351. Late complications after hematopoietic stem cell transplantation.
- Author
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Tichelli A, Rovó A, Passweg J, Schwarze CP, Van Lint MT, Arat M, and Socié G
- Subjects
- Bone Diseases etiology, Bone Diseases prevention & control, Bronchiolitis Obliterans etiology, Bronchiolitis Obliterans prevention & control, Cardiovascular Diseases etiology, Cardiovascular Diseases prevention & control, Central Nervous System Diseases etiology, Central Nervous System Diseases prevention & control, Endocrine System Diseases etiology, Endocrine System Diseases prevention & control, Gonadal Disorders etiology, Gonadal Disorders prevention & control, Graft vs Host Disease etiology, Graft vs Host Disease prevention & control, Humans, Kidney Diseases etiology, Kidney Diseases prevention & control, Liver Diseases diagnosis, Liver Diseases prevention & control, Neoplasms etiology, Neoplasms prevention & control, Hematopoietic Stem Cell Transplantation adverse effects
- Abstract
Hematopoietic stem cell transplantation (HSCT) offers the opportunity for cure to patients with leukemia, lymphoma and severe non-malignant diseases. More than 40,000 HSCTs are performed annually worldwide. Therefore, the number of long-term survivors, free of the disease for which they were transplanted is continuously increasing. Despite the improved prognosis of HSCT, long-term outcome may be impaired by transplant-associated morbidity and mortality. Long-term survivors can present a variety of malignant and non-malignant complications, impairing physical and psychological performance, normal integration in family and social life, and quality of life. Conditioning regimens, particularly when including total-body irradiation as well as graft-versus-host disease, play a key role in the development of late effects. However, with increasing time since transplantation new types of late effects may emerge. Awareness on long-term effects after HSCT is crucial to provide adapted pretransplant counseling, and recommendations for post-transplant screening, prevention and early treatment.
- Published
- 2009
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