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Simulators are the most dominant and eminent tool for analyzing and investigating different type of networks. The simulations can be executed with less cost as compared to largescale experiment as less computational resources are required and if the simulation model is carefully designed then it can be more practical than any well brought-up mathematical model. Generally P2P research is based on the principle of simulate first and then experiment in the real world and there is no reason that simulation results cannot be reproducible. A lack of standard documentation makes verification of results harder as well as due to such poor documentation implementation of well-known overlay algorithms was very difficult. This Paper describes different types of existing P2P simulators as well as provides a survey and comparison of existing P2Psimulators and extracting the best simulator among them. [ABSTRACT FROM AUTHOR]

The l,2- bis(sulphapyridyl)oxamide ligand [L] and its complexes with FeIII, CoII, CuII and ZnII chloride were synthesized and characterized by elemental analyses, i.r., n.m.r., e.p.r. and u.v.–vis. spectroscopy and molar conductance measurements. Spectroscopic studies show that all the complexes are octahedral and covalent. The electrochemical behaviour of the CoII complex was monitored by cyclic voltammetry in a buffer/DMF solution (95:5). The E0 values −0.622 and −0.502 V reveal a reversible one electron redox wave attributed to a CoII/CoI redox couple at a scan rate of 0.1 V s−1. The interaction of the CoII complex with bovine milk casein (BMC) was studied at the same scan rate, which reveals a strong binding as the E0 values shift to more negative potential ( E0 = −0.908 and −0.703 V). The cyclic voltammograms of the CoII complex bound by BMC were recorded at different pH's. The plot of E0 versus pH showed that E0 values are maximal at pH 7.4 indicating good interaction between the BMC and the CoII complex which is further confirmed by kinetic data. The kinetic studies of the CoII complex bound to BMC was monitored in phosphate buffer solution at different pH's by spectrophotometry. The absorbance changes were monitored at 278 nm ( λmax for BMC) with respect to time and pseudo-first-order rate constants, Kobs, were obtained from the slope and intercept of the straight line using the least squares regression method. The plot of absorbance versus time at different pH's was linear up to 80% completion of the reaction. The pH-rate profile data reveals that the reactions are pH dependent. [ABSTRACT FROM AUTHOR]

Background: The global epidemic of hepatitis B and hepatitis C is a serious public-health problem. Chronic hepatitis B and hepatitis C are among the leading causes of preventable death worldwide. World Health Organization (WHO) estimates that up to two billion people in the world have been infected with HBV; about 350 million people live with chronic HBV infection, and about 600,000 people die from HBV- related liver disease or HCC each year. The endemicity of infection is considered high in Yemen. Data for prevalence of HBsAg and HCV antibodies in Ibb city in Yemen is rare and inadequate. Objectives: The study was undertaken to study the epidemiology and prevalence of viral hepatitis (HBV) and (HCV) in Ibb city, Yemen. Patients and Methods: 554 pre-designed questionnaires and sera samples were collected in July 2010. Sera were tested for HBsAg and HCV antibodies by ELISA quantitative technique. Each individual's data were collected in a pre-designed questionnaire. Results: The prevalence of HBV in Ibb city was 1.81 %, whereas, the prevalence of HCV was 1.99 %. Conclusions: This study revealed low level risk of hepatitis B virus and hepatitis C virus infections. Inadequate information on the prevalence and risk determinants of viral hepatitis among the different population groups in Yemen are responsible about morbidity and mortality of HBV and HCV in Ibb city, Yemen. [ABSTRACT FROM AUTHOR]

Aim: A novel nurse‐focused discrete event simulation modelling approach was tested to predict nurse workload and care quality. Background: It can be challenging for hospital managers to quantify the impact of changing operational policy and technical design such as nurse–patient ratios on nurse workload and care quality. Planning tools are needed—discrete event simulation is a potential solution. Method: Using discrete event simulation, a demonstrator "Simulated Care Delivery Unit" model was created to predict the effects of varying nurse–patient ratios. Modelling inputs included the following: patient care data (GRASP systems data), inpatient unit floor plan and operating logic. Model outputs included the following: nurse workload in terms of task‐in‐queue, cumulative distance walked and Care quality in terms of task in queue time, missed care. Results: The model demonstrated that as NPR increases, care quality deteriorated (120% missed care; 20% task‐in‐queue time) and nursing workload increased (120% task‐in‐queue; 110% cumulative walking distance). Conclusions: DES has the potential to be used to inform operational policy and technical design decisions, in terms of impacts on nurse workload and care quality. Implications for Nursing Management: This research offers the ability to quantify the impacts of proposed policy changes and technical design decisions, and provide a more cost‐effective and safe alternative to the current trial and error methodologies. [ABSTRACT FROM AUTHOR]

Propranolol hydrochloride is a beta-blocker used for the management and treatment of hypertension, angina, coronary artery disease, heart failure, fibrillation, tremors, migraine etc. The objective of the present study was to design Propranolol Hydrochloride floating tablets by direct compression method and to explore the role of a new gum as a matrix former. A 22 full factorial design was selected for the present study. Prunus domestica gum and HPMC (K4M) were used as independent variables, swelling index and drug dissolution at 12 hours as dependent variables. Formulations were subjected to pre- and post-compression tests that showed good micromeritics and buoyancy characteristics (Carr's index 11.76%–14.00%, Hausner's ratio 1.13°–1.16°, angle of repose 22.67°–25.21°, floating lag time 56–76 seconds, total floating time 18–25 hours and swelling index 59.87%–139.66%). The cumulative drug release in 0.1 N HCl at 12 hours was 72%–90% (p<0.05). Weibull model was found to be the best fit model (R2>0.99) among all other studied models. Multiple regression showed a significant effect of Prunus domestica gum and HPMC K4M on the swelling index and dissolution profiles of propranolol HCl (p<0.05). On the basis of better in-vitro performance and cost-effectiveness, formulation F4 was the best formulation. It is evident from the results that Prunus domestica gum possesses excellent drug release retardant potential for the floating drug delivery system and this new gum should be further explored alone or with other natural and synthetic polymers in future studies. [ABSTRACT FROM AUTHOR]

The cornerstone of the new imaging technologies to treat complex arrhythmias is the electroanatomic (EAM) mapping. It is based on tissue characterization and in particular on determination of low potential region and dense scar definition. Recently, the identification of fractionated isolated late potentials increased the specificity of the information derived from EAM. In addition, non-invasive tools and their integration with EAM, such as cardiac magnetic resonance imaging and computed tomography scanning, have been shown to be helpful to characterize the arrhythmic substrate and to guide the mapping and the ablation. Finally, intracardiac echocardiography, known to be useful for several practical uses in the setting of electrophysiological procedures, it has been also demonstrated to provide important informations about the anatomical substrate and may have potential to identify areas of scarred myocardium. [ABSTRACT FROM AUTHOR]

Background: This study was an attempt to evaluate the knowledge and awareness among dentists about COVID-19 infection. Methodology: This study was conducted among 580 dental professionals that comprised graduates (BDS), masters (MDS), postgraduates, and PhD fellows. A questionnaire containing information about knowledge, attitude, and awareness about COVID-19 infection was administered and recorded. Results: A total of 493 (85%) respondents replied correct answer that SARS-CoV-2 causes COVID-19. A total of 464 (80%) respondents replied that SARS-CoV-2 is the highest infectious virus among all. A total of 510 (88%) respondents replied the correct answer that 2-14 days is the incubation period of COVID-19 virus. Only 116 (20%) respondents replied the correct answer that MERS has high mortality. Only 87 (15%) respondents were aware of the appropriate mortality rate of COVID-19 disease. A total of 455 (78.4%) respondents had knowledge of the method of detecting COVID-19 infection (real-time reverse transcription-polymerase chain reaction). Knowledge level was good as seen in 81%, fair in 9.5%, and poor in 10.5% of the respondents. Conclusion: The authors found that dental professionals had fair knowledge and awareness regarding COVID-19 infection. [ABSTRACT FROM AUTHOR]

Background: The radial artery is the access of choice in many catheterization labs around the world due to its proven benefits over the femoral artery access. There has been growing interest in the left radial artery. We sought to evaluate the feasibility, safety and complication rates of the left distal radial artery (ldTRA) access for cardiac catheterization.Methods: This is a single arm retrospective study evaluating the feasibility and safety of performing cardiac catheterization through ldTRA. The procedure was completed using standard diagnostic and guiding catheters. Hemostasis was achieved with a radial band. Feasibility was the ability to cannulate the distal left radial artery as well as completing the procedure without requiring an additional arterial access. The safety point included hematoma, bleeding or neuropathy.Results: ldTRA was attempted in 61 patients. 59 patients had successful completion of the procedure through ldTRA. Conversion occurred in 1 patient (1.7%), requiring an additional arterial access to complete the procedure. 34 patients (55.7%) required percutaneous coronary intervention (PCI). There was no access site bleeds post procedure, no hematomas, with 100% successful hemostasis with a radial hemostatic band. There were 2 cases requiring reaccess of the distal left radial artery access for repeat revascularization, with procedure success and good left radial artery patency.Conclusion: ldTRA is a safe and feasible arterial access in a radial experienced catheterization lab. ldTRA provides improved operator ergonomics and patient's comfort, in addition to the advantage of being able to cannulate the bypass grafts and with a very low risk of vascular complications. [ABSTRACT FROM AUTHOR]

Rumex hastatus being used for medicinal and nutritional purposes as a functional food in various countries is hereby evaluated by the gas chromatography-mass spectroscopy, proximate analysis, physicochemical (fluorescence) analysis, quantitative analysis of secondary metabolites and sensory evaluations studies. Various samples of R. hastatus were also evaluated for in vitro anti-diabetic potential. The investigational study demonstrated that R. hastatus is a rich source of carbohydrate, i.e., 432.4 mg/g. Moisture content, protein, fiber, ash content and fats were recorded as 22.8%, 133.9 mg/g, 124.4 mg/g, 54.5 mg/g and 25.6 mg/g, respectively. In the same way, the secondary metabolite displayed a relatively greater amount of flavonoids (84.5 mg/g) followed by saponins (65.5 mg/g) and alkaloids (49.5 mg/g). Similarly, the GC (FID-MS) analysis of R. hastatus revealed the detection of 120 compounds. Out of those identified compounds, selected anti-diabetic compounds were sorted out, viz butyl phthalate, phytol, ethylthreonine, dihydrobenzofuran, indoline, guanidine, nerolidol, myristic acid, palmitic acid, caryophyllene, anozol. In physicochemical fluorescence analysis and the sensory evaluation, data were also recorded along with the anti-diabetic with IC50 value of 42.09 µg/ml. The overall investigational analysis of R. hastatus obviously demonstrated that this plant was a rich source of primary and secondary metabolites. It may be concluded from the GC (FID-MS) analysis that R. hastatus is a potential source of anti-diabetic constituents, which may confer hypoglycemic potential. Based on the recorded data it may also be inferred that R. hastatus is among safe and nutritious herbs, which can be used in lieu of green vegetables and functional food with anti-diabetic potential. [ABSTRACT FROM AUTHOR]

Despite consistent monitoring by the Department of Islamic Development Malaysia (JAKIM), the fabrication of fake halal logos and certificates by irresponsible parties continues to challenge the integrity and authenticity of halal products. Malaysia’s Halal Certification Procedures (Second Revision, 2012) state that companies operating in Malaysia need to develop their Halal Assurance System (HAS) to strengthen the management of halal-related matters within organizations. The purpose of this study is to investigate the influence of perceived benefits and traceability practices on readiness for Halal Assurance System (HAS) implementation. The study was conducted through a cross-sectional survey, and simple random sampling was employed. At the end of the data collection period, a total of 139 responses from halal-certified small and medium enterprises (SMEs) were obtained. Structural equation modeling with Amos graphics was used to perform a confirmatory factor analysis (CFA) and a causal path analysis. Results indicate that perceived market/competition benefits and perceived operational benefits are positively related to traceability systems implementation and readiness for HAS. It was found that traceability systems are fully needed to bridge the connection between perceived benefits and readiness for HAS. This paper has important implications for resource-based theory, literature on HAS and traceability, SMEs, and halal authorities and certifying bodies. Limitations and directions for future studies are provided. [ABSTRACT FROM AUTHOR]

Ventricular arrhythmias (VAs) arising from the right ventricular outflow tract (RVOT) are a common and heterogeneous entity. Idiopathic right ventricular arrhythmias (IdioVAs) are generally benign, with excellent ablation outcomes and long-term arrhythmia-free survival, and must be distinguished from other conditions associated with VAs arising from the right ventricle: the differential diagnosis with arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is therefore crucial because VAs are one of the most important causes of sudden cardiac death (SCD) in young individuals even with early stage of the disease. Radiofrequency catheter ablation (RFCA) is a current option for the treatment of VAs but important differences must be considered in terms of indication, purposes and procedural strategies in the treatment of the two conditions. In this review, we comprehensively discuss clinical and electrophysiological features, diagnostic and therapeutic techniques in a compared analysis of these two entities. [ABSTRACT FROM AUTHOR]

Most of interventional procedures in cardiology are carried out under fluoroscopic imaging guidance. Besides other peri-interventional risks, radiation exposure should be considered for its stochastic (inducing malignancy) and deterministic effects on health (tissue reactions like erythema, hair loss and cataracts). In this article we analized the radiation risk from cardiovascular imaging to both patients and medical staff and discusses how customize the X-ray system and how to implement shielding measures in the cath lab. Finally, we reviewed the most recent developments and the latest findings in catheter navigation and 3D electronatomical mapping systems that may help to reduce patient and operator exposure. [ABSTRACT FROM AUTHOR]

A hydroethanolic extract (HE-ext) of Bacopa monnieri (BM) was studied for antinociceptive effect in the animal models of acetic-acid-induced writhing test and antilocomotive effect in mice. Standard centrally 13 acting analgesic, morphine (MP), and peripherally-acting one, diclofenac (Diclo), were also tested along with the extract for comparison. The extract exhibited significant antinociceptive effect (p < 0.001) in this test, not antagonized by the opioid receptor antagonist, naloxone (NLX) in a fashion similar to diclofenac. This excluded the involvement of opioids in the mediation of antinociceptive response of Bacopa monnieri. Moreover, the BM HE-ext exhibited highly significant antilocomotive (p < 0.0001) that was also unaffected by naloxone. These results indicate that Bacopa monnieri possesses antinociceptive and antilocomotive effect that may be mediated through non-opioidergic mechanism. [ABSTRACT FROM AUTHOR]

• A series of sulfonated esters of piroxicam 1–19 were synthesized. • The structures were confirmed by 1H-NMR, MS, IR, UV and elemental analysis. • All derivatives of piroxicam showed varying degree of antiglycation potential with IC50 values in range of 178.9 - 636.41 µM. • The structure-activity relationship was established. A series of sulfonated esters of piroxicam 1–19 were synthesized by substitution of "H" from hydroxyl "OH" group of piroxicam with different alkyl/aryl sulfonyl chloride by continuous stirring at room temperature. The derivatives were elucidated through various spectroscopic procedures like 1H NMR, MS, IR, UV and elemental analysis. Piroxicam derivatives were screened for antiglycation activity, in order to analyze the effect of substitution for the management of late diabetic complications. The preliminary results showed that the compounds 2 exhibited potent antiglycation activity far better than the reference (rutin IC 50 = 274.5 ± 0.05 µM), while the compounds 5 and 8 were near with IC 50 values of 178.9 ± 1.55 µM, 237 ± 2.01 µM, and 256.5 ± 2.56 µM respectively. Moreover a negative effect of electron withdrawing groups was observed over the inhibition potential of different analogues depending upon the number and the positions of the substituents. [Display omitted] [ABSTRACT FROM AUTHOR]