario, Tavoni, Antonio Gaetano, D’Angelo, Salvatore, Campochiaro, Corrado, Motta, Francesca, De Santis, Maria, Bilia, Silvia, Bruno, Caterina, De Luca, Giacomo, Visentini, Marcella, Ciaffi, Jacopo, Mancarella, Luana, Brusi, Veronica, D’Onghia, Martina, Cuomo, Giovanna, Fusaro, Enrico, Cipriani, Paola, Dagna, Lorenzo, Guiducci, Serena, Meliconi, Riccardo, Iannone, Florenzo, Iagnocco, Annamaria, Giacomelli, Roberto, and Ferri, Clodoveo

Published
2022
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11. Absent or suboptimal response to booster dose of COVID-19 vaccine in patients with autoimmune systemic diseases

Author

Ferri, Clodoveo, Gragnani, Laura, Raimondo, Vincenzo, Visentini, Marcella, Giuggioli, Dilia, Lorini, Serena, Foti, Rosario, Cacciapaglia, Fabio, Caminiti, Maurizio, Olivo, Domenico, Cuomo, Giovanna, Pellegrini, Roberta, Pigatto, Erika, Urraro, Teresa, Naclerio, Caterina, Tavoni, Antonio, Puccetti, Lorenzo, Cavazzana, Ilaria, Ruscitti, Piero, Vadacca, Marta, La Gualana, Francesca, Cozzi, Franco, Spinella, Amelia, Visalli, Elisa, Bosco, Ylenia Dal, Amato, Giorgio, Masini, Francesco, Mariano, Giuseppa Pagano, Brittelli, Raffaele, Aiello, Vincenzo, Scorpiniti, Daniela, Rechichi, Giovanni, Varcasia, Giuseppe, Monti, Monica, Elia, Giusy, Franceschini, Franco, Casato, Milvia, Ursini, Francesco, Giacomelli, Roberto, Fallahi, Poupak, Santini, Stefano Angelo, Iannone, Florenzo, Salvarani, Carlo, Zignego, Anna Linda, and Antonelli, Alessandro

Published
2022
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12. Management of nonviral mixed cryoglobulinemia vasculitis refractory to rituximab: Data from a European collaborative study and review of the literature

Author

Pouchelon, Clara, Visentini, Marcella, Emmi, Giacomo, le Guern, Véronique, Quartuccio, Luca, Samson, Maxime, Venhoff, Nils, Briantais, Antoine, Casato, Milvia, Chatelus, Emmanuel, Chilles, Marie, Cid, Maria C., Diot, Elisabeth, Ebbo, Mikael, Faguer, Stanislas, Hellmich, Bernhard, Jachiet, Marie, Moulinet, Thomas, Perrin, François, Quémeneur, Thomas, Sinico, Renato Alberto, and Terrier, Benjamin

Published
2022
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14. Targeting CD38 with monoclonal antibodies disrupts key survival pathways in paediatric Burkitt's lymphoma malignant B cells.

Author

Kläsener, Kathrin, Herrmann, Nadja, Håversen, Liliana, Sundell, Timothy, Sundqvist, Martina, Lundqvist, Christina, Manna, Paul T, Jonsson, Charlotte A, Visentini, Marcella, Ljung Sass, Diana, McGrath, Sarah, Grimstad, Kristoffer, Aranburu, Alaitz, Mellgren, Karin, Fogelstrand, Linda, Forsman, Huamei, Ekwall, Olov, Borén, Jan, Gjertsson, Inger, and Reth, Michael

Subjects
BURKITT'S lymphoma, B cell lymphoma, METABOLIC reprogramming, MEMBRANE proteins, CELL proliferation
Abstract

Objectives: Paediatric Burkitt's lymphoma (pBL) is the most common childhood non‐Hodgkin B‐cell lymphoma. Despite the encouraging survival rates for most children, treating cases with relapse/resistance to current therapies remains challenging. CD38 is a transmembrane protein highly expressed in pBL. This study investigates the effectiveness of CD38‐targeting monoclonal antibodies (mAbs), daratumumab and isatuximab, in impairing crucial cellular processes and survival pathways in pBL malignant cells. Methods: In silico analyses of patient samples, combined with in vitro experiments using the Ramos cell line, were conducted to assess the impact of daratumumab and isatuximab on cellular proliferation, apoptosis and the phosphoinositide 3‐kinase (PI3K) pathway. Results: Isatuximab was found to be more effective than daratumumab in disrupting B‐cell receptor signalling, reducing cellular proliferation and inducing apoptosis. Additionally, isatuximab caused a significant impairment of the PI3K pathway and induced metabolic reprogramming in pBL cells. The study also revealed a correlation between CD38 and MYC expression levels in pBL patient samples, suggesting CD38 involvement in key oncogenic processes. Conclusion: The study emphasises the therapeutic potential of CD38‐targeting mAbs, particularly isatuximab, in pBL. [ABSTRACT FROM AUTHOR]

Published
2024
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15. COVID-19 vaccine immunogenicity in 16 patients with autoimmune systemic diseases. Lack of both humoral and cellular response to booster dose and ongoing disease modifying therapies

Author

Gragnani, Laura, Visentini, Marcella, Lorini, Serena, La Gualana, Francesca, Santini, Stefano Angelo, Cacciapaglia, Fabio, Tavoni, Antonio, Cuomo, Giovanna, Fallahi, Poupak, Iannone, Florenzo, Antonelli, Alessandro, Casato, Milvia, Zignego, Anna Linda, and Ferri, Clodoveo

Published
2022
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17. Impaired immunogenicity to COVID-19 vaccines in autoimmune systemic diseases. High prevalence of non-response in different patients’ subgroups

Author

Ferri, Clodoveo, Ursini, Francesco, Gragnani, Laura, Raimondo, Vincenzo, Giuggioli, Dilia, Foti, Rosario, Caminiti, Maurizio, Olivo, Domenico, Cuomo, Giovanna, Visentini, Marcella, Cacciapaglia, Fabio, Pellegrini, Roberta, Pigatto, Erika, Urraro, Teresa, Naclerio, Caterina, Tavoni, Antonio, Puccetti, Lorenzo, Varcasia, Giuseppe, Cavazzana, Ilaria, L'Andolina, Massimo, Ruscitti, Piero, Vadacca, Marta, Gigliotti, Pietro, La Gualana, Francesca, Cozzi, Franco, Spinella, Amelia, Visalli, Elisa, Dal Bosco, Ylenia, Amato, Giorgio, Masini, Francesco, Pagano Mariano, Giuseppa, Brittelli, Raffaele, Aiello, Vincenzo, Caminiti, Rodolfo, Scorpiniti, Daniela, Rechichi, Giovanni, Ferrari, Tommaso, Monti, Monica, Elia, Giusy, Franceschini, Franco, Meliconi, Riccardo, Casato, Milvia, Iannone, Florenzo, Giacomelli, Roberto, Fallahi, Poupak, Santini, Stefano Angelo, Zignego, Anna Linda, and Antonelli, Alessandro

Published
2021
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18. Correction to: Management of mixed cryoglobulinemia with rituximab: evidence and consensus-based recommendations from the Italian Study Group of Cryoglobulinemia (GISC)

Author

Quartuccio, Luca, Bortoluzzi, Alessandra, Scirè, Carlo Alberto, Marangoni, Antonio, Del Frate, Giulia, Treppo, Elena, Castelnovo, Laura, Saccardo, Francesco, Zani, Roberta, Candela, Marco, Fraticelli, Paolo, Mazzaro, Cesare, Renoldi, Piero, Scaini, Patrizia, Filippini, Davide Antonio, Visentini, Marcella, Scarpato, Salvatore, Giuggioli, Dilia, Mascia, Maria Teresa, Sebastiani, Marco, Zignego, Anna Linda, Lauletta, Gianfranco, Fiorilli, Massimo, Casato, Milvia, Ferri, Clodoveo, Pietrogrande, Maurizio, Pioltelli, Pietro Enrico, De Vita, Salvatore, Monti, Giuseppe, and Galli, Massimo

Published
2023
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19. Surface antigen serocleared hepatitis B virus infection increases the risk of mixed cryoglobulinemia vasculitis in male patients with chronic hepatitis C.

Author

Morrone, Anna, Fiorilli, Valerio, Cinti, Lilia, Roberto, Piergiorgio, Ferri, Alejandro L., Visentini, Marcella, Pulsoni, Alessandro, Spinelli, Francesca Romana, De Santis, Adriano, Antonelli, Guido, Basili, Stefania, Tosti, Maria Elena, Conti, Fabrizio, and Casato, Milvia

Subjects
HEPATITIS associated antigen, HEPATITIS B, CHRONIC hepatitis B, CHRONIC hepatitis C, CRYOGLOBULINEMIA, VASCULITIS, HEPATITIS C virus
Abstract

Mixed cryoglobulinemia vasculitis (MCV) is caused in ~90% of cases by chronic hepatitis C virus (HCVpos MCV) and more rarely by hepatitis B virus (HBV) infection, or apparently noninfectious. HCVpos MCV develops in only ~5% of patients with chronic hepatitis C (CHC), but risk factors other than female gender have not been identified so far. We conducted a retrospective case control study investigating whether past active HBV infection, defined by hepatitis B surface antigen (HBsAg) seroclearance and anti-core antibody (HBcAb) pos itivity, could be a risk factor for developing HCVpos MCV. The prevalence of HBsAg seroclearance was 48% within 123 HCVpos MCV patients and 29% within 257 CHC patients (p=0.0003). Multiple logistic regression including as variables gender, birth year, age at HBV testing, cirrhosis, and hepatocellular carcinoma, confirmed an association of HBsAg seroclearance with HCVpos MCV [adjusted odds ratio (OR) 2.82, 95% confidence interval (95% CI) 1.73-4.59, p<0.0001]. Stratification by gender, however, showed that HBsAg seroclearance was associated with HCVpos MCV in male [OR 4.63, 95% CI 2.27-9.48, p<0.0001] and not in female patients [OR 1.85, 95% 95% CI 0.94-3.66, p=0.076]. HBsAg seroclearance, and more likely occult HBV infection, is an independent risk factor for HCVpos MCV in male CHC patients. [ABSTRACT FROM AUTHOR]

Published
2024
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22. P115 Belimumab treatment rapidly restores B cell homeostasis and reduces atypical T-bet+ B cell expansion in patients with systemic lupus erythematosus

Author

Ceccarelli, Fulvia, primary, Gualana, Francesca La, additional, Cusa, Gabriella, additional, Picciariello, Licia, additional, Olivieri, Giulio, additional, Petriti, Begi, additional, Natalucci, Francesco, additional, Sciannamea, Maddalena, additional, Visentini, Marcella, additional, and Conti, Fabrizio, additional

Published
2024
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23. CD38 as a therapeutic target in pediatric Burkitt’s Lymphoma: insights from a comparative approach (Running title: Targeting CD38 in pediatric Burkitt's Lymphoma)

Author

Kläsener, Kathrin, primary, Herrmann, Nadja, additional, Håversen, Liliana, additional, Sundell, Timothy, additional, Sundqvist, Martina, additional, Lundqvist, Christina, additional, Manna, Paul T., additional, Jonsson, Charlotte A., additional, Visentini, Marcella, additional, Sass, Diana Ljung, additional, McGrath, Sarah, additional, Grimstad, Kristoffer, additional, Aranburu, Alaitz, additional, Mellgren, Karin, additional, Fogelstrand, Linda, additional, Forsman, Huamei, additional, Ekwall, Olov, additional, Borén, Jan, additional, Gjertsson, Inger, additional, Reth, Michael, additional, Mårtensson, Inga-Lill, additional, and Camponeschi, Alessandro, additional

Published
2024
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24. Safety and effectiveness of biosimilar of Rituximab CT-P10 in the treatment of cryoglobulinemic vasculitis: the MARBLe study (Mixed cryoglobulinemiA Rituximab BiosimiLar)

Author

Vacchi, Caterina, Visentini, Marcella, Gragnani, Laura, Fraticelli, Paolo, Tavoni, Antonio, Filippini, Davide, Saccardo, Francesco, Lauletta, Gianfranco, Colantuono, Stefania, Atzeni, Fabiola, Pioltelli, Pietro, Manfredi, Andreina, Casato, Milvia, Zignego, Anna Linda, Monti, Giuseppe, Pietrogrande, Maurizio, Galli, Massimo, and Sebastiani, Marco

Published
2021
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25. Interferon-free compared to interferon-based antiviral regimens as first-line therapy for B-cell lymphoproliferative disorders associated with hepatitis C virus infection

Author

Frigeni, Marco, Besson, Caroline, Visco, Carlo, Fontaine, Helene, Goldaniga, Maria, Visentini, Marcella, Pulsoni, Alessandro, Torres, Harrys A., Peveling-Oberhag, Jan, Rossotti, Roberto, Zaja, Francesco, Rigacci, Luigi, Merli, Michele, Dorival, Céline, Alric, Camille, Piazza, Francesco, Gentile, Massimo, Ferrari, Angela, Pirisi, Mario, Nassi, Luca, Rattotti, Sara, Frustaci, Annamaria, Milella, Michele, Cencini, Emanuele, Defrancesco, Irene, Ferretti, Virginia Valeria, Bruno, Raffaele, Hermine, Olivier, and Arcaini, Luca

Published
2020
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27. Long-Term Outcome of WHIM Syndrome in 18 Patients: High Risk of Lung Disease and HPV-Related Malignancies

Author

Dotta, Laura, Notarangelo, Lucia Dora, Moratto, Daniele, Kumar, Rajesh, Porta, Fulvio, Soresina, Annarosa, Lougaris, Vassilios, Plebani, Alessandro, Smith, C. I. Edvard, Norlin, Anna-Carin, Gòmez Raccio, Andrea Cecilia, Bubanska, Eva, Bertolini, Patrizia, Amendola, Giovanni, Visentini, Marcella, Fiorilli, Massimo, Venuti, Aldo, and Badolato, Raffaele

Published
2019
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29. Dual stimulation by autoantigen and CpG fosters the proliferation of exhausted rheumatoid factor-specific CD21low B cells in hepatitis C virus-cured mixed cryoglobulinemia.

Author

Del Padre, Martina, Marrapodi, Ramona, Minafò, Ylenia A., Mortari, Eva Piano, Radicchio, Giovanna, Bocci, Chiara, Gragnani, Laura, Camponeschi, Alessandro, Colantuono, Stefania, Stefanini, Lucia, Basili, Stefania, Carsetti, Rita, Fiorilli, Massimo, Casato, Milvia, and Visentini, Marcella

Subjects
B cells, B cell receptors, CRYOGLOBULINEMIA, HEPATITIS B, IMMUNE complexes, RHEUMATOID factor
Abstract

Introduction: Hepatitis C virus (HCV) causes mixed cryoglobulinemia (MC) by driving clonal expansion of B cells expressing B cell receptors (BCRs), often encoded by the VH1-69 variable gene, endowed with both rheumatoid factor (RF) and anti-HCV specificity. These cells display an atypical CD21low phenotype and functional exhaustion evidenced by unresponsiveness to BCR and Toll-like receptor 9 (TLR9) stimuli. Although antiviral therapy is effective on MC vasculitis, pathogenic B cell clones persist long thereafter and can cause virus-independent disease relapses. Methods: Clonal B cells from patients with HCV-associated type 2 MC or healthy donors were stimulated with CpG or heath-aggregated IgG (as surrogate immune complexes) alone or in combination; proliferation and differentiation were then evaluated by flow cytometry. Phosphorylation of AKT and of the p65 NF-kB subunit were measured by flow cytometry. TLR9 was quantified by qPCR and by intracellular flow cytometry, and MyD88 isoforms were analyzed using RT-PCR. Discussion: We found that dual triggering with autoantigen and CpG restored the capacity of exhausted VH1-69pos B cells to proliferate. The signaling mechanism for this BCR/TLR9 crosstalk remains elusive, since TLR9 mRNA and protein as well as MyD88 mRNA were normally expressed and CpG-induced phosphorylation of p65 NF-kB was intact in MC clonal B cells, whereas BCR-induced p65 NF-kB phosphorylation was impaired and PI3K/Akt signaling was intact. Our findings indicate that autoantigen and CpG of microbial or cellular origin may unite to foster persistence of pathogenic RF B cells in HCV-cured MC patients. BCR/TLR9 crosstalk might represent a more general mechanism enhancing systemic autoimmunity by the rescue of exhausted autoreactive CD21low B cells. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Correction to: Reduced Lysosomal Acid Lipase Activity in Blood and Platelets Is Associated With Nonalcoholic Fatty Liver Disease

Author

Ferri, Flaminia, Mischitelli, Monica, Tozzi, Giulia, Messina, Emanuele, Mignini, Irene, Mazzuca, Sergio, Pellone, Monica, Parisse, Simona, Marrapodi, Ramona, Visentini, Marcella, Baratta, Francesco, Del Ben, Maria, Pastori, Daniele, Perciballi, Roberta, Attilia, Maria Luisa, Carbone, Martina, De Santis, Adriano, Violi, Francesco, Angelico, Francesco, and Corradini, Stefano Ginanni

Published
2020
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31. Reduced Lysosomal Acid Lipase Activity in Blood and Platelets Is Associated With Nonalcoholic Fatty Liver Disease

Author

Ferri, Flaminia, Mischitelli, Monica, Tozzi, Giulia, Messina, Emanuele, Mignini, Irene, Mazzuca, Sergio, Pellone, Monica, Parisse, Simona, Marrapodi, Ramona, Visentini, Marcella, Baratta, Francesco, Del Ben, Maria, Pastori, Daniele, Perciballi, Roberta, Attilia, Maria Luisa, Carbone, Martina, De Santis, Adriano, Violi, Francesco, Angelico, Francesco, and Ginanni Corradini, Stefano

Published
2020
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32. Platelets from patients with decompensated cirrhosis display pro-inflammatory features

Author

Di Cola, Simone, primary, Stefanini, Lucia, additional, Lombardi, Ludovica, additional, Fonte, Stefano, additional, Maiorca, Francesca, additional, Pallucci, Davide, additional, Marrapodi, Ramona, additional, Sabetta, Annamaria, additional, Miglionico, Marzia, additional, Cangemi, Roberto, additional, Visentini, Marcella, additional, Riggio, Oliviero, additional, Merli, Manuela, additional, and Basili, Stefania, additional

Published
2023
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33. Inflammatory rheumatic diseases with onset after SARS-CoV-2 infection or COVID-19 vaccination: a report of 267 cases from the COVID-19 and ASD group

Author

Ursini, Francesco, primary, Ruscitti, Piero, additional, Addimanda, Olga, additional, Foti, Rosario, additional, Raimondo, Vincenzo, additional, Murdaca, Giuseppe, additional, Caira, Virginia, additional, Pigatto, Erika, additional, Cuomo, Giovanna, additional, Lo Gullo, Alberto, additional, Cavazzana, Ilaria, additional, Campochiaro, Corrado, additional, Naclerio, Caterina, additional, De Angelis, Rossella, additional, Ciaffi, Jacopo, additional, Mancarella, Luana, additional, Brusi, Veronica, additional, Marchetti, Elena, additional, Motta, Francesca, additional, Visentini, Marcella, additional, Lorusso, Sebastiano, additional, De Santis, Maria, additional, De Luca, Giacomo, additional, Massaro, Laura, additional, Olivo, Domenico, additional, Pellegrini, Roberta, additional, Francioso, Francesca, additional, Luppino, Jessica, additional, Di Cola, Ilenia, additional, Foti, Roberta, additional, Varcasia, Giuseppe, additional, Caso, Francesco, additional, Reta, Massimo, additional, Dagna, Lorenzo, additional, Selmi, Carlo, additional, Iagnocco, Annamaria, additional, Giacomelli, Roberto, additional, Iannone, Florenzo, additional, and Ferri, Clodoveo, additional

Published
2023
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34. Interferon-free antiviral treatment in B-cell lymphoproliferative disorders associated with hepatitis C virus infection

Author

Arcaini, Luca, Besson, Caroline, Frigeni, Marco, Fontaine, Hélène, Goldaniga, Maria, Casato, Milvia, Visentini, Marcella, Torres, Harrys A., Loustaud-Ratti, Veronique, Peveling-Oberhag, Jan, Fabris, Paolo, Rossotti, Roberto, Zaja, Francesco, Rigacci, Luigi, Rattotti, Sara, Bruno, Raffaele, Merli, Michele, Dorival, Céline, Alric, Laurent, Jaccard, Arnaud, Pol, Stanislas, Carrat, Fabrice, Ferretti, Virginia Valeria, Visco, Carlo, and Hermine, Olivier

Published
2016
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35. Persistence of monoclonal B‐cell expansion and intraclonal diversification despite virus eradication in patients affected by hepatitis C virus‐associated lymphoproliferative disorders.

Author

Mazzaro, Cesare, Visentini, Marcella, Gragnani, Laura, Vit, Filippo, Tissino, Erika, Pozzo, Federico, Papotti, Robel, Casato, Milvia, Zignego, Anna Linda, Bittolo, Tamara, Zucchetto, Antonella, Degan, Massimo, Bomben, Riccardo, and Gattei, Valter

Subjects
*LYMPHOPROLIFERATIVE disorders, *HEPATITIS C, *HEPATITIS C virus, *HEPATITIS, *ANTIVIRAL agents, *FLOW cytometry
Abstract

Summary: We investigated 23 hepatitis C virus (HCV)‐infected patients with overt lymphoproliferative diseases (15 cases) or monoclonal B lymphocytosis (8 cases) treated with direct agent antiviral (DAAs) per clinical practice. DAA therapy yielded undetectable HCV‐RNA, the complete response of cryoglobulinemia vasculitis and related signs, whilst the presence of B‐cell clones (evaluated by flow cytometry, IGHV, and BCL2‐IGH rearrangements), detected in 19/23 cases at baseline, was maintained (17/19). Similarly, IGHV intraclonal diversification, supporting an antigen‐driven selection mechanism, was identified in B‐cell clones at baseline and end of follow‐up. DAA therapy alone, despite HCV eradication and good immunological responses, was less effective on the pathological B‐cell clones. [ABSTRACT FROM AUTHOR]

Published
2023
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36. Opposite Effects of mRNA-Based and Adenovirus-Vectored SARS-CoV-2 Vaccines on Regulatory T Cells: A Pilot Study

Author

La Gualana, Francesca, primary, Maiorca, Francesca, additional, Marrapodi, Ramona, additional, Villani, Francesca, additional, Miglionico, Marzia, additional, Santini, Stefano Angelo, additional, Pulcinelli, Fabio, additional, Gragnani, Laura, additional, Piconese, Silvia, additional, Fiorilli, Massimo, additional, Basili, Stefania, additional, Casato, Milvia, additional, Stefanini, Lucia, additional, and Visentini, Marcella, additional

Published
2023
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37. Dual stimulation by autoantigen and CpG fosters the proliferation of exhausted rheumatoid factor-specific CD21low B cells in hepatitis C virus-cured mixed cryoglobulinemia

Author

Del Padre, Martina, primary, Marrapodi, Ramona, additional, Minafò, Ylenia A., additional, Piano Mortari, Eva, additional, Radicchio, Giovanna, additional, Bocci, Chiara, additional, Gragnani, Laura, additional, Camponeschi, Alessandro, additional, Colantuono, Stefania, additional, Stefanini, Lucia, additional, Basili, Stefania, additional, Carsetti, Rita, additional, Fiorilli, Massimo, additional, Casato, Milvia, additional, and Visentini, Marcella, additional

Published
2023
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38. Hepatitis B virus-infection related cryoglobulinemic vasculitis. Clinical manifestations and the effect of antiviral therapy: A review of the literature

Author

Mazzaro, Cesare, primary, Bomben, Riccardo, additional, Visentini, Marcella, additional, Gragnani, Laura, additional, Quartuccio, Luca, additional, Saccardo, Francesco, additional, Sebastiani, Marco, additional, Filippini, Davide, additional, Lauletta, Gianfranco, additional, Monti, Giuseppe, additional, and Gattei, Valter, additional

Published
2023
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39. Efficacy of low-dose rituximab for the treatment of mixed cryoglobulinemia vasculitis: Phase II clinical trial and systematic review

Author

Visentini, Marcella, Tinelli, Carmine, Colantuono, Stefania, Monti, Monica, Ludovisi, Serena, Gragnani, Laura, Mitrevski, Milica, Ranieri, Jessica, Fognani, Elisa, Piluso, Alessia, Granata, Massimo, De Silvestri, Annalisa, Scotti, Valeria, Mondelli, Mario U., Zignego, Anna Linda, Fiorilli, Massimo, and Casato, Milvia

Published
2015
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40. Inflammatory rheumatic diseases with onset after SARS-CoV-2 infection or COVID-19 vaccination: a report of 267 cases from the COVID-19 and ASD group

Author

Ursini, Francesco, Ruscitti, Piero, Addimanda, Olga, Foti, Rosario, Raimondo, Vincenzo, Murdaca, Giuseppe, Caira, Virginia, Pigatto, Erika, Cuomo, Giovanna, Lo Gullo, Alberto, Cavazzana, Ilaria, Campochiaro, Corrado, Naclerio, Caterina, De Angelis, Rossella, Ciaffi, Jacopo, Mancarella, Luana, Brusi, Veronica, Marchetti, Elena, Motta, Francesca, Visentini, Marcella, Lorusso, Sebastiano, De Santis, Maria, De Luca, Giacomo, Massaro, Laura, Olivo, Domenico, Pellegrini, Roberta, Francioso, Francesca, Luppino, Jessica, Di Cola, Ilenia, Foti, Roberta, Varcasia, Giuseppe, Caso, Francesco, Reta, Massimo, Dagna, Lorenzo, Selmi, Carlo, Iagnocco, Annamaria, Giacomelli, Roberto, Iannone, Florenzo, and Ferri, Clodoveo

Subjects
Arthritis, Autoimmune Diseases, COVID-19, Polymyalgia Rheumatica, Vaccination
Published
2023

42. Might IgA be a Biomarker of Disease Activity in Takayasu Arteritis?

Author

Marcella Visentini Marcella Visentini, Giuseppina Cusano Giuseppina Cusano, Marzia Miglionico Marzia Miglionico, Chiara Pellicano Chiara Pellicano, and Lorenzo Vantaggio

Subjects
Internal Medicine
Abstract

Takayasu arteritis is a systemic vasculitis of the large vessels and mainly affects Japanese and Southeast Asian women in the second and third decades of life. Inflammatory infiltrate affects the full thickness of the vessel wall, inducing progressive lumen stenosis and occlusion. The main biomarkers of disease activity are the ESR, CRP and serum levels of circulating cytokines. This case report describes the clinical history of a young woman with Takayasu disease with high serum levels of IgA at onset. IgA remained elevated with persistence of disease activity, and normalized only when the patient was treated with an anti-TNF agent (infliximab), which also induced a clinical response in the vasculitis. IgA levels, together with other inflammatory parameters, may be considered a biomarker of disease activity.

Published
2022
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44. Correction to: Management of mixed cryoglobulinemia with rituximab: evidence and consensus-based recommendations from the Italian Study Group of Cryoglobulinemia (GISC)

Author

Quartuccio, Luca, primary, Bortoluzzi, Alessandra, additional, Scirè, Carlo Alberto, additional, Marangoni, Antonio, additional, Del Frate, Giulia, additional, Treppo, Elena, additional, Castelnovo, Laura, additional, Saccardo, Francesco, additional, Zani, Roberta, additional, Candela, Marco, additional, Fraticelli, Paolo, additional, Mazzaro, Cesare, additional, Renoldi, Piero, additional, Scaini, Patrizia, additional, Filippini, Davide Antonio, additional, Visentini, Marcella, additional, Scarpato, Salvatore, additional, Giuggioli, Dilia, additional, Mascia, Maria Teresa, additional, Sebastiani, Marco, additional, Zignego, Anna Linda, additional, Lauletta, Gianfranco, additional, Fiorilli, Massimo, additional, Casato, Milvia, additional, Ferri, Clodoveo, additional, Pietrogrande, Maurizio, additional, Pioltelli, Pietro Enrico, additional, De Vita, Salvatore, additional, Monti, Giuseppe, additional, and Galli, Massimo, additional

Published
2022
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45. Increased von Willebrand Factor Platelet-Binding Capacity Is Related to Poor Prognosis in COVID-19 Patients

Author

Stefanini, Lucia, primary, Ruberto, Franco, primary, Curreli, Mariaignazia, additional, Chistolini, Antonio, additional, Schiera, Eleonora, additional, Marrapodi, Ramona, additional, Visentini, Marcella, additional, Ceccarelli, Giancarlo, additional, D'Ettorre, Gabriella, additional, Santoro, Cristina, additional, Gandini, Orietta, additional, Moro, Emilia F., additional, Zullino, Veronica, additional, Pugliese, Francesco, additional, and Pulcinelli, Fabio M., additional

Published
2022
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47. Management of mixed cryoglobulinemia with rituximab: evidence and consensus-based recommendations from the Italian Study Group of Cryoglobulinemia (GISC)

Author

Quartuccio, Luca, primary, Bortoluzzi, Alessandra, additional, Scirè, Carlo Alberto, additional, Marangoni, Antonio, additional, Del Frate, Giulia, additional, Treppo, Elena, additional, Castelnovo, Laura, additional, Saccardo, Francesco, additional, Zani, Roberta, additional, Candela, Marco, additional, Fraticelli, Paolo, additional, Mazzaro, Cesare, additional, Renoldi, Piero, additional, Scaini, Patrizia, additional, Filippini, Davide Antonio, additional, Visentini, Marcella, additional, Scarpato, Salvatore, additional, Giuggioli, Dilia, additional, Mascia, Maria Teresa, additional, Sebastiani, Marco, additional, Zignego, Anna Linda, additional, Lauletta, Gianfranco, additional, Fiorilli, Massimo, additional, Casato, Milvia, additional, Ferri, Clodoveo, additional, Pietrogrande, Maurizio, additional, Pioltelli, Pietro Enrico, additional, De Vita, Salvatore, additional, Monti, Giuseppe, additional, and Galli, Massimo, additional

Published
2022
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49. Human CD38 regulates B cell antigen receptor dynamic organization in normal and malignant B cells

Author

Camponeschi, Alessandro, primary, Kläsener, Kathrin, additional, Sundell, Timothy, additional, Lundqvist, Christina, additional, Manna, Paul T., additional, Ayoubzadeh, Negar, additional, Sundqvist, Martina, additional, Thorarinsdottir, Katrin, additional, Gatto, Mariele, additional, Visentini, Marcella, additional, Önnheim, Karin, additional, Aranburu, Alaitz, additional, Forsman, Huamei, additional, Ekwall, Olov, additional, Fogelstrand, Linda, additional, Gjertsson, Inger, additional, Reth, Michael, additional, and Mårtensson, Inga-Lill, additional

Published
2022
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