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Your search keyword '"Moccia, M."' showing total 503 results
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503 results on '"Moccia, M."'

501. ODN-based drugs for targeting of extracellular proteins.

Author

Bucci EM, Valente M, Musumeci D, Sapio R, Anrò V, Roviello GN, and Moccia M

Subjects
Binding Sites, Blood Proteins antagonists & inhibitors, Blood Proteins chemistry, Drug Design, Gene Targeting, HMGB1 Protein antagonists & inhibitors, HMGB1 Protein chemistry, HMGB1 Protein genetics, Humans, Macromolecular Substances, Models, Molecular, Oligodeoxyribonucleotides chemistry, Blood Proteins genetics, Oligodeoxyribonucleotides genetics, Oligodeoxyribonucleotides pharmacology
Abstract

In this work a novel approach to identify new therapeutic targets consisting of serum proteins which contain an oligonucleotide binding domain is presented.

Published
2007
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502. dabPNA: design, synthesis, and DNA binding studies.

Author

Roviello GN, Musumeci D, Moccia M, Castiglione M, Sapio R, Valente M, Bucci EM, Perretta G, and Pedone C

Subjects
Drug Design, Glycine chemistry, Peptide Nucleic Acids chemistry, Butyric Acid chemistry, DNA chemistry, Glycine analogs & derivatives, Peptide Nucleic Acids chemical synthesis
Abstract

In continuing our research efforts for developing new oligodeoxynucleotide (ODN)-like drugs and diagnostics, we designed diaminobutyric peptide nucleic acids (dabPNAs), nucleopeptides characterized by a diaminobutyric-based building block that is an isomer of the aminoethylglycyl PNA (aegPNA) unit and the acyclic modification of the aminoprolyl PNA (ampPNA) monomer. In this work we present the solid phase synthesis of a dabPNA oligomer and of two aegPNAs containing a single dabPNA unit. A study relative to their binding ability towards DNA is also reported even in comparison with the well known aegPNAs.

Published
2007
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503. Bent oligonucleotide duplexes as HMGB1 inhibitors: a comparative study.

Author

Musumeci D, Roviello GN, Moccia M, Pedone C, Bucci EM, Sapio R, Valente M, and Fumero S

Subjects
Humans, DNA chemistry, DNA pharmacology, HMGB1 Protein antagonists & inhibitors, Oligonucleotides chemistry, Oligonucleotides pharmacology
Abstract

In this work we explore the ability of a chimeric LNA/DNA bent duplex, in which the kink is induced by 2 unpaired adenines in the middle of one strand, to bind HMGB1, a protein involved in many inflammatory processes. The LNA/DNA duplex was compared with the corresponding full DNA and PNA/DNA chimera duplexes from a thermodynamic and spectroscopic point of view.

Published
2007
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