301. The Emerging Role of N6-Methyladenosine RNA Methylation as Regulators in Cancer Therapy and Drug Resistance.
- Author
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Chen Z, Hu Y, Jin L, Yang F, Ding H, Zhang L, Li L, and Pan T
- Abstract
N6-methyladenosine (m
6 A) RNA methylation has been considered the most prevalent, abundant, and conserved internal transcriptional modification throughout the eukaryotic mRNAs. Typically, m6 A RNA methylation is catalyzed by the RNA methyltransferases (writers), is removed by its demethylases (erasers), and interacts with m6 A-binding proteins (readers). Accumulating evidence shows that abnormal changes in the m6 A levels of these regulators are increasingly associated with human tumorigenesis and drug resistance. However, the molecular mechanisms underlying m6 A RNA methylation in tumor occurrence and development have not been comprehensively clarified. We reviewed the recent findings on biological regulation of m6 A RNA methylation and summarized its potential therapeutic strategies in various human cancers., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Chen, Hu, Jin, Yang, Ding, Zhang, Li and Pan.)- Published
- 2022
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