482 results on '"Tatsuo Hosoya"'
Search Results
452. Human mesenchymal stem cells in rodent whole-embryo culture are reprogrammed to contribute to kidney tissues.
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Takashi Yokoo, Toya Ohashi, Un Song Shen, Ken Sakurai, Yoichi Miyazaki, Yasunori Utsunomiya, Masanori Takahashi, Yoshio Terada, Yoshikatsu Eto, Tetsuya Kawamura, Noriko Osum, and Tatsuo Hosoya
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STEM cells ,EMBRYOS ,TISSUES ,TRANSPLANTATION of organs, tissues, etc. ,CELLS ,ORGANS (Anatomy) - Abstract
The use of stem cells has enabled the successful generation of simple organs. However, anatomically complicated organs such as the kidney have proven more refractory to stem-cell-based regenerative techniques. Given the limits of allogenic organ transplantation, an ultimate therapeutic solution is to establish self-organs from autologous stem cells and transplant them as syngrafts back into donor patients. To this end, we have striven to establish an in vitro organ factory to build up complex organ structures from autologous adult stem cells by using the kidney as a target organ. Cultivation of human mesenchymal stem cells in growing rodent embryos enables their differentiation within a spatially and temporally appropriate developmental milieu, facilitating the first step of nephrogenesis. We show that a combination of whole-embryo culture, followed by organ culture, encourages exogenous human mesenchymal stem cells to differentiate and contribute to functional complex structures of the new kidney. [ABSTRACT FROM AUTHOR]
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- 2005
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453. TWO CASES OF XANTHINURIA IN BROTHERS
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Hideo KONO, Tatsuo HOSOYA, Kazuya KODOMA, Akira MATSUMOTO, YOSHITAKA ODA, Yosuke OGURA, Soichi SAKAI, and Tadashi MIYAHARA
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General Medicine - Published
- 1984
454. Determination of Uric Acid in Human Serum: Reversed-Phase Liquid Chromatography with Electrochemical Detection
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Masahiko Yoshiura, Tatsuo Hosoya, Kono H, Takeo Iwamoto, Keiji Iriyama, and Tadashi Miyahara
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chemistry.chemical_compound ,Chromatography ,chemistry ,Electrochemical detector ,Molecular Medicine ,Uric acid ,Perchloric acid ,Reversed-phase chromatography ,Electrochemical detection - Abstract
A method for the simultaneous determination of uric acid in human serum by reversed-phase high-performance liquid chromatography with electrochemical detection has been developed. Human serum (0.5 ml) was mixed with 0.5 ml of 0.2 N perchloric acid solution and the mixture was centrifuged at 3,000 g for 20 min. An aliquot (10 μl) of the supernatant (deproteinized human serum) was injected into the chromatographic system employed in this study. The assay limit for quantitation was about 10 pg for uric acid. Complete separation of uric acid was achieved in about 8 min under the present chromatographic conditions.
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- 1983
455. Oxidative stress is enhanced in correlation with renal dysfunction: Examination with the redox state of albumin
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Kenichi Yamada, Hiroyuki Terawaki, Kazunobu Yoshimura, Yukie Matsuyama, Masato Matsushima, Tatsuo Hosoya, Seiichi Era, Masaaki Nakayama, Tsuneo Negawa, and Toshio Hasegawa
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Adult ,Male ,Nephrology ,mercapto group ,medicine.medical_specialty ,medicine.medical_treatment ,Serum albumin ,Renal function ,Serum Albumin, Human ,medicine.disease_cause ,chemistry.chemical_compound ,chronic renal failure ,Internal medicine ,creatinine clearance ,medicine ,Humans ,Protein Isoforms ,oxidative stress ,Renal Insufficiency ,Chromatography, High Pressure Liquid ,Serum Albumin ,Dialysis ,Aged ,Creatinine ,biology ,predialysis ,business.industry ,Albumin ,Middle Aged ,medicine.disease ,Endocrinology ,chemistry ,biology.protein ,redox state of albumin ,Female ,business ,Oxidation-Reduction ,Biomarkers ,Oxidative stress ,Kidney disease - Abstract
Oxidative stress is enhanced in correlation with renal dysfunction: Examination with the redox state of albumin.BackgroundCardiovascular disease is known to be the most important complication among patients with renal failure, and oxidative stress has been proposed to play a major role as the source of such complications. Human serum albumin (HSA) is composed of human mercaptoalbumin (HMA) with cysteine residues having reducing powers, of reversibly oxidized human non-mercaptoalbumin-1 (HNA-1), and strongly oxidized human non-mercaptoalbumin-2 (HNA-2).MethodsWe used the “redox state of HSA” as a marker to investigate the current status of oxidative stress in predialysis patients with renal failure. The subjects were 55 nondialysis patients (31 males and 24 females) with chronic renal diseases, and having various degrees of renal function. The subjects' redox state of HSA was determined by a high-performance liquid chromatographic (HPLC) procedure, and the results presented in terms of the ratios between HNA-total(HNA-1 + HNA-2) and HNA-2.ResultsThe values for each fraction of HNA-total (f(HNA-total)) and f(HNA-2) were increased with a decrease of renal functions, and a significant positive correlation with serum creatinine (R = 0.529, P < 0.0001 and R = 0.618, P < 0.0001) was detected. Multiple (forward stepwise) regression analysis using f(HNA-total) and f(HNA-2) as the criterion variables was performed, and creatinine was adopted as significant explanatory variable in both equations.ConclusionWe found that even before dialysis, oxidative stress was enhanced in correlation with the level of renal dysfunction among patients with chronic renal failure. In the future, antioxidant strategies should become part of treatment for predialysis renal failure.
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456. The predictive value of attenuated proteinuria at 1 year after steroid therapy for renal survival in patients with IgA nephropathy
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Yoichi Miyazaki, Nobuo Tsuboi, Masato Ikeda, Hideo Okonogi, Tetsuya Kawamura, Masato Matsushima, Yasunori Utsunomiya, Tatsuo Hosoya, Makoto Ogura, Keita Hirano, and Kazushige Hanaoka
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Adult ,Male ,Nephrology ,medicine.medical_specialty ,Physiology ,Urology ,Renal function ,Clinical remission ,urologic and male genital diseases ,Nephropathy ,Cohort Studies ,Excretion ,chemistry.chemical_compound ,Adrenal Cortex Hormones ,Internal medicine ,Physiology (medical) ,medicine ,Humans ,Proportional Hazards Models ,Tonsillectomy ,Creatinine ,Endocapillary hypercellularity ,Proteinuria ,Proportional hazards model ,business.industry ,Threshold ,Glomerulonephritis, IGA ,Glomerulonephritis ,Prognosis ,medicine.disease ,Corticosteroid therapy ,Endocrinology ,chemistry ,Female ,Original Article ,medicine.symptom ,business ,Glomerular Filtration Rate - Abstract
Background The relationship between the urinary protein excretion (UPE) initially achieved after steroid therapy and the long-term renal outcome of IgA nephropathy (IgAN) has not been clarified. We investigated the threshold UPE at 1 year after steroid therapy which predicts a favorable renal survival. Methods We enrolled 141 IgAN patients who received 6 months of steroid therapy. The endpoint was defined as a 50 % increase in serum creatinine from baseline. The spline model was used to define the threshold UPE predicting renal survival. Results Thirteen patients (9.2 %) reached the endpoint at a median follow-up of 3.8 years. When evaluating the relative hazard ratio (HR) of the UPE at 1 year for the endpoint, we found an inflection point at 0.40 g/day on the spline curve. The multivariate Cox model revealed that, in addition to the Disappeared category of UPE (range
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457. Effects of topiroxostat on the serum urate levels and urinary albumin excretion in hyperuricemic stage 3 chronic kidney disease patients with or without gout
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Shinsuke Nomura, Tatsuo Hosoya, Shin Fujimori, Shigeko Hara, Shunya Uchida, Tetsuya Yamamoto, Iwao Ohno, and Ichiro Hisatome
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Male ,Nephrology ,Gout ,Pyridines ,Physiology ,Blood Pressure ,Comorbidity ,chemistry.chemical_compound ,Prevalence ,Hyperuricemia ,Enzyme Inhibitors ,Stage (cooking) ,Xanthine oxidase inhibitor ,Middle Aged ,Topiroxostat ,Treatment Outcome ,Creatinine ,Female ,Original Article ,Adiponectin ,Glomerular Filtration Rate ,musculoskeletal diseases ,Xanthine Oxidase ,congenital, hereditary, and neonatal diseases and abnormalities ,medicine.medical_specialty ,medicine.drug_class ,Urology ,Excretion ,Double-Blind Method ,Internal medicine ,Physiology (medical) ,Nitriles ,CKD ,medicine ,Albuminuria ,Humans ,Renal Insufficiency, Chronic ,Aged ,business.industry ,nutritional and metabolic diseases ,FYX-051 ,medicine.disease ,Uric Acid ,chemistry ,business ,Kidney disease - Abstract
Background Topiroxostat, a selective xanthine oxidase inhibitor, shows effective reduction in the serum urate level in hyperuricemic patients with or without gout. The objective of this study was to evaluate the efficacy and safety of topiroxostat in hyperuricemic stage 3 chronic kidney disease patients with or without gout. Methods The study design was a 22-week, randomized, multicenter, double-blind study. The enrolled patients were randomly assigned to treatment with topiroxostat 160 mg/day (n = 62) or to the placebo (n = 61). The endpoints were the percent change in the serum urate level, change in the estimated glomerular filtration rate, the urinary albumin-to-creatinine ratio, the proportion of patients with serum urate levels of 356.88 μmol/L or less, blood pressure, and serum adiponectin. Results After 22 weeks, although the changes in the estimated glomerular filtration rate and blood pressure were not significant, the percent change in the serum urate level (−45.38 vs. −0.08 %, P
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458. Serum uric acid and the incidence of CKD and hypertension
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Yukio Maruyama, Naoki Sugano, Tatsuo Hosoya, Yasuhito Takahashi, Satoshi Kidoguchi, Daisuke Takahashi, Shinichiro Nishio, Satoru Kuriyama, Chisa Kobayashi, and Takashi Yokoo
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Nephrology ,Adult ,Male ,medicine.medical_specialty ,Hypertension, Renal ,Physiology ,Renal function ,Kaplan-Meier Estimate ,urologic and male genital diseases ,Gastroenterology ,Body Mass Index ,Cohort Studies ,chemistry.chemical_compound ,Sex Factors ,Predictive Value of Tests ,Internal medicine ,Physiology (medical) ,medicine ,CKD ,Humans ,Estimated glomerular filtration rate ,Renal Insufficiency, Chronic ,Tokyo ,Survival analysis ,business.industry ,Incidence (epidemiology) ,Incidence ,Cholesterol, HDL ,Middle Aged ,medicine.disease ,Survival Analysis ,female genital diseases and pregnancy complications ,Uric Acid ,Endocrinology ,Treatment Outcome ,chemistry ,Hypertension ,Uric acid ,Female ,Original Article ,business ,Body mass index ,Cohort study ,Kidney disease ,Glomerular Filtration Rate - Abstract
Background Uric acid (UA) levels correlate positively with the prevalence of chronic kidney disease (CKD) and/or hypertension. We tested the hypothesis that UA may also have a link to a new incidence of CKD and hypertension. Methods Study design is a cohort study and the predictor is UA levels. Of the 15,470 screened cases, 8223 participants without CKD were eligible for the analysis of the incidence of CKD. Among these CKD candidates, 7569 participants were eligible for the analysis of the new development of hypertension. The observation period was 4 years. Results Relationship of UA with new cases of CKD. Higher UA levels had a closer association with the new development of CKD; 1.1 % (UA
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459. Gene delivery using human cord blood–derived CD34+cells into inflamed glomeruli in NOD/SCID mice
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Jin-Song Shen, Toya Ohashi, Yasunori Utsunomiya, Takashi Yokoo, Tadao Tanaka, Tatsuo Hosoya, Takahide Suzuki, Tetsuya Kawamura, and Aikou Okamoto
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Lipopolysaccharides ,NOD/SCID mouse ,Genetic Vectors ,Kidney Glomerulus ,CD34 ,Antigens, CD34 ,Blood Component Transfusion ,Mice, SCID ,Biology ,Transfection ,Monocytes ,Mice ,Mice, Inbred NOD ,medicine ,Animals ,Humans ,gene delivery ,Glucuronidase ,Severe combined immunodeficiency ,Transplantation Chimera ,Blood Cells ,Monocyte ,Gene Transfer Techniques ,Hematopoietic Stem Cell Transplantation ,Cell Differentiation ,medicine.disease ,Fetal Blood ,Transplantation ,stem cell ,Haematopoiesis ,medicine.anatomical_structure ,Retroviridae ,Nephrology ,Cord blood ,Immunology ,Bone marrow ,Stem cell ,glomerulonephritis - Abstract
Gene delivery using human cord blood–derived CD34 + cells into inflamed glomeruli in NOD/SCID mice. Background Bone marrow reconstitution using genetically-modified hematopoietic stem cells has been reported to confer resistance to inflammation and prevent renal injury in glomerulonephritis. Although this strategy has potentials for clinical use, taking hematopoietic stem cells from bone marrow is highly stressful for patients. In this regard, umbilical cord blood may be a useful alternative and, therefore, we focused on their suitability as a source of hematopoietic stem cells for transplantation-based therapy for glomerulonephritis. Methods CD34 + cells were obtained from human umbilical cord blood, retrovirally transduced with human β-glucuronidase (HBG) gene, and transplanted into nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mice. After confirming the successful chimerism, these mice were treated with lipopolysaccharide (LPS), and local HBG expression in glomeruli was examined using immunohistochemical analysis, HBG bioassay, and Western blot analysis. Results Clonogenic assay showed that 88.4 ± 5.9% burst-forming unit-erythroid (BFU-E), 79.7 ± 11.4% in colony-forming unit-macrophage (CFU-M), and 81.1 ± 14.1% in colony-forming unit-granulocyte (CFU-G), respectively, possessed the transgene after transfection, suggesting that precommited cells were susceptible to retroviral infection. Flow cytometric analysis revealed that 24.1 ± 14.5% of bone marrow cells in these chimera mice expressed human lymphocyte antigen (HLA) 8weeks after transplantation. Also, clonogenic assay showed that a sustained engraftment of human hematopoietic cells expressed HBG. CD14-positive cells were recruited into the glomeruli upon LPS treatment and they secreted bioactive HBG, suggesting that cord blood–derived CD34 + cells may differentiate into monocyte lineage while maintaining the expression of the transgene. Conclusion These data indicate that umbilical cord blood cells can be utilized as a source of hematopoietic stem cells for the transplantation-based therapy of glomerulonephritis.
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460. Antihypertensive effect of a fixed-dose combination of losartan /hydrochlorothiazide in patients with uncontrolled hypertension: a multicenter study
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Makoto Ogura, Haruo Tomonari, Kiyoaki Akaba, Fumihiro Hayashi, Satoru Kuriyama, Iwao Ohno, Masahiro Ishikawa, Tatsuya Kanai, Masato Ikeda, Tetsuya Kawamura, Goro Tokudome, Tatsuo Hosoya, and Michimasa Soejima
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Adult ,Male ,medicine.medical_specialty ,Physiology ,Fixed-dose combination ,Losartan/hydrochlorothiazide ,Urology ,Renal function ,Blood Pressure ,Hyperuricemia ,Pharmacology ,Losartan ,Young Adult ,Hydrochlorothiazide ,Japan ,Internal medicine ,Physiology (medical) ,Natriuretic Peptide, Brain ,medicine ,Albuminuria ,Humans ,Prospective Studies ,Antihypertensive Agents ,Aged ,business.industry ,Blood Pressure Determination ,Middle Aged ,medicine.disease ,Uric Acid ,Drug Combinations ,Treatment Outcome ,Blood pressure ,Nephrology ,Creatinine ,Hypertension ,Original Article ,Female ,medicine.symptom ,business ,BNP ,Glomerular Filtration Rate ,medicine.drug - Abstract
Background Achieving adequate blood pressure (BP) control often requires more than one antihypertensive agent. The purpose of this study was to determine whether a fixed-dose formulation of losartan (LOS) plus hydrochlorothiazide (HCTZ) (LOS/HCTZ) is effective in achieving a greater BP lowering in patients with uncontrolled hypertension. Methods The study was a prospective, multicenter, observational trial exploring the antihypertensive effect of a single tablet of LOS 50 mg/HCTZ 12.5 mg. A total of 228 patients whose BP had previously been treated with more than one antihypertensive agents without having achieved BP goal below 130/80 mmHg enrolled in the study. Results A significant decrease in systolic and diastolic BP was observed in both clinic and home measurement after switching from the previous treatment to LOS/HCTZ. There was a significant decrease in both B-type natriuretic peptide (BNP) and urinary albumin creatinine (Cr) excretion ratio (ACR), especially in patients with elevated values. In contrast, there was a significant increase in serum Cr concentration in conjunction with a decrease in estimated glomerular filtration rate (eGFR). Overall serum uric acid (UA) concentration increased, whereas in patients with hyperuricemia there was a significant reduction in this value. Conclusion Switching to LOS/HCTZ provides a greater reduction in clinic and home BP in patients with uncontrolled hypertension. This combination therapy may lead to cardio-, reno protection and improve UA metabolism.
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461. Anxiety for the influenza of the patient with dialysis: choice of the HD/PD combination therapy.
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Keitaro Yokoyama, Nanae Matsuo, Yasuo Kimura, Yukio Maruyama, Ichiro Ohkido, Kazushige Hanaoka, Hiroyasu Yamamoto, and Tatsuo Hosoya
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- 2010
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462. SUPPLEMENTARY: RENAL DISORDERS OF GOUTY SUBJECTS
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Tatsuo Hosoya, Hiroo Naito, and Hiroshi Yonezawa
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medicine.medical_specialty ,business.industry ,Internal medicine ,medicine ,General Medicine ,business ,RENAL DISORDERS - Published
- 1979
463. Clinicobiochemical Analysis of Four Cases of Xanthine Oxidase Deficiency
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Kiyonobu Mikanagi, Tatsuo Hosoya, Hisashi Yamanaka, Kusuki Nishioka, and Toshihiro Nishina
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medicine.medical_specialty ,business.industry ,Urinary system ,Xanthine ,medicine.disease ,Gastroenterology ,chemistry.chemical_compound ,Xanthine oxidase activity ,chemistry ,Internal medicine ,Medicine ,Uric acid ,Xanthinuria ,Hypouricemia ,business ,Xanthine oxidase ,Hypoxanthine - Abstract
Xanthinuria is a rare hereditary disease characterized by a deficiency of xanthine oxidase (E C 1,2,3,2), which metabolized hypoxanthine and xanthine to uric acid. In Japan, two cases of xanthinuria have been reported. However, during the past two years, we have investigated four patients with hypouricemia, hypouricosuria and xanthinuria. In almost all of these patients, hypouricemia (less than 1.0 mg/dl) was the most important index information to make a definite diagnosis of this disorder. After clinical profiles of these four patients were described, an easy method of detection of xanthine oxidase activity from the duodenal mucosa was developed by the authors. Urinary oxypurine was also analyzed by high-pressure liquid chromatography, and the results are reported here.
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- 1984
464. [An autopsy case of congenital hepatic fibrosis and medullary sponge kidney with secondary gout]
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Tadashi Miyahara, Hitoshi Ikeda, Kimiyoshi Ichida, Tetsuya Kawamura, Kono H, Tatsuo Hosoya, and Yuichiro Ishida
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Adult ,Liver Cirrhosis ,Male ,Pathology ,medicine.medical_specialty ,Gout ,Medullary Sponge Kidney ,Secondary gout ,business.industry ,General Medicine ,Autopsy case ,medicine.disease ,Medullary sponge kidney ,medicine ,Congenital hepatic fibrosis ,Humans ,business - Abstract
先天性肝線維症,髄質嚢胞腎に痛風関節炎を合併した剖検例を経験したので報告する.症例は26才,男性で右母趾基関節痛の精査のため入院し腎不全,痛風と診断し,画像診断では肝線維症が示唆された.しかしHBs抗原陽性である以外肝機能障害は認めなかった.経過中肝機能障害が出現,激症肝炎の像を呈し肝不全にて死亡した.剖検で肝は先天性肝線維症に激症肝炎が加わった所見であり,腎は髄質嚢胞腎に尿酸塩の沈着による二次的な障害の加わった所見であった.本例のごとく先天性肝線維症に合併した髄質嚢胞腎に尿酸塩沈着を認めたとの報告はなく貴重な症例と考え報告した.
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- 1987
465. The effect of angiotensin receptor blockade ARB on the regression of left ventricular hypertrophy in hemodialysis patients: comparison between patients with D allele and non-D allele ACE gene polymorphism
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Tatsuo Hosoya, Yoshiko Iwasaki, Masaaki Nakayama, Keitaro Yokoyama, H. Nakano, Yoshinari Tsuruta, Nobuo Tsuboi, Takeshi Kurosawa, and Masafumi Fukagawa
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Male ,Nephrology ,Angiotensin receptor ,medicine.medical_specialty ,medicine.medical_treatment ,Peptidyl-Dipeptidase A ,Left ventricular hypertrophy ,Gastroenterology ,Losartan ,Muscle hypertrophy ,Basal (phylogenetics) ,Renal Dialysis ,Internal medicine ,Humans ,Medicine ,Alleles ,Polymorphism, Genetic ,biology ,business.industry ,Angiotensin-converting enzyme ,General Medicine ,Middle Aged ,medicine.disease ,Endocrinology ,biology.protein ,Female ,Hypertrophy, Left Ventricular ,Hemodialysis ,business ,Angiotensin II Type 1 Receptor Blockers ,medicine.drug - Abstract
OBJECTIVE It is revealed that LVH is one of risk factors for the development of cardiac complications in long-term HD patients. Therefore, maneuvers to reduce hypertrophy of cardium are very important for improving life prognosis. Angiotensin II receptor blockade (ARB) could reduce LVH in general populations without renal failure. However, no conclusive data has been available regarding the clinical consequences of ARB administration on the regression of LVH in HD patients. Furthermore, it has not clearly determined if ACE gene polymorphism has a possible influential effect on it. This study is conducted to clarify these issues. SUBJECTS AND METHOD 32 hypertensive patients on regular HD (male/female: 21/11, mean age: 60.5 years, mean duration of HD: 52.8 months) were studied. Patients were classified into two groups according to the different type of ACE gene polymorphism: cases with D allele (DD/ID; D group: n = 13) and those without (II; non-D group: n = 19). All patients were administered ARB (losartan 50 - 100 mg/day) and echocardiography (UCG) was performed at 6-month-interval regularly until the end of observation (24 months). RESULTS Before the commencement of ARB, no differences were found between the two groups, neither in mean blood pressure (MBP: D group/non-D group: 120 +/- 13 vs. 115 +/- 14 mmHg) nor in left ventricular mass index (LVMI: D/non-D: 172 +/- 41 vs. 165 +/- 41 g/m2). During the 24r-month follow-up, there were significant and similar reductions in MBP in both groups. In respect to LVMI, a significant reduction of LVMI was found in the D group after six months (p < 0.01 vs. basal) with a final reduction rate (FRR) -26 +/- 13%, whereas in the non-D group it was found at 24 months (p < 0.01 vs. basal) with FRR -11 +/- 16% (p < 0.01 vs. D group). There were significant differences between the two groups at all points (p < 0.05 at 6, 18 and 24 months, p < 0.005 at 12 months, respectively). CONCLUSION It is indicated that ARB could insert a regression effect on LVH predominantly in patients with D allele ACE polymorphism, due partly to factor (s) independent of its anti-hypertensive effect.
466. Oxidative stress suppresses the endothelial secretion of endothelin
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Kazuwa Nakao, Tatsuo Hosoya, Jun K. Yamashita, Tokuji Tanaka, Katsuyoshi Tojo, Naoya Sawada, Yasuo Mori, Yoshihiko Saito, Yasutomo Fukunaga, Toshio Igaki, Ken Masatsugu, Mayumi Inoue, Kentaro Doi, Hiroshi Itoh, Takatoshi Saito, and Tae Hwa Chun
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medicine.medical_specialty ,Endothelium ,Radioimmunoassay ,medicine.disease_cause ,Internal medicine ,medicine ,Animals ,Secretion ,RNA, Messenger ,Northern blot ,Cells, Cultured ,Pharmacology ,biology ,Endothelins ,Hydrogen Peroxide ,Blotting, Northern ,Oxidants ,Endothelin 1 ,Molecular biology ,Nitric oxide synthase ,Endothelial stem cell ,Oxidative Stress ,Carotid Arteries ,Endocrinology ,medicine.anatomical_structure ,Culture Media, Conditioned ,biology.protein ,Cattle ,Endothelium, Vascular ,Reactive Oxygen Species ,Cardiology and Cardiovascular Medicine ,Endothelin receptor ,Oxidative stress - Abstract
To address endothelial function on vascular walls exposed to oxidative stress, we investigated the effect of oxidative stress on the secretion of endothelin-l (ET-1) from cultured bovine carotid artery endothelial cells (BAECs). Concentrations of ET-I in the media were measured by a specific radioimmunoassay and ET-I mRNA expression was estimated by Northern blot analysis. Treatment of BAECs with 0.5-2.0 mM H 2 O 2 for 3 h suppressed both ET-I secretion and ET-1 mRNA expression in a dose-dependent manner compared to control. Attenuation of ET-1 mRNA expression by H 2 O 2 was revealed to take place at the transcriptional level. The addition of N G -nitro-L-arginine-methyl ester (L-NAME) 10 μM a specific nitric oxide synthase inhibitor. had no effect on H 2 O 2 -induced suppression of ET-I mRNA expression. Suppression of ET secretion under oxidative stress observed in the present study is proposed to be a compensatory mechanism of endothelial cells to inhibit vasoconstriction and proliferation during oxidative stress.
467. Biochemical studies on the purine metabolism of four cases with hereditary xanthinuria
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Tsukasa, Kojima, primary, Toshihiro, Nishina, additional, Motoshi, Kitamura, additional, Tatsuo, Hosoya, additional, and Kusuki, Nishioka, additional
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- 1984
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468. Laparoscopic approach for the evaluation of peritoneal injury
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Keitaro Yokoyama, Tatsuo Hosoya, and Yudo Tanno
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medicine.medical_specialty ,Text mining ,medicine.diagnostic_test ,Nephrology ,business.industry ,General surgery ,Predictive value of tests ,MEDLINE ,Medicine ,business ,Laparoscopy - Full Text
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469. II. Gouty Kidney (2) (Supplementary) Renal Disorders of Gouty Subjects
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Hiroo Naito, Tatsuo Hosoya, and Hiroshi Yonezawa
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Kidney ,medicine.medical_specialty ,medicine.anatomical_structure ,business.industry ,Internal medicine ,Medicine ,General Medicine ,business ,RENAL DISORDERS ,Gastroenterology - Published
- 1980
470. The effect of febuxostat to prevent a further reduction in renal function of patients with hyperuricemia who have never had gout and are complicated by chronic kidney disease stage 3: study protocol for a multicenter randomized controlled study
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Satoshi Iimuro, Tetsuya Yamamoto, Masanari Kuwabara, Hirofumi Makino, Hiroshi Hayakawa, Masaaki Inaba, Shunya Uchida, Tatsuo Hosoya, Sadayoshi Itoh, Yasuhiko Tomino, Yugo Shibagaki, Seiichi Matsuo, Iwao Ohno, Kenjiro Kimura, and Naohiko Imai
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Reduced renal function ,medicine.medical_specialty ,Time Factors ,medicine.drug_class ,Urology ,Renal function ,Administration, Oral ,Medicine (miscellaneous) ,Hyperuricemia ,Kidney ,Severity of Illness Index ,Drug Administration Schedule ,Gout Suppressants ,Study Protocol ,Pharmacotherapy ,Xanthine oxidase inhibitor ,Febuxostat ,Clinical Protocols ,Double-Blind Method ,Japan ,Randomized controlled study ,Risk Factors ,Chronic kidney disease ,Medicine ,Humans ,Pharmacology (medical) ,Prospective Studies ,Renal Insufficiency, Chronic ,Prospective cohort study ,Urate-lowering therapy ,Placebo ,business.industry ,medicine.disease ,Gout ,Surgery ,Up-Regulation ,Uric Acid ,Thiazoles ,Treatment Outcome ,Research Design ,business ,Biomarkers ,medicine.drug ,Kidney disease ,Glomerular Filtration Rate ,Tablets - Abstract
Background Hyperuricemia is a risk factor for the onset of chronic kidney disease (CKD) and is significantly associated with the progression of CKD. However, there is no sufficient evidence by interventional research supporting a cause-effect relationship. Hyperuricemic patients without gouty arthritis, whose serum urate (SUA) concentration is ≥8.0 mg/dL and who have a complication, are treated by pharmacotherapy in addition to lifestyle guidance. Nevertheless, there is no evidence that rationalizes pharmacotherapy for patients with hyperuricemia who have no complication and whose SUA concentration is below 9.0 mg/dL. Methods/Design The FEATHER (FEbuxostat versus placebo rAndomized controlled Trial regarding reduced renal function in patients with Hyperuricemia complicated by chRonic kidney disease stage 3) study is a prospective, multicenter, double-blind, randomized, placebo-controlled trial of febuxostat—a novel, nonpurine, selective, xanthine oxidase inhibitor. The present study will enroll, at 64 medical institutions in Japan, 400 Japanese patients aged 20 years or older who have hyperuricemia without gouty arthritis, who present CKD stage 3, and whose SUA concentration is 7.1-10.0 mg/dL. Patients are randomly assigned to either the febuxostat or the control group, in which febuxostat tablets and placebo are administered orally, respectively. The dosage of the study drugs should be one 10-mg tablet/day at weeks 1 to 4 after study initiation, increased to one 20-mg tablet/day at weeks 5 to 8, and elevated to one 40-mg tablet/day at week 9 and then maintained until week 108. The primary endpoint is estimated glomerular filtration rate (eGFR) slope. The secondary endpoints include the amount and percent rate of change in eGFR from baseline to week 108, the amount and percent rate of change in SUA concentration from baseline to week 108, the proportion of patients who achieved an SUA concentration ≤6.0 mg/dL, and the incidence of renal function deterioration. Discussion The present study aims to examine whether febuxostat prevents a further reduction in renal function as assessed with eGFR in subjects and will (1) provide evidence to indicate the inverse association between a reduction in SUA concentration and an improvement in renal function and (2) rationalize pharmacotherapy for subjects and clarify its clinical relevance. Trial registration UMIN Identifier: UMIN000008343
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471. Investigation of coronary artery calcification and stenosis by coronary angiography (CAG) in haemodialysis patients.
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Hiraku Yoshida, Keitaro Yokoyama, Yukio Maruvama, Hiroyasu Yamanoto, Satoru Yoshida, and Tatsuo Hosoya
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- 2006
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472. Multicenter, open-label study of long-term administration of febuxostat (TMX-67) in japanese patients with hyperuricemia including gout.
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Naoyuki, Kamatani, Shin, Fujimori, Toshikazu, Hada, Tatsuo, Hosoya, Kenjiro, Kohri, Toshitaka, Nakamura, Takanori, Ueda, Tetsuya, Yamamoto, Hisashi, Yamanaka, and Yuji, Matsuzawa
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- 2011
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473. Changes in the glomerular density and size in serial renal biopsies during the progression of IgA nephropathy.
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Nobuo Tsuboi, Tetsuya Kawamura, Takeo Ishii, Yasunori Utsunomiya, and Tatsuo Hosoya
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IGA glomerulonephritis ,RENAL biopsy ,KIDNEY glomerulus ,KIDNEY function tests ,CLINICAL pathology ,HISTOPATHOLOGY ,KIDNEY physiology - Abstract
Background. Although there have been many reports on clinicopathological studies of IgAN, information is limited regarding the long-term evolution of a renal histology by analysing samples obtained not only during normal renal function but also after the establishment of an impaired renal function in individual patients. Methods. We analysed 18 pairs of serial biopsy specimens from 18 patients with IgA nephropathy (IgAN) in whom the first renal biopsies were performed while normal renal function was still present and the second biopsies were performed after impaired renal function was established. The glomerular density (GD, number of non-sclerotic glomeruli per renal cortical area) and mean glomerular area (MGA) were compared between the specimens. Results. The GD at the first biopsy of each patient showed a striking variation (1.3–5.2/mm2). As a whole, the GD decreased (2.7 ± 1.2 versus 1.4 ± 0.7/mm2) and the MGA increased (19.7 ± 4.2 × 103 versus 23.5 ± 4.5 × 103 mm2) between the biopsies, respectively. The degrees of change in the GD and the MGA between the biopsies differed remarkably among the individuals. The patients with a high GD in the first biopsy progressed slowly, but showed a large decrease in the GD and a large increase in the MGA between the biopsies, respectively. The patients with a low GD, who already had enlarged glomeruli in the first biopsy, tended to progress rapidly. Conclusions. Our results suggest that both the nephron number and glomerular enlargement play a crucial role as compensatory mechanisms against renal functional deterioration in progressive IgAN. The GD during normal renal function may determine these compensatory changes and thereby make it possible to predict the renal prognosis in IgAN. [ABSTRACT FROM AUTHOR]
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- 2009
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474. Regression of parathyroid gland swelling by treatment with cinacalcet.
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Hiroyuki Terawaki, Hirofumi Nakano, Fumihiro Takeguchi, Toshio Hasegawa, Masaaki Nakayama, Masao Okazaki, and Tatsuo Hosoya
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- 2009
475. The effect of eicosapentaenoic acid on renal function and volume in patients with ADPKD.
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Eiji Higashihara, Kikuo Nutahara, Shigeo Horie, Satoru Muto, Tatsuo Hosoya, Kazushige Hanaoka, Ken Tuchiya, Kouichi Kamura, Kenmei Takaichi, Yoshifumi Ubara, Miho Itomura, and Tomohito Hamazaki
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DOCOSAHEXAENOIC acid ,UNSATURATED fatty acids ,KIDNEY diseases ,MEDICAL radiography - Abstract
Background. Soy protein ameliorates rat polycystic kidney disease with concomitant renal enrichment of ω3-polyunsaturated fatty acids. A study was conducted to examine the effects of eicosapentaenoic acids (EPA) on renal volume and function in patients with autosomal dominant polycystic kidney disease (ADPKD). Methods. Non-azotemic patients were randomized to either a control group (n = 20) or an EPA group (n = 21). EPA capsules (2.4 g/day) were administered in the EPA group for 2 years. Twenty-four hours of urine was collected for the creatinine clearance (Ccr) measurement every year. At baseline and 24 months, fatty acid compositions in erythrocytes were measured and computerized tomographies were obtained for calculation of renal volume by the modified ellipsoid and volumetric methods. Results. In the EPA group, the EPA concentration (1.80 ± 0.99 versus 4.40 ± 1.79 area%, P < 0.001) and the ω3/ω6 ratio in the erythrocyte increased, but docosahexaenoic acid (DHA) (6.76 ± 1.19 versus 5.64 ± 1.45 area%, P < 0.010) concentration decreased. Ccr decreased by 8.5 ± 9.5 and 9.0 ± 13.0 ml/min/1.73 m2/2 years in the control and EPA groups, respectively (NS). The increases in renal volume calculated by either method were not significantly different between the two groups. Conclusions. A beneficial effect of EPA on renal function and kidney volume in ADPKD patients could not be confirmed in the present study. Administration of EPA with DHA supplementation and/or longer intervention might be necessary to demonstrate preventive effects of ω3-polyunsaturated fatty acids on progression of ADPKD. [ABSTRACT FROM AUTHOR]
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- 2008
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476. Elevated oxidative stress measured as albumin redox state in continuous ambulatory peritoneal dialysis patients correlates with small uraemic solutes.
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Hiroyuki Terawaki, Yukie Matsuyama, Seiichi Era, Nanae Matsuo, Masato Ikeda, Makoto Ogura, Keitaro Yokoyama, Hiroyasu Yamamoto, Tatsuo Hosoya, and Masaaki Nakayama
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- 2007
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477. Successful living-related kidney transplantation in hereditary renal hypouricaemia.
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Izumi Yamamoto, Hiroyasu Yamamoto, Kimiyoshi Ichida, Jun Mitome, Yudo Tanno, Naohiko Katoh, Keitaro Yokoyama, and Tatsuo Hosoya
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- 2006
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478. A repeated oral administration study of febuxostat (TMX-67), a non-purine-selective inhibitor of xanthine oxidase, in patients with impaired renal function in Japan: pharmacokinetic and pharmacodynamic study.
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Hosoya T and Ohno I
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- Administration, Oral, Adult, Aged, Chromatography, High Pressure Liquid, Dose-Response Relationship, Drug, Febuxostat, Female, Follow-Up Studies, Glomerular Filtration Rate, Gout Suppressants administration & dosage, Gout Suppressants pharmacokinetics, Humans, Hyperuricemia complications, Hyperuricemia metabolism, Male, Middle Aged, Oxypurinol urine, Renal Insufficiency metabolism, Renal Insufficiency physiopathology, Thiazoles administration & dosage, Treatment Outcome, Uric Acid antagonists & inhibitors, Xanthine Oxidase blood, Young Adult, Hyperuricemia drug therapy, Renal Insufficiency complications, Thiazoles pharmacokinetics, Uric Acid blood, Xanthine Oxidase antagonists & inhibitors
- Abstract
Background: Allopurinol has been widely used for treatment of hyperuricemia, however, it may be associated with various adverse effects. Febuxostat has been identified as a potentially safe and efficacious alternative., Objectives: A multicenter, open-label, parallel, between-group comparative study was conducted to investigate the effects of renal function on the pharmacokinetics, pharmacodynamics, and safety of febuxostat, a novel inhibitor of uric acid synthesis., Methods: Based on creatinine clearance (Ccr), 29 subjects were assigned to 3 groups: normal renal function (Ccr ≥ 80 mL/min), mild renal dysfunction (80 mL/min > Ccr ≥ 50 mL/min), or moderate renal dysfunction (50 mL/min > Ccr ≥ 30 mL/min). Febuxostat was repeatedly orally administered at a dose of 20 mg/d for 7 days., Results: Impaired renal function caused a slight increase in systemic exposure to unchanged febuxostat and its oxidative metabolites, but the exposure did not increase through repeated administration. Moreover, renal impairment did not markedly reduce the effects of febuxostat on plasma uric acid levels. There were no clinically significant adverse events even in patients with impaired renal function., Conclusions: Febuxostat is considered an inhibitor of uric acid synthesis that could be used in patients with mild to moderate renal impairment without dose adjustment.
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- 2011
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479. A new standard of care? Studies on febuxostat in the management of hyperuricemia with and without gout.
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Kamatani N and Hosoya T
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- Febuxostat, Gout blood, Gout drug therapy, Humans, Hyperuricemia blood, Hyperuricemia complications, Treatment Outcome, Xanthine Oxidase antagonists & inhibitors, Gout complications, Gout Suppressants therapeutic use, Hyperuricemia drug therapy, Primary Health Care standards, Thiazoles therapeutic use, Uric Acid blood
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- 2011
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480. Placebo-controlled, double-blind study of the non-purine-selective xanthine oxidase inhibitor Febuxostat (TMX-67) in patients with hyperuricemia including those with gout in Japan: phase 3 clinical study.
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Kamatani N, Fujimori S, Hada T, Hosoya T, Kohri K, Nakamura T, Ueda T, Yamamoto T, Yamanaka H, and Matsuzawa Y
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- Adult, Central Nervous System Diseases blood, Central Nervous System Diseases complications, Dental Enamel abnormalities, Diabetes Mellitus, Type 2 blood, Diabetes Mellitus, Type 2 complications, Dose-Response Relationship, Drug, Double-Blind Method, Febuxostat, Female, Follow-Up Studies, Gout blood, Gout complications, Gout Suppressants administration & dosage, Humans, Japan, Kidney Diseases, Cystic blood, Kidney Diseases, Cystic complications, Male, Middle Aged, Thiazoles administration & dosage, Treatment Outcome, Xanthine Oxidase blood, Central Nervous System Diseases drug therapy, Diabetes Mellitus, Type 2 drug therapy, Gout drug therapy, Gout Suppressants therapeutic use, Kidney Diseases, Cystic drug therapy, Thiazoles therapeutic use, Uric Acid blood, Xanthine Oxidase antagonists & inhibitors
- Abstract
Background: : Allopurinol has been widely used for treatment of hyperuricemia, however, it may be associated with various adverse effects. Febuxostat has been identified as a potentially safe and efficacious alternative., Objectives: : A multicenter study with randomized, placebo-controlled, double-blind, parallel-group comparison was carried out to evaluate the efficacy and safety of febuxostat in 103 patients with hyperuricemia (including patients with gout) in Japan., Methods: : Subjects were treated with febuxostat (20 or 40 mg/d) or a placebo for 8 weeks. The variables evaluated were the percentage of patients achieving serum uric acid levels 6.0 mg/dL or less and the percent change in serum uric acid levels after 8 weeks., Results: : The percentage of patients achieving serum uric acid levels 6.0 mg/dL or less after 8 weeks was 91.2% in the febuxostat 40-mg/d group, 45.7% in the 20-mg/d group, and 0.0% in the placebo group. The percent changes in serum uric acid levels after 8 weeks were -44.9% in the febuxostat 40-mg/d group, -28.9% in the 20-mg/d group, and -0.6% to -0.5% in the placebo group. No severe or medically significant adverse reaction attributable to febuxostat was noted, and there was no event that could pose a clinical problem. The efficacy did not differ depending on the presence/absence of gout history., Conclusions: : These results suggest that febuxostat (20 or 40 mg/d) is useful as a new means of treating hyperuricemia and is capable of reducing serum uric acid levels to 6.0 mg/dL or less (goal of treatment) with high safety regardless of the presence/absence of gout history.
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- 2011
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481. An allopurinol-controlled, multicenter, randomized, open-label, parallel between-group, comparative study of febuxostat (TMX-67), a non-purine-selective inhibitor of xanthine oxidase, in patients with hyperuricemia including those with gout in Japan: phase 2 exploratory clinical study.
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Kamatani N, Fujimori S, Hada T, Hosoya T, Kohri K, Nakamura T, Ueda T, Yamamoto T, Yamanaka H, and Matsuzawa Y
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- Administration, Oral, Dose-Response Relationship, Drug, Double-Blind Method, Febuxostat, Female, Follow-Up Studies, Gout blood, Gout complications, Humans, Hyperuricemia blood, Hyperuricemia complications, Japan, Male, Middle Aged, Time Factors, Treatment Outcome, Xanthine Oxidase blood, Allopurinol administration & dosage, Gout drug therapy, Gout Suppressants administration & dosage, Hyperuricemia drug therapy, Thiazoles administration & dosage, Uric Acid blood, Xanthine Oxidase antagonists & inhibitors
- Abstract
Background: Allopurinol has been widely used for the treatment of hyperuricemia, however, it may be associated with various adverse effects. Febuxostat has been identified as a potentially safe and efficacious alternative., Objectives: Febuxostat was administered to patients with hyperuricemia including gout in Japan to compare its efficacy and safety with those of allopurinol., Methods: The starting dose of febuxostat and allopurinol was 10 and 100 mg/d, respectively, and was increased to the fixed maintenance dose of 40 or 60 mg/d for febuxostat and 300 mg/d for allopurinol for 16 weeks., Results: : The percent change in the serum uric acid level at 16 weeks compared with the baseline serum uric acid level was -42.96% ± 13.33% and -52.47% ± 9.79% for the febuxostat 40- and 60-mg/d groups, respectively, and -36.55% ± 18.59% for the allopurinol group, indicating that the hypouricemic effects of febuxostat increased in a dose-dependent manner and equaled to or surpassed those of allopurinol (P = 0.0239, 2-sample t test). The percentage of patients with serum uric acid levels of 6.0 mg/dL or less at 16 weeks was 88.9% and 100% for the febuxostat 40- and 60-mg/d groups, respectively, and 68.8% for the allopurinol group, showing higher achievements for the febuxostat groups compared with the allopurinol group. All adverse drug reactions were mild to moderate in severity, and there were no severe symptoms or reactions leading to drug discontinuation., Conclusions: These results suggest that febuxostat is safe at doses of 40 and 60 mg/d and has equal or greater efficacy than 300 mg/d allopurinol.
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- 2011
- Full Text
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482. Placebo-controlled double-blind dose-response study of the non-purine-selective xanthine oxidase inhibitor febuxostat (TMX-67) in patients with hyperuricemia (including gout patients) in japan: late phase 2 clinical study.
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Kamatani N, Fujimori S, Hada T, Hosoya T, Kohri K, Nakamura T, Ueda T, Yamamoto T, Yamanaka H, and Matsuzawa Y
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- Administration, Oral, Dose-Response Relationship, Drug, Double-Blind Method, Febuxostat, Female, Follow-Up Studies, Gout blood, Gout complications, Humans, Hyperuricemia blood, Hyperuricemia complications, Japan, Male, Middle Aged, Treatment Outcome, Gout drug therapy, Gout Suppressants administration & dosage, Hyperuricemia drug therapy, Thiazoles administration & dosage, Uric Acid blood, Xanthine Oxidase antagonists & inhibitors
- Abstract
Background: Allopurinol has been widely used for the treatment of hyperuricemia, however, it may be associated with various adverse effects. Febuxostat has been identified as a potentially safe and efficacious alternative., Objectives: A multicenter study with randomized, placebo-controlled, double-blind, parallel, intergroup comparison was carried out to evaluate the dose-response relationship, efficacy, and safety of febuxostat in 202 patients with hyperuricemia (including patients with gout) in Japan., Methods: The subjects were treated with febuxostat at fixed maintenance doses (20-80 mg/d) or a placebo for 16 weeks. The percentage of patients achieving serum uric acid levels 6.0 mg/dL or less and the percent change in serum uric acid levels after 16 weeks of treatment were evaluated., Results: The percentage of patients achieving serum uric acid levels 6.0 mg/dL or less at 16 weeks was 87.8% in the 80-mg/d dose group, 83.3% in the 60-mg/d group, 82.9% in the 40-mg/d group, 46.5% in the 20-mg/d group, and 2.6% in the placebo group (P < 0.001, Mantel-Haenszel test). A statistically significant dose-response relationship was found. The percent change in serum uric acid levels after 16 weeks of treatment differed significantly between each febuxostat dose group and the placebo group and increased in a dose-dependent manner above 40 mg/d. No deaths, events posing a clinical problem, or serious adverse reactions attributable to febuxostat were noted. Similar results were obtained regardless of gout history., Conclusions: Febuxostat can safely reduce serum uric acid levels to 6.0 mg/dL or less in 80% or more of patients with hyperuricemia (including gout) at doses of 40 mg/d or higher.
- Published
- 2011
- Full Text
- View/download PDF
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