351. Targeting drug delivery systems for circumventing multidrug resistance of cancers.
- Author
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Ju RJ, Mu LM, and Lu WL
- Subjects
- Animals, Drug Resistance, Multiple, Humans, Liposomes, Micelles, Mitochondria drug effects, Neoplastic Stem Cells drug effects, Neoplastic Stem Cells physiology, Drug Delivery Systems, Drug Resistance, Neoplasm, Neoplasms drug therapy
- Abstract
Multidrug resistance is a major obstacle to successful chemotherapy of cancer. To overcome multidrug resistance, our research is to develop new liposome and nanomicelle delivery systems. Investigations are focusing on certain aspects, including resistant cancer cell membranes, cancer stem cells, mitochondria, apoptosis genes, vasculogenic mimicry and heterogeneity of cancer cells. Evaluations have been performed on cancer cells, cancer spheroids and cancer animal models. These nanoscale formulations demonstrated an enhanced chemotherapy efficacy in resistant cancer and cancer stem cells in vitro and in vivo.
- Published
- 2013
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