467 results on '"Cherel Y"'
Search Results
452. Brief fasting decreases protein synthesis in the brain of adult rats.
- Author
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Cherel Y, Attaix D, Rosolowska-Huszcz D, Arnal M, and Le Maho Y
- Subjects
- Animals, Body Weight, Male, Nerve Tissue Proteins genetics, RNA genetics, RNA metabolism, Rats, Rats, Inbred Strains, Starvation physiopathology, Tritium, Valine metabolism, Brain metabolism, Fasting physiology, Nerve Tissue Proteins biosynthesis
- Abstract
The influence of starvation on protein synthesis in the adult rat brain was studied in vivo by an intravenous injection of a flooding dose of unlabeled valine including a tracer dose of L-[3,4(n)-3H]valine. Brief starvation (24 hours) induced a 20% decline in fractional and absolute rates of brain protein synthesis. This decline resulted from a 20% decrease in the efficiency of protein synthesis (microgram protein synthesized per day per microgram RNA) whereas the capacity for protein synthesis (microgram RNA per mg protein) was maintained. Prolonged starvation (5 days) was marked by no further significant changes in the fractional rate, absolute rate and efficiency of protein synthesis, whereas the capacity for protein synthesis decreased slightly. The relative contribution of brain to whole-body protein synthesis increased during fasting, and neither the protein nor the RNA brain content did change during the experiment. These results clearly indicate that brain proteins are spared in response to brief and prolonged food deprivation, and that brain protein synthesis is very sensitive to short-term fasting.
- Published
- 1991
- Full Text
- View/download PDF
453. Refeeding after the late increase in nitrogen excretion during prolonged fasting in the rat.
- Author
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Cherel Y and Le Maho Y
- Subjects
- Animals, Circadian Rhythm physiology, Drinking physiology, Lipid Mobilization physiology, Male, Motor Activity physiology, Rats, Rats, Inbred Strains, Eating physiology, Fasting physiology, Nitrogen urine, Proteins metabolism
- Abstract
Recovery of body mass, food intake and body composition was studied in the laboratory rat after the late increase in nitrogen excretion that characterizes prolonged fasting in mammals and birds. The rats lost 43% of their body mass during 13 days of food deprivation. They all regained their prefasting body mass within a shorter period of 11 days of refeeding. These results confirm that the late increase in nitrogen excretion in rats, as in spontaneously fasting birds, is reversible and is a part of the physiological adaptations to long-term food deprivation. Water intake of the rats continuously decreased during fasting, and the animals virtually stopped drinking as protein utilization increased. On refeeding, changes in water intake paralleled those in food intake. The refed rats progressively increased their daily food intake, that was always higher than the prefasting value (8.0-10.4 vs. 6.7% of body mass). The comparison of organ weights between fed and ad lib refed rats of similar body weight indicates that muscle mass was regained earlier than body fat during refeeding. The laboratory rat therefore appears to be a good experimental model to investigate the metabolic and behavioural changes that occur during spontaneous anorexia and refeeding in wild animals.
- Published
- 1991
- Full Text
- View/download PDF
454. Late clinical expression of lameness related to associated osteomyelitis and tibial dyschondroplasia in male breeding turkeys.
- Author
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Wyers M, Cherel Y, and Plassiart G
- Subjects
- Animals, Disease Outbreaks veterinary, Lameness, Animal epidemiology, Male, Osteochondrodysplasias complications, Osteochondrodysplasias epidemiology, Osteomyelitis complications, Osteomyelitis epidemiology, Osteomyelitis etiology, Poultry Diseases epidemiology, Stress, Physiological complications, Stress, Physiological etiology, Stress, Physiological veterinary, Tibia pathology, Transportation, Lameness, Animal etiology, Osteochondrodysplasias veterinary, Osteomyelitis veterinary, Poultry Diseases etiology, Turkeys
- Abstract
A sudden outbreak of lameness related to transport stress is described in a flock of male breeding turkeys. Most of the affected turkeys exhibited obvious unilateral leg disorders. All were affected with tibial or metatarsal dyschondroplasia with at least one lesion associated with a large focus of necrosis. By histological examinations, bone lesions showed the typical feature of osteomyelitis. The inflammatory bone lesions appeared at only single isolated sites and were always associated with obvious sequestra of dyschondroplastic retained cartilage. Osteomyelitis seems to be an unexpected acute complication of previous dyschondroplasia in relation with different breeding stress situations. The resulting pain of the associated lesions could be the main cause of clinical expression of lameness. The pathogenesis of the phenomenon remains uncertain.
- Published
- 1991
455. [Tibial dyschondroplasia in meat turkeys: morphometric study of its relationship with lameness].
- Author
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Cherel Y, Wyers M, and Evain L
- Subjects
- Animals, Male, Osteochondrodysplasias pathology, Tarsus, Animal pathology, Lameness, Animal pathology, Osteochondrodysplasias veterinary, Poultry Diseases pathology, Tibia pathology, Turkeys
- Abstract
The tibiotarsal bones from 1,084 15-week-old growing commercial male turkeys, half of which clinically lame, were examined for dyschondroplasia. Lesions were a cone of retained cartilage, confined to the postero-medial area of the proximal metaphysis of the tibiotarsus. Dense woven bone was present around the largest lesions associated with thickening of the diaphyseal cortex below the lesion. Length of abnormal cartilage varied from 0.1 cm to 5.3 cm. Width never exceeded 2.9 cm. Half of the affected turkeys showed unilateral localization of dyschondroplastic lesions. The percentage of damaged tibias was 54 per cent and the percentage of affected turkeys was more than 70 per cent. The incidence of dyschondroplasia was the same in lame and clinically healthy turkeys but, on average, lame turkeys exhibited longer lesions than clinically normal birds. The tibias of lame turkeys were more curved than the tibias of healthy ones as well in the anterio-posterior projection as in the latero-medial one. The latero-medial projection of incurvation was correlated with the length of dyschondroplastic lesions.
- Published
- 1990
456. Plasma hormone levels in relation to lipid and protein metabolism during prolonged fasting in king penguin chicks.
- Author
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Le Ninan F, Cherel Y, Sardet C, and Le Maho Y
- Subjects
- Animals, Blood Proteins metabolism, Glucagon blood, Insulin blood, Lipids blood, Time Factors, Birds metabolism, Corticosterone blood, Fasting, Lipid Mobilization, Pancreatic Hormones blood, Proteins metabolism
- Abstract
Chicks of king penguin (Aptenodytes patagonica), while only 3-4 months old, tolerate 4-6 months of fasting when they are abandoned by their parents during the subantarctic winter. The body mass of nine chicks, which were followed during this natural winter fast, was 13.1 kg at capture and 3.4 kg after 150 days of fasting, a 74% decrease. The longer phase II (129 days) was marked by lipid mobilization and protein sparing, as indicated by a continuous increase in plasma levels of free fatty acids, glycerol, and beta-hydroxybutyrate, whereas plasma alanine, uric acid, and urea remained stable at low values. In phase III, by contrast, plasma concentrations of lipid-derived metabolites decreased, while plasma alanine, uric acid, and urea increased markedly, indicating an increase in protein utilization. Plasma insulin concentration did not significantly change during either phase II or phase III. Plasma glucagon remained constant during phase II and at the beginning of phase III but increased 2.6 times afterward. Plasma corticosterone increased only slightly during the first 4 months of the fast but reached very high values at the end of phase II and the beginning of phase III (4.7 times basal values); moreover, it further increased 3.1 times before phase III was stopped. Altogether, these data accord with the idea that the outstanding resistance of king penguin chicks to starvation is due to the ability to extensively prolong the situation of protein sparing, which seems to require the maintenance of low plasma concentrations of corticosterone and insulin for up to 4 months.(ABSTRACT TRUNCATED AT 250 WORDS)
- Published
- 1988
- Full Text
- View/download PDF
457. Fasting in king penguin. I. Hormonal and metabolic changes during breeding.
- Author
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Cherel Y, Robin JP, Walch O, Karmann H, Netchitailo P, and Le Maho Y
- Subjects
- Aldosterone blood, Animals, Birds blood, Blood Proteins metabolism, Body Composition, Corticosterone blood, Glucagon blood, Hematocrit, Homeostasis, Insulin blood, Lipids blood, Thyroid Hormones blood, Birds physiology, Fasting, Hormones blood, Reproduction
- Abstract
During long-term fasting in birds and mammals, protein utilization initially decreases (phase I), is thereafter maintained at a low value (phase II), and then further increases (phase III). To delineate hormonal and biochemical changes responsible for these modifications, the effect of food deprivation for 50 days was studied in 6 male king penguins captured at the beginning of their natural breeding fast. During phase II, both rate of mass loss and plasma uric acid concentration remained at low levels, whereas plasma beta-hydroxybutyrate concentration increased. In phase III there was by contrast a 2.5-fold increase in the rate of mass loss, an eightfold increase in plasma uric acid, and an 80% drop in plasma beta-hydroxybutyrate. Plasma corticosterone was low and steady in phase II and increased three times in phase III. During the overall fast, there were no significant variations in plasma insulin, but there was a fourfold increase in plasma glucagon and a decrease in plasma thyroxine and triiodothyronine. These findings suggest that protein sparing (phase II) requires low levels of corticosterone, insulin, and thyroid hormones, whereas the further increase in protein utilization (phase III) is due to an increase in plasma corticosterone. The high plasma glucagon concentration in phase III is presumably responsible for a transient increase in plasma glucose observed at this stage; such increase in glucagon could enhance gluconeogenesis from amino acids.
- Published
- 1988
- Full Text
- View/download PDF
458. Development of sensitivity to cAMP-inducing hormones in the rat stomach.
- Author
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Gespach C, Cherel Y, and Rosselin G
- Subjects
- Animals, Cimetidine pharmacology, Female, Gastric Mucosa drug effects, Male, Rats, Rats, Inbred Strains, Receptors, Cyclic AMP drug effects, Receptors, Histamine H2 drug effects, Receptors, Histamine H2 metabolism, Somatostatin pharmacology, Stimulation, Chemical, Vasoactive Intestinal Peptide pharmacology, Weaning, Cyclic AMP metabolism, Gastric Mucosa metabolism, Glucagon pharmacology, Histamine pharmacology, Receptors, Cyclic AMP metabolism, Secretin pharmacology
- Abstract
Development of cAMP responses to secretin, pancreatic glucagon, and histamine was measured in gastric glands of fetal (day 20), postnatal (days 1-30), and adult rats (day 65). cAMP stimulation by these hormones was already detected on day 20 of gestation. cAMP generation showed biphasic variations during the 1st days of life and at the onset of weaning (day 20). Anticipated weaning at day 14 triggered precocious maturation (efficacies) of the cAMP-generating systems sensitive to secretin, glucagon, and histamine without changing the potencies of the hormones. During development, the general characteristics (potency and pharmacological or regulatory properties) of the receptor-cAMP systems studied were comparable with those evidenced in adult rats. At days 5, 20, and 65, vasoactive intestinal peptide and the peptide having N-terminal histidine and C-terminal isoleucine amide (PHI) were about 100 times less potent than secretin (EC50 = 1.5 X 10(-9) M secretin). The histamine action could be blocked by the competitive H2-receptor antagonist cimetidine (70-100% inhibition) as well as by the noncompetitive inhibitor somatostatin (37-62% inhibition). The data indicate that these regulatory hormones (secretin, glucagon(s), histamine, and somatostatin) might have a direct effect on gastric glands and may modulate their biological activities (metabolism, differentiation, proliferation, and exocrine and endocrine secretions) from the neonatal period in rats. The important physiological role of weaning on the final maturation of the cAMP-generating systems in rat gastric glands is underlined.
- Published
- 1984
- Full Text
- View/download PDF
459. [Ontogenesis of the production of cyclic AMP mediated by histamine H2 receptors in glands isolated from gastric mucosa of the rat].
- Author
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Cherel Y, Gespach C, and Rosselin G
- Subjects
- Aging, Animals, Histamine pharmacology, Rats, Rats, Inbred Strains, Time Factors, Cyclic AMP biosynthesis, Gastric Mucosa metabolism, Receptors, Histamine physiology, Receptors, Histamine H2 physiology
- Published
- 1981
460. In vivo glucose utilization in rat tissues during the three phases of starvation.
- Author
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Cherel Y, Burnol AF, Leturque A, and Le Maho Y
- Subjects
- Adipose Tissue metabolism, Animals, Blood Glucose metabolism, Body Weight, Brain metabolism, Carbon Radioisotopes, Male, Muscles metabolism, Myocardium metabolism, Organ Specificity, Rats, Rats, Inbred Strains, Reference Values, Skin metabolism, Time Factors, Glucose metabolism, Starvation
- Abstract
Three phases of starvation have been described from changes in protein and lipid utilization in birds and mammals. In the present study, tissue glucose utilization was measured in vivo during these three phases, using a 2-deoxy-[1-3H]glucose technique in the anesthetized rat. According to this technique, the term glucose utilization therefore refers to transport and phosphorylation of glucose in tissues, ie, whatever is the fate of glucose. Whole-body glucose turnover rate, which was determined by a continuous infusion of [3-3H]glucose, decreased by 40% during the first two days of starvation (phase 1); it did not change thereafter, neither in the protein-sparing phase 2 nor in phase 3, which is marked by an increase in net protein breakdown. Two days of starvation caused a marked decrease in the glucose utilization in skeletal muscles; this decrease was higher in oxidative muscles (65% in diaphragm, 66% in soleus) than in glycolytic muscles (31% in extensor digitorum longus, 34% in epitrochlearis). Glucose utilization also decreased in heart atria (75%), heart ventricles (93%), and white adipose tissue (54%); by contrast, there was a two-fold increase in glucose utilization in brown adipose tissue and no change in brain and skin. No variations were observed in glucose utilization in any of the tissues from phase 1 to phase 2. However, phase 3 was marked by a decrease in glucose utilization in extensor digitorum longus (45%), brown adipose tissue (76%), brain (29%), and skin (40%), whereas there was a 2.3- and 3.4-fold increase in glucose utilization in diaphragm and heart ventricles, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
- Published
- 1988
- Full Text
- View/download PDF
461. [Augmentation of nitrogen efficiency and hyperphagia associated with refeeding after prolonged fast in the domestic goose].
- Author
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Robin JP, Cherel Y, Girard H, Chaban C, and Le Maho Y
- Subjects
- Animals, Body Weight, Energy Intake, Kinetics, Male, Nitrogen Fixation, Proteins metabolism, Eating, Fasting, Food, Geese physiology, Nitrogen metabolism
- Abstract
The domestic goose is hyperphagic after a fast resulting in a 40% decrease in body mass (a decrease similar to that during breeding anorexia). Food intake is maximum on the 8th day of refeeding. As it is then an average of 2.5 times higher than before the fast, food intake may thus reach the value during forced-feeding for "foie gras". Since nitrogen assimilation rate also increases 2.5 times, nitrogen fixation is increased 6.8 times, suggesting a high level of protein synthesis.
- Published
- 1988
462. Fasting in king penguin. II. Hormonal and metabolic changes during molt.
- Author
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Cherel Y, Leloup J, and Le Maho Y
- Subjects
- Aldosterone blood, Animals, Body Composition, Corticosterone blood, Feathers, Glucagon blood, Hematocrit, Insulin blood, Reference Values, Thyroid Hormones blood, Birds physiology, Fasting, Hormones blood
- Abstract
The coincidence of fast and molt in penguins is an interesting condition for investigating the factors controlling protein metabolism; avian molt involves the utilization of amino acids for synthesis of new feathers, whereas a major factor for adaptation to fasting in birds, as for mammals, is reduction in net protein breakdown. Hormonal and biochemical changes were studied in seven molting king penguins. Their initial body mass was 18 kg. It decreased by 58% over 41 days of fasting. Feather synthesis lasted for the first 3 wk of the fast. It was marked by plasma concentrations of alanine and uric acid 1.5 to 2 times those for nonmolting fast, and plasma thyroxine was increased five times. At the completion of molt all these values returned to levels comparable to those in nonmolting fast. As indicated by high plasma levels of beta-hydroxybutyrate, lipid stores were mobilized readily during molting. The fast ended by a phase of enhancement in protein utilization that was characterized by a fivefold increase in uricacidemia and coincided with an 80% drop in plasma beta-hydroxybutyrate and a fourfold increase in plasma corticosterone. These data suggest that two different hormones control the two successive periods marked by an increased protein mobilization during the molting fast, i.e., thyroxine during feather growth and corticosterone toward the end of the fast, when the molt is completed.
- Published
- 1988
- Full Text
- View/download PDF
463. [Metabolic study of the initial period of fasting in the king penguin chick].
- Author
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Cherel Y and Le Maho Y
- Subjects
- 3-Hydroxybutyric Acid, Alanine blood, Animals, Birds growth & development, Blood Glucose analysis, Body Weight, Hibernation, Hydroxybutyrates blood, Lipid Metabolism, Proteins metabolism, Time Factors, Uric Acid blood, Adaptation, Physiological, Birds metabolism, Fasting
- Abstract
There is an 80% decrease in the specific daily change in body mass (dm/m dt) during the first 5-6 days of fasting in king penguin chicks, which characterizes period I of fasting. Parallel decreases in plasma alanine and uric acid concentrations suggest an important reduction in protein degradation. Plasma concentration of beta-hydroxybutyrate and glucose are high, respectively 1.3 and 12.5 mmol X 1(-1), and do not change significantly.
- Published
- 1985
464. Ambient temperature and ketone body plasma concentration in fasting geese.
- Author
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Cherel Y, Robin JP, Nehlig A, Girard H, Lacombe A, Frain M, and Le Maho Y
- Subjects
- 3-Hydroxybutyric Acid, Acetoacetates blood, Animals, Geese, Hydroxybutyrates blood, Male, Proteins metabolism, Time Factors, Cold Temperature, Fasting, Ketone Bodies blood
- Abstract
The effect on ketonemia of alternate exposure to ambient temperatures (Ta) of 25 and 5 degrees C was investigated in fasting geese. Three experimental birds were compared to three controls continuously exposed to 25 degrees C Ta while fasting. During the first 9 days of fasting, when both groups were exposed to 25 degrees C, plasma concentration of beta-hydroxybutyrate (beta-OHB) increased similarly in both, from 0.10 +/- 0.02 to 6.62 +/- 0.71 mmol X L-1. It later plateaued at 8-9 mmol X L-1 in the control birds. When the experimental birds were exposed to 5 degrees C Ta between the 9th and 15th day of the fast, it increased further during the first 24 h but thereafter decreased of 57%, from 8.62 +/- 1.56 to 3.73 +/- 1.24 mmol X L-1. This decrease was reversed within the 6 days of return to 25 degrees C Ta. In both groups, plasma acetoacetate (AcAc) concentration remained very low during the fast: 51 +/- 1 mumol X L-1. This reversible cold-induced effect on ketonemia may be used for investigating the possible role of ketone bodies in protein sparing during fasting.
- Published
- 1986
- Full Text
- View/download PDF
465. Early changes in plasma hormones and metabolites during fasting in king penguin chicks.
- Author
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Le Ninan F, Cherel Y, Robin JP, Leloup J, and Le Maho Y
- Subjects
- Animals, Animals, Newborn blood, Birds blood, Blood Glucose analysis, Corticosterone blood, Lipids blood, Nitrogen metabolism, Pancreatic Hormones blood, Thyroid Hormones blood, Weight Loss, Animals, Newborn metabolism, Birds metabolism, Fasting, Hormones blood
- Abstract
Chicks of the king penguin (Aptenodytes patagonica) can tolerate a fast of 4-6 months during the subantarctic winter. The aim of this work was to study their initial response to food deprivation. Nine chicks were starved for 18 days. Two phases of starvation were defined according to changes in the specific daily loss in body mass: it decreased by 92% in phase I (6.6 +/- 0.3 days) and remained steady and low in phase II. Phase I was marked by a large decline in protein utilization, indicated by decreases in plasma levels of alanine (58%), uric acid (89%) and urea (76%) together with a decrease in circulating corticosterone (60%) and thyroxine (75%). In phase I, plasma insulin concentration decreased (61%) in some birds, but did not change in others; plasma pancreatic glucagon was stable whereas gut-glucagon decreased by 75%. Free fatty acids and beta-hydroxybutyrate concentrations gradually rose during the fast to 5 to 6 times pre-fast levels. Glycemia remained unchanged. Phase II was characterized by no change in plasma concentrations of protein-derived metabolites and by no or little change in circulating hormone levels. From comparison with previous data, we conclude that there are similar early adjustments to food deprivation in king penguin chick, rat and man: (1) a decrease in resting metabolic rate, (2) a decrease in protein utilization, and (3) mobilization of fat stores. The key adaptations to long-term fasting in these species are therefore effectiveness in protein sparing and ability to prolong this situation.(ABSTRACT TRUNCATED AT 250 WORDS)
- Published
- 1988
- Full Text
- View/download PDF
466. Five months of fasting in king penguin chicks: body mass loss and fuel metabolism.
- Author
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Cherel Y and Le Maho Y
- Subjects
- 3-Hydroxybutyric Acid, Alanine blood, Animals, Blood Glucose metabolism, Body Composition, Body Weight, Fasting, Fatty Acids, Nonesterified blood, Glycerol blood, Hematocrit, Hydroxybutyrates blood, Proteins metabolism, Time Factors, Urea blood, Uric Acid blood, Adaptation, Physiological, Birds metabolism, Starvation metabolism
- Abstract
When king penguin chicks are 3-4 mo old, they enter a season of interrupted growth due to long periods of fasting, because they are irregularly fed in winter. Nine captive chicks [mean initial body mass (m) = 12.5 kg] had fasted an average of 5 mo at the end of the experiment; m was then 4.0 kg, a 68% decrease. They probably could have fasted longer, since chicks of parents delayed in the return to the colony die from starvation at an m of 3.0 kg. The long fast could be divided into three periods based on the changes in rate of decrease of m. The remarkable resistance of king penguin chicks to starvation may be partly explained by their ability to maintain protein sparing for as much as 4 mo, the duration of period II; plasma concentrations of uric acid, urea, and alanine were then minimum, 0.1, 0.4, and 0.4 mmol X l-1 respectively. Particular changes during this period, i.e., progressive increase of beta-hydroxybutyrate and decrease of glucose concentrations, might contribute to the efficiency of protein sparing. Period III was marked by a rise in protein utilization, plasma concentrations of uric acid, urea, and alanine increasing to 0.7, 1.5, and 0.8 mmol X l-1, respectively.
- Published
- 1985
- Full Text
- View/download PDF
467. Uric acid and urea in relation to protein catabolism in long-term fasting geese.
- Author
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Robin JP, Cherel Y, Girard H, Géloen A, and Le Maho Y
- Subjects
- Ammonia metabolism, Animals, Body Weight, Female, Kinetics, Male, Nitrogen metabolism, Fasting, Geese metabolism, Proteins metabolism, Urea metabolism, Uric Acid metabolism
- Abstract
Five ganders were subjected to an experimental fast comparable to that which spontaneously occurs during breeding in domestic geese, and during migration and breeding in various wild birds. Plasma uric acid and urea concentrations, and their excretion as a proportion of total nitrogen excretion, were studied in relation to daily change in body mass per unit body mass, mg/mdt. This variable has previously been found to reflect changes in protein catabolism over the three phases of fast: I, dm/mdt and protein utilization both decrease; II, they are maintained at a low value; and III, they increase. In the fed state, daily total nitrogen excretion was 5 gN X 24 h-1; uric acid, ammonia and urea accounted for 51, 15 and 5% respectively. The high remaining proportion of excreted nitrogen (29%), after subtraction of uric acid-N, ammonia-N and urea-N to total nitrogen, accords with the literature. During fasting, the changes in daily excretion of uric acid, urea, ammonia and total nitrogen followed a pattern essentially similar to that for dm/mdt. Uric acid accounted for a progressively increasing fraction of total nitrogen, up to 76% at the end of phase III, while urea remained at a constant 5%. Plasma concentrations of both uric acid and urea followed similar trends during the fast, in particular both increasing during phase III, i.e. when there was a rise in nitrogen excretion. This suggests they could be used as an index in field investigations, to determine whether birds which naturally fast in connection with specific activities have entered into the situation where proteins are no longer spared.
- Published
- 1987
- Full Text
- View/download PDF
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