251. Two pregnancies shortly after transplantation with reduced intensity conditioning in chronic myeloid leukemia.
- Author
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Faraci M, Matthes-Martin S, Lanino E, Morreale G, Ferretti M, Giardino S, Micalizzi C, and Balduzzi A
- Subjects
- Adolescent, Antineoplastic Agents administration & dosage, Dasatinib administration & dosage, Disease-Free Survival, Female, Hematopoietic Stem Cell Transplantation adverse effects, Humans, Hydroxyurea administration & dosage, Imatinib Mesylate administration & dosage, Interferons administration & dosage, Leukemia, Myelogenous, Chronic, BCR-ABL Positive complications, Pregnancy, Primary Ovarian Insufficiency prevention & control, Transplantation Conditioning adverse effects, Treatment Outcome, Young Adult, Drug Administration Schedule, Hematopoietic Stem Cell Transplantation methods, Leukemia, Myelogenous, Chronic, BCR-ABL Positive therapy, Transplantation Conditioning methods
- Abstract
POI is a relevant late complication after HSCT and occurring more frequently after MAC than after RIC regimens. Reports on the frequency of POI after RIC in a large pediatric and adolescent population are lacking. In this study, we describe a girl affected by CML diagnosed at the age of 15 yr and treated with oncarbide and interferon followed by imatinib and dasatinib. She had two pregnancies shortly after RIC performed according to the CML-SCT I-BFM protocol including TT, FLU, and MEL. Hypergonadotropic hypogonadism occurred four months after HSCT; menstruations resumed regularly six months after HSCT. Eight and 20 months after HSCT, the patient became pregnant and then delivered, respectively, two babies at term by cesarean section. Both newborns had no neonatal complications. Donor chimerism at time of two pregnancies and five yr after transplantation demonstrated complete donor engraftment. These findings suggest that I-BFM CML-SCT protocol could be a promising treatment option for adolescents or young adults with CML eligible for HSCT., (© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Published
- 2016
- Full Text
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