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To investigate the protective effects of squid ink in chemotherapy, BALB/c mice were used as animal models of injuries induced by cyclophosphamine, a well known chemotherapeutic drug. The mice were randomly divided into five groups with the same number of males and females in each group. At the end of the experiment, animals were sacrificed to investigate organ indexes and antioxidant ability of the spleen, peripheral blood profile and quantities of bone marrow nucleated cells. Results showed that the hemopoietic function of mice was injured by cyclophosphamine, as indicated by decreases of contents of erythrocytes, leukocytes, hemoglobin and bone marrow nucleated cells (P0.05), as well as modification of organ indexes (P0.05), and reversed the effects of cyclophosphamine on organ indexes and antioxidant ability of spleen (P

Based on the decomposition of the evolution processes of the urban expressway capacity after traffic accidents and the influence factors analysis, an approach for estimating the capacity has been proposed. Firstly, the approach introduces the Decision Tree ID algorithm, solves the accident delay time of different accident types by the Information Gain Value, and determines congestion dissipation time by the Traffic Flow Wave Theory. Secondly, taking the accident delay time as the observation cycle, the maximum number of the vehicles through the accident road per unit time was considered as its capacity. Finally, the attenuation simulation of the capacity for different accident types was calculated by the VISSIM software. The simulation results suggest that capacity attenuation of vehicle anchor is minimal and the rate is 30.074%; the next is vehicles fire, rear-end, and roll-over, and the rate is 38.389%, 40.204%, and 43.130%, respectively; the capacity attenuation of vehicle collision is the largest, and the rate is 50.037%. Moreover, the further research shows that the accident delay time is proportional to congestion dissipation time, time difference, and the ratio between them, but it is an inverse relationship with the residual capacity of urban expressway.

In the crystal structure of the title compound, C11H14ClNO3, intermolecular hydrogen bonds link molecules in the ab plane, forming layers that stack along the c axis.

In the title compound, C6H4ClF3N2, an intermediate in the synthesis of the fungicide fluazinam, the F atoms of the trifluoromethyl group are disordered over two sites in a 0.683 (14):0.317 (14) ratio. In the crystal structure, centrosymmetric dimers arise from pairs of N—H...N hydrogen bonds.

To further understand characteristics and functions of basic fibroblast growth factor (bFGF, FGF-2) as well as its effects on skeletal muscle, a coding sequence of l8kDa-bFGF gene was cloned from Chinese Small Tail Han sheep, an excellent indigenous animal breed in China. The DNA sequence and deduced protein sequence were analyzed and aligned with the counterparts of other published animals. The results indicated that most hallmarks of the newly cloned bFGF gene sequence were found to be similar to those of published species, which implied further that bFGF genes have been conservative in evolution. The complete coding sequence for the gene was inserted into pET-28a plasmid and expressed predicted fusion protein in E. coli. The product was soluble and possessed of biological activity, it is sure to be a good source for further investigation. In addition, effects of the products on proliferation of murine C2C12 myoblasts were investigated. The findings demonstrated that the ovine recombinant bFGF accelerated in vitro the proliferation of murine C2C12 myoblasts, and MEK/ERK-MAPK signaling pathway participated in the regulative mechanism. [ABSTRACT FROM AUTHOR]

Aims. To investigate the treatment of hospitalized patients with coronary artery disease (CAD) and the prognostic factors in Beijing, China. Materials and Methods. A multicenter prospective study was conducted through an integrative platform of clinical and research at 12 hospitals in Beijing, China. The clinical information of 3537 hospitalized patients with CAD was collected from September 2009 to May 2011, and the efficacy of secondary prevention during one-year followup was evaluated. In addition, a logistic regression analysis was performed to identify some factors which will have independent impact on the prognosis. Results. The average age of all patients was 64.88 ± 11.97. Of them, 65.42% are males. The medicines for patients were as follows: antiplatelet drugs accounting for 91.97%, statins accounting for 83.66%, β-receptor blockers accounting for 72.55%, ACEI/ARB accounting for 58.92%, and revascularization (including PCI and CABG) accounting for 40.29%. The overall incidence of cardiovascular events was 13.26% (469/3537). The logistic stepwise regression analysis showed that heart failure (OR, 3.707, 95% CI = 2.756-4.986), age > 65 years old (OR, 2.007, 95% CI = 1.587-2.53), and myocardial infarction (OR, 1.649, 95% CI = 1.322-2.057) were the independent risk factors of others factors for cardiovascular events that occurred during followup of one-year period. Integrative medicine (IM) therapy showed the beneficial tendency for decreasing incidence of cardiovascular events, although no statistical significance was found (OR, 0.797, 95% CI = 0.613-1.036). Conclusions. Heart failure, age > 65 years old, and myocardial infarction were associated with an increase in incidence of cardiovascular events, and treatment with IM showed a tendency for decreasing incidence of cardiovascular events. [ABSTRACT FROM AUTHOR]

• The ratio of the two peak intensities and the evolution of the phase separation with the energy of Crab pulsar are studied. • We simulate the eight-wavelength X-ray light curves of Crab pulsar by joint the core gap and annular gap. • The evolution of the Crab pulsar light curve with frequency provides a stronger constraint for the theoretical model. • By simulating the light curve of crab pulsar, the region of each radiation component is deduced. • This research has certain scientific significance for studying the geometry of the pulsar radiation area and discussing the timing noise of pulsar. Multiwavelength observation is an effective way to test and constrain theoretical models of pulsars. X-ray observations reveal that the light curve of the Crab pulsar has two sharp peaks, with a phase separation of ~ 0.4 spin periods between its first peak (P1) and second peak (P2). Using observations from the Hard X-ray Modulation Telescope (Insight -HXMT) of China, we studied eight-wavelength (from 11 keV to 250 keV) X-ray light curves of the Crab pulsar and found that the phase separation has no significant trend with the energy, while the total intensity ratios of the P2 and bridge emission components to the P1 component have a significant increasing trend with increasing energy. We used three-dimensional magnetospheric models for the core gap (CG) and annular gap (AG) to simulate the eight-wavelength X-ray light curves. It was found that the P1, P2 and bridge emission components at each band can be well reproduced by the two models and that the P1 and P2 emissions could be generated in the AG region, whereas the bridge emission could be generated in the CG region. [ABSTRACT FROM AUTHOR]

Aim: With an aging global population, there has been a growing interest in the subjective well-being (SWB) of older people. As a positive emotion, gratitude has been found to be significantly and positively associated with SWB. However, the mechanisms underlying the relationship between gratitude and SWB remain poorly understood. This study aimed to examine the mediating effects of social support and self-efficacy in the relationship between gratitude and SWB among older Chinese adults in nursing homes., Design: A cross-sectional study., Methods: A sample of 354 older adults in nursing homes aged 60 years and above was recruited across three nursing homes in Guangzhou, China. Participants completed the Gratitude Questionnaire-Six-Item Form, the World Health Organization's well-being index, the General Self-efficacy questionnaire and the Multidimensional Scale of Perceived Social Support. Structural equation modelling was used to evaluate the relationships between gratitude, self-efficacy, social support and SWB. A bootstrap test was performed to test mediating roles of self-efficacy and social support., Results: Gratitude was found to be significantly and positively associated with SWB (β = 0.294, p < 0.001). Self-efficacy and social support independently mediated the relationship between gratitude and SWB (indirect effect of self-efficacy: Standardised β = 0.105, 95% CI [0.061, 0.157]; indirect effect of social support: Standardised β = 0.116, 95% CI [0.444, 0.191], all p < 0.001). Additionally, the results indicated that the mediating effect of self-efficacy was not significantly different from that of social support in the link between gratitude with SWB., Conclusion: These findings presented strong evidence that self-efficacy and social support provided the underlying mechanisms through which gratitude was associated with SWB in Chinese nursing home residents. This highlighted the need to develop interventions aiming at increasing gratitude, self-efficacy and social support to promote SWB among elderly people., Patient or Public Contribution: No patient or public contribution., (© 2024 The Author(s). Nursing Open published by John Wiley & Sons Ltd.)

Aim: To explore lung transplant recipients' perceptions of well-being when they are facing uncertain health outcomes, including identifying the factors to enhance well-being., Design: A qualitative descriptive study., Methods: A purposive sample of 11 lung transplantation recipients who were hospitalised in the Department of Organ Transplantation of a tertiary university hospital was recruited in China. A descriptive qualitative study using thematic analysis of semistructured interviews. Themes were organised within a PERMA model. Colaizzi's qualitative analysis was used to analyse the data., Results: Five major themes and 11 categories were generated: (1) mindset shift [optimism and hope and living in the moment]; (2) meaning in life [self-care, priority change and value realisation]; (3) health benefits [improved health and behavioural changes]; (4) perceived support [support from family, the health care team and others]; (5) unmet support needs., Conclusion: Lung transplant recipients could perceive well-being from five aspects that caused significantly favourable transformation across a variety of aspects in patients' lives. These findings may support nursing staff when caring for this patient group, making them aware of multifaceted nature of well-being. They could offer insight into potential pathways for the development of nurse-led tailored interventions, based on specific elements of PERMA model., Impact: This work adds to a growing body of knowledge about well-being amongst lung transplant patients. These findings may support nursing staff when caring for this patient group, making them aware of multifaceted nature of well-being and illustrating factors that promote positive well-being in this group, based on specific elements of PERMA model., Reporting Method: This study followed the Consolidated Criteria for Reporting Qualitative Research checklist., Patient or Public Contribution: Two lung transplant recipients were involved in the early phases of this study. They helped in formulating the interview outline., (© 2024 John Wiley & Sons Ltd.)

Ohmic heating (OH), an innovative heating technology, presents potential applications in the pasteurization of liquid foods. Therefore, the study was conducted to evaluate the effect of OH at various voltage gradients (10 V/cm, 12.5 V/cm, and 15 V/cm) and water bath (WB) on microbial inactivation, physicochemical and sensory properties and microbial flora of pasteurized milk. Results indicated that OH with higher voltage could effectively inactivate microorganisms in milk, requiring less heating time and energy. Moreover, OH treatment at higher voltages could decelerate lipid oxidation and better maintain the sensory quality and essential amino acids content of milk. Additionally, all treatments significantly altered the microbial community, and during storage, the microbial community in milk treated with 10 V/cm and 12.5 V/cm OH remained relatively stable. OH treatments with voltage gradients exceeding 12.5 V/cm could effectively inactive microorganisms and maintain the quality attributes of milk., Competing Interests: Declaration of competing interest All authors declare that they have no conflict of interest., (Copyright © 2023. Published by Elsevier B.V.)

Nowadays, obtaining a thin and large-area perovskite single-crystal (SC) is still challenging. Herein, we report a novel strategy to prepare a laminar MAPbBr 3 SC with a controllable thickness of 16 μm and a size of 6 × 8 mm. Additionally, the SC solar cell achieves an intriguing efficiency of 7.11% with an impressive stability, maintaining 93% initial PCE after aging for 1000 h.

Organometal trihalide perovskites have been attracting intense attention due to their enthralling optoelectric characteristics. Thus far, most applications focus on polycrystalline perovskite, which however, is overshadowed by single crystal perovskite with superior properties such as low trap density, high mobility, and long carrier diffusion length. In spite of the inherent advantages and significant optoelectronic applications in solar cells and photodetectors, the fabrication of large-area laminar perovskite single crystals is challenging. In this report, an ingenious space-limited inverse temperature crystallization method is first demonstrated to the in situ synthesis of 120 cm 2 large-area CH 3 NH 3 PbBr 3 crystal film on fluorine-doped tin oxide (FTO) glass. Such CH 3 NH 3 PbBr 3 perovskite crystal film is successfully applied to narrowband photodetectors, which enables a broad linear response range of 10 -4 -10 2 mW cm -2 , 3 dB cutoff frequency (f 3 dB ) of ≈110 kHz, and high narrow response under low bias -1 V., (© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Utilizing photoelectrochemical (PEC) cells to directly collecting solar energy into chemical fuels (e.g., H 2 via water splitting) is a promising way to tackle the energy challenge. α-Fe 2 O 3 has emerged as a desirable photoanode material in a PEC cell due to its wide spectrum absorption range, chemical stability, and earth abundant component. However, the short excited state lifetime, poor minority charge carrier mobility, and long light penetration depth hamper its application. Recently, the elegantly designed hierarchical macroporous composite nanomaterial has emerged as a strong candidate for photoelectrical applications. Here, a novel 3D antimony-doped SnO 2 (ATO) macroporous structure is demonstrated as a transparent conducting scaffold to load 1D hematite nanorod to form a composite material for efficient PEC water splitting. An enormous enhancement in PEC performance is found in the 3D electrode compared to the controlled planar one, due to the outstanding light harvesting and charge transport. A facile and simple TiCl 4 treatment further introduces the Ti doping into the hematite while simultaneously forming a passivation layer to eliminate adverse reactions. The results indicate that the structural design and nanoengineering are an effective strategy to boost the PEC performance in order to bring more potential devices into practical use.

Light-harvesting and charge collection have attracted increasing attention in the domain of photovoltaic cells, and can be facilitated dramatically by appropriate design of a photonic nanostructure. However, the applicability of current light-harvesting photoanode materials with single component and/or morphology (such as, particles, spheres, wires, sheets) is still limited by drawbacks such as insufficient electron-hole separation and/or light-trapping. Herein, we introduce a universal method to prepare hierarchical assembly of macroporous material-nanowire coated homogenous or heterogeneous metal oxide composite electrodes (TiO2 -TiO2 , SnO2 -TiO2 , and Zn2 SnO4 -TiO2 ; homogenous refers to a material in which the nanowire and the macroporous material have the same composition, i.e. both are TiO2 . Heterogeneous refers to a material in which the nanowires and the macroporous material have different compositions). The dye-sensitized solar cell based on a TiO2 -macroporous material-TiO2 -nanowire homogenous composition electrode shows an impressive conversion efficiency of 9.51 %, which is much higher than that of pure macroporous material-based photoelectrodes to date., (© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)