301. Torsion analysis in the early detection of anthracycline-mediated cardiomyopathy.
- Author
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Motoki H, Koyama J, Nakazawa H, Aizawa K, Kasai H, Izawa A, Tomita T, Miyashita Y, Kumazaki S, Takahashi M, and Ikeda U
- Subjects
- Analysis of Variance, Cardiomyopathies chemically induced, Female, Heart Ventricles pathology, Humans, Male, Middle Aged, Prognosis, Prospective Studies, Statistics as Topic, Time Factors, Ventricular Dysfunction, Left pathology, Anthracyclines adverse effects, Cardiomyopathies diagnostic imaging, Heart Ventricles diagnostic imaging, Torsion, Mechanical, Ultrasonography, Doppler, Ventricular Dysfunction, Left diagnostic imaging
- Abstract
Aims: Anthracyclines have profound consequences on the structure and function of the heart, which over time cause a cardiomyopathy that leads to congestive heart failure. Early detection of subclinical left ventricular (LV) dysfunction following a low dose of anthracyclines may be a preventive strategy. The aim of this study was to determine torsion analysis using two-dimensional speckle-tracking imaging (STI), useful for detecting early anthracycline-mediated cardiotoxicity., Methods and Results: Conventional and Doppler echocardiography images were obtained from 25 patients (mean age 58 ± 11 years) before chemotherapy and 1 and 3 months after treatment. The cumulative anthracycline doses were 98 ± 59 and 170 ± 87 g/m(2) at 1 and 3 months, respectively. After standard echocardiography, LV torsion and twisting velocity profiles from apical and basal short-axis images were analysed using STI. LV dimensions and ejection fraction did not change throughout follow-up. Although isovolumic relaxation time showed prolongation 3 months after chemotherapy, other Doppler indices did not show significant changes. However, significant deteriorations in torsion (P < 0.0001 by ANOVA), twisting rate (P < 0.0001 by ANOVA), and untwisting rate (P < 0.001 by ANOVA) were found 1 month after chemotherapy. A significant negative correlation was observed between cumulative anthracycline doses and torsion (r = -0.524, P < 0.0001)., Conclusion: LV torsion analysis could be a useful non-invasive approach for early detection of subclinical anthracycline cardiotoxicity.
- Published
- 2012
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