551. Erythema multiforme in a patient with T cell chronic lymphocytic leukemia.
- Author
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Margolis RJ, Bhan A, Mihm MC Jr, and Bernhardt M
- Subjects
- Aged, Antibodies, Monoclonal, Erythema Multiforme complications, Erythema Multiforme pathology, Female, Fluorescent Antibody Technique, HLA-DR Antigens, Histocompatibility Antigens Class II immunology, Humans, Immunoenzyme Techniques, Leukemia, Lymphoid complications, Leukemia, Lymphoid pathology, Skin immunology, Skin pathology, T-Lymphocytes classification, Erythema Multiforme immunology, Leukemia, Lymphoid immunology, T-Lymphocytes immunology
- Abstract
A patient with T4+ (helper-inducer) T cell chronic lymphocytic leukemia developed an erythema multiforme-like eruption, the diagnosis of which was supported by routine light microscopic findings. Immunopathologic studies using monoclonal antibodies demonstrate that despite an overwhelming majority of leukemic T4+ cells in the peripheral blood and dermal infiltrate, the predominant cells in the epidermal infiltrate are T8+ (cytotoxic-suppressor) cells. These findings are different from those seen in epidermotropic T cell leukemic infiltrates and are similar to those previously reported in erythema multiforme. Thus it is likely that the leukemic T4+ cells are participating in this cutaneous hypersensitivity reaction along with residual, normal T8+ cells. more...
- Published
- 1986
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