Search

The production of Σ 0 hyperons in proton proton collisions at a beam kinetic energy of 3.5 GeV impinging on a liquid hydrogen target was investigated using data collected with the HADES setup. The total production cross section is found to be σ (p K + Σ 0) = 17.7 ± 1.7 (s t a t) ± 1.6 (s y s t) µb. Differential cross section distributions of the exclusive channel p p → p K + Σ 0 were analyzed in the center-of-mass, Gottfried–Jackson and helicity reference frames for the first time at the excess energy of 556 MeV. The data support the interplay between pion and kaon exchange mechanisms and clearly demonstrate the contribution of interfering nucleon resonances decaying to K + Σ 0 . The Bonn–Gatchina partial wave analysis was employed to analyse the data. Due to the limited statistics, it was not possible to obtain an unambiguous determination of the relative contribution of intermediate nucleon resonances to the final state. However nucleon resonances with masses around 1.710 GeV / c 2 ( N ∗ (1710) ) and 1.900 GeV / c 2 ( N ∗ (1900) or Δ ∗ (1900) ) are preferred by the fit. [ABSTRACT FROM AUTHOR]

High-precision measurements of flow coefficients v n ( n = 1 - 4 ) for protons, deuterons and tritons relative to the first-order spectator plane have been performed in Au+Au collisions at s NN = 2.4 GeV with the High-Acceptance Di-Electron Spectrometer (HADES) at the SIS18/GSI. Flow coefficients are studied as a function of transverse momentum p t and rapidity y cm over a large region of phase-space and for several classes of collision centrality. A clear mass hierarchy, as expected by relativistic hydrodynamics, is found for the slope of v 1 , d v 1 / d y ′ | y ′ = 0 where y ′ is the scaled rapidity, and for v 2 at mid-rapidity. Scaling with the number of nucleons is observed for the p t dependence of v 2 and v 4 at mid-rapidity, which is indicative for nuclear coalescence as the main process responsible for light nuclei formation. v 2 is found to scale with the initial eccentricity ⟨ ϵ 2 ⟩ , while v 4 scales with ⟨ ϵ 2 ⟩ 2 and ⟨ ϵ 4 ⟩ . The multi-differential high-precision data on v 1 , v 2 , v 3 , and v 4 provides important constraints on the equation-of-state of compressed baryonic matter. [ABSTRACT FROM AUTHOR]

A feasibility study has been performed in order to investigate the performance of the HADES detector to measure the electromagnetic decays of the hyperon resonances Σ (1385) 0 , Λ (1405) and Λ (1520) as well as the production of double strange baryon systems Ξ - and Λ Λ in p + p reactions at a beam kinetic energy of 4.5 GeV . The existing HADES detector will be upgraded by a new Forward Detector, which extends the detector acceptance into a range of polar angles that plays a crucial role for these investigations. The analysis of each channel is preceded by a consideration of the production cross-sections. Afterwards the expected signal count rates using a target consisting of either liquid hydrogen or polyethylene are summarized. [ABSTRACT FROM AUTHOR]

We present results on the K*(892)+ production in proton-proton collisions at a beam energy of E = 3.5 GeV, which is hitherto the lowest energy at which this mesonic resonance has been observed in nucleon-nucleon reactions. The data are interpreted within a two-channel model that includes the 3-body production of K*(892)+ associated with the Lambda- or Sigma-hyperon. The relative contributions of both channels are estimated. Besides the total cross section sigma(p+p→K*(892)++X) = 9.5 +- 0.9 +1.1-0.9±0.7 μub, that adds a new data point to the excitation function of the K*(892)+ production in the region of low excess energy, transverse momenta and angular spectra are extracted and compared with the predictions of the two-channel model. The spin characteristics of K*(892)+ are discussed as well in terms of the spin-alignment. [ABSTRACT FROM AUTHOR]

Results on the production of the double strange cascade hyperon ΞH- are reported for collisions of p(3.5 GeV) + Nb, studied with the High Acceptance Di-Electron Spectrometer (HADES) at SIS18 at GSI Helmholtzzentrum for Heavy-Ion Research, Darmstadt. For the first time, subthreshold Ξ- production is observed in proton-nucleus interactions. Assuming a Ξ- phase-space distribution similar to that of Λ hyperons, the production probability amounts to PΞ- = [2.0 ± 0.4(stat) ± 0.3(norm) ± 0.6(syst)] × 10-4 resulting in a Ξ- / (Λ + Σ0) ratio of PΞ- / PΛ+Σ0 = [1.2 ± 0.3(stat) ± 0.4(syst)] × 10-2. Available model predictions are significantly lower than the measured Ξ- yield. [ABSTRACT FROM AUTHOR]

Employing the Bonn–Gatchina partial wave analysis framework (PWA), we have analyzed HADES data of the reaction p ( 3.5 GeV ) + p → p K + Λ . This reaction might contain information about the kaonic cluster “ p p K − ” (with quantum numbers J P = 0 − and total isospin I = 1 / 2 ) via its decay into pΛ . Due to interference effects in our coherent description of the data, a hypothetical K ¯ N N (or, specifically “ p p K − ”) cluster signal need not necessarily show up as a pronounced feature (e.g. a peak) in an invariant mass spectrum like pΛ . Our PWA analysis includes a variety of resonant and non-resonant intermediate states and delivers a good description of our data (various angular distributions and two-hadron invariant mass spectra) without a contribution of a K ¯ N N cluster. At a confidence level of CL s = 95 % such a cluster cannot contribute more than 2–12% to the total cross section with a p K + Λ final state, which translates into a production cross-section between 0.7 μb and 4.2 μb, respectively. The range of the upper limit depends on the assumed cluster mass, width and production process. [ABSTRACT FROM AUTHOR]

An exclusive analysis of the four-body final states +p+p++Ko and So+p+p++Ko measured with HADES for p+p collisions at a beam kinetic energy of 3.5 GeV is presented. The analysis uses various phase space variables, such as missing mass and invariant mass distributions, in the four-particle event selection (p,p+,p+,p-) to find cross sections of the different production channels, contributions of the intermediate resonances ++ and S(1385)+, and corresponding angular distributions. A dominant resonant production is seen, where the reaction ++++K0 has a cross section about ten times higher (29.45±0.08+1.67-1.46±2.06µb) than the analogous nonresonant reaction (2.57±0.02+0.21-1.98±0.18µb). A similar result is obtained in the corresponding S0 channels with 9.26±0.05+1.41-0.31±0.65µb in the resonant and 1.35±0.02+0.10-1.35±0.09µb in the nonresonant reactions [ABSTRACT FROM AUTHOR]

Abstract: We present a search for the decay of a hypothetical dark photon, also named U vector boson, in inclusive dielectron spectra measured by HADES in the p(3.5 GeV) + p, Nb reactions, as well as the Ar ( ) + KCl reaction. An upper limit on the kinetic mixing parameter squared at 90% CL has been obtained for the mass range and is compared with the present world data set. For masses , the limit has been lowered with respect to previous results, allowing now to exclude a large part of the parameter region favored by the muon anomaly. Furthermore, an improved upper limit on the branching ratio of has been set on the helicity-suppressed direct decay of the eta meson, , at 90% CL. [Copyright &y& Elsevier]

Abstract: The reaction can be studied to search for the existence of kaonic bound states like leading to this final state. This effort has been motivated by the assumption that in collisions the resonance can act as a doorway to the formation of the kaonic bound states. The status of this analysis within the HADES Collaboration, with particular emphasis on the comparison to simulations, is shown in this work and the deviation method utilized by the DISTO Collaboration in a similar analysis is discussed. The outcome suggests the employment of a partial wave analysis do disentangle the different contributions to the measured final state. [Copyright &y& Elsevier]

With the HADES spectrometer at GSI we have studied dilepton production in various collision systems from elementary N+N, over p+A, up to the medium-heavy Ar+KCl system. We have confirmed the puzzling results of the former DLS collaboration at the Bevalac. While we have traced the origin of the excess pair yield in C+C collisions to elementary p+p and n+p processes, we find a significant contribution from the dense phase of the collision in larger Ar+KCl system. From recently obtained e+e- pair spectra in p+p and p+Nb interactions at 3.5 GeV kinetic beam energy the inclusive production cross sections for neutral pions, η , ω and ρ mesons are extracted for the first time at this beam energy. Furthermore, the production mechanisms of the vector mesons, which are not known at these energies, are investigated. The direct comparison of p+p and p+Nb data allows us to investigate in-medium mass modifications of vector mesons at nuclear ground state density. On the other hand, exclusive production of ω and η mesons in p+p reactions at 3.5 GeV were studied via their π+π-π0 decay channel. Production cross sections and angular distributions for both states were determined. [ABSTRACT FROM AUTHOR]

Abstract: One of the main goals of the HADES experiment is to achieve a detailed understanding of dielectron emission from hadronic systems at moderate bombarding energies. Results obtained on electron pair production in elementary N+N collisions pave the way to a better understanding of the origin of the pair excess seen in heavy-ion collisions. This puzzling excess, reported first by the former DLS experiment, is now being investigated systematically by HADES. [Copyright &y& Elsevier]

Flow coefficients v_{n} of the orders n=1-6 are measured with the High-Acceptance DiElectron Spectrometer (HADES) at GSI for protons, deuterons, and tritons as a function of centrality, transverse momentum, and rapidity in Au+Au collisions at sqrt[s_{NN}]=2.4  GeV. Combining the information from the flow coefficients of all orders allows us to construct for the first time, at collision energies of a few GeV, a multidifferential picture of the angular emission pattern of these particles. It reflects the complicated interplay between the effect of the central fireball pressure on the emission of particles and their subsequent interaction with spectator matter. The high precision information on higher order flow coefficients is a major step forward in constraining the equation of state of dense baryonic matter.

Background: Modified Lapidus arthrodesis (MLA) is a well-established treatment modality for hallux valgus deformities (HVD) associated with instability of the first ray. Although the three-dimensional (3D) nature of HVD has long been recognized, diagnostics still focus on plain radiographs. The objective of this study was to validate 3D Cone Beam CT (CBCT) in the perioperative assessment of HVD with focus on the alignment of the forefoot., Methods: In a prospective clinical study, MLA was performed on 30 patients (25 females, 5 males; mean age: 63.2 years). Pre- and postoperatively standard radiographs and CBCT with full weight-bearing were acquired. For the CBCT based assessment, reproducible criteria have been defined, measured, and correlated with established radiological indicators., Results: Evaluation of standard radiographic parameters (hallux-valgus angle [HVA], intermetatarsal angle 1-2 [IMA 1-2], distal metatarsal articular angle [DMAA], tibial sesamoid position [TSP]) showed significant improvement postoperatively. Comparison of measurements obtained from plain radiographs and CBCT were significantly correlated between both measuring techniques, indicating high reliability. Pronation of the first metatarsal and the sesamoids were significantly reduced by the procedure. Due to this repositioning effect, the second metatarsal head was elevated by 3.1mm, and the lateral sesamoid was lowered by 3.8mm. However, there was no correlation between the amount of pronation and conventional radiographic measures., Conclusions: Compared to plain radiographs, CBCT allows a more detailed view of the forefoot alignment in the coronal plain after MLA. MLA was able to recenter the sesamoids under der first metatarsal head and conversely led to elevation of the second metatarsal head., (Copyright © 2019 European Foot and Ankle Society. Published by Elsevier Ltd. All rights reserved.)

We present the first observation of K^{-} and ϕ absorption within nuclear matter by means of π^{-}-induced reactions on C and W targets at an incident beam momentum of 1.7  GeV/c studied with HADES at SIS18/GSI. The double ratio (K^{-}/K^{+})_{W}/(K^{-}/K^{+})_{C} is found to be 0.319±0.009(stat)_{-0.012}^{+0.014}(syst) indicating a larger absorption of K^{-} in heavier targets as compared to lighter ones. The measured ϕ/K^{-} ratios in π^{-}+C and π^{-}+W reactions within the HADES acceptance are found to be equal to 0.55±0.04(stat)_{-0.07}^{+0.06}(syst) and to 0.63±0.06(stat)_{-0.11}^{+0.11}(syst), respectively. The similar ratios measured in the two different reactions demonstrate for the first time experimentally that the dynamics of the ϕ meson in nuclear medium is strongly coupled to the K^{-} dynamics. The large difference in the ϕ production off C and W nuclei is discussed in terms of a strong ϕN in-medium coupling. These results are relevant for the description of heavy-ion collisions and the structure of neutron stars.

- Luminal B (HER2 negative) subtype is the most diversiform type of breast cancers, with a high Ki-67 proliferation index (>20%) or/and low progesterone (PR; <20%) with various intensity and distribution of hormone receptors. Considerable difference has also been noticed in disease outcome, wherefore there is the need for a more detailed classification of this tumor subtype. The clinical and pathologic parameters of 147 luminal B (HER2 negative) breast cancers were examined. The expression of hormone receptors in correlation with other prognostic factors and disease outcome was analyzed by Kaplan-Meier curves and multivariate Cox regression analysis. The Kaplan-Mayer analysis showed that low positivity of estrogen (ER) and PR receptors in tumors was associated with a significantly worse disease outcome (overall survival (ER), p=0.020; disease free survival (ER), p=0.019; overall survival (PR), p=0.026; disease free survival (PR), p=0.038)), unlike Ki-67, which did not show a statistically significant connection (overall survival, p=0.343; disease free survival, p=0.322). The intensity of receptor staining and Ki-67 relative to other histopathologic prognostic factors showed a statistically significant correlation solely with histologic grade of tumor. By using the Cox regression model, PR proved to be an independent prognostic factor for overall survival (p=0.004) and disease free survival (p=0.029). The luminal B (HER2 negative) breast cancer with low expression of hormone receptors, independent of the Ki-67 proliferation index, and in correlation with a higher histologic grade, could be a unique subtype of cancer.

Nectins are Ca2 + -independent immunoglobulin (Ig) superfamily proteins that participate in the organization of epithelial and endothelial junctions and regulate several cellular activities including the entry of some viruses. Nectin-4 has recently been shown as a metastasis-associated protein in several cancers. In the following study, we have evaluated the expression of Nectin-4 inthe luminal B HER2 negative subtype breast cancer. The study group consisted of 147 patients presenting with primary unilateral breast carcinoma with no evidence of distant metastases. Nectin-4 protein expression was assessed by immunohistochemistry and the results were correlated with the clinical data using Kaplan-Meier curves, univariate and multivariate stepwise proportional-hazard analysis (Cox model). Nectin-4 overexpression was significantly correlated with the tumour size (p<0.05; Fisher's Exact Test), also Nectin-4 expression was negatively associated with overall survival, disease free survival and distant relapse free survival with the same significance (p<0,001; Kaplan-Meier, Cox model). We did not find statistically significant correlation between Nectin-4 and age, ER, PR, age, lymph node metastasis, tumour differentiation, histologicalsubtype and Ki-67proliferation index. We suggest that Nectin-4 is a relevant prognostic factor and a therapeutic target in luminalB (HER2 negative) breast cancer., (Copyright © 2017 Elsevier GmbH. All rights reserved.)

Results on the production of the double strange cascade hyperon Ξ^{-} are reported for collisions of p(3.5  GeV)+Nb, studied with the High Acceptance Di-Electron Spectrometer (HADES) at SIS18 at GSI Helmholtzzentrum for Heavy-Ion Research, Darmstadt. For the first time, subthreshold Ξ^{-} production is observed in proton-nucleus interactions. Assuming a Ξ^{-} phase-space distribution similar to that of Λ hyperons, the production probability amounts to P&#95;{Ξ^{-}}=[2.0±0.4(stat)±0.3(norm)±0.6(syst)]×10^{-4} resulting in a Ξ^{-}/(Λ+Σ^{0}) ratio of P&#95;{Ξ^{-}}/P&#95;{Λ+Σ^{0}}=[1.2±0.3(stat)±0.4(syst)]×10^{-2}. Available model predictions are significantly lower than the measured Ξ^{-} yield.

We have analyzed data of the DISTO experiment on the exclusive pp --> pLambdaK+ reaction at 2.85 GeV to search for a strongly bound compact K- pp(approximately = X) state to be formed in the pp --> K+ + X reaction. The observed spectra of the K+ missing mass and the pLambda invariant-mass with high transverse momenta of p and K+ revealed a broad distinct peak of 26-sigma confidence with a mass M(X)=2267+/-3(stat)+/-5(syst) MeV/c2 and a width Gamma(X)=118+/-8(stat)+/-10(syst) MeV. The enormously large cross section indicates formation of a compact K- pp with a large binding energy of B(K)=103 MeV, which can be a possible gateway toward cold and dense kaonic nuclear matter.

We report first results on a deep subthreshold production of the doubly strange hyperon Xi;{-} in a heavy-ion reaction. At a beam energy of 1.76A GeV the reaction Ar + KCl was studied with the High Acceptance Di-Electron Spectrometer at SIS18/GSI. A high-statistics and high-purity Lambda sample was collected, allowing for the investigation of the decay channel Xi;{-} --> Lambdapi;{-}. The deduced Xi;{-}/(Lambda + Sigma;{0}) production ratio of (5.6 +/- 1.2&#95;{-1.7};{+1.8}) x 10;{-3} is significantly larger than available model predictions.

The invariant-mass spectrum of e+e- pairs produced in 12C+12C collisions at an incident energy of 2 GeV per nucleon has been measured for the first time. The measured pair production probabilities span over 5 orders of magnitude from the pi(0)-Dalitz to the rho/omega invariant-mass region. Dalitz decays of pi(0) and eta account for all the yield up to 0.15 GeV/c(2), but for only about 50% above this mass. A comparison with model calculations shows that the excess pair yield is likely due to baryon-resonance and vector-meson decays. Transport calculations based on vacuum spectral functions fail, however, to describe the entire mass region.

Hsp27 is considered a potential marker for cell differentiation in diverse tissues. Several aspects linked to the differentiation process and to the transition from high to low metastatic potential were analyzed in melanoma cells transfected with Hsp27. E-cadherin plays a central role in cell differentiation, migration, and normal development. Loss of expression or function of E-cadherin has been documented in a variety of human malignancies. We observed by fluorescence-activated cell sorter (FACS) as well as immunofluorescence (IF) analysis a pronounced expression of E-cadherin in Hsp27-transfected A375 melanoma cells compared with control melanoma cells. The expression of the adhesion molecule MUC18/MCAM correlates directly with the metastatic potential of melanoma cells. In contrast to wild-type and neotransfected melanoma cells, in Hsp27-transfected cells the expression of MUC18/MCAM could not be detected by FACS and IF analysis. The plasminogen activator (PA) system plays a central role in mediating extracellular proteolysis and also in nonproteolytic events such as cell adhesion, migration, and transmembrane signaling. Hsp27 transfectants revealed elevated messenger ribonucleic acid expression of the urokinase-type PA (uPA) and its inhibitor, PA inhibitor type 1, which might indicate a neutralization effect of the proteolytic activity of uPA. Control cells failed to express both these molecules. The influence of Hsp27 expression on uPA activity and the involvement of E-cadherin could be demonstrated by use of anti-E-cadherin-blocking antibody. Our data provide evidence for an inhibitory-regulatory role of Hsp27 in tumor progression as found in our system.

Total and differential cross sections for the exclusive reaction pp-->pp rho observed via the pi(+)pi(-) decay channel have been measured at p(beam)=3.67 GeV/c. The observed total meson production cross section is determined to be (23.4+/-0.8+/-8) mu b and is significantly lower than typical cross sections used in model calculations for heavy-ion collisions. The differential cross sections measured indicate a strong anisotropy (approximately cos(theta(CM)(rho)) in the rho(0) meson production.

Overexpression of the small heat shock protein Hsp27 has been shown by us to inhibit the in vitro proliferation rate and to delay tumor development of a human melanoma cell line (A375) in nude mice. We hypothesized that Hsp27 may influence the neoplastic phenotype. In the present study Hsp27 transfectants from this cell line were analyzed for various cellular aspects associated with the metastatic process. We found that Hsp27-overexpressing clones exhibited an altered cellular morphology as compared with control transfected cells. The Hsp27-positive cells tended to develop an epithelial-like phenotype growing in clusters and were characterized by a loss of transcytoplasmic stressfibers. In parallel, Hsp27-expressing cells lost the ability to form colonies in soft agar. The invasive potential was studied in vitro by the use of a reconstituted extracellular matrix-coated filter (Matrigel). Compared with controls, Hsp27-overexpressing cells showed decreased cell invasiveness through Matrigel. A correlation between invasion and activation of matrix metalloproteinases (MMPs) has been shown in several cell models. Secretion of MMPs (MMP-2 and MMP-9) was studied by gelatin-substrate zymogram analysis, as well as by a sensitive gelatinase activity assay. The Hsp27-transfected A375 melanoma cell line showed decreased secretion of MMP-2 and MMP-9 as compared with the control transfected cells. Integrins are adhesion receptors and function in cell invasion by mediating cell movement on matrix molecules and by regulating the expression of MMPs. Both fluorescence-activated cell sorter analysis and immunofluorescence analysis revealed a loss of alpha(v)beta3 integrin in Hsp27-transfected cell colonies. Our results demonstrate that Hsp27 overexpression has a profound impact on several parameters regulating the invasive and metastatic potential of melanoma cells in vitro.

Heat shock protein hsp27 is a molecular chaperone and identification of hsp27-binding proteins might help to elucidate its functional role in keratinocyte biology. In the present investigation we used a human epidermal cell carcinoma cell line (A431) transfected with hsp27 (A431/16) to study interference between hsp27 protein and other proteins. Immunoprecipitation experiments with anti-hsp27 antibody revealed a multicomponent complex when analysed by silver staining. By immunoblotting analysis we could demonstrate that hsp27 associates with actin, the mutant form of p53, hsp70 and hsp90. Immunofluorescence analysis showed a co-localization between hsp27 and p53, hsp70 and hsp90. To control for the specificity of the observed interactions, immuno-precipitations with antibodies to actin, p53, hsp70 and hsp90 respectively, were performed. All of the tested proteins demonstrated a coimmunoprecipitation with hsp27. We conclude that hsp27, like the other heat shock proteins, is part of a complex system of molecular chaperones in epidermal keratinocytes., (Copyright 2002 Academic Press.)

Polymorphonuclear neutrophils (PMN), through their ability to release oxygen-free radicals and other tissue-damaging molecules, play a major role in the pathogenesis of multiple organ failure syndrome (MOFS). There is evidence that heat shock proteins (stress proteins; HSPs) are involved in cellular repair mechanisms, and are protecting cells against oxidative injury. In this study, we analyzed the spontaneous expression of the 72 kD HSP (HSP72) in peripheral blood PMN of 20 critically ill patients (16 polytrauma victims, four patients after major surgery) admitted to an intensive care unit. The expression of HSP72 was investigated in PMN of patients and healthy donors by immunohistochemistry. We found spontaneous expression of HSP72 in PMN of 12 (60%) of 20 patients. No specific staining was detected in PMN of healthy donors (n = 10). In PMN of six of 12 patients expressing HSP72 without previous heat treatment, we found an impairment of respiratory burst activity (RBA) compared to the control population. These results demonstrate for the first time the in vivo expression of HSP72 in human leukocytes without previous heat treatment, and suggest a possible role of this protein in patients suffering from severe tissue injury.

The influence of somatostatin on tumor cell growth was studied in vivo in mice (sarcoma 180 ascites tumor and Lewis lung tumor) and in vitro on nontransformed and polyoma-transformed cell lines. 4 or 20 micrograms/100 g of cyclic somatostatin and 4 micrograms/100 g of linear protamin Zn-bound somatostatin were injected s.c. twice daily in the in vivo study. Cyclic somatostatin (1, 4 or 10 micrograms/ml) was added twice daily to the cell cultures. Somatostatin administration influenced neither the survival of animals nor the growth rate of cultured cell lines.